Stochastic Feedback and the Regulation of Biological Rhythms

We propose a general approach to the question of how biological rhythms spontaneously self-regulate, based on the concept of ``stochastic feedback''. We illustrate this approach by considering the neuroautonomic regulation of the heart rate. The model generates complex dynamics and successfully accounts for key characteristics of cardiac variability, including the $1/f$ power spectrum, the functional form and scaling of the distribution of variations, and correlations in the Fourier phases. Our results suggest that in healthy systems the control mechanisms operate to drive the system away from extreme values while not allowing it to settle down to a constant output.Comment: 15 pages, latex2e using rotate and epsf, with 4 ps figures. Submitted to PR

The first direct measurement of ¹²C (¹²C,n) ²³Mg at stellar energies

Neutrons produced by the carbon fusion reaction ¹²C(¹²C,n)²³Mg play an important role in stellar nucleosynthesis. However, past studies have shown large discrepancies between experimental data and theory, leading to an uncertain cross section extrapolation at astrophysical energies. We present the first direct measurement that extends deep into the astrophysical energy range along with a new and improved extrapolation technique based on experimental data from the mirror reaction ¹²C(¹²C,p)²³Na. The new reaction rate has been determined with a well-defined uncertainty that exceeds the precision required by astrophysics models. Using our constrained rate, we find that ¹²C(¹²C,n)²³Mg is crucial to the production of Na and Al in Pop-III Pair Instability Supernovae. It also plays a non-negligible role in the production of weak s-process elements as well as in the production of the important galacti

Technologies of sleep research

Sleep is investigated in many different ways, many different species and under many different circumstances. Modern sleep research is a multidisciplinary venture. Therefore, this review cannot give a complete overview of all techniques used in sleep research and sleep medicine. What it will try to do is to give an overview of widely applied techniques and exciting new developments. Electroencephalography has been the backbone of sleep research and sleep medicine since its first application in the 1930s. The electroencephalogram is still used but now combined with many different techniques monitoring body and brain temperature, changes in brain and blood chemistry, or changes in brain functioning. Animal research has been very important for progress in sleep research and sleep medicine. It provides opportunities to investigate the sleeping brain in ways not possible in healthy volunteers. Progress in genomics has brought new insights in sleep regulation, the best example being the discovery of hypocretin/orexin deficiency as the cause of narcolepsy. Gene manipulation holds great promise for the future since it is possible not only to investigate the functions of different genes under normal conditions, but also to mimic human pathology in much greater detail

On the uniqueness and global dynamics of AdS spacetimes

We study global aspects of complete, non-singular asymptotically locally AdS spacetimes solving the vacuum Einstein equations whose conformal infinity is an arbitrary globally stationary spacetime. It is proved that any such solution which is asymptotically stationary to the past and future is itself globally stationary. This gives certain rigidity or uniqueness results for exact AdS and related spacetimes.Comment: 18pp, significant revision of v

Closed Timelike Curves and Holography in Compact Plane Waves

We discuss plane wave backgrounds of string theory and their relation to Goedel-like universes. This involves a twisted compactification along the direction of propagation of the wave, which induces closed timelike curves. We show, however, that no such curves are geodesic. The particle geodesics and the preferred holographic screens we find are qualitatively different from those in the Goedel-like universes. Of the two types of preferred screen, only one is suited to dimensional reduction and/or T-duality, and this provides a ``holographic protection'' of chronology. The other type of screen, relevant to an observer localized in all directions, is constructed both for the compact and non-compact plane waves, a result of possible independent interest. We comment on the consistency of field theory in such spaces, in which there are closed timelike (and null) curves but no closed timelike (or null) geodesics.Comment: 21 pages, 3 figures, LaTe

M-branes and N=2 Strings

The string field theory of N=(2,1) heterotic strings describes a set of self-dual Yang-Mills fields coupled to self-dual gravity in 2+2 dimensions. We show that the exact classical action for this field theory is a certain complexification of the Green-Schwarz/Dirac-Born-Infeld string action, closely related to the four dimensional Wess-Zumino action describing self-dual gauge fields. This action describes the world-volume of a 2+2d ``M-brane'', which gives rise upon different null reductions to critical strings and membranes. We discuss a number of further properties of N=2 heterotic strings, such as the geometry of null reduction, general features of a covariant formulation, and possible relations to BPS and GKM algebras.Comment: 49 pages, harvmac; 1 figure (uses epsf.tex). References adde

Herschel-ATLAS: VISTA VIKING near-IR counterparts in the Phase 1 GAMA 9h data

We identify near-infrared Ks band counterparts to Herschel-ATLAS sub-mm sources, using a preliminary object catalogue from the VISTA VIKING survey. The sub-mm sources are selected from the H-ATLAS Phase 1 catalogue of the GAMA 9h field, which includes all objects detected at 250, 350 or 500 um with the SPIRE instrument. We apply and discuss a likelihood ratio (LR) method for VIKING candidates within a search radius of 10" of the 22,000 SPIRE sources with a 5 sigma detection at 250 um. We find that 11,294(51%) of the SPIRE sources have a best VIKING counterpart with a reliability $R\ge 0.8$, and the false identification rate of these is estimated to be 4.2%. We expect to miss ~5% of true VIKING counterparts. There is evidence from Z-J and J-Ks colours that the reliable counterparts to SPIRE galaxies are marginally redder than the field population. We obtain photometric redshifts for ~68% of all (non-stellar) VIKING candidates with a median redshift of 0.405. Comparing to the results of the optical identifications supplied with the Phase I catalogue, we find that the use of medium-deep near-infrared data improves the identification rate of reliable counterparts from 36% to 51%.Comment: 20 pages, 20 figures, 3 tables, accepted by MNRA

Goedel-type Universes and the Landau Problem

We point out a close relation between a family of Goedel-type solutions of 3+1 General Relativity and the Landau problem in S^2, R^2 and H_2; in particular, the classical geodesics correspond to Larmor orbits in the Landau problem. We discuss the extent of this relation, by analyzing the solutions of the Klein-Gordon equation in these backgrounds. For the R^2 case, this relation was independently noticed in hep-th/0306148. Guided by the analogy with the Landau problem, we speculate on the possible holographic description of a single chronologically safe region.Comment: Latex, 21 pages, 1 figure. v2 missing references to previous work on the subject adde

Genotype-phenotype correlation in a family with Arg135Leu rhodopsin retinitis pigmentosa

Aim: To describe the clinical characteristics and disease course of a large family with retinitis pigmentosa (RP) from an Arg135Leu change in rhodopsin