Alterations in thoracolumbosacral movement when pain causing lameness has been improved by diagnostic analgesia

Lameness, thoracolumbosacral pain and reduced range of motion (ROM) often coexist; better understanding of their relationship is needed. The objectives were to determine if thoracolumbosacral movement of horses changes when pain causing lameness is improved by diagnostic analgesia. We hypothesised that reduction of lameness will increase ROM of the thoracolumbosacral region. Thirteen horses with different types of hind limb lameness were trotted in straight lines and lunged on a 10 m diameter circle on left and right reins before and after lameness was subjectively substantially improved by diagnostic analgesia. Inertial sensor data were collected from the withers, thirteenth (T13) and eighteenth thoracic (T18) vertebrae, third lumbar (13) vertebra, tubera sacrale (TS), left and right tubera coxae. ROM of flexion-extension, axial rotation, lateral bending, dorsoventral, lateral-lateral motion and vertical movement symmetry were quantified at each thoracolumbar site. Hiphike difference (HHD), maximum difference (MaxDiff) and minimum difference (MinDiff) for the pelvic sensors were measured. Percentage changes for before and after diagnostic analgesia were calculated; mean standard deviation (SD) or median [interquartile range] were determined. Associations between the change in pelvic versus thoracolumbar movement symmetry after each local analgesic technique were tested. After resolution of lameness, HHD decreased by 7% [68%] (P = 0.006). The MinDiff decreased significantly by 33%[61%] (P = 0.01), 45 +/- 13% (P = 0.005) and 52 +/- 23% (P = 0.04), for TS, L3 and T18, respectively. There was significantly increased ROM in flexion-extension at T13, in axial rotation at T13, T18, 13 and in lateral-lateral ROM at 13. Thoracolumbosacral asymmetry and reduced ROM associated with lameness were both altered immediately by improvement in lameness using diagnostic analgesia. (C) 2017 Elsevier Ltd. All rights reserved

A Preliminary Investigation of Acculturative Stress and Diurnal Cortisol Among Latina Women

The interplay between biological and cultural factors has remained understudied among ethnic minority groups, including Latinos. To the best of our knowledge, minimal to no research has examined the relationship between acculturative stressors and diurnal cortisol among Latina women. This initial exploratory study sought to examine the relationship between cortisol and acculturative stress. Among a small sample of adult Latina women, salivary cortisol was collected at 3 time points (waking, 30 min postwaking, and bedtime) to assess the cortisol awakening response (CAR) and diurnal cortisol response. Information regarding acculturative stress and acculturation was also collected. The major results showed that high levels of acculturative stress were associated with a blunted CAR and a flatter diurnal cortisol response when compared to low levels of acculturative stress. These preliminary findings highlight the potential role of cultural stressors in contributing to the biological stress response

Advanced detectors and signal processing

Continued progress is reported toward development of a silicon on garnet technology which would allow fabrication of advanced detection and signal processing circuits on bubble memories. The first integrated detectors and propagation patterns have been designed and incorporated on a new mask set. In addition, annealing studies on spacer layers are performed. Based on those studies, a new double layer spacer is proposed which should reduce contamination of the silicon originating in the substrate. Finally, the magnetic sensitivity of uncontaminated detectors from the last lot of wafers is measured. The measured sensitivity is lower than anticipated but still higher than present magnetoresistive detectors

Regional scaling of annual mean precipitation and water availability with global temperature change

Changes in regional water availability belong to the most crucial potential impacts of anthropogenic climate change, but are highly uncertain. It is thus of key importance for stakeholders to assess the possible implications of different global temperature thresholds on these quantities. Using a subset of climate model simulations from the fifth phase of the Coupled Model Intercomparison Project (CMIP5), we derive here the sensitivity of regional changes in precipitation and in precipitation minus evapotranspiration to global temperature changes. The simulations span the full range of available emission scenarios, and the sensitivities are derived using a modified pattern scaling approach. The applied approach assumes linear relationships on global temperature changes while thoroughly addressing associated uncertainties via resampling methods. This allows us to assess the full distribution of the simulations in a probabilistic sense. Northern high-latitude regions display robust responses towards wetting, while subtropical regions display a tendency towards drying but with a large range of responses. Even though both internal variability and the scenario choice play an important role in the overall spread of the simulations, the uncertainty stemming from the climate model choice usually accounts for about half of the total uncertainty in most regions. We additionally assess the implications of limiting global mean temperature warming to values below (i) 2 K or (ii) 1.5 K (as stated within the 2015 Paris Agreement). We show that opting for the 1.5 K target might just slightly influence the mean response, but could substantially reduce the risk of experiencing extreme changes in regional water availability

Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge

Altered body lean has been subjectively observed during lungeing in lame horses. The objectives were to quantify the influence of lameness on body lean in trot on the lunge and to investigate the influence of improvement in lameness on the differences in body lean between reins. Thirteen lame horses were trotted in straight lines and lunged on a 10m-diameter circle on both reins before and after lameness was subjectively substantially improved by diagnostic analgesia. A global position system-aided inertial measurement unit attached to the tubera sacrale quantified body lean. Differences between reins in body lean before and after diagnostic analgesia were calculated and means were determined. Five and eight horses had unilateral and bilateral hindlimb lameness, respectively. Two of five horses with unilateral and three of eight horses with bilateral lameness leaned more on the rein with the lame or lamer hindlimb on the inside of the circle (difference between reins 5−8°). Two of five horses with unilateral and two of eight horses with bilateral lameness leaned more on the rein with the lame or lamer hindlimb on the outside of the circle (4−10°). Four horses, one with unilateral and three with bilateral lameness, had only 1° difference in body lean angle between left and right reins. When lameness was improved by diagnostic analgesia, the body lean changed significantly towards similar leaning on left and right reins (mean angle changed from 8.8° to 10.0° (P = 0.03) on one rein and 13.4° to 10.8° (P = 0.002) on the other rein). It was concluded that body lean becomes more symmetrical between reins after improvement in lameness using diagnostic analgesia

Anaplasmosis in Cattle

On September 6, 1975, one cow in a herd of 36 near Aplington, Iowa, was found by the owner as being slow and weak. Dr. Eldon Uhlenhopp was called to examine the cow. The cow\u27s mucous membranes were found to be very pale and icteric. She also had a temperature of 100F. Hemoglobin was determined to be 3 gm %. A differential diagnosis of anaplasmosis or leptospirosis was made

SIGAME simulations of the [CII], [OI] and [OIII] line emission from star forming galaxies at z ~ 6

Of the almost 40 star forming galaxies at z>~5 (not counting QSOs) observed in [CII] to date, nearly half are either very faint in [CII], or not detected at all, and fall well below expectations based on locally derived relations between star formation rate (SFR) and [CII] luminosity. Combining cosmological zoom simulations of galaxies with SIGAME (SImulator of GAlaxy Millimeter/submillimeter Emission) we have modeled the multi-phased interstellar medium (ISM) and its emission in [CII], [OI] and [OIII], from 30 main sequence galaxies at z~6 with star formation rates ~3-23Msun/yr, stellar masses ~(0.7-8)x10^9Msun, and metallicities ~(0.1-0.4)xZsun. The simulations are able to reproduce the aforementioned [CII]-faintness at z>5, match two of the three existing z>~5 detections of [OIII], and are furthermore roughly consistent with the [OI] and [OIII] luminosity relations with SFR observed for local starburst galaxies. We find that the [CII] emission is dominated by the diffuse ionized gas phase and molecular clouds, which on average contribute ~66% and ~27%, respectively. The molecular gas, which constitutes only ~10% of the total gas mass is thus a more efficient emitter of [CII] than the ionized gas making up ~85% of the total gas mass. A principal component analysis shows that the [CII] luminosity correlates with the star formation activity as well as average metallicity. The low metallicities of our simulations together with their low molecular gas mass fractions can account for their [CII]-faintness, and we suggest these factors may also be responsible for the [CII]-faint normal galaxies observed at these early epochs.Comment: 24 pages, 14 figures. Accepted for publication in the Astrophysical Journa