1,977 research outputs found
Measurement of a Sign-Changing Two-Gap Superconducting Phase in Electron-Doped Ba(Fe_{1-x}Co_x)_2As_2 Single Crystals using Scanning Tunneling Spectroscopy
Scanning tunneling spectroscopic studies of (x =
0.06, 0.12) single crystals reveal direct evidence for predominantly two-gap
superconductivity. These gaps decrease with increasing temperature and vanish
above the superconducting transition . The two-gap nature and the slightly
doping- and energy-dependent quasiparticle scattering interferences near the
wave-vectors and are consistent with
sign-changing -wave superconductivity. The excess zero-bias conductance and
the large gap-to- ratios suggest dominant unitary impurity scattering.Comment: 4 pages, 4 figures. Paper accepted for publication in Physical Review
Letters. Contact author: Nai-Chang Yeh ([email protected]
Sigmoid-colonic motility in health and irritable bowel syndrome: A role for 5-hydroxytryptamine
Preserving entanglement under decoherence and sandwiching all separable states
Every entangled state can be perturbed, for instance by decoherence, and stay
entangled. For a large class of pure entangled states, we show how large the
perturbation can be. Our class includes all pure bipartite and all maximally
entangled states. For an entangled state, E, the constucted neighborhood of
entangled states is the region outside two parallel hyperplanes, which sandwich
the set of all separable states. The states for which these neighborhoods are
largest are the maximally entangled ones. As the number of particles, or the
dimensions of the Hilbert spaces for two of the particles increases, the
distance between two of the hyperplanes which sandwich the separable states
goes to zero. It is easy to decide if a state Q is in the neighborhood of
entangled states we construct for an entangled state E. One merely has to check
if the trace of EQ is greater than a constant which depends upon E and which we
determine.Comment: Corrected first author's e-mail address. All the rest remains
unchange
Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson´s disease patient with a triplication of the human SNCA genomic locus. In parallel, comparative studies were performed on two control lines derived from healthy individuals and lines generated from the patient iPS-derived neuroprogenitor lines infected with a lentivirus incorporating a small hairpin RNA to knock down the SNCA mRNA. The SNCA triplication lines exhibited a reduced capacity to differentiate into dopaminergic or GABAergic neurons and decreased neurite outgrowth and lower neuronal activity compared with control cultures. This delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mRNA for genes implicated in neuronal differentiation such as delta-like homolog 1 (DLK1), gamma-aminobutyric acid type B receptor subunit 2 (GABABR2), nuclear receptor related 1 protein (NURR1), G-protein-regulated inward-rectifier potassium channel 2 (GIRK-2) and tyrosine hydroxylase (TH). The differentiated patient cells also demonstrated increased autophagic flux when stressed with chloroquine. We conclude that a two-fold overexpression of α-synuclein caused by a triplication of the SNCA gene is sufficient to impair the differentiation of neuronal progenitor cells, a finding with implications for adult neurogenesis and Parkinson´s disease progression, particularly in the context of bioenergetic dysfunction.Fil: Oliveira, L. M. A.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Falomir Lockhart, Lisandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Botelho, M. G.. Max-Planck-Institut für biophysikalische Chemie; Alemania. Universidade Federal do Rio de Janeiro; BrasilFil: Lin, K. H.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Wales, P.. Universität Göttingen; AlemaniaFil: Koch, J. C.. Universität Göttingen; AlemaniaFil: Gerhardt, Elizabeth. Universität Göttingen; AlemaniaFil: Taschenberger, H.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Outeiro, T. F.. Universität Göttingen; AlemaniaFil: Lingor, P.. Universität Göttingen; AlemaniaFil: Schüele, B.. The Parkinson’s Institute; Estados UnidosFil: Arndt Jovin, D. J.. Max-Planck-Institut für biophysikalische Chemie; AlemaniaFil: Jovin, T. M.. Max-Planck-Institut für biophysikalische Chemie; Alemani
Nonlinear software sensor for monitoring genetic regulation processes with noise and modeling errors
Nonlinear control techniques by means of a software sensor that are commonly
used in chemical engineering could be also applied to genetic regulation
processes. We provide here a realistic formulation of this procedure by
introducing an additive white Gaussian noise, which is usually found in
experimental data. Besides, we include model errors, meaning that we assume we
do not know the nonlinear regulation function of the process. In order to
illustrate this procedure, we employ the Goodwin dynamics of the concentrations
[B.C. Goodwin, Temporal Oscillations in Cells, (Academic Press, New York,
1963)] in the simple form recently applied to single gene systems and some
operon cases [H. De Jong, J. Comp. Biol. 9, 67 (2002)], which involves the
dynamics of the mRNA, given protein, and metabolite concentrations. Further, we
present results for a three gene case in co-regulated sets of transcription
units as they occur in prokaryotes. However, instead of considering their full
dynamics, we use only the data of the metabolites and a designed software
sensor. We also show, more generally, that it is possible to rebuild the
complete set of nonmeasured concentrations despite the uncertainties in the
regulation function or, even more, in the case of not knowing the mRNA
dynamics. In addition, the rebuilding of concentrations is not affected by the
perturbation due to the additive white Gaussian noise and also we managed to
filter the noisy output of the biological systemComment: 21 pages, 7 figures; also selected in vjbio of August 2005; this
version corrects a misorder in the last three references of the published
versio
Multiple and Fast: The Accretion of Ordinary Chondrite Parent Bodies
Although petrologic, chemical and isotopic studies of ordinary chondrites and
meteorites in general have largely helped establish a chronology of the
earliest events of planetesimal formation and their evolution, there are
several questions that cannot be resolved via laboratory measurements and/or
experiments only. Here we propose rationale for several new constraints on the
formation and evolution of ordinary chondrite parent bodies (and by extension
most planetesimals) from newly available spectral measurements and
mineralogical analysis of main belt S-type asteroids (83 objects) and
unequilibrated ordinary chondrite meteorites (53 samples). Based on the latter,
we suggest spectral data may be used to distinguish whether an ordinary
chondrite was formed near the surface or in the interior of its parent body. If
these constraints are correct, the suggested implications include that: i)
large groups of compositionally similar asteroids are a natural outcome of
planetesimal formation and, consequently, meteorites within a given class can
originate from multiple parent bodies; ii) the surfaces of large (up to ~200km)
S-type main-belt asteroids expose mostly the interiors of the primordial
bodies, a likely consequence of impacts by small asteroids (D<10km) in the
early solar system (Ciesla et al. 2013); iii) the duration of accretion of the
H chondrite parent bodies was likely short (instantaneous or in less then ~10^5
yr but certainly not as long as 1 Myr); iv) LL-like bodies formed closer to the
Sun than H-like bodies, a possible consequence of radial mixing and size
sorting of chondrules in the protoplanetary disk prior to accretion.Comment: Accepted for publication in Ap
Data incongruence and the problem of avian louse phylogeny
Recent studies based on different types of data (i.e. morphological and molecular) have supported conflicting phylogenies for the genera of avian feather lice (Ischnocera: Phthiraptera). We analyse new and published data from morphology and from mitochondrial (12S rRNA and COI) and nuclear (EF1-) genes to explore the sources of this incongruence and explain these conflicts. Character convergence, multiple substitutions at high divergences, and ancient radiation over a short period of time have contributed to the problem of resolving louse phylogeny with the data currently available. We show that apparent incongruence between the molecular datasets is largely attributable to rate variation and nonstationarity of base composition. In contrast, highly significant character incongruence leads to topological incongruence between the molecular and morphological data. We consider ways in which biases in the sequence data could be misleading, using several maximum likelihood models and LogDet corrections. The hierarchical structure of the data is explored using likelihood mapping and SplitsTree methods. Ultimately, we concede there is strong discordance between the molecular and morphological data and apply the conditional combination approach in this case. We conclude that higher level phylogenetic relationships within avian Ischnocera remain extremely problematic. However, consensus between datasets is beginning to converge on a stable phylogeny for avian lice, at and below the familial rank
Signal Processing
Contains research objectives and reports on work completed and one research project.Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DA 28-043-AMC-02536(E
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