Aplicación del método del caso al estudio de la contratación en el mercado financiero

El empleo de un instrumento metodológico como el método del caso posibilita el trabajo en equipo y fomenta el aprendizaje cooperativo del estudiante a la vez que, facilita la evaluación de su rendimiento académico y del seguimiento del proyecto, al poder ofrecer indicios día a día de los avances en la adquisición de las competencias del alumno, pues durante las clases prácticas los alumnos son incitados a participar activamente en la resolución pública de los supuestos propuestos y en el análisis de la documentación proporcionada. Si bien, para el alumnado que por primera vez se aproxima al estudio del Derecho mercantil, parece más aconsejable la no aplicación del método del caso en sentido estricto, en el que las situaciones jurídicas son extraídas de la práctica sin adiciones ni supresiones, sino con mayor flexibilidad, mediante casos que con un sustento real son adaptados a las necesidades docentes. Se consigue con ello concentrar en un solo caso cuestiones que la práctica no suele plantear juntas y presentar separadamente diversos aspectos de un mismo problema para facilitar su comprensión.The employment of a methodological instrument like the method of the case does the teamwork possible and promotes the cooperative learning of the student simultaneously that it facilitates the evaluation of the academic performance of the pupil and of the follow-up of the project, to it be able to offer indications day after day of the advances in the acquisition of the competitions of the pupil, since during the practical classes the pupils are incited to inform actively in the public resolution of the practical suppositions and in the analysis of the proportionate documentation. Though, for the student body that for the first time comes closer the study of the Commercial law, application of the method seems to be more advisable not in strict sense, in which the juridical situations are extracted from the practice without additions or suppressions, but with major flexibility, by means of cases that with a veritable sustenance are adapted to the educational needs. There is obtained by it to concentrate in an alone case questions that the practice is not in the habit of considering meetings and presenting separately diverse aspects of the same problem to facilitate his comprehension

Physicians’ perception about predictors of opioid abuse in patients with chronic non-cancer pain: a Delphi study.

APC realizado, el artículo está en Open accessBackground: Opioids are being prescribed widely, and increasingly, for the treatment of chronic non-cancer pain (CNCP). However, several side effects are associated with mid- and long-term opioid use and, for certain patients, with the risk of problematic opioid use. The aim of this study is to know the perception of the physicians about which variables could be associated within creased risk of patients with CNCP developing a problem of abuse or misuse of the prescribed opioid medication. Methods: Twenty-nine physicians with experience in CNCP pain management and opioids prescription participated in a two-round Delphi study focused on the risk factors for opioid misuse and abuse.Results: The variables that reached consensus regarding their relationship with the increased risk of suffering a problem of opioid abuse or misuse were: (1)Experiencing pain on a daily basis, (2) previous use of high-dose opioids, (3)generalized anxiety, (4) hopelessness, (5) benzodiazepine intake, (6) use of opioids for reasons other than pain, (7) family problems, family instability or family breakdown, and (8) having access to several opioid prescribers. The only variable that reached consensus regarding it not being associated to a possible risk of abuse or misuse was having mild pain intensity (0–4 on a NRS-11).Conclusions: This study provides useful information that could help make decisions about the use of opioids for CNCP treatment and prevent future difficulties. Prospective studies testing the relationship of the variables that reached consensus with the risk of opioid misuse and abuse are warranted. Significance: This study shows the variables of CNCP that the professional must take into account in order to avoid possible problems when prescribing opioidsThis work was partly funded by grants from the Spanish Ministry of Science and Competitiveness, PID2019-106086RBI00; the Regional Government of Andalusia, UMA20-FEDERJA118. SG’s salary is supported by a Sara Borrell grant (CD19/ 00022), from ISCIII; RV’s salary is supported by a RYC2018- 024722-I from the Spanish Ministry of Science and Innovation

Time Following a Gluten-Free Diet, Ultra-Processed Food Consumption and Quality of Life in Children with Celiac Disease

Maintaining a strict gluten-free diet (GFD) may affect the quality of life of children with celiac disease (CD) and promote a less healthy diet by substituting gluten-containing foods with ultra-processed foods. We aimed to assess the influences of the GFD and ultra-processed food consumption on parents' perception of the quality of life of children with CD. Fifty-eight children (mean age 8.6 +/- 4.1 years) were included. The participants were divided into groups based on the time following a GFD: = 12 months (n = 37). Their dietary consumption was assessed through a three-day food record. The 20-item Celiac Disease Quality Of Life survey (CD-QOL), which contains four subscales (limitations, dysphoria, health concerns, and inadequate treatment) was used to assess the quality of life. The children who followed a GFD for >= 12 months presented poorer scores in the limitations subscale than those who followed a GFD for <6 months (p = 0.010). The mean % of the energy intake from ultra-processed foods was 47.3 +/- 13.5. Children with CD consuming more than 50% of their total energy from ultra-processed foods showed poorer scores for the limitation and inadequate treatment (both, p = 0.019) subscales than their counterparts. According to parents' perceptions, those children who consumed more than 50% of their energy through ultra-processed foods had more limitations, and their treatment was perceived as less effective.European Commission B-AGR-658Association of Celiacs and Sensitive to Gluten of the Community of MadridSpanish Government FPU17/0371

Clustering and beamforming for efficient communication in wireless sensor networks

Energy efficiency is a critical issue for wireless sensor networks (WSNs) as sensor nodes have limited power availability. In order to address this issue, this paper tries to maximize the power efficiency in WSNs by means of the evaluation of WSN node networks and their performance when both clustering and antenna beamforming techniques are applied. In this work, four different scenarios are defined, each one considering different numbers of sensors: 50, 20, 10, five, and two nodes per scenario, and each scenario is randomly generated thirty times in order to statistically validate the results. For each experiment, two different target directions for transmission are taken into consideration in the optimization process (ɸ = 0º and Ɵ = 45º; ɸ = 45º, and Ɵ = 45º). Each scenario is evaluated for two different types of antennas, an ideal isotropic antenna and a conventional dipole one. In this set of experiments two types of WSN are evaluated: in the first one, all of the sensors have the same amount of power for communications purposes; in the second one, each sensor has a different amount of power for its communications purposes. The analyzed cases in this document are focused on 2D surface and 3D space for the node location. To the authors’ knowledge, this is the first time that beamforming and clustering are simultaneously applied to increase the network lifetime in WSNs.Gobierno de Extremadura y Fondos FEDER: Proyecto IB13113peerReviewe

Influence of an exercise intervention plus an optimal Mediterranean diet adherence during pregnancy on the telomere length of the placenta. The GESTAFIT project

We aimed to investigate whether the effects of exercise on placental relative telomere length (RTL) after delivery are modulated by the Mediterranean diet [MD] adherence in 65 pregnant women (control n = 34, exercise n = 31). No differences were found in placental RTL between the exercise and the control groups (p = 0.557). The interaction-term between exercise and MD adherence with placental RTL was significant (p = 0.001). Specifically, women in the exercise group showed longer placental RTL after birth compared to controls (referent group), only for those women with a high MD adherence (mean difference = 0.467, p=0.010). A concurrentexercise training plus an optimal MD adherence during pregnancy might prevent the placental RTL shorteningRegional Ministry of Health of the Junta de Andalucia PI -0395-2016Research and Knowledge Transfer Fund (PPIT) 2016Excellence Actions Programme: Scientific Units of Excellence (UCEES)European Commission 2021 - 00036Swedish Research Council for Health Working Life & Welfare (Forte) 101027215European Commission FPU17/03715Regional Ministry of Economy, Knowledge, Enterprises and Universit

Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project

Aims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p < .05). Serum total and low-density lipoprotein cholesterol were greater in males’ umbilical cord blood artery compared to females’ new-borns (both, p < .05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth (p < .05). Female’s placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all, p ⩽ .05), and evidence of statistical significance in telomeres length, which were 17% longer (p = .076). Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males’ foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.Regional Ministry of Health, Junta de Andalucia PI-0395-2016University of GranadaJunta de AndaluciaEuropean Commission SOMM17/6107/UGRPlan Propio de Investigacion 2016, Excellence actions (Units of Excellence: Unit of Excellence in Exercise and Health

Physical Education through a joint curriculum in secondary schools

Resumen basado en el de la publicaciónLa Educación Física ha de adoptar un papel principal en la sociedad del bienestar, del tiempo libre y del ocio. Teniendo en cuenta los resultados de diversos estudios a nivel europeo y norteamericano, en relación a la Educación Física recibida por parte de los escolares, se plantea un proyecto con el objetivo principal de diseñar un currículum común del área de Educación Física entre los distintos centros de la zona de Almería, teniendo en cuenta la variedad y novedad de los contenidos a plantear en clase, intentando alejarse de los que tradicionalmente han predominado en las sesiones de Educación Física. Se espera que un mayor y amplio número de experiencias, que parten de los intereses del alumnado, tenga unos efectos positivos en la actitud y motivación de los mismos, tanto en las clases como en un impacto positivo en la adhesión a la actividad física a lo largo de toda su vida.AndalucíaES

Magnetic detection of sentinel lymph node in papillary thyroid carcinoma: The MAGIC-PAT study results

Introduction: Despite the controversy concerning sentinel lymph node biopsy (SLNB) in papillary thyroid carcinoma (PTC), successful detection rates can be achieved by radioguidance and vital dyeing. However, the drawbacks in both techniques are notable. Magnetic-guided SLNB (mSLNB) using superparamagnetic iron oxide (SPIO) nanoparticles is appealing as an alternative procedure. Materials and Methods: mSLNB using the Sentimag-Sienna System ® , total thyroidectomy and central compartment dissection (CCD) were performed on all PTC patients. Lymph node involvement was assessed by postoperative pathological examination. Results: From 2014 to 2016, 33 consecutive patients with PTC were enrolled in the study. A total of 20 patients met the eligibility. mSLNB succeeded in 16 patients, with a detection rate of 80%. A median of two SLN per patient were detected. A median of 10.5 non-sentinel lymph nodes (NSLN) from CCD were examined. Among the patients, 56.25% (9/16) had no metastatic nodes, while 12.5% (2/16) had exclusively SLN involvement. No false negative cases were found. The agreement between SLN and NSLN status was 87.5%. The prediction of NSLN involvement by SLN status showed 100% sensitivity, 81.8% specificity, 71.4% PPV and 100% NPV. Subsequently, mSLNB and the final pathological analysis would discriminate 43.75% (7/16) of patients who would certainly benefit from CCD whilst 56.25% of the total would confirm an unnecessary lymphadenectomy and avoid morbidity. Conclusion: mSLNB showed satisfactory performance in PTC with clinical-negative nodes. We have shown mSLNB to be a good predictor of central compartment status that can improve the staging and management of PTC patients

Knock-down of phosphoenolpyruvate carboxylase 3 negatively impacts growth, productivity, and responses to salt stress in sorghum (Sorghum bicolor L.)

Phosphoenolpyruvate carboxylase (PEPC) is a carboxylating enzyme with important roles in plant metabolism. Most studies in C-4 plants have focused on photosynthetic PEPC, but less is known about non-photosynthetic PEPC isozymes, especially with respect to their physiological functions. In this work, we analyzed the precise roles of the sorghum (Sorghum bicolor) PPC3 isozyme by the use of knock-down lines with the SbPPC3 gene silenced (Ppc3 lines). Ppc3 plants showed reduced stomatal conductance and plant size, a delay in flowering time, and reduced seed production. In addition, silenced plants accumulated stress indicators such as Asn, citrate, malate, and sucrose in roots and showed higher citrate synthase activity, even in control conditions. Salinity further affected stomatal conductance and yield and had a deeper impact on central metabolism in silenced plants compared to wild type, more notably in roots, with Ppc3 plants showing higher nitrate reductase and NADH-glutamate synthase activity in roots and the accumulation of molecules with a higher N/C ratio. Taken together, our results show that although SbPPC3 is predominantly a root protein, its absence causes deep changes in plant physiology and metabolism in roots and leaves, negatively affecting maximal stomatal opening, growth, productivity, and stress responses in sorghum plants. The consequences of SbPPC3 silencing suggest that this protein, and maybe orthologs in other plants, could be an important target to improve plant growth, productivity, and resistance to salt stress and other stresses where non-photosynthetic PEPCs may be implicated.This research was supported by the Junta de Andalucía (P12-FQM-489 and PAI group BIO298), the Basque Government (IT932-16), and the Ministerio de Economía, Industria y Competitividad (AGL2012-35708 and AGL2016-75413-P)

Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence

Objective: the goal of this research has been to evaluate the survival, in long and short term, of the patient receiving liver transplant for hepatocellular carcinoma (HCC), the risk of posttransplant tumor relapse and factors related to this complication. Design: retrospective study of a consecutive series of patients having had liver transplant for HCC. Patients and methodology: transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis. Results: the survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR = 1,7944) (IC 95% = 1,1332-2,8413) and the vascular invasion (OR = 6,6346) (IC 95% = 1,4624-30,1003) as risk factors of relapse. Conclusions: the liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion