1,580 research outputs found
A Model for Zebrafish Ventricular Action Potential
From the '90s, the interest in the use of zebrafish has exponentially grown thanks to the numerous characteristics, very close to the human ones, that make this little fish very attractive in different fields. Thus, zebrafish has been increasingly proposed as a pharmacological and genetic screening model. The growing interest and the relevance of this animal model motivate the development of a mathematical model of the action potential of the zebrafish to facilitate the understanding of the mechanisms associated with its electrophysiological behavior and how they correlated with those observed in humans. This work presents the first attempt to develop a mathematical model of the adult zebrafish action potential. The model is based on the Ten Tusscher formulation of the action potential of human cardiomyocyte in which the main currents have been reparametrized to be adapted to those of the zebrafish, while extending the model to account for the T-type calcium current present in the zebrafish. Preliminary results of the proposed model show an action potential morphology in good agreement with experimental data
Migración intrapélvica (cut-in) en un clavo Gamma. Caso Clínico
Una de las complicaciones de los clavos intramedulares es sin duda la implantación central del tornillo cérvico-cefálico. Aún así, la confluencia de diversos factores (osteoporosis, trazo de la fractura, reducción insuficiente del foco, motorización reiterada, etc.) pueden precipitar la salida de éste (cut-out) que viene a evidenciar una prevalencia del 2 al 4% de las diversas series y, ulterior aflojamiento del montaje. La presencia del cut-in, supone una eventualidad muy ocasional por debajo del 0,3% de la literatura. En este caso se ilustra una consolidación definitiva afortunada, tras un abanico de factores mecánicos y estructurales que encaminaron a una doble cirugía terapéutica. Se analizan los factores biomecánicos implicados en la génesis del cut-in.One common complication of intramedullary nails is the central implantation of the cervico-cephalic screw. However, the confluence of some factors (osteoporosis, fracture line, inadequate focus reduction, repeated motorizing, etc.) can hasten a cut-out, showing a prevalence of 2 to 4% of the diverse series, and further assembly loosening. The presence of cut-in is an infrequent eventuality under the 0.3% of literature. The present case illustrates a fortunate definite consolidation, after a range of mechanical an structural factors leading to a double therapeutic surgery. The biomechanical factors affecting the cut-in origin are analysed.Peer Reviewe
Morbidity and Mortality After Living Kidney Donation, 1999 2001: Survey of United States Transplant Centers
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75563/1/j.1038-5282.2001.00400.x-i1.pd
Text localization in natural images through effective re identification of the MSER
© 2017 Association for Computing Machinery. Text detection and recognition from images have numerous applications for document analysis and information retrieval tasks. An accurate and robust method for detecting texts in natural scene images is proposed in this paper. Text-region candidates are detected using maximally stable extremal regions (MSER) and a machine learning based method is then applied to refine and validate the initial detection. The effectiveness of features based on aspect ratio, GLSM, LBP, HOG descriptors are investigated. Text-region classifiers of MLP, SVM and RF are trained using selections of these features and their combination. A publicly available multilingual dataset ICDAR 2003,2011 has been used to evaluate the method. The proposed method achieved excellent performance on both databases and the improvements are significant in terms of Precision, Recall, and F-measure. The results show that using a suitable feature combination and selection approach can can significantly increase the accuracy of the algorithms
De Novo Assembly of the Dirofilaria immitis Genome by Long-Read Nanopore-Based Sequencing Technology on an Adult Worm from a Canine Cardiopulmonary Dirofilariosis Case
Dirofilaria immitis is a zoonotic parasitic nematode that infects domestic and wild canids, among its vertebrate hosts. The genetic analysis of D. immitis nowadays transcends the need for genetic taxonomy of nematodes, such as the study of resistance to macrocyclic lactone. We expanded the use of long-read nanopore-based sequencing technology on nematodes by performing genomic de novo assembly of a D. immitis specimen retrieved from a canine cardiopulmonary dirofilariasis case using the ONT MinION platform, followed by the study of macrocyclic lactone resistance. The assembled genome of D. immitis consists of 110 contigs with an N50 of 3687191. The genome size is 87899012 and contains a total of 9741 proteins; 6 ribosomal RNAs, with three belonging to the small subunit (18S) and three to the large subunit (28S); and 73 tRNAs. Subsequent analysis of six loci previously characterized as being associated to macrocyclic lactone resistance selection pressure showed that four have a genotype associated with either some loss of efficacy or the resistance phenotype. Considering the zoonotic potential of D. immitis, the identification of a resistant parasite alerts for the overuse of macrocyclic lactone in the region, which poses a potential risk to both veterinary and human public health. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work was supported by national funds through the Fundação para a Ciência e Tec-nologia (FCT, Portuguese Foundation for Science and Technology) under projects UIDB/04750/2020, LA/P/0064/2020, UIDB/CVT/00772/2020, and LA/P/0059/2020
Evaluation of the automatic ELISA Triturus analyser
The objective was to evaluate the automatic ELISA Triturus analyser in order to assess its practicability and imprecision. The analyser was evaluated according to the guidelines of the Spanish Society of Clinical Chemistry. The evaluation was performed in two steps: evaluation of the imprecision and the inaccuracy of a semiquantitative and qualitative technique, and study of the practicability. The within-run imprecision rate ranged from 8.9 (VC) to 10.2% (VC) for the semiquantitative test, and from 11 (VC) to 17.2% (VC) for the qualitative one. The between-run imprecision rate ranged from 6 (VC) to 9.7% (VC) for the semiquantitative test, and from 8.8 (VC) to 18%(VC) for the qualitative technique. No sample-related carryover was detected in negative samples. The relative inaccuracy was correct for both techniques. Non-specific binding caused by waste products from the analysed circuits was not detected. The Triturus analyser is a reliable open analytical system with a considerable working capability, rendering this apparatus adequate for conventional laboratories with a medium-to-high work charge
Generic 3D Representation via Pose Estimation and Matching
Though a large body of computer vision research has investigated developing
generic semantic representations, efforts towards developing a similar
representation for 3D has been limited. In this paper, we learn a generic 3D
representation through solving a set of foundational proxy 3D tasks:
object-centric camera pose estimation and wide baseline feature matching. Our
method is based upon the premise that by providing supervision over a set of
carefully selected foundational tasks, generalization to novel tasks and
abstraction capabilities can be achieved. We empirically show that the internal
representation of a multi-task ConvNet trained to solve the above core problems
generalizes to novel 3D tasks (e.g., scene layout estimation, object pose
estimation, surface normal estimation) without the need for fine-tuning and
shows traits of abstraction abilities (e.g., cross-modality pose estimation).
In the context of the core supervised tasks, we demonstrate our representation
achieves state-of-the-art wide baseline feature matching results without
requiring apriori rectification (unlike SIFT and the majority of learned
features). We also show 6DOF camera pose estimation given a pair local image
patches. The accuracy of both supervised tasks come comparable to humans.
Finally, we contribute a large-scale dataset composed of object-centric street
view scenes along with point correspondences and camera pose information, and
conclude with a discussion on the learned representation and open research
questions.Comment: Published in ECCV16. See the project website
http://3drepresentation.stanford.edu/ and dataset website
https://github.com/amir32002/3D_Street_Vie
Young giants of intermediate mass: Evidence of rotation and mixing
Context. In the search of a sample of metal-poor bright giants using Strömgren photometry, we serendipitously found a sample of 26 young (ages younger than 1 Gyr) metal-rich giants, some of which have high rotational velocities. Aims. We determined the chemical composition and rotational velocities of these stars in order to compare them with predictions from stellar evolution models. These stars where of spectral type A to B when on the main sequence, and we therefore wished to compare their abundance pattern to that of main-sequence A and B stars. Methods. Stellar masses were derived by comparison of the position of the stars in the colour-magnitude diagram with theoretical evolutionary tracks. These masses, together with Gaia photometry and parallaxes, were used to derive the stellar parameters. We used spectrum synthesis and model atmospheres to determine chemical abundances for 16 elements (C, N, O, Mg, Al, Ca, Fe, Sr, Y, Ba, La, Ce, Pr, Nd, Sm, and Eu) and rotational velocities. Results. The age-metallicity degeneracy can affect photometric metallicity calibrations. We identify 15 stars as likely binary stars. All stars are in prograde motion around the Galactic centre and belong to the thin-disc population. All but one of the sample stars present low [C/Fe] and high [N/Fe] ratios together with constant [(C+N+O)/Fe], suggesting that they have undergone CNO processing and first dredge-up. The observed rotational velocities are in line with theoretical predictions of the evolution of rotating stars
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