622 research outputs found
PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD
Stimulation of N-methyl-D-aspartic acid receptors (NMDARs) and the resulting increase of nitric oxide (NO) production are critical for fear memory formation. Following NMDAR activation, efficient production of NO requires linking the 95 kDa postsynaptic density protein (PSD95), a scaffolding protein to neuronal nitric oxide synthase (nNOS). A variety of previously studied NMDAR antagonists and NOS inhibitors can disrupt fear conditioning, but they also affect many other CNS functions such as motor activity, anxiety, and learning. We hypothesized that disrupting nNOS and PSD95 interaction in the amygdala, a critical site for fear memory formation, will reduce conditioned fear. Our results show that systemic treatment with ZL006, a compound that disrupts PSD95/nNOS binding, attenuates fear memory compared to its inactive isomer ZL007. Co-immunoprecipitation after fear conditioning showed a robust increase in the amygdala PSD95/nNOS binding, which was blocked by systemic pre-administration of ZL006. Treatment of amygdala slices with ZL006 also impaired long-term potentiation (LTP), a cellular signature of synaptic plasticity. Direct intra-amygdala infusion of ZL006 also attenuated conditioned fear. Finally, unlike NMDAR antagonist MK-801, ZL006 does not affect locomotion, social interaction, object recognition memory, and spatial memory. These findings support the hypothesis that disrupting the PSD95/nNOS interaction downstream of NMDARs selectively reduces fear memory, and highlights PSD95/nNOS interaction as a novel target for fear-related disorders, such as posttraumatic stress disorder
Electronic structure of nuclear-spin-polarization-induced quantum dots
We study a system in which electrons in a two-dimensional electron gas are
confined by a nonhomogeneous nuclear spin polarization. The system consists of
a heterostructure that has non-zero nuclei spins. We show that in this system
electrons can be confined into a dot region through a local nuclear spin
polarization. The nuclear-spin-polarization-induced quantum dot has interesting
properties indicating that electron energy levels are time-dependent because of
the nuclear spin relaxation and diffusion processes. Electron confining
potential is a solution of diffusion equation with relaxation. Experimental
investigations of the time-dependence of electron energy levels will result in
more information about nuclear spin interactions in solids
Limits on Production of Magnetic Monopoles Utilizing Samples from the DO and CDF Detectors at the Tevatron
We present 90% confidence level limits on magnetic monopole production at the
Fermilab Tevatron from three sets of samples obtained from the D0 and CDF
detectors each exposed to a proton-antiproton luminosity of
(experiment E-882). Limits are obtained for the production cross-sections and
masses for low-mass accelerator-produced pointlike Dirac monopoles trapped and
bound in material surrounding the D0 and CDF collision regions. In the absence
of a complete quantum field theory of magnetic charge, we estimate these limits
on the basis of a Drell-Yan model. These results (for magnetic charge values of
1, 2, 3, and 6 times the minimum Dirac charge) extend and improve previously
published bounds.Comment: 18 pages, 17 figures, REVTeX
Dispatcher-assisted cardiopulmonary resuscitation for paediatric out-of-hospital cardiac arrest
Aim
To evaluate communication issues during dispatcher-assisted cardiopulmonary resuscitation (DACPR) for paediatric out-of-hospital cardiac arrest in a structured manner to facilitate recommendations for training improvement.
Methods
A retrospective observational study evaluated DACPR communication issues using the SACCIA ® Safe Communication typology (Sufficiency, Accuracy, Clarity, Contextualization, Interpersonal Adaptation). Telephone recordings of 31 cases were transcribed verbatim and analysed with respect to encoding, decoding and transactional communication issues.
Results
Sixty SACCIA communication issues were observed in the 31 cases, averaging 1.9 issues per case. A majority of the issues were related to sufficiency (35%) and accuracy (35%) of communication between dispatcher and caller. Situation specific guideline application was observed in CPR practice, (co)counting and methods of compressions.
Conclusion
This structured evaluation identified specific issues in paediatric DACPR communication. Our training recommendations focus on situation and language specific guideline application and moving beyond verbal communication by utilizing the smart phone’s functions. Prospective efforts are necessary to follow-up its translation into better paediatric DACPR outcomes
Symmetry-breaking Effects for Polariton Condensates in Double-Well Potentials
We study the existence, stability, and dynamics of symmetric and anti-symmetric states of quasi-one-dimensional polariton condensates in double-well potentials, in the presence of nonresonant pumping and nonlinear damping. Some prototypical features of the system, such as the bifurcation of asymmetric solutions, are similar to the Hamiltonian analog of the double-well system considered in the realm of atomic condensates. Nevertheless, there are also some nontrivial differences including, e.g., the unstable nature of both the parent and the daughter branch emerging in the relevant pitchfork bifurcation for slightly larger values of atom numbers. Another interesting feature that does not appear in the atomic condensate case is that the bifurcation for attractive interactions is slightly sub-critical instead of supercritical. These conclusions of the bifurcation analysis are corroborated by direct numerical simulations examining the dynamics of the system in the unstable regime.MICINN (Spain) project FIS2008- 0484
Approach to ergodicity in quantum wave functions
According to theorems of Shnirelman and followers, in the semiclassical limit
the quantum wavefunctions of classically ergodic systems tend to the
microcanonical density on the energy shell. We here develop a semiclassical
theory that relates the rate of approach to the decay of certain classical
fluctuations. For uniformly hyperbolic systems we find that the variance of the
quantum matrix elements is proportional to the variance of the integral of the
associated classical operator over trajectory segments of length , and
inversely proportional to , where is the Heisenberg
time, being the mean density of states. Since for these systems the
classical variance increases linearly with , the variance of the matrix
elements decays like . For non-hyperbolic systems, like Hamiltonians
with a mixed phase space and the stadium billiard, our results predict a slower
decay due to sticking in marginally unstable regions. Numerical computations
supporting these conclusions are presented for the bakers map and the hydrogen
atom in a magnetic field.Comment: 11 pages postscript and 4 figures in two files, tar-compressed and
uuencoded using uufiles, to appear in Phys Rev E. For related papers, see
http://www.icbm.uni-oldenburg.de/icbm/kosy/ag.htm
Polarized deep-inelastic scattering from nuclei: a relativistic approach.
We discuss spin-dependent, deep-inelastic scattering from nuclei within a covariant framework. In the relativistic impulse approximation this is described in terms of the amplitude for forward, virtual-photon scattering from an off-mass-shell nucleon. The general structure of the off-shell nucleon hadronic tensor is derived, and the leading behavior of the off-shell nucleon structure functions computed in the Bjorken limit. The formalism, which is valid for nucleons bound inside nuclei with spin 1/2 or 1, is applied to the case of the deuteron.Piller, G. ; Melnitchouk, W. ; Thomas, A.W
Neutron structure function and inclusive DIS from H-3 and He-3 at large Bjorken-x
A detailed study of inclusive deep inelastic scattering (DIS) from mirror A =
3 nuclei at large values of the Bjorken variable x is presented. The main
purpose is to estimate the theoretical uncertainties on the extraction of the
neutron DIS structure function from such nuclear measurements. On one hand,
within models in which no modification of the bound nucleon structure functions
is taken into account, we have investigated the possible uncertainties arising
from: i) charge symmetry breaking terms in the nucleon-nucleon interaction, ii)
finite Q**2 effects neglected in the Bjorken limit, iii) the role of different
prescriptions for the nucleon Spectral Function normalization providing baryon
number conservation, and iv) the differences between the virtual nucleon and
light cone formalisms. Although these effects have been not yet considered in
existing analyses, our conclusion is that all these effects cancel at the level
of ~ 1% for x < 0.75 in overall agreement with previous findings. On the other
hand we have considered several models in which the modification of the bound
nucleon structure functions is accounted for to describe the EMC effect in DIS
scattering from nuclei. It turns out that within these models the cancellation
of nuclear effects is expected to occur only at a level of ~ 3%, leading to an
accuracy of ~ 12 % in the extraction of the neutron to proton structure
function ratio at x ~ 0.7 -0.8$. Another consequence of considering a broad
range of models of the EMC effect is that the previously suggested iteration
procedure does not improve the accuracy of the extraction of the neutron to
proton structure function ratio.Comment: revised version to appear in Phys. Rev. C; main modifications in
Section 4; no change in the conclusion
A Measurement of Psi(2S) Resonance Parameters
Cross sections for e+e- to hadons, pi+pi- J/Psi, and mu+mu- have been
measured in the vicinity of the Psi(2S) resonance using the BESII detector
operated at the BEPC. The Psi(2S) total width; partial widths to hadrons,
pi+pi- J/Psi, muons; and corresponding branching fractions have been determined
to be Gamma(total)= (264+-27) keV; Gamma(hadron)= (258+-26) keV, Gamma(mu)=
(2.44+-0.21) keV, and Gamma(pi+pi- J/Psi)= (85+-8.7) keV; and Br(hadron)=
(97.79+-0.15)%, Br(pi+pi- J/Psi)= (32+-1.4)%, Br(mu)= (0.93+-0.08)%,
respectively.Comment: 8 pages, 6 figure
Measurements of the Mass and Full-Width of the Meson
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five different decay
channels: , , (with ), (with
) and . From a combined fit of all five
channels, we determine the mass and full-width of to be
MeV/ and
MeV/.Comment: 9 pages, 2 figures and 4 table. Submitted to Phys. Lett.
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