Doxorubicin-associated Cardiomyopathy: New Approaches to Pharmacological Correction Using 3-(2,2,2-trimethylhydrazinium) Propionate Derivatives

The cardioprotective effect of the derivatives (nicotinate, 5-hydroxynicotinate) of 3-(2,2,2-trimethylhydrazini- um) propionate) and reference medicine meldonium in the case of doxorubicin (DOX) (20 mg/kg, intraperitoneally for 48 hours) cardiomyopathy was evaluated by the results of a functional test with high-frequency stimulation (480 bpm

Combined use of arginase II inhibitors and tadalafil for the correction of monocrotaline pulmonary hypertension

The concept of the regulatory role of endothelium in the pathogenesis of pulmonary hypertension (PH) is fundamental. To study the protective effects of the selective arginase II inhibitors L207-0525 and L327-0346 in combination with tadalafil in a monocrotaline model of pulmonary hypertension in rat

Synthesis of Ni/NiO Nanopowder by Thermal Decomposition of Nickel Acetate Amine

Ni/NiO nanopowders have been synthesized using thermal decomposition of nickel acetate hexaammine in air. Obtained powders have been characterized by IR-spectroscopy, XRD and TG, DTA, DTG and HR TEM. Thermal decomposition of nickel ammine complexes occurs with forming nickel hydroxide, carbonate and hydroxocarbonate ammines precursors. Mean particle size of nickel and nickel oxide phases in powders depends on temperature. In the temperature range from 350 to 500 degrees Celsius the particle size of nickel oxide has grown from 5 to 25 nm and nickel from 50 to 55 nm. Particle size of 5 nm for nickel hydroxide ammine remained unchanged with temperature. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3481

Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium

Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. Key issue is the possibility of drug effects on the mitochondria of cardiomyocytes that controls the aerobic metabolism and maintenance of ATP admission into cardiomyocyte

Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85 . 72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypy ridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high h eart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusat

Experimental approaches to the assessment of potential cardioprotective means with doxorubicin-associated cardiomyopathy

Development of methodological approaches for evaluation of cardioprotective activity of drugs in doxorubicin cardiomyopath

Evaluation of cardioprotective effects of the incritinmimetics exenatideand vildagliptin in the experiment

The results of experimental and clinical trials make it clear that incretin mimetics possess pleiotropic effects and demonstrate the value in terms of assessment of their potential opportunities as cardioprotectors. Goals: To study the cardioprotective effects of exenatide and vildagliptin on the model of doxorubicin-induced cardiomyopath

Effect of pharmacological preconditioning with incretinomimetics exenatide and vildagliptin on the survival of ischemic tissues

Currently, much attention is paid to the pleiotropic effects of entretenimiento. Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, damage of liver and skin graft during the experiment. During the experimental study we used a comprehensive approach to the study of the antiischemic effects of entretenimento: doksorubitsinola model of cardiomyopathy, hypo/reperfusion of the isolated heart, ischemia/reperfusion of the liver and the modeling of the skin flap on the supply le

Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivative