An advanced microcomputer design for processing of semiconductor materials

In the Get Away Special 330 payload two germanium samples doped with gallium will be processed. The aim of the experiments is to create a planar solid/liquid interface, and to study the breakdown of this interface as the crystal growth rate increases. For the experiments a gradient furnace was designed which is heated by resistive heaters. Cooling is provided by circulating gas from the atmosphere in the cannister through cooling channels in the furnace. The temperature along the sample are measured by platinum/rhodium thermocouples. The furnace is controlled by a microcomputer system, based upon the processor 80C88. A data acquisition system is integrated into the system. In order to synchronize the different actions in time, a multitask manager is used

Hypertriglyceridaemia‐induced pancreatitis prompted by acute corticosteroid treatment: caution for clinicians

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148397/1/imj14228.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148397/2/imj14228_am.pd

Current state of the art and use case description on geofencing for traffic management

This report is a result of a literature review and document gathering focused on geofence use cases specific for road traffic management. It presents geofence use cases that are trialled or to be trialled, implemented use cases, as well as conceptual and potential future use cases, showing for which type of transport they are used and how geofence zones are applied or to be applied. The report was conducted in the project GeoSence – Geofencing strategies for implementation in urban traffic management and planning. It is a Joint programme initiative (JPI) Urban Europe project funded by European Union´s Horizon 2020, under ERA-NET Cofund Urban Accessibility and Connectivity and gather project partners from Germany, Norway, Sweden and UK. The goal is to present the current state of art, and describe use cases, based on the working definition of geofencing in the project, where geofence is defined as a virtual geographically located boundary, statically or dynamically defined. The study shows that for implemented and real-traffic trial use case, geofencing has been applied within private car transport, shared micro-mobility, freight and logistics, public bus transportation and ridesourcing. For the future use cases, geofencing has been tested or conceptually developed also for automated vehicles and shared automated mobility, among others. The report summarises main use cases and find them to answering to especially four challenges in traffic management: safety, environment, efficiency, and tracking and data collection. Some of the use cases however answer to several of these challenges, such as differentiated road charging, and the use cases in micro-mobility. Further, the system and functionality of the trialled and/or implemented use cases, show different types of regulation geofence use cases can be used for, from informing, assisting, full enforcement, incentivising and penalisation. Guidelines and recommendations so far form national authorities show that the existence of joint regulation or guidelines for the use of geofencing for different use cases is low – with some exceptions. Digital representation of traffic regulation will be crucial for enabling geofencing

Capturing emergent phenomena in social-ecological systems: an analytical framework

Social-ecological systems (SES) are complex adaptive systems. Social-ecological system phenomena, such as regime shifts, transformations, or traps, emerge from interactions among and between human and nonhuman entities within and across scales. Analyses of SES phenomena thus require approaches that can account for (1) the intertwinedness of social and ecological processes and (2) the ways they jointly give rise to emergent social-ecological patterns, structures, and dynamics that feedback on the entities and processes that generated them. We have developed a framework of linked action situations (AS) as a tool to capture those interactions that are hypothesized to have jointly and dynamically generated a social-ecological phenomenon of interest. The framework extends the concept of an action situation to provide a conceptualization of SES that focusses on social-ecological interactions and their links across levels. The aim of our SE-AS (social-ecological action situations) framework is to support a process of developing hypotheses about configurations of ASs that may explain an emergent social-ecological phenomenon. We suggest six social-ecological ASs along with social and ecological action situations that can commonly be found in natural resource or ecosystem management contexts. We test the ability of the framework to structure an analysis of processes of emergence by applying it to different case studies of regime shifts, traps, and sustainable resource use. The framework goes beyond existing frameworks and approaches, such as the SES framework or causal loop diagrams, by establishing a way of analyzing SES that focuses on the interplay of social-ecological interactions with the emergent outcomes they produce. We conclude by discussing the added value of the framework and discussing the different purposes it can serve: from supporting the development of theories of the emergence of social-ecological phenomena, enhancing transparency of SES understandings to serving as a boundary object for interdisciplinary knowledge integration

Automated and interactive evaluation of welding producibility in an multidisciplinary design optimization environment for aircraft components

The automation capabilities and virtual tools within engineering disciplines, such as structural mechanics and aerodynamics, enable efficient Multidisciplinary Design Optimization (MDO) approaches to evaluate and optimize the performance of a large number of design variants during early design stages of aircraft components. However, for components that are designed to be welded, in which multiple functional requirements are satisfied by one single welded structure, the automation and simulation capabilities to evaluate welding-producibility and predict welding quality (geometrical deformation, weld bead geometrical quality, cracks, pores, etc) are limited. Besides the complexity of simulating all phenomena within the welding process, one of the main problems in welded integrated components is the existing coupling between welding quality metrics and product geometry. Welding quality can vary for every new product geometrical variant. Thus, there is a need of analyzing rapidly and virtually the interaction and sensitivity coefficients between design parameters and welding quality to predict welding producibility. This paper presents as a result an automated and interactive welding-producibility evaluation approach. This approach incorporates a data-based of welding-producibility criteria, as well as welding simulation and metamodel methods, which enable an interactive and automated evaluation of welding quality of a large number of product variants. The approach has been tested in an industrial use-case involving a multidisciplinary design process of aircraft components. The results from analyzing the welding-producibility of a set of design variants have been plotted together with the analysis results from other engineering disciplines resulting in an interactive tool built with parallel coordinate graphs. The approach proposed allows the generation and reuse of welding producibility information to perform analyses within a big spectrum of the design space in a rapid and interactive fashion, thus supporting designers on dealing with changes and taking fact-based decisions during the multidisciplinary design process

Relativistic quantum clocks

The conflict between quantum theory and the theory of relativity is exemplified in their treatment of time. We examine the ways in which their conceptions differ, and describe a semiclassical clock model combining elements of both theories. The results obtained with this clock model in flat spacetime are reviewed, and the problem of generalizing the model to curved spacetime is discussed, before briefly describing an experimental setup which could be used to test of the model. Taking an operationalist view, where time is that which is measured by a clock, we discuss the conclusions that can be drawn from these results, and what clues they contain for a full quantum relativistic theory of time.Comment: 12 pages, 4 figures. Invited contribution for the proceedings for "Workshop on Time in Physics" Zurich 201

PR3-ANCA:a promising biomarker in primary sclerosing cholangitis (PSC)

BACKGROUND AND AIMS:The only recognized biomarker for primary sclerosing cholangitis (PSC) is atypical anti-neutrophil cytoplasmic antibodies (aANCA), which, in addition to having low sensitivity and specificity, is an indirect immunofluorescence (IIF) test lacking the advantages of high throughput and objectivity. Recent reports have shown that antibodies to proteinase-3 (PR3-ANCA) might add diagnostic value in inflammatory bowel disease (IBD), specifically in ulcerative colitis (UC). As PSC is associated with IBD, the objective of this study was to evaluate the frequency and clinical significance of PR3-ANCA in a large cohort of patients. METHODS:A total of 244 PSC and 254 control [autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), hepatitis C viral infection (HCV), hepatitis B viral infection (HBV), and healthy controls] sera and their clinical correlations were retrospectively analyzed for PR3-ANCA determined by ELISA and a new chemiluminescence immunoassay (CIA). Testing was also performed for aANCA by IIF. RESULTS:When measured by CIA, PR3-ANCA was detected in 38.5% (94/244) of PSC patients compared to 10.6% (27/254) controls (p<0.0001). By ELISA, PR3-ANCA was detected in 23.4% (57/244) of PSC patients compared to 2.7% (6/254) controls (p<0.0001). PR3-ANCA in PSC patients was not associated with the presence or type of underlying IBD, and, in fact, it was more frequent in Crohn's disease (CD) patients with PSC than previously reported in CD alone. PR3-ANCA in PSC measured by CIA correlated with higher liver enzymes. CONCLUSION:PR3-ANCA is detected in a significant proportion of PSC patients compared to other liver diseases including PBC and AIH. PR3-ANCA is associated with higher liver enzyme levels in PSC, and is not solely related to underlying IBD

Assessment in higher education : the potential for a community of practice to improve inter-marker reliability

The design, delivery and assessment of a complete educational scheme, such as a degree programme or a professional qualification course, is a complex matter. Maintaining alignment between the stated aims of the curriculum and the scoring of student achievement is an overarching concern. The potential for drift across individual aspects of an educational scheme (teaching, learning and assessment), together with emerging criticism in extant literature of the reliability of marking processes, suggests that, in practice, maintaining alignment might be more difficult than had previously been assumed. In this paper, the concept of a Community of Practice (CoP) is employed as an analytical lens through which the notion of a markers’ standardisation meeting that focuses on maintaining alignment between the curriculum, the marking scheme and the scoring of student scripts can be critically examined. Given that the aims and subject content of management learning are both multidimensional and contextual, such meetings have the potential to develop a shared approach to the elaboration and application of the marking scheme. A further role of the CoP is in the calibration of markers to accommodate further variations in student responses as they arise in the actual marking process. In this respect, the CoP has both descriptive and prescriptive potential in terms of aiding the development of markers of professional accounting examinations and also, we suggest, within accounting education more generally

Integrating isotopes and documentary evidence : dietary patterns in a late medieval and early modern mining community, Sweden

We would like to thank the Archaeological Research Laboratory, Stockholm University, Sweden and the Tandem Laboratory (Ångström Laboratory), Uppsala University, Sweden, for undertaking the analyses of stable nitrogen and carbon isotopes in both human and animal collagen samples. Also, thanks to Elin Ahlin Sundman for providing the δ13C and δ15N values for animal references from Västerås. This research (Bäckström’s PhD employment at Lund University, Sweden) was supported by the Berit Wallenberg Foundation (BWS 2010.0176) and Jakob and Johan Söderberg’s foundation. The ‘Sala project’ (excavations and analyses) has been funded by Riksens Clenodium, Jernkontoret, Birgit and Gad Rausing’s Foundation, SAU’s Research Foundation, the Royal Physiographic Society of Lund, Berit Wallenbergs Foundation, Åke Wibergs Foundation, Lars Hiertas Memory, Helge Ax:son Johnson’s Foundation and The Royal Swedish Academy of Sciences.Peer reviewedPublisher PD

A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer

<p>Abstract</p> <p>Background</p> <p>The relationship between <it>Helicobacter pylori </it>infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the association between <it>H. pylori </it>seropositivity and the risk for pancreatic cancer in a nested case-control study within a population based cohort.</p> <p>Methods</p> <p>Selected birth-year cohorts (born 1921–1949) of residents in Malmö, Sweden, were invited to a health screening investigation. A total of 33 346 subjects participated. Cases with pancreatic cancer (n = 87) were matched to controls (n = 263) using age, sex and time for baseline investigation as matching variables. <it>H. pylori </it>serology was analysed in stored serum samples using an enzyme-linked immunosorbent assay. Odds ratios (OR) for pancreatic cancer were calculated with 95% confidence intervals (CI) using logistic regression.</p> <p>Results</p> <p><it>H. pylori </it>seropositivity was not associated with pancreatic cancer in the total cohort (adjusted OR 1.25 (0.75–2.09)). However, a statistically significant association was found in never smokers (OR 3.81 (1.06–13.63) adjusted for alcohol consumption) and a borderline statistically significant association was found in subjects with low alcohol consumption (OR 2.13 (0.97–4.69) adjusted for smoking).</p> <p>Conclusion</p> <p>We conclude that no association between <it>H. pylori </it>infection and the risk for pancreatic cancer was found in the total cohort. However, in never smokers and in subjects with low risk alcohol consumption, a positive <it>H. pylori </it>serology was associated with an increased risk for pancreatic cancer. These findings should be interpreted cautiously due to the limited number of cases in these subgroups.</p