Mineral Concentrates As a Factor of the Khibiny Apatite-Nepheline Ores Efficiency Improvement

Apatite-nepheline ores of the Khibiny deposits contain the largest phosphorus-bearing resources in the world, and, at the same time, they contain associated valuable components in the rock-forming minerals — apatite, nepheline, sphene and titanium magnetite. Intensive development of the Khibiny deposits with production of only apatite concentrate and a small part of nepheline concentrate resulted in the accumulation of over 1.0 billion tons of wastes in tailing storage facilities and dumps during 90 years of JSC Apatit operation. The possibility of increasing the efficiency of the use of the main concentrates of apatite-nepheline ores of the Khibiny deposits and wastes for their processing is considered through the use of technological developments of the FRC KSC RAS, JSC RIFI and JSC Apatit to obtain traditional and new target products. A fundamentally new approach to the problem of sustainable use of natural resources is focused on establishment of the whole production chain in the region, from mining and processing operations to manufacturers of final high technology products (rare-earth products, welding and construction materials, coloring agents and other materials). They also determine the level of industrial technical progress. Keywords: Khibiny apatite-nepheline ores, mineral raw materials, extraction and processing, new material

Efficiency of local therapy with the use of a new preparation for oral care at periodontitis in the course of hyperpeptic gastritis after tobacco smoke intoxication

Periodontal diseases, arising against a background of stomach pathology at tobacco addiction remain an acute problem of modern dentistry. The aim of the work is an experimental study of efficiency of application of the new preparation for oral care during treatment of periodontitis simulated against a background of hyperpeptic gastritis under conditions of intoxication by tobacco smoke. At the first stage all experimental animals were divided into 4 groups: І - intact, II - with simulated periodontitis, III - with simulated periodontitis against a background of simulated hyperpeptic gastritis, IV - with simulated periodontitis against a background of hyperpeptic gastritis under conditions of tobacco smoking. Biochemical researches at periodontitis in rats were conducted for determination of influencing stomach pathology and tobacco smoke. On the II stage efficiency of local therapy was studied with the use of the new preparation for oral care and a comparator agent.Results: At experimental periodontitis against a background of hyperpeptic gastritis under conditions of smoking the considerable changes in periodontal tissues typical for the inflammatory process develop. The local therapy at rats with the use of the new preparation resulted in accelerating removing harmful influence of damaging factors and restoring the state of periodontal tissues, than in case of application of the comparator agent. The efficiency of the new preparation consists in normalizing influence on processes of lipid peroxidation, inflammation and activation of the protective systems of oral cavity during periodontitis which arises up against a background of hyperpeptic gastritis

Cytogenetic aspects of occupational carcinogenic hazard

© 2016,International Journal of Pharmacy and Technology. All rights reserved.The effect of chemical factors of the production environment is studied with a wide range of test systems,among which the short-term tests with high sensitivity are in the foreground. We conducted a study to assess the cytogenetic status of servicemen. Micronucleus test was a convenient method of substance screening that can quickly determine the presence or absence of various compounds of cytogenetic nature. We have identified a relationship between exposure of occupational hazards and the level of micronuclei in human peripheral blood. Excess in number of micronuclei occurs at almost three times the rate in the retired servicemen. Indicator in this contingent group was 92.7%. Subject to the age,the risk group of the high chance of malignancy development is the people over age 70. 3N micronuclei level in this age group was found in 96.3%. 3N micronuclei level is found in 71.4% of representatives of the employment group of 3-9 years,while in the employment group of 30-39 years - only in 68.7%. Subject to the military force,the risk group of the high chance of malignancy development are missile,ground,and motorized rifle troops

Развитие трудового потенциала работниц с детьми до 3 лет после профессионального обучения (переобучения) по направлению службы занятости (опыт Свердловской области)

Одним из решений задачи по развитию экономической самостоятельности семьи как приоритет государственной демографической и семейной политики является создание условий для профессиональной реадаптации, повышения конкурентоспособности на рынке труда женщин, находящихся в отпуске по уходу за ребенком до достижения им возраста трех лет, путем организации их профессионального обучения (переобучения). Мероприятие по организации профессионального обучения (переобучения) женщин в период отпуска по уходу за ребенком до достижения им возраста трех лет реализуется органами службы занятости населения Свердловской области в рамках государственной программы Свердловской области «Содействие занятости населения Свердловской области до 2024 года» с 2012 г. Проведен ретроспективный анализ региональной практики организации профессионального обучения (переобучения) женщин, находящихся в отпуске по уходу за ребенком в возрасте до трех лет, в целях оценки эффективности и конкретизации политики по развитию их трудового потенциала. Проведенный анализ статистических данных свидетельствует о том, что государственная услуга по профессиональному обучению (переобучению) востребована у женщин на пике репродуктивного возраста, распределение мест возобновления женщинами трудовой деятельности в организациях после профессионального обучения (переобучения) различается и зависит от типа поселения, а профессиональное обучение (переобучение) женщин повышает их профессиональную мобильность, способствует реализации их жизненных и профессиональных планов

Indicators of hormonal status of the military servicemen in the modern type of military technogenesis

© 2016, International Journal of Pharmacy and Technology. All rights reserved.The paper presents the results of the evaluation of the testosterone level in the military servicemen. The work at the military enterprises is characterized by storage and disposal of chemical weapons and the presence of a number of harmful factors. The effect of carcinogens and reproductive hazards in the operation environment on the hormonal system changes the levels of hormones responsible for the reproductive function of the body. It is known that the reduction in the concentration of testosterone leads to male infertility, and its increase with age can trigger the development of prostate cancer. Testosterone indicators in our study were distributed subject to the contingent, age, length of service and a type of troops. Determination of hormone was conducted by enzyme-linked immunosorbent assay (ELISA) of blood. The study revealed hormonal disorders in all contingents examined. A high-risk group involves retired and former military servicemen (high levels of testosterone were found in 52.1% of the surveyed of this contingent), persons over 70 years old (high levels of testosterone were found in 61.5% of the surveyed in this age group), the workers with length of service of 30-39 years (high levels of testosterone were found in 55.2% of the surveyed with this length of service). Low levels of testosterone were found in private soldiers (3.6% of the surveyed of this contingent), in persons aged 18-29 years (3.3% of the surveyed in this age group), and in those with length of service of 1-2 years (3.6% of the surveyed with this length of service)

Clinical case of primary immunodeficiency: X-linked agammaglobulinemia

Aclinical case ofprimary immunodeficiency state (PIDS) is described: X-linked agammaglobulinemia in the boy of 8 years old. The results of molecular genetic studies: gene btk (ex 1-19) genome version GRCh38.p5, transcript version ENST00000308731 single nucleotide substitution identified с.1027С > Т in homozygous state leading to premature stop codon p.Gln343Ter (p.Q343*). The presented clinical case reflects the low alertness of pediatricians for PIDS. At the same time, a delay in diagnosis and prescription of treatment aggravates the prognosis of the disease course and reduces the quality of the patient life

Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc

Трансплантация печени у детей: опыт последних десятилетий, актуальные проблемы и пути их решения

Liver transplantation today is the only radical method of treatment decompensating fulminant and chronic liver failure. The operation technic and patient care improvement made it possible to achieve a high survival rate. Transplantation has become an available and safe method for children, including patients weighing less than 10 kg. However, at the moment there are a number of unsolved problems. Postoperative complications can significantly affect the results of transplantation. This article provides a Russian and foreign literature overview, reflecting the achievements in the field of liver, identifying current problems and solutions.Трансплантация печени сегодня является единственным радикальным методом лечения пациентов с фульминантной и хронической печеночной недостаточностью в стадии декомпенсации. Усовершенствование техники операции и тактики ведения пациентов позволило добиться высокого процента выживаемости, трансплантация стала доступным и безопасным методом и для детей, в том числе с массой тела менее 10 кг. Однако на данный момент существует ряд нерешенных проблем, связанных с послеоперационными осложнениями, значительно влияющих на результаты трансплантации. В данной статье представлен обзор российской и зарубежной литературы, отражающей достижения в области трансплантации печени за последние десятилетия, обозначение актуальных проблем и путей их решения

The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome

Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in the human genome, and suggested that the insulator protein CTCF may help to demarcate these domains. Here, we report the detailed structure of LADs in Drosophila cells, and investigate the putative roles of five insulator proteins in LAD organization. We found that the Drosophila genome is also organized in discrete LADs, which are about five times smaller than human LADs but contain on average a similar number of genes. Systematic comparison to new and published insulator binding maps shows that only SU(HW) binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions. By knockdown and overexpression studies we demonstrate that SU(HW) weakens genome – NL interactions through a local antagonistic effect, but we did not obtain evidence that it is essential for border formation. Our results provide insights into the evolution of LAD organization and identify SU(HW) as a fine-tuner of genome – NL interactions