59 research outputs found
Anforderungen an Virtuelle Rathäuser:ein Leitfaden für die herstellerunabhängige Softwareauswahl
Im Rahmen des E-Government sollen dem Bürger Verwaltungsdienstleistungen durch moderne Informations- und Kommunikationstechnik (IKT) auf elektronischem Wege einfacher zugänglich gemacht werden. Ermöglicht wird dieses Vorhaben auf kommunaler Ebene durch das so genannte Virtuelle Rathaus. Im Virtuellen Rathaus bietet die Verwaltung den Bürgern über elektronische Medien die Möglichkeit, jederzeit und überall ihre Informations-, Kommunikations- und Transaktionsdienstleistungen in Anspruch zu nehmen. Das Projektseminar „ProService“ des Lehrstuhls für Wirtschaftsinformatik und Informationsmanagement der Westfälischen Wilhelms-Universität Münster, hat in Zusammenarbeit mit der Firma citeq, einem kommunalem Rechenzentrum und einer Einrichtung der Stadt Münster, eine Anforderungsanalyse in Bezug auf das Virtuelle Rathaus durchgeführt. Die Ergebnisse werden in diesem Dokument präsentiert
Fachkonzeptionelle Spezifikation von Virtuellen Rathäusern:ein Konzept zur Unterstützung der Implementierung von Virtuellen Rathäusern
Kommunalverwaltungen bedienen sich des Mediums Internet, um Bürgern und Wirtschaft zu jeder Zeit und an jedem Ort die Möglichkeit zu bieten, Informations-, Kommunikations- und Transaktionsdienstleistungen der Verwaltung in Anspruch nehmen zu können. Bevor Verwaltungsdienstleistungen vollständig digital und medienbruchfrei sowohl bei der externenInanspruchnahme als auch bei der internen Bearbeitung durchgeführt werden können, sollte den Anspruchsgruppen zunächst in adäquater Weise qualitativ hochwertige Informationen und Kommunikationsmöglichkeiten zu den Verwaltungsdienstleistungen zur Verfügung gestellt werden. Das „Virtuelle Rathaus“ ist probates Mittel zur Erreichung dieser Zielsetzung. Die Studie „Virtuelles Rathaus Münsterland 2004“ hat gezeigt, dass bei den derzeitigen Realisierungen im Münsterland einige Leistungslücken erkennbar sind. So fehlt es z. B. an einheitlichen und intuitiv verständlichen Navigationskonzepten, an strukturierten und einheitlichen Dienstleistungsbeschreibungen und an einem umfangreicheren Angebot. Weiterhin wurde festegestellt, dass gerade kleine und mittlere Verwaltungen keinerlei Konzepte und informationstechnische Unterstützung für die Realisierung des Virtuellen Rathauses besitzen. Dieser Status quo motivierte umfangreiche E-Government Projekttätigkeit im Münsterland. Das Projektseminar „ProService“, des Lehrstuhls für Wirtschaftsinformatik und Informationsmanagement der Westfälischen Wilhelms-Universität Münster, hat in Zusammenarbeit mit dem Kreis Warendorf und dem Kommunalrechenzentrum citeq, eine umfassende Anforderungsanalyse in Bezug auf das Virtuelle Rathaus durchgeführt. Basierend auf den ermittelten Anforderungen wird in diesem Dokument ein produktunabhängiges Fachkonzept vorgestellt
EEGManyPipelines: A Large-scale, Grassroots Multi-analyst Study of Electroencephalography Analysis Practices in the Wild
The ongoing reproducibility crisis in psychology and cognitive neuroscience has sparked increasing calls to re-evaluate and reshape scientific culture and practices. Heeding those calls, we have recently launched the EEGManyPipelines project as a means to assess the robustness of EEG research in naturalistic conditions and experiment with an alternative model of conducting scientific research. One hundred sixty-eight analyst teams, encompassing 396 individual researchers from 37 countries, independently analyzed the same unpublished, representative EEG data set to test the same set of predefined hypotheses and then provided their analysis pipelines and reported outcomes. Here, we lay out how large-scale scientific projects can be set up in a grassroots, community-driven manner without a central organizing laboratory. We explain our recruitment strategy, our guidance for analysts, the eventual outputs of this project, and how it might have a lasting impact on the field
Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis
<p>Abstract</p> <p>Background</p> <p>S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties. S100A7 protein levels are decreased in nasal lavage fluid from individuals with ongoing allergic rhinitis, suggesting a role for S100A7 in allergic airway inflammation. The aims of this study were to describe genetic variation in <it>S100A7 </it>and search for associations between this variation and allergic rhinitis.</p> <p>Methods</p> <p>Peripheral blood was collected from 184 atopic patients with a history of pollen-induced allergic rhinitis and 378 non-atopic individuals, all of Swedish origin. DNA was extracted and the <it>S100A7 </it>gene was resequenced in a subset of 47 randomly selected atopic individuals. Nine polymorphisms were genotyped in 184 atopic and 378 non-atopic individuals and subsequently investigated for associations with allergic rhinitis as well as skin prick test results. Haplotypes were estimated and compared in the two groups.</p> <p>Results</p> <p>Thirteen polymorphisms were identified in <it>S100A7</it>, of which 7 were previously undescribed. rs3014837 (G/C), which gives rise to an Asp → Glu amino acid shift, had significantly increased minor allele frequency in atopic individuals. The major haplotype, containing the major allele at all sites, was more common in non-atopic individuals, while the haplotype containing the minor allele at rs3014837 was equally more common among the atopic individuals. Additionally, heterozygotes at this site had significantly higher scores in skin prick tests for 9 out of 11 tested allergens, compared to homozygotes.</p> <p>Conclusion</p> <p>This is the first study describing genetic variation, associated with allergy, in <it>S100A7</it>. The results indicate that rs3014837 is linked to allergic rhinitis in our Swedish population and render S100A7 a strong candidate for further investigations regarding its role in allergic inflammation.</p
Seismic risk assessment for developing countries : Pakistan as a case study
Modern Earthquake Risk Assessment (ERA) methods usually require seismo-tectonic information for Probabilistic Seismic Hazard Assessment (PSHA) that may not be readily available in developing countries. To bypass this drawback, this paper presents a practical event-based PSHA method that uses instrumental seismicity, available historical seismicity, as well as limited information on geology and tectonic setting. Historical seismicity is integrated with instrumental seismicity to determine the long-term hazard. The tectonic setting is included by assigning seismic source zones associated with known major faults. Monte Carlo simulations are used to generate earthquake catalogues with randomized key hazard parameters. A case study region in Pakistan is selected to demonstrate the effectiveness of the method. The results indicate that the proposed method produces seismic hazard maps consistent with previous studies, thus being suitable for generating such maps in regions where limited data are available. The PSHA procedure is developed as an integral part of an ERA framework named EQRAM. The framework is also used to determine seismic risk in terms of annual losses for the study region
Development and Psychometric Validation of the Pandemic-Related Traumatic Stress Scale for Children and Adults
To assess the public health impact of the COVID-19 pandemic on mental health, investigators from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) research program developed the Pandemic-Related Traumatic Stress Scale (PTSS). Based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) acute stress disorder symptom criteria, the PTSS is designed for adolescent (13–21 years) and adult self-report and caregiver-report on 3–12-year-olds. To evaluate psychometric properties, we used PTSS data collected between April 2020 and August 2021 from non-pregnant adult caregivers (n = 11,483), pregnant/postpartum individuals (n = 1,656), adolescents (n = 1,795), and caregivers reporting on 3–12-year-olds (n = 2,896). We used Mokken scale analysis to examine unidimensionality and reliability, Pearson correlations to evaluate relationships with other relevant variables, and analyses of variance to identify regional, age, and sex differences. Mokken analysis resulted in a moderately strong, unidimensional scale that retained nine of the original 10 items. We detected small to moderate positive associations with depression, anxiety, and general stress, and negative associations with life satisfaction. Adult caregivers had the highest PTSS scores, followed by adolescents, pregnant/postpartum individuals, and children. Caregivers of younger children, females, and older youth had higher PTSS scores compared to caregivers of older children, males, and younger youth, respectively
RETRACTED ARTICLE: Mechanistic attributes of S100A7 (psoriasin) in resistance of anoikis resulting tumor progression in squamous cell carcinoma of the oral cavity
Tables of amplitude and energy ratios for plane SV waves : VESIAC special project
http://deepblue.lib.umich.edu/bitstream/2027.42/4422/5/bab3695.0001.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/4422/4/bab3695.0001.001.tx
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