Patterns in recent and Holocene pollen accumulation rates across Europe - the Pollen Monitoring Programme Database as a tool for vegetation reconstruction

The collection of modern, spatially extensive pollen data is important for the interpretation of fossil pollen assemblages and the reconstruction of past vegetation communities in space and time. Modern datasets are readily available for percentage data but lacking for pollen accumulation rates (PARs). Filling this gap has been the motivation of the pollen monitoring network, whose contributors monitored pollen deposition in modified Tauber traps for several years or decades across Europe. Here we present this monitoring dataset consisting of 351 trap locations with a total of 2742 annual samples covering the period from 1981 to 2017. This dataset shows that total PAR is influenced by forest cover and climate parameters, which determine pollen productivity and correlate with latitude. Treeless vegetation produced PAR values of at least 140 grains cm(-2) yr(-1). Tree PAR increased by at least 400 grains cm(-2) yr(-1) with each 10% increase in forest cover. Pollen traps situated beyond 200 km of the distribution of a given tree species still collect occasional pollen grains of that species. The threshold of this long-distance transport differs for individual species and is generally below 60 grains cm(-2) yr(-1). Comparisons between modern and fossil PAR from the same regions show similar values. For temperate taxa, modern analogues for fossil PARs are generally found downslope or southward of the fossil sites. While we do not find modern situations comparable to fossil PAR values of some taxa (e.g. Corylus), CO2 fertilization and land use may cause high modern PARs that are not documented in the fossil record. The modern data are now publicly available in the Neotoma Paleoecology Database and aid interpretations of fossil PAR data.Peer reviewe

Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer : A systematic review

Publisher Copyright: © 2016 Endzeliņš et al.Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of prostate cancer, however it also led to overdiagnosis and subsequent overtreatment of patients with an indolent disease. Treatment outcome and management of prostate cancer could be improved by the development of non-invasive biomarker assays that aid in increasing the sensitivity and specificity of prostate cancer screening, help to distinguish aggressive from indolent disease and guide therapeutic decisions. Prostate cancer cells release miRNAs into the bloodstream, where they exist incorporated into ribonucleoprotein complexes or extracellular vesicles. Later, cell-free miRNAs have been found in various other biofluids. The initial RNA sequencing studies suggested that most of the circulating cell-free miRNAs in healthy individuals are derived from blood cells, while specific disease-associated miRNA signatures may appear in the circulation of patients affected with various diseases, including cancer. This raised a hope that cell-free miRNAs may serve as non-invasive biomarkers for prostate cancer. Indeed, a number of cell-free miRNAs that potentially may serve as diagnostic, prognostic or predictive biomarkers have been discovered in blood or other biofluids of prostate cancer patients and need to be validated in appropriately designed longitudinal studies and clinical trials. In this review, we systematically summarise studies investigating cell-free miRNAs in biofluids of prostate cancer patients and discuss the utility of the identified biomarkers in various clinical scenarios. Furthermore, we discuss the possible mechanisms of miRNA release into biofluids and outline the biological questions and technical challenges that have arisen from these studies.publishersversionPeer reviewe

Overview of JET results for optimising ITER operation

The JET 2019–2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019–2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (α) physics in the coming D–T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D–T benefited from the highest D–D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER

Reconstruction of palaeovegetation and sedimentation conditions in the area of ancient Lake Burtnieks, northern Latvia

Palaeobotanical investigations were carried out with the aim of reconstructing the development of palaeovegetation and formation of sediments in the northeastern area of ancient Lake Burtnieks. Pollen and plant macroremain studies provide information on vegetation development in the surroundings of the lake, including Stone Age settlements of Braukšas I and Braukšas II. Results of the investigations indicate that the development of vegetation together with sedimentation conditions in the palaeolake have changed since the Younger Dryas until today. Vegetation composition varies in different parts of the ancient Lake Burtnieks area due to past changes in lake water level which reached different sites at different times. Data from the northern part of ancient Lake Burtnieks indicate its gradual overgrowing since the Preboreal. Deposition of minerogenic lacustrine sediments (silt, clayey silt and sand) lasted until the Boreal or the Atlantic time, depending on the water depth of the lake locality. Clastic sediments were overlain by gyttja, which in turn was later covered by well-decomposed fen (sedge, sedge–grass) peat that started to form at the end of Atlantic time. Pollen and plant macroremain composition of lacustrine sediments and fen peat sequences suggests that people have inhabited the area since Preboreal–Boreal times. However, weak traces of possible presence of people are found already at the very end of the Younger Dryas.Fluctuating curves of broadleaved tree pollen, a significant amount of pollen of cultivated plants and charcoal dust in sediments indicate activities of an early man and refer to start of crop growing in the area in the second half of the Atlantic chronozone

Power centres and marginal landscapes: Tracking pre- and post-conquest (late Iron Age and Medieval) land-use in the Cēsis Castle hinterland, Central Latvia

During the late Iron Age, the eastern Baltic was inhabited by Finno-Ugric and Baltic speaking societies whose territories were conquered in the thirteenth century as a result of the crusades. This paper examines the degree to which indigenous landscapes were transformed as a result of the crusades, and the evidence for maintenance of indigenous land-use practices. Vegetation and land-use history are reconstructed using palynological data from Cēsis castle and its terriitory. Comparison is made with selected palynological, archaeological and documentary data across Livonia (Latvia and Estonia) and contrasted with the greater impact of the crusades in nearby Prussia. Despite the emergence of key power centres in the medieval period, including towns and castles such as Cēsis, many parts of the rural landscape remained largely unchanged by the crusades, particularly in those more marginal landscapes studied in this paper. Lower intensity land-use can be linked to poor agricultural soils but also reflect the limited colonisation of rural landscapes beyond the major towns and castles. Indigenous societies and practices survived to a greater degree, with later agricultural intensification in the fourteenth century reflecting the increasing political stability, growth of urban centres, establishment of serfdom and the development of the manorial system