Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease

Participant demographic and clinical characteristics, and urine BMP phospholipid levels. For each participant, sample collection site is provided as: BCN (Barcelona), VIE (Vienna), DND (Dundee), or SSB (San Sebastian). Also provided are age at study participation, age at PD diagnosis (where applicable), sex (M, for male, and F, for female), experimental group (control, iPD –idiopathic PD –, LRRK2 G2019S, LRRK2 R1441G/C, VPS35 D620N, GBA, or other), and PD status (NMC for non-manifesting mutation carriers, or PD). Values for all measured BMP species presented as ng of BMP per mg of creatinine are provided. Additionally, urine creatinine (mg/ml) and non-normalized BMP levels are provided. BQL designates BMP levels that were below quantification level and NM designates values that were not measured for a particular individual

Алкогольная зависимость у женщин с асоциальным поведением

АСОЦИАЛЬНОЕ ПОВЕДЕНИЕЖЕНСКИЙ АЛКОГОЛИЗМАЛКОГОЛЬНАЯ ЗАВИСИМОСТЬПредставлено систематизированное описание клинических проявлений и диагностических критериев алкогольной зависимости у женщин. Рассматриваются клинические и патопсихологические закономерности развития изменений личности у женщин с алкогольной зависимостью. Даны рекомендации по применению организационных и терапевтических методов, а также профилактики алкогольной зависимости у женщин с асоциальным поведением

Electro-acoustic performance of the new bone vibrator Radioear B81: A comparison with the conventional Radioear B71

Objective: The objective is to evaluate the electro-acoustic performance of a new audiometric bone vibrator, the B81 from Radioear Corporation, USA. Comparison will be made with the widely used B71 which has well-known limitations at low frequencies. Design: The B81 is based on the balanced electromagnetic separation transducer (BEST) principle where static forces are counterbalanced so that nonlinear distortion forces are reduced and maximum hearing levels can be increased. Study sample: Maximum hearing level, total harmonic distortion (THD), frequency response, and electrical impedance were measured for six devices of each bone vibrator type on an artificial mastoid. Results: It was found that B81 reaches 10.7-22.0 dB higher maximum (@ THD. 6% or V-in. 6 V-RMS) hearing levels than B71 for frequencies below 1500 Hz, and had significantly lower THD up to 1000 Hz. There was no statistically significant difference between their frequency response, except a deviation at the mid frequencies (alpha = 0.01) where B81 was more efficient and the electrical impedances were practically the same. Conclusions: In general, B81 had an improved electro-acoustic performance compared to B71 and is compatible with same audiometers. In particular, B81 allows for sensorineural hearing loss to be measured at considerably higher hearing levels than with B71 below 1500 Hz

Electro-acoustic performance of the new bone vibrator Radioear B81: A comparison with the conventional Radioear B71

Objective: The objective is to evaluate the electro-acoustic performance of a new audiometric bone vibrator, the B81 from Radioear Corporation, USA. Comparison will be made with the widely used B71 which has well-known limitations at low frequencies. Design: The B81 is based on the balanced electromagnetic separation transducer (BEST) principle where static forces are counterbalanced so that nonlinear distortion forces are reduced and maximum hearing levels can be increased. Study sample: Maximum hearing level, total harmonic distortion (THD), frequency response, and electrical impedance were measured for six devices of each bone vibrator type on an artificial mastoid. Results: It was found that B81 reaches 10.7-22.0 dB higher maximum (@ THD. 6% or V-in. 6 V-RMS) hearing levels than B71 for frequencies below 1500 Hz, and had significantly lower THD up to 1000 Hz. There was no statistically significant difference between their frequency response, except a deviation at the mid frequencies (alpha = 0.01) where B81 was more efficient and the electrical impedances were practically the same. Conclusions: In general, B81 had an improved electro-acoustic performance compared to B71 and is compatible with same audiometers. In particular, B81 allows for sensorineural hearing loss to be measured at considerably higher hearing levels than with B71 below 1500 Hz

Suberhard NbB2-x thin films deposited by dc magnetron sputtering

We have deposited weakly textured substoichiometric NbB2 −x thin films by magnetron sputtering from an NbB2 target. The films exhibit superhardness (42 ± 4 GPa), previously only observed in overstoichiometric TiB2 thin films, and explained by a self-organized nanostructuring, where thin TiB2 columnar grains hinder nucleation and slip of dislocations and a B-rich tissue phase between the grains prevent grain-boundary sliding. The wide homogeneity range for the NbB2 phase allows a similar ultra-thin B-rich tissue phase to form between thin (5–10 nm) columnar NbB2 −x grains also for films with a B/Nb atomic ratio of 1.8, as revealed here by analytical aberration-corrected scanning transmission electron microscopy. Furthermore, a coefficient of friction of 0.16 is measured for an NbB2 −x film sliding against stainless steel with a wear rate of 5 × 10− 7 mm3/Nm. X-ray photoelectron spectroscopy results suggest that the low friction is due to the formation of a lubricating boric acid film

VEMP using a new low-frequency bone conduction transducer [Erratum]

Håkansson B, Fredén Jansson KJ, Tengstrand T, et al. Med Devices (Auckl). 2018;11:301–312.On page 307, Table 1, there is an error in the placement of the lines in the “Average” column. All measured values in Table 1 are correct, but the lines to the right, showing how the conclusive values “39 dB” and “32 dB” were calculated, were erroneously scaled in the final preparation, and point to wrong values in their lower end. The correct placement of the lines is shown in the corrected version in this erratum.Read the original article

VEMP using a new low-frequency bone conduction transducer

Bo Håkansson,1 Karl-Johan Fredén Jansson,1 Tomas Tengstrand,2 Leif Johannsen,3 Måns Eeg-Olofsson,4 Cristina Rigato,1 Elisabeth Dahlström,4 Sabine Reinfeldt1 1Department of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Audiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 3Ortofon A/S, Nakskov, Denmark; 4Department of Otolaryngology, Head and Neck Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Objective: A new prototype bone conduction (BC) transducer B250, with an emphasized low-frequency response, is evaluated in vestibular evoked myogenic potential (VEMP) investigations. The aim was to compare cervical (cVEMP) and ocular (oVEMP) responses using tone bursts at 250 and 500 Hz with BC stimulation using the B250 and the conventional B81 transducer and by using air conduction (AC) stimulation.Methods: Three normal subjects were investigated in a pilot study. BC stimulation was applied to the mastoids in cVEMP, and both mastoid and forehead in oVEMP investigations.Results: BC stimulation was found to reach VEMP thresholds at considerably lower hearing levels than in AC stimulation (30–40 dB lower oVEMP threshold at 250 Hz). Three or more cVEMP and oVEMP responses at consecutive 5 dB increasing mastoid stimulation levels were only obtained in all subjects using the B250 transducer at 250 Hz. Similar BC thresholds were obtained for both ipsilateral and contralateral mastoid stimulation. Forehead stimulation, if needed, may require a more powerful vibration output.Conclusion: Viable VEMP responses can be obtained at a considerably lower hearing level with BC stimulation than by AC stimulation. The cVEMP and oVEMP responses were similar when measured on one side and with the B250 attached to both ipsilateral and contralateral mastoids. Keywords: vestibular investigation, air conduction, bone conduction, VEMP, cVEMP, oVEM