1,252 research outputs found
The White Dwarf in EM Cygni: Beyond The Veil
We present a spectral analysis of the FUSE spectra of EM Cygni, a Z Cam DN
system. The FUSE spectrum, obtained in quiescence, consists of 4 individual
exposures (orbits): two exposures, at orbital phases phi ~ 0.65 and phi ~ 0.90,
have a lower flux; and two exposures, at orbital phases phi =0.15 and 0.45,
have a relatively higher flux. The change of flux level as a function of the
orbital phase is consistent with the stream material (flowing over and below
the disk from the hot spot region to smaller radii) partially masking the white
dwarf. We carry out a spectral analysis of the FUSE data, obtained at phase
0.45 (when the flux is maximual, using the codes TLUSTY and SYNSPEC. Using a
single white dwarf spectral component, we obtain a white dwarf temperature of
40,000K, rotating at 100km/s. The white dwarf, or conceivably, the material
overflowing the disk rim, shows suprasolar abundances of silicon, sulphur and
possibly nitrogen. Using a white dwarf+disk composite model, we obtain that the
white dwarf temperature could be even as high as 50,000K, contributing more
than 90% of the FUV flux, and the disk contributing less than 10% must have a
mass accretion rate reaching 1.E-10 Msun/yr.In both cases, however, we obtain
that the white dwarf temperature is much higher than previously estimated.Comment: accepted for publication in ApJ, 3 Tables, 12 Figures (including
color figures), 33 pages in present format (possibly 10 pages in ApJ format
Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule.
The hypoxia-inducible transcription factor (HIF) co-ordinates the response of tumours to low oxygen by stimulating genes involved in metabolism and angiogenesis. HIF pathway activation is associated with decreased progression-free survival and increased mortality; compounds that target this pathway are potential agents for the treatment of a range of solid tumour malignancies. Renal cancers are likely to be particularly sensitive to inhibition of the HIF pathway since ~80% show constitutive activation of HIF. We have previously described the di-substituted naphthalene derivative, CL67, which binds to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro. We show here that CL67 blocks HIF expression leading to inhibition of HIF-transactivation and down-regulation of downstream target genes and proteins in renal carcinoma cell lines and in a mouse xenograft model of renal cancer. This inhibition is independent of pathways that control HIF abundance through oxygen-dependant degradation and oxygen dependant HIF sub-unit expression
On the segmentation of astronomical images via level-set methods
Astronomical images are of crucial importance for astronomers since they
contain a lot of information about celestial bodies that can not be directly
accessible. Most of the information available for the analysis of these objects
starts with sky explorations via telescopes and satellites. Unfortunately, the
quality of astronomical images is usually very low with respect to other real
images and this is due to technical and physical features related to their
acquisition process. This increases the percentage of noise and makes more
difficult to use directly standard segmentation methods on the original image.
In this work we will describe how to process astronomical images in two steps:
in the first step we improve the image quality by a rescaling of light
intensity whereas in the second step we apply level-set methods to identify the
objects. Several experiments will show the effectiveness of this procedure and
the results obtained via various discretization techniques for level-set
equations.Comment: 24 pages, 59 figures, paper submitte
Serum and bal beta-d-glucan for the diagnosis of Pneumocystis pneumonia in HIV positive patients
Background/purposeThe diagnosis of patients with pulmonary infiltrates and human immunodeficiency virus (HIV) infection remains a challenge. In current clinical practice the gold standard for Pneumocystis jirovecii pneumonia (PCP) diagnosis remains the identification of the organism in bronco alveolar lavage (BAL) using microscopy (e.g., silver stain). (1->3)-β -d-glucan (BG) is a polysaccharide that is present within the cell wall of Pneumocystis and other fungi.MethodsWe analyzed serum and BAL lavage fluid from a cohort of 119 patients that did have HIV, a diagnosis of pneumonia and underwent bronchoscopy (FOB) for diagnosis of PCP.ResultsThe discriminative power of serum BG for the diagnosis of PCP in this group of patients was very high. Using a cutoff of 300 pg/mL, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 91%, 92%, 89% and 93% respectively. A model for ROC with just serum BG (N = 108) had an AUC of 0.95. Serum procalcitonin (PCT) and BAL BG were not as accurate for the diagnosis of PCP. For BAL BG using a cutoff of 783 pg/mL, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 72%, 79%, 72% and 79% respectively. The differences between the medians for serum PCT between the group with a without PCP did not reach statistical significance (p = 0.6137).ConclusionThe measurement of serum BG should be incorporated in the diagnostic work up of HIV positive patients with dyspnea and infiltrates on chest X X-ray. Our study confirms the diagnostic value of serum BG previously reported by others but we add a cutoff value that we believe is more accurate for patients with AIDS and suspicion of PCP
The ``Outside-In'' Outburst of HT Cassiopeiae
We present results from photometric observations of the dwarf nova system HT
Cas during the eruption of November 1995. The data include the first
two--colour observations of an eclipse on the rise to outburst. They show that
during the rise to outburst the disc deviates significantly from steady state
models, but the inclusion of an inner-disc truncation radius of about 4
and a ``flared'' disc of semi-opening angle of produces
acceptable fits. The disc is found to have expanded at the start of the
outburst to about , as compared to quiescent measurements. The
accretion disc then gradually decreases in radius reaching during
the last stages of the eruption. Quiescent eclipses were also observed prior to
and after the eruption and a revised ephemeris is calculated.Comment: 9 pages, 11 figures, to appear in MNRA
Simultaneous UBVRI observations of the cataclysmic variable AE Aquarii: temperature and mass of fireballs
We report simultaneous multicolour observations in 5 bands (UBVRI) of the
flickering variability of the cataclysmic variable AE Aqr. Our aim is to
estimate the parameters (colours, temperature, size) of the fireballs that
produce the optical flares.
The observed rise time of the optical flares is in the interval 220 - 440
sec. We estimate the dereddened colours of the fireballs: (U-B)_0 in the range
0.8-1.4, (B-V)_0 ~ 0.03-0.24, (V-I)_0 ~ 0.26-0.78. We find for the fireballs a
temperature in the range 10000 - 25000 K, mass (7-90).10^{19} g, size
(3-7).10^9 cm (using a distance of d=86 pc). These values refer to the peak of
the flares observed in UBVRI bands.
The data are available upon request from the authors.Comment: 8 pages, accepted in A
On the accretion disc properties in eclipsing dwarf nova EM Cyg
In this paper we analyzed the behavior of the unusual dwarf nova EM Cyg using
the data obtained in April-October, 2007 in Vyhorlat observatory (Slovak
Republic) and in September, 2006 in Crimean Astrophysical Observatory
(Ukraine). During our observations EM Cyg has shown outbursts in every 15-40
days. Because on the light curves of EM Cyg the partial eclipse of an accretion
disc is observed we applied the eclipse mapping technique to reconstruct the
temperature distribution in eclipsed parts of the disc. Calculations of the
accretion rate in the system were made for the quiescent and the outburst
states of activity for different distances.Comment: 6 pages, 3 figures, accepted in Astrophysics and Space Scienc
Recruitment of ethnic minority patients to a cardiac rehabilitation trial: The Birmingham Rehabilitation Uptake Maximisation (BRUM) study [ISRCTN72884263]
Background: Concerns have been raised about low participation rates of people from minority ethnic groups
in clinical trials. However, the evidence is unclear as many studies do not report the ethnicity of participants and
there is insufficient information about the reasons for ineligibility by ethnic group. Where there are data, there
remains the key question as to whether ethnic minorities more likely to be ineligible (e.g. due to language) or
decline to participate. We have addressed these questions in relation to the Birmingham Rehabilitation Uptake
Maximisation (BRUM) study, a randomized controlled trial (RCT) comparing a home-based with a hospital-based
cardiac rehabilitation programme in a multi-ethnic population in the UK.
Methods: Analysis of the ethnicity, age and sex of presenting and recruited subjects for a trial of cardiac
rehabilitation in the West-Midlands, UK.
Participants: 1997 patients presenting post-myocardial infarction, percutaneous transluminal coronary angioplasty
or coronary artery bypass graft surgery.
Data collected: exclusion rates, reasons for exclusion and reasons for declining to participate in the trial by ethnic
group.
Results: Significantly more patients of South Asian ethnicity were excluded (52% of 'South Asian' v 36% 'White
European' and 36% 'Other', p < 0.001). This difference in eligibility was primarily due to exclusion on the basis of
language (i.e. the inability to speak English or Punjabi). Of those eligible, similar proportions were recruited from
the different ethnic groups (white, South Asian and other). There was a marked difference in eligibility between
people of Indian, Pakistani or Bangladeshi origin
Herd-level risk factors of bovine tuberculosis in England and Wales after the 2001 foot-and-mouth disease epidemic
We present the results of a 2005 case–control study of bovine tuberculosis (bTB) breakdowns in English and Welsh herds. The herd management, farming practices, and environmental factors of 401matched pairs of case and control herds were investigated to provide a picture of herd-level risk factors in areas of varying bTB incidence. A global conditional logistic regression model, with region-specific variants, was used to compare case herds that had experienced a confirmed bTB breakdown to contemporaneous control herds matched on region, herd type, herd size, and parish testing interval. Contacts with cattle from contiguous herds and sourcing cattle from herds with a recent history of bTB were associated with an increased risk in both the global and regional analyses. Operating a farm over several premises, providing cattle feed inside the housing, and the presence of badgers were also identified as significantly associated with an increased bTB risk. Steps taken to minimize cattle contacts with neighboring herds and altering trading practices could have the potential to reduce the size of the bTB epidemic. In principle, limiting the interactions between cattle and wildlife may also be useful; however this study did not highlight any specific measures to implement
Ovine Fetal Immune Response to Cache Valley Virus Infection
Cache Valley virus (CVV)-induced malformations have been previously reproduced in ovine fetuses. To evaluate the development of the antiviral response by the early, infected fetus, before the development of immunocompetency, ovine fetuses at 35 days of gestation were inoculated in utero with CVV and euthanized at 7, 10, 14, 21, and 28 days postinfection. The antiviral immune response in immature fetuses infected with CVV was evaluated. Gene expression associated with an innate, immune response was quantified by real-time quantitative PCR. The upregulated genes in infected fetuses included ISG15, Mx1, Mx2, IL-1, IL-6, TNF-α, TLR-7, and TLR-8. The amount of Mx1 protein, an interferon-stimulated GTPase capable of restricting growth of bunyaviruses, was elevated in the allantoic and amniotic fluid in infected fetuses. ISG15 protein expression was significantly increased in target tissues of infected animals. B lymphocytes and immunoglobulin-positive cells were detected in lymphoid tissues and in the meninges of infected animals. These results demonstrated that the infected ovine fetus is able to initiate an innate and adaptive immune response much earlier than previously known, which presumably contributes to viral clearance in infected animals
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