168 research outputs found
Liberating Efimov physics from three dimensions
When two particles attract via a resonant short-range interaction, three
particles always form an infinite tower of bound states characterized by a
discrete scaling symmetry. It has been considered that this Efimov effect
exists only in three dimensions. Here we review how the Efimov physics can be
liberated from three dimensions by considering two-body and three-body
interactions in mixed dimensions and four-body interaction in one dimension. In
such new systems, intriguing phenomena appear, such as confinement-induced
Efimov effect, Bose-Fermi crossover in Efimov spectrum, and formation of
interlayer Efimov trimers. Some of them are observable in ultracold atom
experiments and we believe that this study significantly broadens our horizons
of universal Efimov physics.Comment: 17 pages, 5 figures, contribution to a special issue of Few-Body
Systems devoted to Efimov Physic
Universality in the Three-Body Problem for 4He Atoms
The two-body scattering length a for 4He atoms is much larger than their
effective range r_s. As a consequence, low-energy few-body observables have
universal characteristics that are independent of the interaction potential.
Universality implies that, up to corrections suppressed by r_s/a, all
low-energy three-body observables are determined by a and a three-body
parameter \Lambda_*. We give simple expressions in terms of a and \Lambda_* for
the trimer binding energy equation, the atom-dimer scattering phase shifts, and
the rate for three-body recombination at threshold. We determine \Lambda_* for
several 4He potentials from the calculated binding energy of the excited state
of the trimer and use it to obtain the universality predictions for the other
low-energy observables. We also use the calculated values for one potential to
estimate the effective range corrections for the other potentials.Comment: 23 pages, revtex4, 6 ps figures, references added, universal
expressions update
The ^4He trimer as an Efimov system
We review the results obtained in the last four decades which demonstrate the
Efimov nature of the He three-atomic system.Comment: Review article for a special issue of the Few-Body Systems journal
devoted to Efimov physic
Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study
Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.Molecular tumour pathology - and tumour geneticsMTG2 - Moleculaire genetica van gastrointestinale tumore
Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants
New oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral anticoagulants DOACs (dabigtran, rivaroxban, apixban, and edoxban) in the treatment of adults with atri-al fibrillation. Electronic databases including Medline, Embase, International Pharmaceutical Abstract (IPA), Scopus, CINAHL, the Web of Science and Cochrane were searched from 2008 through 2016 for original articles. Studies pub-lished in English reporting MRPs of DOACs in adult patients with AF were in-cluded. Seventeen studies were identified using standardized protocols, and two reviewers serially abstracted data from each article. Most articles were inconclusive on major safety end points including major bleeding. Data on major safety end points were combined with efficacy. Most studies inconsistently reported adverse drug reactions and not adverse events or medication error, and no definitions were consistent across studies. Some harmful drug effects were not assessed in studies and may have been overlooked. Little evidence is provided on MRPs of DOACs in patients with AF and, therefore, further studies are needed to establish the safety of DOACs in real-life clinical practice
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
GPI Spectra of HR 8799 c, d, and e from 1.5 to 2.4 μm with KLIP Forward Modeling
Stars and planetary system
GPI Spectra of HR 8799 c, d, and e from 1.5 to 2.4 μm with KLIP Forward Modeling
Stars and planetary system
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