Sedimentological effects of tsunamis, with particular reference to impact-generated and volcanogenic waves

Impulse-generated waves (tsunamis) may be produced, at varying scales and global recurrence intervals (RI), by several processes. Meteorite-water impacts will produce tsunamis, and asteroid-scale impacts with associated mega-tsunamis may occur. A bolide-water impact would undoubtedly produce a major tsunami, whose sedimentological effects should be recognizable. Even a bolide-land impact might trigger major submarine landslides and thus tsunamis. In all posulated scenarios for the K/T boundary event, then, tsunamis are expected, and where to look for them must be determined, and how to distinguish deposits from different tsunamis. Also, because tsunamis decrease in height as they move away from their source, the proximal effects will differ by perhaps orders of magnitude from distal effects. Data on the characteristics of tsunamis at their origin are scarce. Some observations exist for tsunamis generated by thermonuclear explosions and for seismogenic tsunamis, and experimental work was conducted on impact-generated tsunamis. All tsunamis of interest have wave-lengths of 0(100) km and thus behave as shallow-water waves in all ocean depths. Typical wave periods are 0(10 to 100) minutes. The effect of these tsunamis can be estimated in the marine and coastal realm by calculating boundary shear stresses (expressed as U*, the shear velocity). An event layer at the K/T boundary in Texas occurs in mid-shelf muds. Only a large, long-period wave with a wave height of 0(50) m, is deemed sufficient to have produced this layer. Such wave heights imply a nearby volcanic explosion on the scale of Krakatau or larger, or a nearby submarine landslide also of great size, or a bolide-water impact in the ocean

Skylab M518 multipurpose furnace convection analysis

An analysis was performed of the convection which existed on ground tests and during skylab processing of two experiments: vapor growth of IV-VI compounds growth of spherical crystals. A parallel analysis was also performed on Skylab experiment indium antimonide crystals because indium antimonide (InSb) was used and a free surface existed in the tellurium-doped Skylab III sample. In addition, brief analyses were also performed of the microsegregation in germanium experiment because the Skylab crystals indicated turbulent convection effects. Simple dimensional analysis calculations and a more accurate, but complex, convection computer model, were used in the analysis

Ricoeur between Levinas and Heidegger: Another's Further Alterity

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Taming Violence: Ricoeur and Derrida

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Introduction: VIolence: And Postmodernity

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Ricoeur and Marcel: An Alternative to Postmodern Deconstruction

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Compositional uniformity, domain patterning and the mechanism underlying nano-chessboard arrays

We propose that systems exhibiting compositional patterning at the nanoscale, so far assumed to be due to some kind of ordered phase segregation, can be understood instead in terms of coherent, single phase ordering of minority motifs, caused by some constrained drive for uniformity. The essential features of this type of arrangements can be reproduced using a superspace construction typical of uniformity-driven orderings, which only requires the knowledge of the modulation vectors observed in the diffraction patterns. The idea is discussed in terms of a simple two dimensional lattice-gas model that simulates a binary system in which the dilution of the minority component is favored. This simple model already exhibits a hierarchy of arrangements similar to the experimentally observed nano-chessboard and nano-diamond patterns, which are described as occupational modulated structures with two independent modulation wave vectors and simple step-like occupation modulation functions.Comment: Preprint. 11 pages, 11 figure

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 after previous approval in Europe and other countries. However, tolvaptan is moderately effective and may negatively impact a patient's quality of life due to potentially significant side effects. Additional and improved therapies are still urgently needed, and several clinical trials are underway, which are discussed in the companion paper Müller and Benzing (Management of autosomal-dominant polycystic kidney disease-state-of-the-art) Clin Kidney J 2018; 11: i2-i13. Here, we discuss new therapeutic avenues that are currently being investigated at the preclinical stage. We focus on mammalian target of rapamycin and dual kinase inhibitors, compounds that target inflammation and histone deacetylases, RNA-targeted therapeutic strategies, glucosylceramide synthase inhibitors, compounds that affect the metabolism of renal cysts and dietary restriction. We discuss tissue targeting to renal cysts of small molecules via the folate receptor, and of monoclonal antibodies via the polymeric immunoglobulin receptor. A general problem with potential pharmacological approaches is that the many molecular targets that have been implicated in ADPKD are all widely expressed and carry out important functions in many organs and tissues. Because ADPKD is a slowly progressing, chronic disease, it is likely that any therapy will have to continue over years and decades. Therefore, systemically distributed drugs are likely to lead to potentially prohibitive extra-renal side effects during extended treatment. Tissue targeting to renal cysts of such drugs is one potential way around this problem. The use of dietary, instead of pharmacological, interventions is another

The "exterior approach" applied to the inverse obstacle problem for the heat equation

International audienceIn this paper we consider the " exterior approach " to solve the inverse obstacle problem for the heat equation. This iterated approach is based on a quasi-reversibility method to compute the solution from the Cauchy data while a simple level set method is used to characterize the obstacle. We present several mixed formulations of quasi-reversibility that enable us to use some classical conforming finite elements. Among these, an iterated formulation that takes the noisy Cauchy data into account in a weak way is selected to serve in some numerical experiments and show the feasibility of our strategy of identification. 1. Introduction. This paper deals with the inverse obstacle problem for the heat equation, which can be described as follows. We consider a bounded domain D ⊂ R d , d ≥ 2, which contains an inclusion O. The temperature in the complementary domain Ω = D \ O satisfies the heat equation while the inclusion is characterized by a zero temperature. The inverse problem consists, from the knowledge of the lateral Cauchy data (that is both the temperature and the heat flux) on a subpart of the boundary ∂D during a certain interval of time (0, T) such that the temperature at time t = 0 is 0 in Ω, to identify the inclusion O. Such kind of inverse problem arises in thermal imaging, as briefly described in the introduction of [9]. The first attempts to solve such kind of problem numerically go back to the late 80's, as illustrated by [1], in which a least square method based on a shape derivative technique is used and numerical applications in 2D are presented. A shape derivative technique is also used in [11] in a 2D case as well, but the least square method is replaced by a Newton type method. Lastly, the shape derivative together with the least square method have recently been used in 3D cases [18]. The main feature of all these contributions is that they rely on the computation of forward problems in the domain Ω × (0, T): this computation obliges the authors to know one of the two lateral Cauchy data (either the temperature or the heat flux) on the whole boundary ∂D of D. In [20], the authors introduce the so-called " enclosure method " , which enables them to recover an approximation of the convex hull of the inclusion without computing any forward problem. Note however that the lateral Cauchy data has to be known on the whole boundary ∂D. The present paper concerns the " exterior approach " , which is an alternative method to solve the inverse obstacle problem. Like in [20], it does not need to compute the solution of the forward problem and in addition, it is applicable even if the lateral Cauchy data are known only on a subpart of ∂D, while no data are given on the complementary part. The " exterior approach " consists in defining a sequence of domains that converges in a certain sense to the inclusion we are looking for. More precisely, the nth step consists, 1. for a given inclusion O n , in approximating the temperature in Ω n × (0, T) (Ω n := D \ O n) with the help of a quasi-reversibility method, 2. for a given temperature in Ω n × (0, T), in computing an updated inclusion O n+1 with the help of a level set method. Such " exterior approach " has already been successfully used to solve inverse obstacle problems for the Laplace equation [5, 4, 15] and for the Stokes system [6]. It has also been used for the heat equation in the 1D case [2]: the problem in this simple case might be considered as a toy problem since the inclusion reduces to a point in some bounded interval. The objective of the present paper is to extend the " exterior approach " for the heat equation to any dimension of space, with numerical applications in the 2D case. Let us shed some light on the two steps o

New obstructions to symplectic embeddings

In this paper we establish new restrictions on symplectic embeddings of certain convex domains into symplectic vector spaces. These restrictions are stronger than those implied by the Ekeland-Hofer capacities. By refining an embedding technique due to Guth, we also show that they are sharp.Comment: 80 pages, 3 figures, v2: improved exposition and minor corrections, v3: Final version, expanded and improved exposition and minor corrections. The final publication is available at link.springer.co