950 research outputs found
Supporting children with genetic syndromes in the classroom: the example of 22q deletion syndrome
An increasing number of children are likely to have a known genetic cause for their special educational needs. One such genetic condition is 22q11.2 deletion syndrome (22qDS), a genetic syndrome associated with early speech and language difficulties, global and specific cognitive impairments, difficulties with attention and difficulties with social-emotional functioning. In this article the learning and behavioural strengths and needs of this genetic syndrome are described along with recommendations for classroom-based interventions. Suggested recommendations in the learning and emotional-behavioural domains for the syndrome draw on a number of approaches that have been found to be useful for children with a range of conditions including ADHD, ASD and dyscalculia. While teachers cannot be expected to know about all potential genetic causes for special educational needs, knowing that a genetic condition is likely to be associated with a pattern of relative cognitive and behavioural strengths and needs is important
Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians
PURPOSE: The precise etiology of autoimmune hepatitis (AIH) remains unknown, although a number of genetic loci have been implicated in the susceptibility of type 1 AIH. The purpose of this study was to test for association of these loci with type 1 AIH in New Zealand Caucasians. METHODS: 77 AIH patients and 485 healthy controls were genotyped for the SNPs rs2187668 (HLA-DRB*03:01), rs660895 (HLA-DRB*04:01), rs3749971 (HLA-A1-B8-DR3), rs231775 (CLTLA4), rs1800629 (TNF), and rs1800682 (FAS) using predesigned TaqMan SNP genotyping assays. Chi square analysis was used to test for association of allele and genotype with overall AIH, and with severe fibrosis and ALT levels at 6 months. RESULTS: Significant risk of AIH was conferred by the minor alleles of rs2187668 (OR = 2.45, 95% CI 1.65-3.61, p < 0.0001), rs3749971 (OR = 1.89, 95% CI 1.21-2.94, p = 0.004) and rs1800629 (OR = 2.06, 95% CI 1.41-3.01, p = 0.0001). Multivariate analysis showed that rs2187668 was independently associated with type 1 AIH susceptibility (OR = 2.40, 95% CI 1.46-3.93, p = 0.001). The C allele of FAS SNP rs1800682 was associated with increased risk of severe fibrosis at diagnosis (OR = 2.03, 95% CI 1.05-3.93, p = 0.035) and with incomplete normalization of ALT levels at 6 months post-diagnosis (OR = 3.94, 95% CI 1.62-9.54, p = 0.0015). CONCLUSIONS: This is the first population-based study to investigate genetic risk loci for type 1 AIH in New Zealand Caucasians. We report significant independent association of HLA-DRB1*03:01 with overall susceptibility to type 1 AIH, as well as FAS with a more aggressive disease phenotype
Is it possible to detect gravitational waves with atom interferometers?
We investigate the possibility to use atom interferometers to detect
gravitational waves. We discuss the interaction of gravitational waves with an
atom interferometer and analyze possible schemes
Gravitomagnetism and Relative Observer Clock Effects
The gravitomagnetic clock effect and the Sagnac effect for circularly
rotating orbits in stationary axisymmetric spacetimes are studied from a
relative observer point of view, clarifying their relationships and the roles
played by special observer families. In particular Semer\'ak's recent
characterization of extremely accelerated observers in terms of the two-clock
clock effect is shown to be complemented by a similarly special property of the
single-clock clock effect.Comment: 19 pages, LaTeX, IOP macros with package epsf and 1 eps figure, to
appear in Classical and Quantum Gravity, slight revisio
Side-by-Side Testing of Commercial Office Lighting Systems: Two-lamp Fluorescent Fixtures
Lighting systems in commercial office
buildings are primary determinants of building
energy use. In warmer climates, lighting energy use
has important implications for building cooling loads
as well as those directly associated with illumination
tasks. To research the comparative performance of
conventional and advanced office lighting systems,
Florida Solar Energy Center (FSEC) set up the
Lighting Flexible Test Facility (LFTF) which allows
side-by-side comparison of lighting options in two
otherwise identical 2.7 m x 3.7 m (9' x 12') south
facing offices.
The ceiling of the LFTF contains 0.61 m x
1.2 m (2' x 4') recessed fluorescent fixtures designed
to be easily changed. Differing lighting systems were
comparatively tested against each other over weeklong
periods. Data on power consumption (watts),
power quality (power factor), work-plane interior
lighting levels (lux), bulb-wall, fixture and plenum
temperatures were recorded every 15 minutes on a
multi-channel data logger. This data allows realistic
analysis of comparative lighting system performance
including interactions with daylighting
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A longitudinal examination of the relationship between trauma-related cognitive factors and internalising and externalising psychopathology in physically injured children
Cognitive models of posttraumatic stress disorder (PTSD) highlight maladaptive posttrauma appraisals, trauma memory qualities, and coping strategies, such as rumination or thought suppression, as key processes that maintain PTSD symptoms. Anxiety, depression and externalising symptoms can also present in children in the aftermath of trauma, yet there has been little empirical investigation of the potential relevance of posttrauma cognitive processes for such difficulties. Here, we examined whether: a) acute maladaptive cognitive processes (specifically, maladaptive appraisals, memory qualities, and cognitive coping) were associated with symptoms of PTSD, internalising, and externalising at 1-month posttrauma (T1); and b) changes in these cognitive processes predicted symptom change at a follow-up assessment 6 months later (T2). We recruited 132 6–13 year old children and their parents from emergency departments following the child’s experience of an acute trauma. Children self-reported on their maladaptive appraisals, trauma-memory and cognitive coping strategies, along with symptoms of PTSD, anxiety and depression. Parents also rated children’s internalising and externalising symptoms. We found each cognitive process to be robustly associated with PTSD and non-PTSD internalising symptoms at T1, and change in each predicted change in symptoms to T2. Maladaptive appraisals and cognitive coping were unique predictors of children’s posttrauma internalising. Effects were partially retained even controlling for co-occurring PTSD symptoms. There was less evidence that trauma-specific cognitive processes were associated with externalising symptoms. Findings suggest aspects of cognitive models of PTSD are applicable to broader posttrauma psychopathology, and have implications for how we understand and target children’s posttrauma psychological adjustment
Anatomy and Neurophysiology of the Taste System in Aged Animals a
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72005/1/j.1749-6632.1989.tb20989.x.pd
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