Gaze-contingent flicker pupil perimetry detects scotomas in patients with cerebral visual impairments or glaucoma

The pupillary light reflex is weaker for stimuli presented inside as compared to outside absolute scotomas. Pupillograph perimetry could thus be an objective measure of impaired visual processing. However, the diagnostic accuracy in detecting scotomas has remained unclear. We quantitatively investigated the accuracy of a novel form of pupil perimetry. The new perimetry method, termed gaze-contingent flicker pupil perimetry, consists of the repetitive on, and off flickering of a bright disk (2 hz; 320 cd/m; 4° diameter) on a gray background (160 cd/m) for 4 seconds per stimulus location. The disk evokes continuous pupil oscillations at the same rate as its flicker frequency, and the oscillatory power of the pupil reflects visual sensitivity. We monocularly presented the disk at a total of 80 locations in the central visual field (max. 15°). The location of the flickering disk moved along with gaze to reduce confounds of eye movements (gaze-contingent paradigm). The test lasted ~5 min per eye and was performed on 7 patients with cerebral visual impairment (CVI), 8 patients with primary open angle glaucoma (age >45), and 14 healthy, age/gender-matched controls. For all patients, pupil oscillation power (FFT based response amplitude to flicker) was significantly weaker when the flickering disk was presented in the impaired as compared to the intact visual field (CVI: 12%, AUC = 0.73; glaucoma: 9%, AUC = 0.63). Differences in power values between impaired and intact visual fields of patients were larger than differences in power values at corresponding locations in the visual fields of the healthy control group (CVI: AUC = 0.95; glaucoma: AUC = 0.87). Pupil sensitivity maps highlighted large field scotomas and indicated the type of visual field defect (VFD) as initially diagnosed with standard automated perimetry (SAP) fairly accurately in CVI patients but less accurately in glaucoma patients. We provide the first quantitative and objective evidence of flicker pupil perimetry's potential in detecting CVI-and glaucoma-induced VFDs. Gaze-contingent flicker pupil perimetry is a useful form of objective perimetry and results suggest it can be used to assess large VFDs with young CVI patients whom are unable to perform SAP

Maximum augmented empirical likelihood estimation of categorical marginal models for large sparse contingency tables

Categorical marginal models (CMMs) are flexible tools for modelling dependent or clustered categorical data, when the dependencies themselves are not of interest. A major limitation of maximum likelihood (ML) estimation of CMMs is that the size of the contingency table increases exponentially with the number of variables, so even for a moderate number of variables, say between 10 and 20, ML estimation can become computationally infeasible. An alternative method, which retains the optimal asymptotic efficiency of ML, is maximum empirical likelihood (MEL) estimation. However, we show that MEL tends to break down for large, sparse contingency tables. As a solution, we propose a new method, which we call maximum augmented empirical likelihood (MAEL) estimation and which involves augmentation of the empirical likelihood support with a number of well-chosen cells. Simulation results show good finite sample performance for very large contingency tables

Measurement of the CMS Magnetic Field

The measurement of the magnetic field in the tracking volume inside the superconducting coil of the Compact Muon Solenoid (CMS) detector under construction at CERN is done with a fieldmapper designed and produced at Fermilab. The fieldmapper uses 10 3-D B-sensors (Hall probes) developed at NIKHEF and calibrated at CERN to precision 0.05% for a nominal 4 T field. The precise fieldmapper measurements are done in 33840 points inside a cylinder of 1.724 m radius and 7 m long at central fields of 2, 3, 3.5, 3.8, and 4 T. Three components of the magnetic flux density at the CMS coil maximum excitation and the remanent fields on the steel-air interface after discharge of the coil are measured in check-points with 95 3-D B-sensors located near the magnetic flux return yoke elements. Voltages induced in 22 flux-loops made of 405-turn installed on selected segments of the yoke are sampled online during the entire fast discharge (190 s time-constant) of the CMS coil and integrated offline to provide a measurement of the initial magnetic flux density in steel at the maximum field to an accuracy of a few percent. The results of the measurements made at 4 T are reported and compared with a three-dimensional model of the CMS magnet system calculated with TOSCA.Comment: 4 pages, 5 figures, 15 reference

Binary Models for Marginal Independence

Log-linear models are a classical tool for the analysis of contingency tables. In particular, the subclass of graphical log-linear models provides a general framework for modelling conditional independences. However, with the exception of special structures, marginal independence hypotheses cannot be accommodated by these traditional models. Focusing on binary variables, we present a model class that provides a framework for modelling marginal independences in contingency tables. The approach taken is graphical and draws on analogies to multivariate Gaussian models for marginal independence. For the graphical model representation we use bi-directed graphs, which are in the tradition of path diagrams. We show how the models can be parameterized in a simple fashion, and how maximum likelihood estimation can be performed using a version of the Iterated Conditional Fitting algorithm. Finally we consider combining these models with symmetry restrictions

Measurement of the solenoid magnetic field

We describe the machine used to map the solenoid field and the data sets that were collected. The bulk of the note describes the analysis of this data. A series of small corrections are made; some taken from surveys and some derived from the data itself. Two fitting methods are defined and applied to all data sets. The final result is that the field map at normal operating current can be fitted to a function that obeys Maxwell with an r.m.s. residual of less than 5 Gauss. Systematic errors on the measurement of track sagitta due to the field uncertainty are estimated to be in the range 2.3E-4 to 12E-4, depending on the track rapidity. Finally, the representation of the map in Athena is briefly described

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membrane, resulting in disruption of DNA integrity and a decrease in motility. Established biomarkers for OS include free thiols and malondialdehyde (MDA), both representing different components of the reactive species interactome (RSI). This exploratory study aimed to investigate seminal plasma-free thiol and MDA levels in relation to semen parameters as defined by the World Health Organization (WHO) to determine if these markers are adequate to define local OS status. Furthermore, this study investigated if there is a relation between systemic and local OS status by comparing seminal concentrations of free thiol (R-SH, sulfhydryl groups, representing the extracellular redox status) and MDA (lipid peroxidation product) levels to those measured in serum. Free thiol and MDA measurements in both serum and semen plasma were performed in 50 males (18–55 y) of couples seeking fertility treatment. A significant positive correlation was found between seminal plasma-free thiol levels and sperm concentration and progressive motility (r = 0.383, p = 0.008 and r = 0.333, p = 0.022, respectively). In addition, a significant positive correlation was found between MDA levels in seminal plasma and sperm concentration (r = 0.314, p = 0.031). This study supports that seminal plasma-free thiols may be promising as local OS biomarkers. No associations were observed between local and systemic OS biomarker concentrations

Measurement of the ATLAS solenoid magnetic field

ATLAS is a general purpose detector designed to explore a wide range of physics at the Large Hadron Collider. At the centre of ATLAS is a tracking detector in a 2 T solenoidal magnetic field. This paper describes the machine built to map the field, the data analysis methods, the final results, and their estimated uncertainties. The remotely controlled mapping machine used pneumatic motors with feedback from optical encoders to scan an array of Hall probes over the field volume and log data at more than 20 000 points in a few hours. The data were analysed, making full use of the physical constraints on the field and of our knowledge of the solenoid coil geometry. After a series of small corrections derived from the data itself, the resulting maps were fitted with a function obeying Maxwell's equations. The fit residuals had an r.m.s. less than 0.5 mT and the systematic error on the measurement of track sagitta due to the field uncertainty was estimated to be in the range 0.02 % to 0.12 % depending on the track rapidity