Evolução do teor de esteróis e alcoóis triterpénicos no envelhecimento de azeites monovarietais e loteados de seis cultivares no Norte Alentejano

Comunicação apresentada no III Simpósio Nacional de Olivicultura que decorreu em Castelo Branco, na Escola Superior Agrária do Instituto Politécnico de Castelo Branco, de 29 a 31 de Outubro de 2003.A legislação europeia limita os teores de alguns esteróis no azeite virgem: valores máximos de colesterol, de brassicasterol, de campesterol, de estigmasterol e de ∆7-estigmastenol; e valores mínimos do β-sitosterol aparente e do total de esteróis. O presente trabalho mostra o efeito de um ano de envelhecimento – em frascos de vidro âmbar a 25 °C – nos teores destes esteróis em azeites monovarietais e loteados de seis cultivares no Norte Alentejano, da campanha de 2001/02. O envelhecimento foi geralmente acompanhado pelo aumento dos teores de β-sitosterol aparente, de ∆5-avenasterol e de esteróis totais e pela diminuição dos teores de campesterol e de estigmasterol

Total esophagogastrectomy in the neoplasms of the esophagus and esofagogastric junction: when must be indicated?

to analyse the indications and results of the total esophagogastrectomy in cancers of the distal esophagus and esophagogastric junction. twenty patients with adenocarcinomas were operated with a mean age of 55 ± 9.9 years (31-70 years), and 14 cases were male (60%). Indications were 18 tumors of the distal esophagus and esophagogastric junction (90%) and two with invasion of gastric fundus (10%) in patients with previous gastrectomy. Preoperative colonoscopy to exclude colonic diseases was performed in ten cases. the surgical technique consisted of median laparotomy and left cervicotomy, followed by transhiatal esophagectomy associated with D2 lymphadenectomy. The reconstructions were performed with eight esophagocoloduodenoplasty and the others were Roux-en-Y esophagocolojejunoplasty to prevent the alkaline reflux. Three cases were stage I / II, while 15 cases (85%) were stages III / IV, reflecting late diagnosis of these tumors. The operative mortality was 5 patients (25%): a mediastinitis secondary to necrosis of the transposed colon, abdominal cellulitis secondary to wound infection, severe pneumonia, an irreversible shock and sepsis associated with colojejunal fistula. Four patients died in the first year after surgery: 3 (15%) were due to tumor recurrence and 1 (5%) secondary to bronchopneumonia. The 5-year survival was 15%. the total esophagogastrectomy associated with esophagocoloplasty has high morbidity and mortality, requiring precise indication, and properly selected patients benefit from the surgery, with the risk-benefit acceptable, contributing to increased survival and improved quality of life.To analyse the indications and results of the total esophagogastrectomy in cancers of the distal esophagus and esophagogastric junction. twenty patients with adenocarcinomas were operated with a mean age of 55 ± 9.9 years (31-70 years), and 14 cases were426360365sem informaçãosem informaçã

Esophageal mucosal resection versus esophagectomy: a comparative study of surgical results in patients with advanced megaesophagus

The surgical treatment of advanced megaesophagus has no consensus, being esophagectomy the more commonly used method. Since it has high morbimortality--inconvenient for benign disease -, in recent years an alternative has been introduced: the esophageal mucosal resection. To compare early and late results of the two techniques evaluating the operative time, length of ICU stay; postoperative hospitalization; total hospitalization; intra- and postoperative complication rates; mortality; and long-term results. Were evaluated retrospectively 40 charts, 23 esophagectomies and 17 mucosectomies. In assessing postoperative results, interviews were conducted by using a specific questionnaire. Comparing the means of esophagectomy and mucosal resection, respectively, the data were: 1) surgical time--310.2 min and 279.7 min (p > 0.05); 2) length of stay in ICU--5 days and 2.53 days (p 0.05); 4) length of hospital stay after surgery--19.05 days and 14.94 days (p> 0.05); 5) presence of intraoperative complications--65% and 18% (p 0.05). In the assessment of late postoperative score (range 0-10) esophagectomy (n = 5) obtained 8.8 points and 8.8 points also got mucosal resection (n = 5). Esophageal mucosal resection proved to be good alternative for surgical treatment of megaesophagus. It was advantageous in the immediate postoperative period by presenting a lower average time in operation, the total hospitalization, ICU staying and complications rate. In the late postoperative period, the result was excellent and good in both operations.The surgical treatment of advanced megaesophagus has no consensus, being esophagectomy the more commonly used method. Since it has high morbimortality--inconvenient for benign disease -, in recent years an alternative has been introduced: the esophageal m2812831sem informaçãosem informaçã

Studies Of Distribution And Recurrence Of Helicobacter Spp. Gastric Mucosa Of Dogs After Triple Therapy [estudos Da Distribuição E Recorrência Do Helicobacter Spp. Na Mucosa Gástrica De Cães Após Terapia Tríplice]

Purpose: To analyze the triple antimicrobial therapy in positive Helicobacter spp. dogs and to investigate recurrence. Methods: A total of 20 dogs underwent endoscopy followed by gastric biopsy using the rapid urease test and histopathology stained with Giemsa. Ten animals were treated with triple therapy recommended for humans and divided into control and experimental group. The control group was kept in isolation while the experimental group was placed in contact with positive animals during 60 days. Results: The prevalence of infection in animals in this experiment was 100%, and more frequent in the fundus and the gastric body. Therapy for 7 days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of the animals. Recurrence of the infection in 80% of dogs in the experimental group, while the control group remained eradicated after 60 days. Conclusion: Crowded environments associated with close contact with dogs infected with helicobacter are a determinant for transmission of Helicobacter spp. between canines.2628287Ladeira, M.S.P., Salvador, D.M.F., Rodrigues, M.A.M., Biopatologia do Helicobacter pylori (2003) J Bras Patol Med Lab, 39 (4), pp. 335-342Marshall, B.J., Warren, J.R., Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration (1984) Lancet, 1, pp. 1311-1315Carvalho, G.D., Pinto, P.S.A., Vilória, M.I.V., Nero, L.A., Aspectos zoonóticos de Helicobacter spp (2008) Biosci J, 24 (4), pp. 121-130Escobar, M.L., Kawakami, E., Evidence of mother child transmission of Helicobacter pylori infection (2004) Arq Gastroenterol, 41 (4), pp. 239-244Parente, J.M.L., Silva, B.B., Palha-Dias, M.P.S., Zaterca, S., Nishimura, N.F., Zeitune, J.M.R., Helicobacter pylori infection in children of low and high socioeconomic status in northeastern Brazil (2006) Am Soc Trop Med Hyg, 75 (3), pp. 509-512Strauss-Ayali, D., Simpson, K.W., Gastric Helicobacter infeccion in dogs (1999) Vet Clin N Am Small Anim Pract, 29 (2), pp. 397-414Neiger, R., Simpson, K.W., Helicobacter infection in dogs and cats: Facts and fiction (2000) J Vet Intern Med, 14 (2), pp. 125-133Happonen, E.U., Saari, S., Castren, L., Tyni, O., Hänninen, M.L., Westermarck, E., Comparison of diagnostic methods for detecting gastric Helicobacter like organisms in dogs and cats (1996) J Comparat Pathol, 115 (2), pp. 117-127Mendall, M.A., Northfeld, T.C., Transmission of Helicobacter pylori infection (1995) Gut, 37, pp. 1-3Fox, J.G., Non-human reservoirs of Helicobacter pylori (1995) Aliment Pharmacol Ther, 9 (2), pp. 93-103Coelho, L.G.V., Mattos, A.A., Francisconi, C.F.M., Castro, L.P., Suraia, A.B., Effcacy of the dosing regimen of pantoprazole 40 mg, amoxicillin 1000 mg and clarithromycin 500 mg, twice daily of 7 days, in the eradication of Helicobacter pylori in patients with peptic ulcer (2004) Arq Gastroenterol, 41 (1), pp. 71-76Coelho, L.G.V., Zaterca, S., Second Brazilian Consensus Conference on Helicobacter pylori infection (2005) Arq Gastroenterol, 42 (2), pp. 128-132Chether, L., Rodrigues, L., Faria, C.M., Recorrência da infecção por H. pylori na Unifesp (2005) GED, 24 (3), pp. 121-130Mesquita, M.A., Lorena, S.L., Zeitune, J.M.R., Montes, C.G., Guerrazzi, F., Carvalho, A.F., Santos, J.O.M., Almeida, J.R.S., Recurrence of Helicobacter pylori infection after eradication therapy in brazilian patients with peptic ulcer (2005) J Clin Gastroenterol, 39 (5), p. 447Moutinho, F.Q., Thomassian, A., Watanabe, M.J., Suzano, S.M.C., Sequeira, J.L., Prevalence of helicobacters and alterations in gastric mucosa of healthy dogs (2007) Arq Bras Med Vet Zootec, 59 (4), pp. 1080-1083Eaton, K.A., Dewhirst, F.E., Paster, B.J., Tzellas, N., Coleman, B.E., Paola, J., Sherding, N., Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: Animal and public health implications (1996) J Clin Microbiol, 34, pp. 3165-3170Hänninen, M.L., Happonen, I., Saari, S., Jalava, K., Culture and characteristic of Helicobacter bizzozeronii, a new gastric canine Helicobacter sp (1996) Int J Syst Bacteriol, 46 (1), pp. 160-166Lee, A., Hazell, S.L., O'Rourke, J.L., Kouprach, S., Isolation of a spiral shaped bacterium from the cat stomach (1988) Infect Immunol, 56 (11), pp. 2843-2850Paster, B.L., Lee, A., Fox, J.G., Dewhirst, F.E., Tordoff, L.A., Fraser, G.J., O'Rouke, J.L., Ferrero, R., Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and related bacteria (1991) Int J Syst Bacteriol, 41, pp. 31-38Javala, K., Kaartinen, M., Utriainen, M., Happonen, I., Hänninen, M.L., Helicobacter salomonis sp. nov., a canine gastric Helicobacter sp. Related to H. felis and H. bizzozeronii (1997) Int J Syst Bacteriol, 52, pp. 975-980Takemura, L.S., Camargo, P.L., Alferi, A.A., Bracarense, A.P., Helicobacter spp. in cats: Association between infecting species and epithelial proliferation within the gastric lamina propria (2009) J Comp Pathol, 141 (2-3), pp. 127-134Hernández, C.A., Gallon, G., Restrepo, L.F., Análises de biópsias gástricas endoscópicas em caninos (2007) Rev Colom Cienc Pecua, 20 (3), pp. 250-259Coelho-Neto, J.S., Andreollo, N.A., Lopes, L.R., Nishimura, N.F., Brandalise, N.A., Leonardi, L.S., Late follow-up of gastrectomized patients for peptic ulcer: Clinical, endoscopic and histopathological aspects (2005) Arq Gastroenterol, 42 (3), pp. 146-152Ferreira, L.E.V.V.C., Meirelles, G.S.P., Vieira, R.C., Bragagnolo, M.A., Chebli, J.M.F., Souza, A.F.M., (2001) Changes In Ultra Rapid Urease Test and Histopathological Examination For Helicobacter Pylori By Antisecretory Drugs Arq Gastroenterol, 38 (1), pp. 3-8Happonen, E.U., Linden, J., Westermarck, E., Effect of triple therapy on eradication of canine gastric helicobacters and gastric disease (2008) J Small Anim Pract, 41 (1), pp. 1-6Leib, M.S., Duncan, R.B., Ward, D.L., Triple antimicrobial therapy and acid suppression in dogs with chronic vomiting and gastric Helicobacter spp (2008) J Vet Intern Med, 21 (6), pp. 1185-1192Pereira, G.A.S., Detección de Helicobacter pylori en placa dental y en mucosa gástrica de pacientes sometidos a endoscopia digestiva (2005) Acta Odontol Venez, 43 (2), pp. 113-118Recordati, C., Gualdi, V., Tosi, S., Facchini, R.V., Pengo, G., Luini, M., Simpson, K.W., Scanziania, E., Detection of Helicobacter spp. DNA in the oral cavity of dogs (2007) Vet Microbiol, 119 (24), pp. 346-351Souza, M.L., Kobayasi, S., Rodrigues, M.A.M., Hossne, R.O.G., Naresse, L.E., Prevalence of Helicobacter in canines from animal colony of the State University of Sao Paulo (UNESP)-Botucatu (2004) Acta Cir Bras, 19 (5), pp. 565-570Schütze, K., Hentschel, E., Dragosics, B., Hischl, A.M., Helicobacter pylori reinfection with indentical organisms: Transmission by the patients' spouses (1995) Gut, 36, pp. 831-83

Morphometric Study In Stomach Of Rabbits [estudio Morfométrico Del Estómago En Conejos]

Thirty three healthy, New Zealand rabbits, underwent a total gastrectomy via laparotomy and subsequent evaluation of gastric dimensions. Were measured the lengths of theu lesser and greater gastric curvature, in addition to the largest diameters of the organ. They presented average overall length of the lesser and greater curvature, respectively 6.7 cm and 27.3 cm. In addition, open surgical specimen presented a total area of 172.6 cm2. The sample was divided into two groups by age to perform comparisons between weight and stomach measures. Group 1 consisted of animals with age equal or less than 138 days and group 2 those with more than 138 days. No significant differences were found between the groups. This may suggest the use of younger animals to perform experiments related to surgical training involving the stomach, without dimensional prejudice of organ or generation of technical difficulties. Finally, it was noted also the predominance of the left gastric artery in the irrigation of the gastric wall and the presence of a transparent film between the liver and stomach in all animals.321227231Abidu-Figueiredo, M., Xavier-Silva, B., Cardinot, T.M., Babinski, M.A., Chagas, M.A., Celiac artery in New Zealand rabbit: Anatomical study of its origin and arrangement for experimental research and surgical practice (2008) Pesq. Vet. Bras, 28 (5), pp. 237-240Alves, J.R., Lopes, L.R., Sasasaki, T., Perioperative care in an animal model for training in abdominal surgery: Is it necessary a preoperative fasting? (2011) Acta Cir. Bras, 26 (6), pp. 541-548Amorim, M.J.A.A.L., Amorim, J.R.A.A., Villarouco, F.M.O., Capacid del estómago de conejos sin raza definida (Oryctolagus cuniculus) (2001) Rev. Chil. Anat, 19 (3), pp. 259-262Bensley, B.A., Craigie, E.H., (1948) Practical Anatomy of the Rabbit, , 8th ed. Canada, University of Toronto PressBrewer, N., Biology of the rabbit (2006) J. Am. Assoc. Lab. Anim. Sci, 45 (1), pp. 8-24Calasans-Maia, M.D., Monteiro, M.L., Áscoli, F.O., Granjeiro, J.M., The rabbit as an animal model for experimental surgery (2009) Acta Cir. Bras, 24 (4), pp. 325-328Conover, W.J., (1971) Practical Nonparametric Statistics, , New York, John Wiley & Sons, IncGalvão, F.H.F., Farias, A.Q., Pompeu, E., Waisberg, D.R., Teixeira, A.R.F., de Mello, E.S., Costa, A.C., D'Albuquerque, L.A.C., Endoscopic features in a model of multivisceral xenotransplantation (2010) Xenotransplantation, 17 (6), pp. 423-428Ghoshal, N.G., Bal, H.S., Comparative morphology of the stomach of some laboratory mammals (1989) Lab Anim, 23 (1), pp. 21-29Hristov, H., Kostov, D., Vladova, D., Topographical anatomy of some abdominal organs in rabbits (2006) Trakia J. Sci, 4 (3), pp. 7-10Hulley, S.B., Cummings, S.R., Browner, W.S., Grady, D., Hearst, N., Newman, T.B., (2003) Delineando a Pesquisa Clínica: Uma Abordagem Epidemiológica. 2a Ed, , Porto Alegre, ArtmedJohnson-Delaney, C.A., (2006) Anatomy and Physiology of the Rabbit and Rodent Gastrointestinal System, , http://www.chincare.com/HealthLifestyle/HLdocs2/gastrointestinal.pdfMeredith, A., Jepson, L., (2011) The Rabbit, , http://www.morfz.com/THERABBIT.pdf, Head of Exotic Animal Services Royal (Dick) School of Veterinary Studies University of EdinburghOliveira, L.R., Molinari, S.L., Natali, M.R.M., Michelan, A.C., Scapinello, C., Morphologic considerations about the wall of the glandular stomach of young rabbits (Oryctolagus cuniculus) (2001) Rev. Chil. Anat, 19 (3), pp. 253-258Piasecki, C., Wyatt, C., Patterns of blood supply to the gastric mucosa. A comparative study revealing an end-artery model (1986) J. Anat, 149, pp. 21-39Rodrígues-Alarcón, C., Pérez, E., Martín, U., Rivera, R., Hernández, A., Vivo, J., Beristain, M., Usón, J., Morfometría del Esófago Abdominal y del Estómago del Conejo (Orycotolagus cuniculus): Aplicaciones a la Cirugía Laparoscópica (2010) Int. J. Morphol, 28 (1), pp. 27-3

Dysphagia after antireflux fundoplication: endoscopic, radiological and manometric evaluation

The transient dysphagia after fundoplication is common and most often disappears until six weeks postoperatively. Analyze a group of patients who presented late and persistent dysphagia postoperatively. Forty-one patients after Nissen fundoplication, 14 male and 27 female, mean age 48 year, were evaluated based on medical history, esophagogastroduodenoscopy, contrast radiographic examination and esophageal manometry. The results were compared with another 19 asymptomatic individuals. Contrast radiographic examination of the esophagus revealed in six cases delayed emptying, characterizing that four patients had achalasia and two diffuse spasm of the esophagus. Esophageal manometry showed that maximal expiratory pressure of the lower sphincter ranged from 10 to 38 mmHg and mean respiratory pressure from 14 to 47 mmHg, values similar to controls. Residual pressure ranged from 5 to 31 mmHg, and 17 patients had the same values as the control group. The residual pressure of the lower sphincter was higher and statistically significant in patients with dysphagia compared with those operated without dysphagia. Future studies individualizing and categorizing each motility disorder, employing other techniques of manometry, and the analysis of the residual pressure may contribute to understand of persistent dysphagia in the postoperative fundoplication.The transient dysphagia after fundoplication is common and most often disappears until six weeks postoperatively. Analyze a group of patients who presented late and persistent dysphagia postoperatively. Forty-one patients after Nissen fundoplication, 14 m274251255sem informaçãosem informaçã

Quality Of Life Of Esophagectomized Patients: Adenocarcinoma Versus Squamous Cell Carcinoma [qualidade De Vida De Doentes Esofagectomizados: Adenocarcinoma Versus Carcinoma Epidermoide]

Objective: To evaluate and compare the quality of life (QOL) of patients undergoing esophagectomy for treatment of adenocarcinoma of the esophagogastric junction and squamous cell carcinoma. Methods: We conducted a cross-sectional study in postoperative patients submitted to esophagectomy for adenocarcinoma of the esophagogastric junction (ACA) and squamous cell carcinoma (SCC), using the SF-36 questionnaire applied in 24 patients (10 ACAs and 14 SCCs), from the 5th months postoperatively, including clinical symptoms and weight change. Results: The assessment of QOL showed the best functional capacity (p = 0.018) in the ACA group. There was a correlation between the domains "mental health" and "Role of Emotions" (p = 0.003) and between "pain" and "physical aspects limitation" (p = 0.003) in both histological types. Weight loss was greater in ACA (45.9 kg), with no significant difference between current BMI (p> 0.66). Dysphagia was reported by 83.3% of patients, anorexia by58.3%, chewing difficulty by 42%, nausea and vomiting by 41.7% and diarrhea by 29.2%, with no correlation with QOL reported (p> 0.05). Conclusion: The highest score for functional capacity indicates that ACA patients were able to perform all types of physical activity, including the more demanding, at a higher level than patients with SCC. Some symptoms persisted postoperatively, but did not affect the quality of life of patients.40139Corley, D.A., Buffler, P.A., Oesophageal and gastric cardia adenocarcinomas: Analysis of regional variation using the Cancer Incidence in Five Continents database (2001) Int J Epidemiol, 30 (6), pp. 1415-1425Jankowski, J.A., Perry, I., Harrison, R.F., Gastro-oesophageal cancer: Death at the junction (2000) BMJ, 321 (7259), pp. 463-464Tercioti, V., Lopes, L.R., Coelho Neto, J.S., Andreollo, N.A., New aspects of the neo-adjuvant therapy in esophageal squamous cell carcinoma. A review of medical literature (2009) ABCD, Arq Bras Cir Dig, 22 (1), pp. 33-40Steffen, A., Schulze, M.B., Pischon, T., Dietrich, T., Molina, E., Chirlaque, M.D., Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition (2009) Cancer Epidemiol Biomarkers Prev, 18 (7), pp. 2079-2089de Boer, A.G., van Lanschot, J.J., van Sandick, J.W., Hulscher, J.B., Stalmeier, P.F., de Haes, J.C., Quality of life after transhiatal compared with extended transthoracic resection for adenocarcinoma of the esophagus (2004) J Clin Oncol, 22 (20), pp. 4202-4208Cense, H.A., Visser, M.R., van Sandick, J.W., de Boer, A.G., Lamme, B., Obertop, H., Quality of life after colon interposition by necessity for esophageal cancer replacement (2004) J Surg Oncol, 88 (1), pp. 32-38Blazeby, J.M., Farndon, J.R., Donovan, J., Alderson, D., A prospective longitudinal study examining the quality of life of patients with esophageal carcinoma (2000) Cancer, 88 (8), pp. 1781-1787Rosmolen, W.D., Boer, K.R., de Leeuw, R.J., Gamel, C.J., van Berge Henegouwen, M.I., Bergman, J.J., Quality of life and fear of cancer recurrence after endoscopic and surgical treatment for early neoplasia in Barrett's esophagus (2010) Endoscopy, 42 (7), pp. 525-531de Boer, A.G., Genovesi, P.I., Sprangers, M.A., van Sandick, J.W., Obertop, H., van Lanschot, J.J., Quality of life in long-term survivors after curative transhiatal oesophagectomy for oesophageal carcinoma (2000) Br J Surg, 87 (12), pp. 1716-1721McLarty, A.J., Deschamps, C., Trastek, V.F., Allen, M.S., Pairolero, P.C., Harmsen, W.S., Esophageal resection for cancer of the esophagus: Long- term function and quality of life (1997) Ann Thorac Surg, 63 (6), pp. 1568-1572Kirby, J.D., Quality of life after oesophagectomy: The patients' perspective (1999) Dis Esophagus, 12 (3), pp. 168-171(1993) El Estado Físico: Uso E Interpretación De La Antropometria, , OMS, Informe de un comité de Expertos de la OMS. Serie de informes técnicos 854, Genebra: OMSLipschitz, D.A., Screening for nutritional status in the elderly (1994) Prim Care, 21 (1), pp. 55-67Ware Jr., J.E., Sherbourne, C.D., The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection (1992) Med Care, 30 (6), pp. 473-483Ciconelli, R.M., Ferraz, M.B., Santos, W., Meinão, I., Quaresma, M.R., Tradução para a lingua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (Brasil SF-36) (1999) Rev Bras Reumatol, 39 (3), pp. 143-150Aaronson, N.K., Muller, M., Cohen, P.D., Essink-Bot, M.L., Fekkes, M., Sanderman, R., Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations (1998) J Clin Epidemiol, 51 (11), pp. 1055-1068Jung, K.W., Talley, N.J., Romero, Y., Katzka, D.A., Schleck, C.D., Zinsmeister, A.R., Epidemiology and natural history of intestinal metaplasia of the gastroesophageal junction and Barrett's esophagus: A population-based study (2011) Am J Gastroenterol, 106 (8), pp. 1447-1455Modena, S.F., Meirelles, L.R., Araujo, M.R., Are the nitrites important in a Genesis of the adenocarcinoma associated to the Barrett esophagus? (2008) ABCD, Arq Bras Cir Dig, 21 (3), pp. 124-129Cooper, G.S., Yuan, Z., Chak, A., Rimm, A.A., Association of prediagnosis endoscopy with stage and survival in adenocarcinoma of the esophagus and gastric cardia (2002) Cancer, 95 (1), pp. 32-38Schembre, D., Arai, A., Levy, S., Farrel-Ross, M., Low, D., Quality of life esophagectomy and endoscopic therapy for Barrett's esophagus with dysplasia (2010) Dis Esophagus, 23 (6), pp. 458-464Sundelöf, M., Ye, W., Dickman, P.W., Lagergren, J., Improved survival in both histologic types of oesophageal cancer in Sweden (2002) Int J Cancer, 99 (5), pp. 751-754Brown, L.F., Kroenke, K., Theobald, D.E., Wu, J., (2011) Comparison of SF-36 Vitality Scale and Fatigue Symptom Inventory In Assessing Cancer-related Fatigue, 19 (8), pp. 1255-1259Zieren, H.U., Jacobi, C.A., Zieren, J., Müller, J.M., Quality of life following resection of oesophageal carcinoma (1996) Br J Surg, 83 (12), pp. 1772-1775Djärv, T., Lagergren, J., Blazeby, J.M., Lagergren, P., Long-term health-related quality of life following surgery for oesophageal cancer (2008) Br J Surg, 95 (9), pp. 1121-1126Tercioti Júnior, V., Lopes, L.R., Coelho Neto, J.S., Carvalheira, J.B., Andreollo, N.A., Eficácia local e complicações da terapêutica neoadjuvante no carcinoma epidermoide: Radioterapia versus ra-dioterapia associada à quimioterapia (2011) Rev Col Bras Cir, 38 (4), pp. 227-234Steinglass, P., Ostroff, J.S., Steinglass, A.S., Multiple family groups for adult cancer survivors and their families: A 1-day workshop model (2011) Fam Process, 50 (3), pp. 393-40

Laparoscopic antireflux surgery in patients with extra esophageal symptoms related to asthma

Asthma, laryngitis and chronic cough are atypical symptoms of the gastroesophageal reflux disease. To analyze the efficacy of laparoscopic surgery in the remission of extra-esophageal symptoms in patients with gastroesophageal reflux, related to asthma. Were reviewed the medical records of 400 patients with gastroesophageal reflux disease submitted to laparoscopic Nissen fundoplication from 1994 to 2006, and identified 30 patients with extra-esophageal symptoms related to asthma. The variables considered were: gender, age, gastroesophageal symptoms (heartburn, acid reflux and dysphagia), time of reflux disease, treatment with proton pump inhibitor, use of specific medications, treatment and evolution, number of attacks and degree of esophagitis. Data were subjected to statistical analysis, comparing the pre- and post-surgical findings. The comparative analysis before surgery (T1) and six months after surgery (T2) showed a significant reduction on heartburn and reflux symptoms. Apart from that, there was a significant difference between the patients with daily crises of asthma (T1 versus T2, 45.83% to 16.67%, p=0.0002) and continuous crises (T1, 41.67% versus T2, 8.33%, p=0.0002). Laparoscopic Nissen fundoplication was effective in improving symptoms that are typical of reflux disease and clinical manifestations of asthma.Asthma, laryngitis and chronic cough are atypical symptoms of the gastroesophageal reflux disease. To analyze the efficacy of laparoscopic surgery in the remission of extra-esophageal symptoms in patients with gastroesophageal reflux, related to asthma. W2729295sem informaçãosem informaçã

Effect of surgical treatment on the cellular immune response of gastric cancer patients

Patients with gastric cancer have a variety of immunological abnormalities. In the present study the lymphocytes and their subsets were determined in the peripheral blood of patients with gastric cancer (N = 41) both before and after surgical treatment. The percent of helper/inducer CD4 T cells (43.6 ± 8.9) was not different after tumor resection (43.6 ± 8.2). The percent of the cytotoxic CD8+ T cell population decreased significantly, whether patients were treated surgically (27.2 ± 5.8%, N = 20) or not (27.3 ± 7.3%, N = 20) compared to individuals with inflammatory disease (30.9 ± 7.5%) or to healthy individuals (33.2 ± 7.6%). The CD4/CD8 ratio consequently increased in the group of cancer patients. The peripheral blood lymphocytes of gastric cancer patients showed reduced responsiveness to mitogens. The defective blastogenic response of the lymphocytes was not associated with the production of transforming growth factor beta (TGF-ß) since the patients with cancer had reduced production of TGF-ß1 (269 ± 239 pg/ml, N = 20) in comparison to the normal individuals (884 ± 175 pg/ml, N = 20). These results indicate that the immune response of gastric cancer patients was not significantly modified by surgical treatment when evaluated four weeks after surgery and that the immunosuppression observed was not due to an increase in TGF-ß1 production by peripheral leukocytes.33934

Azeites da ‘Galega Vulgar’ - efeito do loteamento e do armazenamento

Comunicação apresentada no III Simpósio Nacional de Olivicultura que decorreu em Castelo Branco, na Escola Superior Agrária do Instituto Politécnico de Castelo Branco, de 29 a 31 de Outubro de 2003.O presente trabalho aborda: o efeito do loteamento de azeites ‘Galega’ com azeites ‘Azeiteira’, ‘Arbequina’, ‘Carrasquenha’, ‘Cobrançosa’ e ‘Picual’; e o efeito do tempo de armazenamento em parâmetros analíticos determinantes na sua qualidade. São investigados: a acidez, o índice de peróxido, as absorvâncias no UV, o sabor amargo (K225), a estabilidade oxidativa (RANCIMAT), a composição em ácidos gordos e o teor em polifenóis totais. Durante o armazenamento, verifica-se que a estabilidade oxidativa e o sabor amargo decresceram inicialmente de forma acentuada, tendendo a estabilizar posteriormente. Dada a impossibilidade legal de introduzir a ‘Picual’ na Denominação de Origem Protegida “Azeites do Norte Alentejano”, o lote ‘Galega’/’Cobrançosa’ revelou-se como o mais interessante para a DOP: trata-se do lote mais estável e mais frutado, sem ser, contudo, excessivamente amargo