22 research outputs found

    Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: Implications for pathogenesis.

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    OBJECTIVE: Erdheim-Chester disease (ECD) is a rare form of non-Langerhans' cell histiocytosis (LCH) of unknown etiology, characterized by diffuse histiocyte infiltration of bones and soft tissue. The purpose of this study was to assess cell proliferation and expression of cytokines, chemokines, and chemokine receptors that may potentially be important in histiocyte accumulation in ECD lesions. METHODS: Biopsies were performed on 3 patients with ECD. The diagnosis of the disease was based on clinical signs including typical radiologic osteosclerosis, and on the detection of foamy CD68+,CD1a- non-Langerhans' cell histiocytes on histologic examination. The expression of the proliferation marker Ki-67 as well as of selected chemokine/chemokine receptor pairs and cytokines was analyzed by immunohistochemistry. RESULTS: In all samples, Ki-67 was undetectable in CD68+ histiocytes. Conversely, these cells expressed the chemokines CCL2 (monocyte chemotactic protein 1), CCL4/macrophage inflammatory protein 1beta (MIP-1beta), CCL5/RANTES, CCL20/MIP-3alpha, and CCL19/MIP-3beta, and their counter-receptors CCR1, CCR2, CCR3, CCR5, CCR6, and CCR7. Moreover, ECD histiocytes expressed interferon-gamma-inducible 10-kd protein (CXCL10), which is specifically induced by interferon-gamma, and interleukin-6 and RANKL, which are both implicated in bone remodeling. Finally, all cases showed a Th1-type lymphocyte infiltrate. CONCLUSION: Our data indicate that, similar to LCH, ECD lesions are characterized by a complex cytokine and chemokine network, which may orchestrate histiocyte activation and accumulation through an autocrine loop and contribute to the pathogenesis of the disease

    Modulo interdisciplinare di ricerca e progetto "PROGETTO DI LUOGHI E SPAZI DEL SACRO" AA 2007-2008

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    Attivit\ue0 di studio, ricerca e progetto sull'architettura sacra contemporanea, svolta in collaborazione formalizzata con la FTER - Facolt\ue0 Teologica dell'Emilia Romagna

    Bologna delle Chiese

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    note intorno ad una rifunzionalizzazione dello spazio di culto per la citt\ue0 di Bologna, problematiche di resturo e gestione

    architettura per le chiese contemporanee

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    Convegno “ACHITETTURA PER LE CHIESE CONTEMPORANEE” sul dibattito contemporaneo sull'architettura per la liturgia crisitana nelle città contemporanee, a conclusione del Modulo Didattico Interdisciplinare "PROGETTO DI LUOGHI E SPAZI DEL SACRO" AA 2008-2009. Evento organizzato presso l’Urban Center di Bologna da Dipartimento di Architettura e Pianificazione Territoriale, Facoltà Teologica dell’Emilia Romagna, Centro Studi Cherubino Ghirardacci, Urban Center Bologna, OICOS riflessioni, con il patrocinio di Comune di Bologna – Settore Cultura e Rapporti con l’Università, Festival of festival, Impresa Schiavina SRL, Fondazione Cattolica – Cattolica Assicurazioni, Unicredit Banca

    il paesaggio mutante nel Ravennate dall'osservatorio dei progetti della CQAP di Ravenna"

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    limiti degli attuali sistemi urbanistici per la gestione delle trasformazioni architettoniche e funzionali del territorio di Ravenn

    A relapsing inflammatory syndrome and active human herpesvirus 8 infection

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    We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles

    Wegener's granulomatosis: an analysis of 50 patients

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    Objectives: Two evaluate the rate of different organs involvement in 50 patients with Wegener's Granulomatosis (GW), and to describe their clinical manifestations and their response to treatment. Methods: We evaluated 50 consecutive patients with GW, come to our attention from January 1987 to May 2003. 43 patients met the 1990 American College of Rheumatology (ACR) criteria for classification of GW; 7 patients the 1993 ELK criteria. Results: 82% of patients presented Ear/Nose/Throat (ENT) involvement, which is the most common site of inflammation. 22% of our patients had ENT-restricted disease; in 78% of cases disease extended to other organs. Lungs were involved in 72% of cases; kidney in 36%; eye in 24%; nervous system (NS) in 14% (central NS in 10% and peripheral NS in 4%); skin in 10%; heart in 8%; testis in 4%. Arthritis was present in 10% of patients. We discuss treatment of all patients and response to therapy of those 28 whose follow-up is available. Conclusions: Involvement of airways and kidney is by far the most common in GW, though potentially any other organ or system may be affected. The total rate of other organs involvement is 70%

    Peripheral neuropathy in scleroderma

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    Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensory motor neuropathy and PSS. In both, the sural nerve biopsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy
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