The accumulation of exercise and postprandial endothelial function in boys

The purpose of this study was to investigate the effect of accumulating 60 min of exercise on endothelial function and triacylglycerol concentrations following the ingestion of a high-fat breakfast and lunch in fourteen adolescent boys (aged 12 to 14 years). Two, 2-day main trials (control and exercise) were completed in a counter-balanced, cross-over design. Participants were inactive on day 1 of the control trial but on day 1 of the exercise trial completed 6 x 10 min runs at 70% of peak oxygen uptake, spread over the day. On day 2 triacylglycerol concentrations and flow-mediated dilation (FMD) were measured prior to, and following, ingestion of the high-fat meals. In the control trial FMD was reduced by 30% and 33% (P0.05). These results support the concept of accumulating physical activity for health in adolescents as the accumulated exercise attenuated the decline in FMD seen following the consumption of high-fat meals

The Problem of Contextuality and the Impossibility of Experimental Metaphysics Thereof

Recently a new impulse has been given to the experimental investigation of contextuality. In this paper we show that for a widely used definition of contextuality there can be no decisive experiment on the existence of contextuality. To this end, we give a clear presentation of the hidden variable models due to Meyer, Kent and Clifton (MKC), which would supposedly nullify the Kochen-Specker Theorem. Although we disagree with this last statement, the models play a significant role in the discussion on the meaning of contextuality. In fact, we introduce a specific MKC-model of which we show that it is non-contextual and completely in agreement with quantum mechanical predictions. We also investigate the possibility of other definitions of non-contextuality --with an emphasis on operational definitions-- and argue that any useful definition relies on the specification of a theoretical framework. It is therefore concluded that no experimental test can yield any conclusions about contextuality on a metaphysical level

The White Dwarf in EM Cygni: Beyond The Veil

We present a spectral analysis of the FUSE spectra of EM Cygni, a Z Cam DN system. The FUSE spectrum, obtained in quiescence, consists of 4 individual exposures (orbits): two exposures, at orbital phases phi ~ 0.65 and phi ~ 0.90, have a lower flux; and two exposures, at orbital phases phi =0.15 and 0.45, have a relatively higher flux. The change of flux level as a function of the orbital phase is consistent with the stream material (flowing over and below the disk from the hot spot region to smaller radii) partially masking the white dwarf. We carry out a spectral analysis of the FUSE data, obtained at phase 0.45 (when the flux is maximual, using the codes TLUSTY and SYNSPEC. Using a single white dwarf spectral component, we obtain a white dwarf temperature of 40,000K, rotating at 100km/s. The white dwarf, or conceivably, the material overflowing the disk rim, shows suprasolar abundances of silicon, sulphur and possibly nitrogen. Using a white dwarf+disk composite model, we obtain that the white dwarf temperature could be even as high as 50,000K, contributing more than 90% of the FUV flux, and the disk contributing less than 10% must have a mass accretion rate reaching 1.E-10 Msun/yr.In both cases, however, we obtain that the white dwarf temperature is much higher than previously estimated.Comment: accepted for publication in ApJ, 3 Tables, 12 Figures (including color figures), 33 pages in present format (possibly 10 pages in ApJ format

Microbial community composition of transiently wetted Antarctic Dry Valley soils

During the summer months, wet (hyporheic) soils associated with ephemeral streams and lake edges in the Antarctic Dry Valleys (DVs) become hotspots of biological activity and are hypothesized to be an important source of carbon and nitrogen for arid DV soils. Recent research in the DV has focused on the geochemistry and microbial ecology of lakes and arid soils, with substantially less information being available on hyporheic soils. Here, we determined the unique properties of hyporheic microbial communities, resolved their relationship to environmental parameters and compared them to archetypal arid DV soils. Generally, pH increased and chlorophyll a concentrations decreased along transects from wet to arid soils (9.0 to ~7.0 for pH and ~0.8 to ~5 μg/cm3 for chlorophyll a, respectively). Soil water content decreased to below ~3% in the arid soils. Community fingerprinting-based principle component analyses revealed that bacterial communities formed distinct clusters specific to arid and wet soils; however, eukaryotic communities that clustered together did not have similar soil moisture content nor did they group together based on sampling location. Collectively, rRNA pyrosequencing indicated a considerably higher abundance of Cyanobacteria in wet soils and a higher abundance of Acidobacterial, Actinobacterial, Deinococcus/Thermus, Bacteroidetes, Firmicutes, Gemmatimonadetes, Nitrospira, and Planctomycetes in arid soils. The two most significant differences at the genus level were Gillisia signatures present in arid soils and chloroplast signatures related to Streptophyta that were common in wet soils. Fungal dominance was observed in arid soils and Viridiplantae were more common in wet soils. This research represents an in-depth characterization of microbial communities inhabiting wet DV soils. Results indicate that the repeated wetting of hyporheic zones has a profound impact on the bacterial and eukaryotic communities inhabiting in these areas

Detecting disease rare alleles using single SNPs in families and haplotyping in unrelated subjects from the Genetic Analysis Workshop 17 data

We present an evaluation of discovery power for two association tests that work well with common alleles but are applied to the Genetic Analysis Workshop 17 simulations with rare causative single-nucleotide polymorphisms (SNPs) (minor allele frequency [MAF] < 1%). The methods used were genome-wide single-SNP association tests based on a linear mixed-effects model for discovery and applied to the familial sample and sliding windows haplotype association tests for replication, implemented within causative genes in the unrelated individuals sample. Both methods are evaluated with respect to the simulated trait Q2. The linear mixed-effects model and haplotype association tests failed to detect the rare alleles of the simulated associations. In contrast, the linear mixed-effects model and haplotype association tests detected effects for the most important simulated SNPs with MAF > 1%. We conclude that these findings reflect inadequate statistical power (the result of small simulated samples) for the complex genetic model that underlies these data

The reliability and validity of a portable three-dimensional scanning system to measure leg volume

(1) Background: The study examined the reliability (test–retest, intra- and inter-day) and validity of a portable 3D scanning method when quantifying human leg volume. (2) Methods: Fifteen males volunteered to participate (age, 24.6 ± 2.0 years; stature, 178.9 ± 4.5 cm; body mass, 77.4 ± 6.5 kg; mean ± standard deviation). The volume of the lower and upper legs was examined using a water displacement method (the criterion) and two consecutive 3D scans. Measurements were taken at baseline, 1 h post-baseline (intra-day) and 24 h post-baseline (inter-day). Reliability and validity of the 3D scanning method was assessed using Bland–Altman limits of agreement and Pearson’s product moment correlations. (3) Results: With respect to the test–retest reliability, the 3D scanning method had smaller systematic bias and narrower limits of agreement (±1%, and 3–5%, respectively) compared to the water displacement method (1–2% and 4–7%, respectively), when measuring lower and upper leg volume in humans. The correlation coefficients for all reliability comparisons (test–retest, intra-day, inter-day) would all be regarded as ‘very strong’ (all 0.94 or greater). (4) Conclusions: The study’s results suggest that a 3D scanning method is a reliable and valid method to quantify leg volume