Exact non-abelian duality

We investigate non-abelian gaugings of WZNW models. When the gauged group is semisimple we are able to present exact formulae for the dual conformal field theory, for all values of the level $k$. The results are then applied to non-abelian target space duality in string theory, showing that the standard formulae are quantum mechanically well defined in the low energy limit if the gauged group is semisimple.Comment: 17 pages uuencoded Z-compressed late

Acetaldehyde adducts in alcoholic liver disease

Chronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition, chronic alcoholic liver disease (ALD), with or without cirrhosis, increases risk for hepatocellular carcinoma (HCC). Acetaldehyde, a major toxic metabolite, is one of the principal culprits mediating fibrogenic and mutagenic effects of alcohol in the liver. Mechanistically, acetaldehyde promotes adduct formation, leading to functional impairments of key proteins, including enzymes, as well as DNA damage, which promotes mutagenesis. Why certain individuals who heavily abuse alcohol, develop HCC (7.2–15%) versus cirrhosis (15–20%) is not known, but genetics and co-existing viral infection are considered pathogenic factors. Moreover, adverse effects of acetaldehyde on the cardiovascular and hematologic systems leading to ischemia, heart failure, and coagulation disorders, can exacerbate hepatic injury and increase risk for liver failure. Herein, we review the role of acetaldehyde adducts in the pathogenesis of chronic ALD and HCC

Valor anormal de hemoglobina materna y riesgo de muerte fetal

Objetivo: Determinar la asociación entre el valor anormal de hemoglobina materna y el riesgo de desarrollar muerte fetal en el Hospital Regional Docente de Trujillo (HRDT) en el período enero 2005 – enero 2015. Material y Métodos: Se realizó a cabo un estudio en el HRDT de tipo observacional, transversal, analítico y retrospectivo de casos y controles en el período enero 2005 – 2015. Incluyéndose un total de 102 casos y 204 controles, se halló la asociación usando el Odds ratio y se empleó el Chi cuadrado para hallar la significancia estadística con un valor de p < 0.01. Resultados: Se halló una prevalencia de anemia gestacional en el grupo de casos de 30.3% y 15.8% para el grupo control, con una asociación estadísticamente significativa entre ambas variables (P < 0.01) y un Odds Ratio de 2.3 (IC 99%). Así mismo, fue la anemia moderada/severa que presento una asociación estadísticamente significativa (P < 0.01) con un Odds Ratio de 27.1 (IC 99%). Sin embargo, no se evidenció asociación estadísticamente significativa entre la anemia leve y el diagnóstico de muerte fetal (P > 0.05). La frecuencia de eritrocitosis (≥ 14.5 gr/dl) en el grupo de gestantes con el diagnóstico de óbito fetal y en el grupo control fue de 4.2% y un 1.2% respectivamente, pero no se halló asociación estadísticamente significativa (p > 0.05). Conclusiones: La anemia gestacional constituye un factor de riesgo para muerte fetal, con un Odds Ratio de 2.3 y una significancia estadística de p < 0,01. Siendo la anemia moderada/severa la que presenta asociación estadísticamente significativa con esta variable. La eritrocitosis gestacional (≥ 14.5 gr/dl) no demostró asociación estadísticamente significativa con el diagnóstico de muerte fetal (p > 0.05).Objective: To determine the association between the abnormal value of maternal hemoglobin and the risk of developing fetal death in the Hospital “Regional Docente De Trujillo” (HRDT) in the period January 2005 - January 2015. Material and Methods: This was an observational and retrospective analytical study of cases and controls at the HRDT in the period January 2005 - 2015. Including a total of 102 cases and 204 controls, the association was found using the Odds ratio and the Chi square to find the statistical significance with a p <0.01 Results: A prevalence of gestational anemia was found in the case group of 30.3% and 15.8% for the control group, with a statistically significant association between both variables (P <0.01) and an Odds Ratio of 2.3 (CI 99%). Likewise, moderate / severe anemia showed a statistically significant association (P <0.01) with an Odds Ratio of 27.1 (CI 99%). However, there was no statistically significant association between mild anemia and the diagnosis of fetal death (P> 0.05). The frequency of erythrocytosis (≥ 14.5 gr/dl) in the group of pregnant women with the diagnosis of fetal death and in the control group was 4.2% and 1.2% respectively, but no statistically significant association was found (p> 0.05). Conclusions: Gestational anemia constitutes a risk factor for fetal death, with an Odds Ratio of 2.3 and a statistical significance of p <0.01. Moderate / severe anemia being the one that presents a statistically significant association with this variable. Gestational erythrocytosis (≥ 14.5 gr / dl) showed no statistically significant association with the diagnosis of fetal death (p> 0.05)Tesi

How much variation in oocyte yield after controlled ovarian stimulation can be explained? A multilevel modelling study

How much variation in oocyte yield after controlled ovarian stimulation (COS) can be accounted for by known patient and treatment characteristics

Blockchain Application Within a Multi-Sensor Satellite Architecture

With the thrust towards multi-sensor satellite architectures for earth and space exploration, such as constellations and swarms, new technologies are required to enable the transition to this future capability. One of the areas of interest is establishing secure, efficient and prioritized data and command communication pathways among ground and space-based sources for such systems. This paper presents early research results on the potential role, capabilities and value of blockchain usage within constellation and swarm satellite architectures. It demonstrates the use of blockchain's smart contract and distributed ledger capabilities for secure and prioritized multi-sensor satellite collaborative data exchanges, as well as the logging and tracking of command and control events. Adapting and utilizing this emerging technology will aid in addressing technology gaps expected from future constellation flight architectures, such as managing collective computational operations (correlation), dynamic and autonomous observation planning, time-critical events, and provenance tied to ground and space-based autonomous operations and control recordkeeping. In this scenario blockchain is applied in encrypted command transmittal to multiple, yet specific, entities enabling acknowledgement transmittals, performance scalability, and automatic event-based triggering

Aspartyl-(asparaginyl) β-Hydroxylase, Hypoxia-Inducible Factor-1α and Notch Cross-Talk in Regulating Neuronal Motility

Aspartyl-(Asparaginyl)-β-Hydroxylase (AAH ) promotes cell motility by hydroxylating Notch. Insulin and insulin-like growth factor, type 1 (IGF-I) stimulate AAH through Erk MAP K and phosphoinositol-3-kinase-Akt (PI3K-Akt). However, hypoxia/oxidative stress may also regulate AAH . Hypoxia-inducible factor-1alpha (HIF-1α) regulates cell migration, signals through Notch, and is regulated by hypoxia/oxidative stress, insulin/IGF signaling and factor inhibiting HIF-1α (FIH) hydroxylation. To examine cross-talk between HIF-1α and AAH , we measured AAH , Notch-1, Jagged-1, FIH, HIF-1α, HIF-1β and the hairy and enhancer of split 1 (HE S-1) transcription factor expression and directional motility in primitive neuroectodermal tumor 2 (PNET2) human neuronal cells that were exposed to H2O2 or transfected with short interfering RNA duplexes (siRNA) targeting AAH , Notch-1 or HIF-1α. We found that: (1) AAH , HIF-1α and neuronal migration were stimulated by H2O2; (2) si-HIF-1α reduced AAH expression and cell motility; (3) si-AAH inhibited Notch and cell migration, but not HIF-1α and (4) si-Notch-1 increased FIH and inhibited HIF-1α. These findings suggest that AAH and HIF-1α crosstalk within a hydroxylation-regulated signaling pathway that may be transiently driven by oxidative stress and chronically regulated by insulin/IGF signaling

A Novel Symmetry in Sigma Models

A class of non-linear sigma models possessing a new symmetry is identified. The same symmetry is also present in Chern-Simons theories. This hints at a possible topological origin for this class of sigma models. The non-linear sigma models obtained by non-Abelian duality are a particular case in this class.Comment: 9 pages, latex, no figure