Eclipsing binaries and fast rotators in the Kepler sample. Characterization via radial velocity analysis from Calar Alto

The Kepler mission has provided high-accurate photometric data in a long time span for more than two hundred thousands stars, looking for planetary transits. Among the detected candidates, the planetary nature of around 15% has been established or validated by different techniques. But additional data is needed to characterize the rest of the candidates and reject other possible configurations. We started a follow-up program to validate, confirm, and characterize some of the planet candidates. In this paper we present the radial velocity analysis (RV) of those presenting large variations, compatible with being eclipsing binaries. We also study those showing large rotational velocities, which prevents us from obtaining the necessary precision to detect planetary-like objects. We present new RV results for 13 Kepler objects of interest (KOIs) obtained with the CAFE spectrograph at the Calar Alto Observatory, and analyze their high-spatial resolution images and the Kepler light curves of some interesting cases. We have found five spectroscopic and eclipsing binaries. Among them, the case of KOI-3853 is of particular interest. This system is a new example of the so-called heartbeat stars, showing dynamic tidal distortions in the Kepler light curve. We have also detected duration and depth variations of the eclipse. We suggest possible scenarios to explain such effect, including the presence of a third substellar body possibly detected in our RV analysis. We also provide upper mass limits to the transiting companions of other six KOIs with large rotational velocities. This property prevents the RV method to obtain the necessary precision to detect planetary-like masses. Finally, we analyze the large RV variations of other two KOIs, incompatible with the presence of planetary-mass objects. These objects are likely to be stellar binaries but a longer timespan is still needed.Comment: Accepted for publication in A&A. 18 pages, 9 figures, 17 tables. This version fixes an error affecting the values of tables A.1-A.13. The text remains unaltere

Kepler-539: a young extrasolar system with two giant planets on wide orbits and in gravitational interaction

We confirm the planetary nature of Kepler-539b (aka Kepler object of interest K00372.01), a giant transiting exoplanet orbiting a solar-analogue G2 V star. The mass of Kepler-539b was accurately derived thanks to a series of precise radial velocity measurements obtained with the CAFE spectrograph mounted on the CAHA 2.2m telescope. A simultaneous fit of the radial-velocity data and Kepler photometry revealed that Kepler-539b is a dense Jupiter-like planet with a mass of Mp = 0.97 Mjup and a radius of Rp = 0.747 Rjup, making a complete circular revolution around its parent star in 125.6 days. The semi-major axis of the orbit is roughly 0.5 au, implying that the planet is at roughly 0.45 au from the habitable zone. By analysing the mid-transit times of the 12 transit events of Kepler-539b recorded by the Kepler spacecraft, we found a clear modulated transit time variation (TTV), which is attributable to the presence of a planet c in a wider orbit. The few timings available do not allow us to precisely estimate the properties of Kepler-539c and our analysis suggests that it has a mass between 1.2 and 3.6 Mjup, revolving on a very eccentric orbit (0.4<e<0.6) with a period larger than 1000 days. The high eccentricity of planet c is the probable cause of the TTV modulation of planet b. The analysis of the CAFE spectra revealed a relatively high photospheric lithium content, A(Li)=2.48 dex, which, together with both a gyrochronological and isochronal analysis, suggests that the parent star is relatively young.Comment: 11 pages, 14 figures, accepted for publication in Astronomy & Astrophysic

Kepler-447b: a hot-Jupiter with an extremely grazing transit

We present the radial velocity confirmation of the extrasolar planet Kepler-447b, initially detected as a candidate by the Kepler mission. In this work, we analyze its transit signal and the radial velocity data obtained with the Calar Alto Fiber-fed Echelle spectrograph (CAFE). By simultaneously modeling both datasets, we obtain the orbital and physical properties of the system. According to our results, Kepler-447b is a Jupiter-mass planet ($M_p=1.37^{+0.48}_{-0.46}~M_{\rm Jup}$), with an estimated radius of $R_p=1.65^{+0.59}_{-0.56}~R_{\rm Jup}$ (uncertainties provided in this work are $3\sigma$ unless specified). This translates into a sub-Jupiter density. The planet revolves every $\sim7.8$ days in a slightly eccentric orbit ($e=0.123^{+0.037}_{-0.036}$) around a G8V star with detected activity in the Kepler light curve. Kepler-447b transits its host with a large impact parameter ($b=1.076^{+0.112}_{-0.086}$), being one of the few planetary grazing transits confirmed so far and the first in the Kepler large crop of exoplanets. We estimate that only around 20% of the projected planet disk occults the stellar disk. The relatively large uncertainties in the planet radius are due to the large impact parameter and short duration of the transit. Planets with such an extremely large impact parameter can be used to detect and analyze interesting configurations such as additional perturbing bodies, stellar pulsations, rotation of a non-spherical planet, or polar spot-crossing events. All these scenarios would periodically modify the transit properties (depth, duration, and time of mid-transit), what could be detectable with sufficient accurate photometry. Short-cadence photometric data (at the 1 minute level) would help in the search for these exotic configurations in grazing planetary transits like that of Kepler-447b.Comment: Accepted for publication in A&A. 13 pages, 8 figures, 4 tables. This version replaces an earlier version of the pape

Physical properties, starspot activity, orbital obliquity, and transmission spectrum of the Qatar-2 planetary system from multi-colour photometry

We present seventeen high-precision light curves of five transits of the planet Qatar-2b, obtained from four defocussed 2m-class telescopes. Three of the transits were observed simultaneously in the SDSS griz passbands using the seven-beam GROND imager on the MPG/ESO 2.2-m telescope. A fourth was observed simultaneously in Gunn grz using the CAHA 2.2-m telescope with BUSCA, and in r using the Cassini 1.52-m telescope. Every light curve shows small anomalies due to the passage of the planetary shadow over a cool spot on the surface of the host star. We fit the light curves with the prism+gemc model to obtain the photometric parameters of the system and the position, size and contrast of each spot. We use these photometric parameters and published spectroscopic measurements to obtain the physical properties of the system to high precision, finding a larger radius and lower density for both star and planet than previously thought. By tracking the change in position of one starspot between two transit observations we measure the orbital obliquity of Qatar-2 b to be 4.3 \pm 4.5 degree, strongly indicating an alignment of the stellar spin with the orbit of the planet. We calculate the rotation period and velocity of the cool host star to be 11.4 \pm 0.5 d and 3.28 \pm 0.13 km/s at a colatitude of 74 degree. We assemble the planet's transmission spectrum over the 386-976 nm wavelength range and search for variations of the measured radius of Qatar-2 b as a function of wavelength. Our analysis highlights a possible H2/He Rayleigh scattering in the blue.Comment: 20 pages, 14 figures, to appear in Monthly Notices of the Royal Astronomical Societ

Simultaneous follow-up of planetary transits: revised physical properties for the planetary systems HAT-P-16 and WASP-21

Context. By now more than 300 planets transiting their host star have been found, and much effort is being put into measuring the properties of each system. Light curves of planetary transits often contain deviations from a simple transit shape, and it is generally difficult to differentiate between anomalies of astrophysical nature (e.g. starspots) and correlated noise due to instrumental or atmospheric effects. Our solution is to observe transit events simultaneously with two telescopes located at different observatories. Aims. Using this observational strategy, we look for anomalies in the light curves of two transiting planetary systems and accurately estimate their physical parameters. Methods. We present the first photometric follow-up of the transiting planet HAT-P-16 b, and new photometric observations of WASP-21 b, obtained simultaneously with two medium-class telescopes located in different countries, using the telescope defocussing technique. We modeled these and other published data in order to estimate the physical parameters of the two planetary systems. Results. The simultaneous observations did not highlight particular features in the light curves, which is consistent with the low activity levels of the two stars. For HAT-P-16, we calculated a new ephemeris and found that the planet is 1.3 \sigma colder and smaller (Rb = 1.190 \pm 0.037 RJup) than the initial estimates, suggesting the presence of a massive core. Our physical parameters for this system point towards a younger age than previously thought. The results obtained for WASP-21 reveal lower values for the mass and the density of the planet (by 1.0 \sigma and 1.4 \sigma respectively) with respect to those found in the discovery paper, in agreement with a subsequent study. We found no evidence of any transit timing variations in either system.Comment: 8 pages, 6 figures, accepted for publication in A&

Physical properties of the WASP-44 planetary system from simultaneous multi-colour photometry

We present ground-based broad-band photometry of two transits in the WASP-44 planetary system obtained simultaneously through four optical (Sloan g', r', i', z') and three near-infrared (NIR; J, H, K) filters. We achieved low scatters of 1-2 mmag per observation in the optical bands with a cadence of 48 s, but the NIR-band light curves present much greater scatter. We also observed another transit of WASP-44 b by using a Gunn-r filter and telescope defocussing, with a scatter of 0.37 mmag per point and an observing cadence around 135 s. We used these data to improve measurements of the time of mid-transit and the physical properties of the system. In particular, we improved the radius measurements of the star and planet by factors of 3 and 4, respectively. We find that the radius of WASP-44 b is 1.002 R_Jup, which is slightly smaller than previously thought and differs from that expected for a core-free planet. In addition, with the help of a synthetic spectrum, we investigated the theoretically-predicted variation of the planetary radius as a function of wavelength, covering the range 370-2440 nm. We can rule out extreme variations at optical wavelengths, but unfortunately our data are not precise enough (especially in the NIR bands) to differentiate between the theoretical spectrum and a radius which does not change with wavelength.Comment: 13 pages, 6 figures, to appear in Monthly Notices of the Royal Astronomical Societ

Effects of a medium cut-off (Theranova&#174;) dialyser on haemodialysis patients: a prospective, cross-over study

Background. Despite significant advances in haemodialysis (HD) in recent decades, current dialysis techniques are limited by inadequate removal of uraemic solutes such as middle molecules and protein-bound uraemic toxins. Novel medium cut-off (MCO) membrane or \u2018expanded haemodialysis\u2019 (HDx) provides diffusive removal of conventional and large middle molecular weight uraemic toxins, with marginal albumin leak. Methods. This prospective, open-label, controlled, cross-over pilot study compared HDx (novel MCO membrane TheranovaVR 400) and conventional HD in 20 prevalent HD patients. Biochemical, dialysis adequacy and safety measures (adverse events, infections and hospitalization frequency) were recorded. Ten patients underwent conventional HD high-flux dialyser and 10 patients underwent HDx for 3 months, and the patients then switched and received the other treatment for a further 3 months. Results. Treatment with HDx was associated with a significant reduction in serum albumin concentration [median (interquartile range) reduction 0.45 g/dL (0.575 to 0.05); P \ubc 0.025]. However, median albumin levels were 3.5 g/dL and no patients had clinical symptoms of hypoalbuminaemia or needed intravenous albumin administration. The number of infections was lower in patients treated with HDx (n \ubc 7/19) compared with patients treated with HD (n \ubc 14/20; P \ubc 0.03). Patients treated with HDx had reduced levels of interleukin (IL)-1b (from 0.06 6 0.02 pg/mL versus 0.28 6 0.18 pg/mL with HD) and IL-6 (6.45 6 1.57 pg/mL versus 9.48 6 2.15 pg/mL), while tumour necrosis factor-a levels remain unchanged. Conclusions. This study demonstrates that the chronic use of the novel MCO dialyser TheranovaVR appears to be safe and well-tolerated, without serious side effects or hypoalbuminaemia, as well as fewer infections. These results need to be confirmed in larger randomized clinical trials

Current Therapy in CKD Patients Can Affect Vitamin K Status

Chronic kidney disease (CKD) patients have a higher risk of cardiovascular (CVD) morbidity and mortality compared to the general population. The links between CKD and CVD are not fully elucidated but encompass both traditional and uremic-related risk factors. The term CKD-mineral and bone disorder (CKD-MBD) indicates a systemic disorder characterized by abnormal levels of calcium, phosphate, PTH and FGF-23, along with vitamin D deficiency, decreased bone mineral density or altered bone turnover and vascular calcification. A growing body of evidence shows that CKD patients can be affected by subclinical vitamin K deficiency; this has led to identifying such a condition as a potential therapeutic target given the specific role of Vitamin K in metabolism of several proteins involved in bone and vascular health. In other words, we can hypothesize that vitamin K deficiency is the common pathogenetic link between impaired bone mineralization and vascular calcification. However, some of the most common approaches to CKD, such as (1) low vitamin K intake due to nutritional restrictions, (2) warfarin treatment, (3) VDRA and calcimimetics, and (4) phosphate binders, may instead have the opposite effects on vitamin K metabolism and storage in CKD patients

New transit observations for HAT-P-30 b, HAT-P-37 b, TrES-5 b, WASP-28 b, WASP-36 b, and WASP-39 b

We present new transit light curves for planets in six extrasolar planetary systems. They were acquired with 0.4-2.2 m telescopes located in west Asia, Europe, and South America. When combined with literature data, they allowed us to redetermine system parameters in a homogeneous way. Our results for individual systems are in agreement with values reported in previous studies. We refined transit ephemerides and reduced uncertainties of orbital periods by a factor between 2 and 7. No sign of any variations in transit times was detected for the planets studied.Comment: Submitted to Acta Astronomic

Multiparametric Whole Blood Dissection: A one-shot comprehensive picture of the human hematopoietic system

Human hematopoiesis is a complex and dynamic system where morphologically and functionally diverse mature cell types are generated and maintained throughout life by bone marrow (BM) Hematopoietic Stem/Progenitor Cells (HSPC). Congenital and acquired hematopoietic disorders are often diagnosed through the detection of aberrant frequency or composition of hematopoietic cell populations. We here describe a novel protocol, called “Whole Blood Dissection” (WBD), capable of analyzing in a single test‐tube, hematopoietic progenitors and all major mature cell lineages composing either BM or peripheral blood (PB) through a multiparametric flow‐cytometry analysis. WBD allows unambiguously identifying in the same tube up to 23 different blood cell types including HSPC subtypes and all the major myeloid and lymphoid lineage compartments at different stages of maturation, through a combination of 17 surface and 1 viability cell markers. We assessed the efficacy of WBD by analyzing BM and PB samples from adult (n = 8) and pediatric (n = 9) healthy donors highlighting age‐related shift in cell composition. We also tested the capability of WBD on detecting aberrant hematopoietic cell composition in clinical samples of patients with primary immunodeficiency or leukemia unveiling expected and novel hematopoietic unbalances. Overall, WBD allows unambiguously identifying >99% of the cell subpopulations composing a blood sample in a reproducible, standardized, cost‐, and time‐efficient manner. This tool has a wide range of potential pre‐clinical and clinical applications going from the characterization of hematopoietic disorders to the monitoring of hematopoietic reconstitution in patients after transplant or gene therapy