8 research outputs found
Dopa-responsive dystonia and early-onset Parkinson's disease in a patient with GTP cyclohydrolase I deficiency?
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51313.pdf (publisher's version ) (Closed access)We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [123I]-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane (123I-FP-CIT) binding ratios indicative of Parkinson's disease. We conclude that the patient probably suffers from a variant of dopa-responsive dystonia (DRD) or two separate movement disorders, normally considered to be differential diagnoses, DRD and early-onset Parkinson's disease with resulting difficulties concerning treatment and prognosis
Dopa-responsive dystonia and early-onset Parkinson's disease in a patient with GTP cyclohydrolase I deficiency?
We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [123I]-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane (123I-FP-CIT) binding ratios indicative of Parkinson's disease. We conclude that the patient probably suffers from a variant of dopa-responsive dystonia (DRD) or two separate movement disorders, normally considered to be differential diagnoses, DRD and early-onset Parkinson's disease with resulting difficulties concerning treatment and prognosis
The origins of Odense â new aspects of early urbanisation in southern Scandinavia
The article presents an updated study of the centuries prior to Odenseâs traditional âbirth certificateâ of AD 988, resulting in a new model for the urbanisation of Odense. The conclusion reached is that there was activity of a permanent and possibly urban character in Odense from the end of the late eighth century until the late tenth century. The townâs development can be followed through three phases. Phases 1 and 2 cover the periods AD 700â900 and AD 900â100, respectively, while phase 3 covers the period AD 1000-1101. During phases 1 and 2, the proto-town develops through bottomup processes, such as network, crafts and possibly trade. After AD 1000, Odense develops into a town proper, under royal influence. The model from Odense provides the background for a fresh view of urbanisation in southern Scandinavia in general. A three-phase model is proposed. Phase 0 constitutes the emporia of the eighthâninth century, which perhaps primarily is satellites in a trading network controlled from the south. Phase 1 takes the form of locally initiated and based incipient urbanisation extending from the end of the eighth century until the tenth century. Phase 2 comprises the royally established towns from around AD 1000 onwards