Single‐trial regression of spatial exploration behavior indicates posterior EEG alpha modulation to reflect egocentric coding

Learning to navigate uncharted terrain is a key cognitive ability that emerges as a deeply embodied process, with eye movements and locomotion proving most useful to sample the environment. We studied healthy human participants during active spatial learning of room-scale virtual reality (VR) mazes. In the invisible maze task, participants wearing a wireless electroencephalography (EEG) headset were free to explore their surroundings, only given the objective to build and foster a mental spatial representation of their environment. Spatial uncertainty was resolved by touching otherwise invisible walls that were briefly rendered visible inside VR, similar to finding your way in the dark. We showcase the capabilities of mobile brain/body imaging using VR, demonstrating several analysis approaches based on general linear models (GLMs) to reveal behavior-dependent brain dynamics. Confirming spatial learning via drawn sketch maps, we employed motion capture to image spatial exploration behavior describing a shift from initial exploration to subsequent exploitation of the mental representation. Using independent component analysis, the current work specifically targeted oscillations in response to wall touches reflecting isolated spatial learning events arising in deep posterior EEG sources located in the retrosplenial complex. Single-trial regression identified significant modulation of alpha oscillations by the immediate, egocentric, exploration behavior. When encountering novel walls, as well as with increasing walking distance between subsequent touches when encountering novel walls, alpha power decreased. We conclude that these oscillations play a prominent role during egocentric evidencing of allocentric spatial hypotheses

A duality theoretic view on limits of finite structures: Extended version

A systematic theory of structural limits for finite models has been developed by Nešetřil and Ossona de Mendez. It is based on the insight that the collection of finite structures can be embedded, via a map they call the Stone pairing, in a space of measures, where the desired limits can be computed. We show that a closely related but finer grained space of (finitely additive) measures arises—via Stone-Priestley duality and the notion of types from model theory—by enriching the expressive power of first-order logic with certain “probabilistic operators”. We provide a sound and complete calculus for this extended logic and expose the functorial nature of this construction. The consequences are two-fold. On the one hand, we identify the logical gist of the theory of structural limits. On the other hand, our construction shows that the duality theoretic variant of the Stone pairing captures the adding of a layer of quantifiers, thus making a strong link to recent work on semiring quantifiers in logic on words. In the process, we identify the model theoretic notion of types as the unifying concept behind this link. These results contribute to bridging the strands of logic in computer science which focus on semantics and on more algorithmic and complexity related areas, respectively

The search for an identification of amino acids, nucleobases and nucleosides in samples returned from Mars

The Mars Sample Return mission will provide us with a unique source of material from our solar system; material which could advance our knowledge of the processes of chemical evolution. As has been pointed out, Mars geological investigations based on the Viking datasets have shown that primordial Mars was in many biologically important ways similar to the primordial Earth; the presence of surface liquid water, moderate surface temperatures, and atmosphere of carbon dioxide and nitrogen, and high geothermal heat flow. Indeed, it would seem that conditions on Earth and Mars were fundamentally similar during the first one billion years or so. As has been pointed out, Mars may well contain the best preserved record of the events that transpired on the early planets. Examination of that early record will involve searching for many things, from microfossils to isotopic abundance data. We propose an investigation of the returned Mars samples for biologically important organic compounds, with emphases on amino acids, the purine and pyrimidine bases, and nucleosides

The search for and identification of amino acids, nucleobases and nucleosides in samples returned from Mars

An investigation of the returned Mars samples for biologically important organic compounds, with emphasis on amino acid, the puring and pyrimidine bases, and nucleosides is proposed. These studies would be conducted on subsurface samples obtained by drilling past the surface oxidizing layer with emphasis on samples containing the larges quantities of organic carbon as determined by the rover gas chromatographic mass spectrometer (GCMS). Extraction of these molecules from the returned samples will be performed using the hydrothermal extraction technique described by Cheng and Ponnamperuma. More rigorous extraction methods will be developed and evaluated. For analysis of the extract for free amino acids or amino acids present in a bound or peptidic form, aliquots will be analyzed by capillary GCMS both before and after hydrolysis with 6N hydrochloric acid. Establishment of the presence of amino acids would then lead to the next logical step which would be the use of chiral stationary gas chromatography phases to determine the enatiomeic composition of the amino acids present, and thus potentially establish their biotic or abiotic origin. Confirmational analyses for amino acids would include ion-exchange and reversed-phase liquid chromatographic analysis. For analyses of the returned Mars samples for nucleobases and nucleosides, affinity and reversed-phase liquid chromatography would be utilized. This technology coupled with scanning UV detection for identification, presents a powerful tool for nucleobase and nucleoside analysis. Mass spectrometric analysis of these compounds would confirm their presence in samples returned form Mars

Dermoscopy of Pitted Keratolysis

Irritated hyperhidrotic soles with multiple small pits are pathognomonic for pitted keratolysis (PK). Here we show the dermatoscopic view of typical pits that can ensure the diagnosis. PK is a plantar infection caused by Gram-positive bacteria, particularly Corynebacterium. Increases in skin surface pH, hyperhidrosis, and prolonged occlusion allow these bacteria to proliferate. The diagnosis is fundamentally clinical and treatment generally consists of a combination of hygienic measures, correcting plantar hyperhidrosis and topical antimicrobials

Idaho Public Health Nursing Study

Public health nursing represents the foundation of the U.S. public health system, particularly in predominantly rural and frontier states. Increasing attention has recently been paid to strengthening the public health infrastructure and workforce in response to disaster preparedness concerns. Major concerns regarding the current and future shortage of public health nurses have been raised at the national and state levels (The Quad Council of Public Health Nursing Organizations, 2006; Health Resources Services Administration, 2005; Gehrke, 2007). Factors contributing to the shortage include the aging nursing workforce, inadequate funding and salaries, lack of qualified applicants, and ineffective recruitment and retention. In some states vacancy rates for public health nurses reach 20 percent with turnover rates up to 14 percent (Association of State and Territorial Health Officials, 2005). Unfortunately there is limited current research information regarding the state of public health nursing in Idaho as well as other, predominantly rural and frontier areas. The purpose of the Idaho Public Health Nursing Study, which was conducted in the spring of 2007, was to describe the current status of public health nursing in Idaho

A manned exobiology laboratory based on the Moon

Establishment of an exobiology laboratory on the Moon would provide a unique opportunity for exploration of extraterrestrial materials on a long-term, ongoing basis, for elucidation of exobiological processes and chemical evolution. A major function of the lunar exobiology laboratory would be to examine samples collected from other planets (e.g., Mars) for the presence of extant or extinct life. By establishing a laboratory on the Moon, preliminary analyses could be conducted away from Earth, thus establishing that extraterrestrial materials are benign before their return to Earth for more extensive investigations. The Moon-based exobiology laboratory would have three major components for study of samples returned from other planets: (1) the search for extant life - this component would focus on the detection and identification of life forms using biological, physical, and chemical methods; (2) the search for extinct life - this component would concentrate on identification of extinct life using micropaleontological physical and chemical means; and (3) the search and evidence of chemical evolution - this component would be devoted to the detection and identification of molecules revealing prebiotic chemical evolution