19 research outputs found
Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver
Konfigurationsstabilität und reduzierte1H-NMR-Verschiebungen (pseudo)tetraedrischer Nickel(II)-Bis-chelate von 1,3-Diiminen1)
Mutational analysis of critical residues of FAD-independent catabolic acetolactate synthase from Enterococcus faecalis V583
Errors in body temperature assessment related to individual variation, measuring technique and equipment
Randomized trial of the effect of intravenous paracetamol on inflammatory biomarkers and outcome in febrile critically ill adults
In Vivo Imaging of Ca2+ Signaling in Astrocytes Using Two-Photon Laser Scanning Fluorescent Microscopy
MS and excitotoxicity
In this section, it will be studied how excitotoxicity contributes to neurodegeneration in the context of multiple sclerosis (MS). MS has long been regarded as an autoimmune inflammatory disease targeting oligodendrocytes of the central nervous system (CNS). However, recent advancement in research questioned whether MS is merely an inflammatory disease despite pathological evidences of degeneration are clearly present. More recent findings further challenge the research focus of MS which previously thought oligodendrocytes as the main target, whereas current debate points towards pathology of MS being primarily dysfunctional glial interaction, i.e., astrocytes and microglia. Herein, a brief overview will be provided on how various aspects of excitotoxicity are evident in MS pathology and its possible roles between interactions of cells in the CNS that ultimately lead to neurodegeneration in inflammatory condition of MS.9 page(s