Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infections

AbstractEfforts to control spread of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are often based on eradication of colonization. However, the role of nasal and non-nasal colonization in the pathogenesis of these infections remains poorly understood. Patients with acute S. aureus skin and soft tissue infection (SSTI) were prospectively enrolled. Each subject's nasal, axillary, inguinal and rectal areas were swabbed for S. aureus and epidemiological risk factors were surveyed. Among the 117 patients enrolled, there were 99 patients who had an SSTI and for whom data could be analysed. Sixty-five patients had a CA-MRSA SSTI. Among these patients, MRSA colonization in the nares, axilla, inguinal area and rectum was 25, 6, 11 and 13%, respectively, and 37% overall were MRSA colonized. Most (96%) MRSA colonization was detected using nose and inguinal screening alone. Non-nasal colonization was 25% among CA-MRSA patients, but only 6% among patients with CA-methicillin-susceptible S. aureus (MSSA) or healthcare-associated MRSA or MSSA. These findings suggest that colonization patterns in CA-MRSA infection are distinct from those in non-CA-MRSA S. aureus infections. The relatively high prevalence of non-nasal colonization may play a key role in CA-MRSA transmission and acquisition of infection

Scaling in the Lattice Gas Model

A good quality scaling of the cluster size distributions is obtained for the Lattice Gas Model using the Fisher's ansatz for the scaling function. This scaling identifies a pseudo-critical line in the phase diagram of the model that spans the whole (subcritical to supercritical) density range. The independent cluster hypothesis of the Fisher approach is shown to describe correctly the thermodynamics of the lattice only far away from the critical point.Comment: 4 pages, 3 figure

Loop effects and non-decoupling property of SUSY QCD in gb→tH−g b\to tH^{-}

One-loop SUSY QCD radiative correction to $gb \to tH^{-}$ cross section is calculated in the Minimal Supersymmetric Standard Model. We found that SUSY QCD is non-decoupling if the gluino mass and the parameter $\mu$, $A_t$ or $A_b$ are at the same order and get large. The non-decoupling contribution can be enhanced by large $\tan\beta$ and therefore large corrections to the hadronic production rates at the Tevatron and LHC are expected in the large $\tan\beta$ limit. The fundamental reason for such non-decoupling behavior is found to be some couplings in the loops being proportional to SUSY mass parameters.Comment: 15 pages, 5 PS figures. A proof of non-decouplings of SUSY-QCD, Comments on corresponding QCD correction and references adde

Natural variation in ovule morphology is influenced by multiple tissues and impacts downstream grain development in barley (Hordeum vulgare L.).

The ovule plays a critical role in cereal yield as it is the site of fertilization and the progenitor of the grain. The ovule primordium is generally comprised of three domains, the funiculus, chalaza, and nucellus, which give rise to distinct tissues including the integuments, nucellar projection, and embryo sac. The size and arrangement of these domains varies significantly between model eudicots, such as Arabidopsis thaliana, and agriculturally important monocotyledonous cereal species, such as Hordeum vulgare (barley). However, the amount of variation in ovule development among genotypes of a single species, and its functional significance, remains unclear. To address this, wholemount clearing was used to examine the details of ovule development in barley. Nine sporophytic and gametophytic features were examined at ovule maturity in a panel of 150 European two-row spring barley genotypes, and compared with grain traits from the preceding and same generation. Correlations were identified between ovule traits and features of grain they produced, which in general highlighted a negative correlation between nucellus area, ovule area, and grain weight. We speculate that the amount of ovule tissue, particularly the size of the nucellus, may affect the timing of maternal resource allocation to the fertilized embryo sac, thereby influencing subsequent grain development.Laura G. Wilkinson, Xiujuan Yang, Rachel A. Burton, Tobias Würschum and Matthew R. Tucke

Spectral functions of the Falicov-Kimball model with electronic ferroelectricity

We calculate the angular resolved photoemission spectrum of the Falicov-Kimball model with electronic ferroelectricity where $d$- and $f$-electrons have different hoppings. In mix-valence regimes, the presence of strong scattering processes between $d$-$f$ excitons and a hole, created by emission of an electron, leads to the formation of pseudospin polarons and novel electronic structures with bandwidth scaling with that of $d$-$f$ excitons. Especially, in the two-dimensional case, we find that flat regions exist near the bottom of the quasiparticle band in a wide range of the $d$- and $f$-level energy difference.Comment: 5 pages, 5 figure

Influence of a low magnetic field on the thermal diffusivity of Bi-2212

The thermal diffusivity of a Bi-2212 polycrystalline sample has been measured under a 1T magnetic field applied perpendicularly to the heat flux. The magnetic contribution to the heat carrier mean free path has been extracted and is found to behave as a simple power law. This behavior can be attributed to a percolation process of electrons in the vortex lattice created by the magnetic field.Comment: 10 pages, 3 figures; to be published in Phys. Rev.

Small angle X-ray diffraction studies on the topography of cannabinoids in synaptic plasma membranes

In a previous publication, we have described in detail how we used small angle x-ray diffraction to determine the topography of (-)-Δ8-tetrahydrocannabinol (Δ8-THC) in dimyristoylphophatidylcholine (DMPC) bilayers, and to deduce the conformation of the THC side chain by using the iodo-analog (5′-I-Δ8-THC) in the model membrane. We have now extended our studies to synaptic plasma membrane systems where the cannabinoids are believed to exert part of their pharmacological effects. Synaptic plasma membranes (SPM) were isolated from fresh bovine brains and Δ8-THC was incorporated into the membranes. By comparing the electron density profiles of drug free and drug-containing SPM preparations, we observed an electron density increase due to the presence of Δ8-THC in a region centered at 9.2 Å from the terminal methyl groups of the membrane bilayer. In an attempt to dissect the effects of different membrane components on the topography of Δ8-THC, we carried out parallel experiments using membrane preparations from the synaptosomal membrane total lipid extract (TLX) as well as from bovine brain phosphatidyl choline extract (PCX) containing 30 mole percent cholesterol (Chol). Our results regarding the topography of Δ8-THC and 5′-I-Δ8-THC in these lipid membranes show that the TLX bilayer simulates the natural membrane environment very closely whereas in the PCX/Chol bilayer Δ8-THC resides at a location approximately 4 Å closer to the membrane interface, similar to that found in our previous study using DMPC model membrane. These x-ray diffraction results provide insights regarding the location of the binding sites on the cannabinoid receptor and indicate that preparations of the total lipid extract from synaptosomal membranes duplicate very well the properties of the intact membrane preparation

Ovule cell wall composition is a maternal determinant of grain size in barley

OnlinePublIn cereal species, seed and grain size is influenced by growth of the ovule integuments (seed coat), the spikelet hull (lemma and palea) and the filial endosperm. It has remained unclear whether a highly conserved ovule tissue, the nucellus, has any impact on grain size. Immunolabelling revealed that the barley nucellus comprises two distinct cell types that differ in terms of cell wall homogalacturonan (HG) accumulation. Transcriptional profiling of the nucellus identified two pectin methylesterase genes, OVULE PECTIN MODIFIER 1 (OPM1) and OPM2, which are expressed in the ovule but absent from the seed. Ovules from an opm1 opm2 mutant, and plants expressing an ovule-specific pectin methylesterase inhibitor (PMEI), exhibit reduced HG accumulation. This results in changes to ovule cell size and shape, and ovules that are longer than wild-type controls. At grain maturity, this is manifested as significantly longer grain. These findings indicate that cell wall composition during ovule development acts to limit ovule and seed growth. The investigation of ovule PME and PMEI activity reveals an unexpected role of maternal tissues in controlling grain growth prior to fertilisation, one that has been lacking from models exploring improvements in grain size.Xiujuan Yang, Laura G. Wilkinson, Matthew K. Aubert, Kelly Houston, Neil J. Shirley, and Matthew R. Tucke

Magnetic field - temperature phase diagram of quasi-two-dimensional organic superconductor lambda-(BETS)_2 GaCl_4 studied via thermal conductivity

The thermal conductivity kappa of the quasi-two-dimensional (Q2D) organic superconductor lambda-(BETS)_2 GaCl_4 was studied in the magnetic field H applied parallel to the Q2D plane. The phase diagram determined from this bulk measurement shows notable dependence on the sample quality. In dirty samples the upper critical field H_{c2} is consistent with the Pauli paramagnetic limiting, and a sharp change is observed in kappa(H) at H_{c2 parallel}. In contrast in clean samples H_{c2}(T) shows no saturation towards low temperatures and the feature in kappa(H) is replaced by two slope changes reminiscent of second-order transitions. The peculiarity was observed below ~ 0.33T_c and disappeared on field inclination to the plane when the orbital suppression of superconductivity became dominant. This behavior is consistent with the formation of a superconducting state with spatially modulated order parameter in clean samples.Comment: 10 pages, 8 figures, new figure (Fig.5) and references added, title change

Nonadiabatic approach to dimerization gap and optical absorption coefficient of the Su-Schrieffer-Heeger model

An analytical nonadiabatic approach has been developed to study the dimerization gap and the optical absorption coefficient of the Su-Schrieffer-Heeger model where the electrons interact with dispersive quantum phonons. By investigating quantitatively the effects of quantum phonon fluctuations on the gap order and the optical responses in this system, we show that the dimerization gap is much more reduced by the quantum lattice fluctuations than the optical absorption coefficient is. The calculated optical absorption coefficient and the density of states do not have the inverse-square-root singularity, but have a peak above the gap edge and there exist a significant tail below the peak. The peak of optical absorption spectrum is not directly corresponding to the dimerized gap. Our results of the optical absorption coefficient agree well with those of the experiments in both the shape and the peak position of the optical absorption spectrum.Comment: 14 pages, 7 figures. to be published in PR