Deep VLT infrared observations of X-ray Dim Isolated Neutron Stars

X-ray observations have unveiled the existence of a family of radio-quiet Isolated Neutron Stars whose X-ray emission is purely thermal, hence dubbed X-ray Dim Isolated Neutron Stars (XDINSs). While optical observations have allowed to relate the thermal emission to the neutron star cooling and to build the neutron star surface thermal map, IR observations are critical to pinpoint a spectral turnover produced by a so far unseen magnetospheric component, or by the presence of a fallback disk. The detection of such a turnover can provide further evidence of a link between this class of isolated neutron stars and the magnetars, which show a distinctive spectral flattening in the IR. Here we present the deepest IR observations ever of five XDINSs, which we use to constrain a spectral turnover in the IR and the presence of a fallback disk. The data are obtained using the ISAAC instrument at the VLT. For none of our targets it was possible to identify the IR counterpart down to limiting magnitudes H = 21.5 - 22.9. Although these limits are the deepest ever obtained for neutron stars of this class, they are not deep enough to rule out the existence and the nature of a possible spectral flattening in the IR. We also derive, by using disk models, the upper limits on the mass inflow rate in a fallback disk. We find the existence of a putative fallback disk consistent (although not confirmed) with our observations.Comment: 6 pages, 2 figures, accepted by A&A on 26-06-200

Optical emission near a high-impedance mirror

Solid state light emitters rely on metallic contacts with high sheet-conductivity for effective charge injection. Unfortunately, such contacts also support surface plasmon polariton (SPP) excitations that dissipate optical energy into the metal and limit the external quantum efficiency. Here, inspired by the concept of radio-frequency (RF) high-impedance surfaces and their use in conformal antennas we illustrate how electrodes can be nanopatterned to simultaneously provide a high DC electrical conductivity and high-impedance at optical frequencies. Such electrodes do not support SPPs across the visible spectrum and greatly suppress dissipative losses while facilitating a desirable Lambertian emission profile. We verify this concept by studying the emission enhancement and photoluminescence lifetime for a dye emitter layer deposited on the electrodes

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important

Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central nervous system (CNS). Migraine, a largely unknown pathology, is strictly related to the glutamate system in the CNS pathologic terms. Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migrain

A two years open-label prospective study of OnabotulinumtoxinA 195 U in medication overuse headache. a real-world experience

BACKGROUND: The efficacy and safety of OnabotulinumtoxinA (BOTOX®) in adults with chronic migraine (CM) were demonstrated in the PREEMPT program. However, the dosage used in this study was flexible from 155 U to 195 U at the physician's discretion. Therefore, the objective of this prospective study was to compare the efficacy and safety of OnabotulinumtoxinA 195 U vs. 155 U for the treatment of CM and medication overuse headache (MOH) during a 2-year period. METHODS: We prospectively evaluated the mean reduction in headache days, migraine days, acute pain medication intake days and Headache Impact Test (HIT)-6 score in 172 patients injected with OnabotulinumtoxinA 195 U. Successively, we compared the efficacy measures with data of 155 patients injected with OnabotulinumtoxinA 155 U and followed up for 2 years. All patients were affected by CM and MOH, and failed one or more previous detoxification and preventative therapies. RESULTS: Both OnabotulinumtoxinA 195 U and 155 U reduced significantly the number of headache and migraine days, acute pain medication intake days and HIT-6 score, when compared with the baseline measures. Nevertheless, OnabotulinumtoxinA 195 U proved to be superior of 155 U in all efficacy measures since the first injection and for all the 2 years of treatment, with the exception of the reduction in pain medication intake days that resulted significantly larger with 195 U only after the 4th injection. The safety and tolerability of the two doses were similar and treatment related adverse events were transient and mild-moderate. CONCLUSIONS: This study represents the largest and longest post-marketing studies of doses comparison with OnabotulinumtoxinA in a real-life clinical setting. Here, we demonstrate the superior efficacy of OnabotulinumtoxinA 195 U compared to 155 U in CM patients with MOH during a 2-year treatment period with similar safety and tolerability profile

Daily variability of Ceres' Albedo detected by means of radial velocities changes of the reflected sunlight

Bright features have been recently discovered by Dawn on Ceres, which extend previous photometric and Space Telescope observations. These features should produce distortions of the line profiles of the reflected solar spectrum and therefore an apparent radial velocity variation modulated by the rotation of the dwarf planet. Here we report on two sequences of observations of Ceres performed in the nights of 31 July, 26-27 August 2015 by means of the high-precision HARPS spectrograph at the 3.6-m La Silla ESO telescope. The observations revealed a quite complex behaviour which likely combines a radial velocity modulation due to the rotation with an amplitude of approx +/- 6 m/s and an unexpected diurnal effect. The latter changes imply changes in the albedo of Occator's bright features due to the blaze produced by the exposure to solar radiation. The short-term variability of Ceres' albedo is on timescales ranging from hours to months and can both be confirmed and followed by means of dedicated radial velocity observations.Comment: 5 pag, 1fig, two tables, MNRAS Letters 201

Epidemiología de las fracturas de la extremidad superior del fémur: a propósito de 322 casos

Se realiza un estudio epidemiológico retrospectivo en una serie de 322 pacientes ancianos con fractura de la extremidad superior del fémur (FEPF), vistos y tratados entre los años 1985-1988, en el Servicio de Traumatología del Hospital del Insalud de Logroño, siendo comparados los resultados con los de otras series. Las caídas casuales por mínimo traumatismo fueron la principal causa de la lesión, con mayor incidencia en la mujer de 78 años y con predominio de las fracturas trocantereas sobre las cervicales. En nuestra serie el 48% de estos pacientes están afectados por más de una enfermedad previa a la fractura y a la intervención. Complicaciones locales postoperatorios (migración de los clavos, infección local, luxación de la prótesis, hematomas), los hemos encontrado en un 12% y entre los generales (Infecciones urinarias, Tromboflebitis, Embolia Pulmonar, escaras, etc.) en un 19%. En la valoración funcional, siguiendo a Nickens, hemos obtenido que un 71% caminaban después de la intervención. Los resultados obtenidos son, en esta Comunidad, análogos a los encontrados por otros autores.A retrospective epydemiologic study was undertaken in a serie of 322 aged patients with fracture of the upper extremity of the femur treated at the traumatology unit of the «Hospital del Insalud» in Logroño beetween 1985 and 1988. Accidental falls with a minimum traumatism were the main cause of the injury, with major incidence on 78 years old women, the trochanteric fractures being more frequent than femoral week fractures. In our serie, 48% of patients were affected by more than one previous disease to the fracture. Local post-operatire complications (nail migration, local infection, haematoma) were found in 12%, and general complications (urinary infection, pulmonary embolism, crust) in 19%. According to Nickens' functional evaluation we found that 71% of patients were able to walk after surgery. The results obtained in this community have been found similar to those reported by other authors

Isotope Spectroscopy

The measurement of isotopic ratios provides a privileged insight both into nucleosynthesis and into the mechanisms operating in stellar envelopes, such as gravitational settling. In this article, we give a few examples of how isotopic ratios can be determined from high-resolution, high-quality stellar spectra. We consider examples of the lightest elements, H and He, for which the isotopic shifts are very large and easily measurable, and examples of heavier elements for which the determination of isotopic ratios is more difficult. The presence of 6Li in the stellar atmospheres causes a subtle extra depression in the red wing of the 7Li 670.7 nm doublet which can only be detected in spectra of the highest quality. But even with the best spectra, the derived $^6$Li abundance can only be as good as the synthetic spectra used for their interpretation. It is now known that 3D non-LTE modelling of the lithium spectral line profiles is necessary to account properly for the intrinsic line asymmetry, which is produced by convective flows in the atmospheres of cool stars, and can mimic the presence of 6Li. We also discuss briefly the case of the carbon isotopic ratio in metal-poor stars, and provide a new determination of the nickel isotopic ratios in the solar atmosphere.Comment: AIP Thinkshop 10 "High resolution optical spectroscopy", invited talk, AN in pres