Brans-Dicke Gravity from Entropic Viewpoint

We interpret the Brans-Dicke gravity from entropic viewpoint. We first apply the Verlinde's entropic formalism in the Einstein frame, then perform the conformal transformation which connects the Einstein frame to the Jordan frame. The transformed result yields the equation of motion of the Brans-Dicke theory in the Jordan frame.Comment: Title changed, minor changes to match the published versio

MODIS Dynamical and Microphysical Regimes as Viewed by AIRS

No abstract availabl

Rotating Black Hole Entropy from Two Different Viewpoints

Using the brick-wall method, we study the entropy of Kerr-Newman black hole from two different viewpoints, a rest observer at infinity and zero angular momentum observer near horizon. We investigate this with scalar field in the canonical quantization approach. An observer at infinity can take one of the two possible frequency ranges; one is with positive frequencies only and the other is with the whole range including negative frequencies. On the other hand, a zero angular momentum observer near horizon can take positive frequencies only. For the observer at infinity the superradiant modes appear in either choice of the frequency ranges and the two results coincide. For the zero angular momentum observer superradiant modes do not appear due to absence of ergoregion. The resulting entropies from the two viewpoints turn out to be the same.Comment: LaTeX 18 pages, 2 figures, Minor modifications in section 3(ZAMO

Relativistic entanglement in single-particle quantum states using Non-Linear entanglement witnesses

In this study, the spin-momentum correlation of one massive spin-1/2 and spin-1 particle states, which are made based on projection of a relativistic spin operator into timelike direction is investigated. It is shown that by using Non-Linear entanglement witnesses (NLEWs), the effect of Lorentz transformation would decrease both the amount and the region of entanglement.Comment: 16 pages, 2 figures; to be published in Quantum Inf Process, 10.1007/s11128-011-0289-z (2011

Results from a Large, Multinational Sample Using the Childhood Trauma Questionnaire

Childhood maltreatment has diverse, lifelong impact on morbidity and mortality. The Childhood Trauma Questionnaire (CTQ) is one of the most commonly used scales to assess and quantify these experiences and their impact. Curiously, despite very widespread use of the CTQ, scores on its Minimization-Denial (MD) subscale—originally designed to assess a positive response bias—are rarely reported. Hence, little is known about this measure. If response biases are either common or consequential, current practices of ignoring the MD scale deserve revision. Therewith, we designed a study to investigate 3 aspects of minimization, as defined by the CTQ’s MD scale: 1) its prevalence; 2) its latent structure; and finally 3) whether minimization moderates the CTQ’s discriminative validity in terms of distinguishing between psychiatric patients and community volunteers. Archival, item-level CTQ data from 24 multinational samples were combined for a total of 19,652 participants. Analyses indicated: 1) minimization is common; 2) minimization functions as a continuous construct; and 3) high MD scores attenuate the ability of the CTQ to distinguish between psychiatric patients and community volunteers. Overall, results suggest that a minimizing response bias—as detected by the MD subscale—has a small but significant moderating effect on the CTQ’s discriminative validity. Results also may suggest that some prior analyses of maltreatment rates or the effects of early maltreatment that have used the CTQ may have underestimated its incidence and impact. We caution researchers and clinicians about the widespread practice of using the CTQ without the MD or collecting MD data but failing to assess and control for its effects on outcomes or dependent variables

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Discovery of small-molecule degraders that activate ubiquitin ligase–mediated ubiquitination and degradation of targeted oncoproteins in cancer cells has been an elusive therapeutic strategy. Here, we report a cancer cell–based drug screen of the NCI drug-like compounds library that enabled identification of small-molecule degraders of the small ubiquitin-related modifier 1 (SUMO1). Structure-activity relationship studies of analogs of the hit compound CPD1 led to identification of a lead compound HB007 with improved properties and anticancer potency in vitro and in vivo. A genome-scale CRISPR-Cas9 knockout screen identified the substrate receptor F-box protein 42 (FBXO42) of cullin 1 (CUL1) E3 ubiquitin ligase as required for HB007 activity. Using HB007 pull-down proteomics assays, we pinpointed HB007’s binding protein as the cytoplasmic activation/proliferation-associated protein 1 (CAPRIN1). Biolayer interferometry and compound competitive immunoblot assays confirmed the selectivity of HB007’s binding to CAPRIN1. When bound to CAPRIN1, HB007 induced the interaction of CAPRIN1 with FBXO42. FBXO42 then recruited SUMO1 to the CAPRIN1-CUL1-FBXO42 ubiquitin ligase complex, where SUMO1 was ubiquitinated in several of human cancer cells. HB007 selectively degraded SUMO1 in patient tumor–derived xenografts implanted into mice. Systemic administration of HB007 inhibited the progression of patient-derived brain, breast, colon, and lung cancers in mice and increased survival of the animals. This cancer cell–based screening approach enabled discovery of a small-molecule degrader of SUMO1 and may be useful for identifying other small-molecule degraders of oncoproteins

Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering

This publication is the Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering from July 6-8, 2022. The EG-ICE International Workshop on Intelligent Computing in Engineering brings together international experts working on the interface between advanced computing and modern engineering challenges. Many engineering tasks require open-world resolution of challenges such as supporting multi-actor collaboration, coping with approximate models, providing effective engineer-computer interaction, search in multi-dimensional solution spaces, accommodating uncertainty, including specialist domain knowledge, performing sensor-data interpretation and dealing with incomplete knowledge. While results from computer science provide much initial support for resolution, adaptation is unavoidable and most importantly, feedback from addressing engineering challenges drives fundamental computer-science research. Competence and knowledge transfer goes both ways. &nbsp

Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering

This publication is the Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering from July 6-8, 2022. The EG-ICE International Workshop on Intelligent Computing in Engineering brings together international experts working on the interface between advanced computing and modern engineering challenges. Many engineering tasks require open-world resolution of challenges such as supporting multi-actor collaboration, coping with approximate models, providing effective engineer-computer interaction, search in multi-dimensional solution spaces, accommodating uncertainty, including specialist domain knowledge, performing sensor-data interpretation and dealing with incomplete knowledge. While results from computer science provide much initial support for resolution, adaptation is unavoidable and most importantly, feedback from addressing engineering challenges drives fundamental computer-science research. Competence and knowledge transfer goes both ways. &nbsp

A Surface Coordination Network Based On Substrate-Derived Metal Adatoms With Local Charge Excess

Surface safari: 9,10-Anthracenedicarbonitrile (DCA) molecules adsorbed on a Cu(111) surface can be titrated by gradual annealing of the substrate to form trigonal planar Cu(DCA)3 complexes and, ultimately, a hexagonal network (see picture) with a Cu2(DCA)3 stoichiometry. As a result of charge donation from the substrate, the coordinated Cu adatom remains electrically neutral despite donating approximately 1/3 charge to each Cu-N bond. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA