Corepressor diversification by alternative mRNA splicing is species specific.

BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another.ResultsWe report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution.ConclusionsWe propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species

Preliminary Survey of the Terrestrial Isopods (Isopoda), Millipedes (Diplopoda), Harvestmen (Opiliones), and Spiders (Araneae) of Toft Point Natural Area, Door County, Wisconsin

Toft Point Natural Area is a National Natural Landmark owned and managed by the University of Wisconsin – Green Bay and located on the Lake Michigan shore of Wisconsin’s Door Peninsula. With twelve biotic communities on 700 acres, Toft Point contains considerable biological diversity. We conducted a preliminary survey of the arachnids (spiders and harvestmen, excluding mites and pseudoscorpions), millipedes (diplopods), and terrestrial isopods (Isopoda: Oniscoidea). Sampling occurred on three dates in 2001 using leaf litter collection with Berlese extraction and a timed collection by hand that incorporated a variety of techniques. Specimens from a 1992 survey and assorted collecting events were also used to compile a species list. The list includes five isopods, four millipedes, six harvestmen, and 113 spiders, including 16 new state records (two millipedes and 14 spiders) and 90 new Door County records. Litter collection and sampling in wetland habitats were both especially productive

Planetary geometry handbook: Venus positional data, 1988 - 2020, volume 2

Graphical data necessary for the analysis of planetary exploration missions to Venus are presented. Positional and geometric information spanning the time period from 1988 through 2020 is provided. The data and the usage are explained

Planetary geometry handbook: Mars positional data, 1990 - 2020, volume 3

Graphical data necessary for the analysis of planetary exploration missions to Mars are presented. Positional and geometric information spanning the time period from 1990 through 2020 is provided. The data and usage are explained

Planetary geometry handbook: Saturn positional data, 1985 - 2020, volume 5

Graphical data necessary for the analysis of planetary exploration missions to Saturn are presented. Positional and geometric information spanning the time period from 1985 through 2020 is provided. The data and their usage are explained

Planetary geometry handbook: Jupiter positional data, 1985 - 2020, volume 4

Graphical data necessary for the analysis of planetary exploration missions to Jupiter are presented. Positional and geometric information spanning the time period from 1985 through 2020 is provided. The data and their usage are explained

Model for reflection and transmission matrices of nanowire end facets

Nanowires show a large potential for various electrooptical devices, such as light emitting diodes, solar cells and nanowire lasers. We present a direct method developed to calculate the modal reflection and transmission matrix at the end facets of a waveguide of arbitrary cross section, resulting in a generalized version of the Fresnel equations. The reflection can be conveniently computed using Fast Fourier Transforms. We demonstrate that the reflection is qualitatively described by two main parameters, the modal field confinement and the average Fresnel reflection of the plane waves constituting the waveguide mode.Comment: 11 pages,14 figure

Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma adenoid cystic carcinoma

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73933/1/j.1365-2559.1999.00761.x.pd

An optical heterodyne densitometer

Researchers are developing an optical heterodyne densitometer with the potential to measure optical density over an unprecedented dynamic range with high accuracy and sensitivity. This device uses a Mach-Zender interferometer configuration with heterodyne detection to make direct comparisons between optical and RF attenuators. Researchers expect to attain measurements of filter transmittance down to 10 to the minus 12th power with better than 1 percent uncertainty. In addition, they intend to extend the technique to the problem of measuring low levels of light scattering from reflective and transmissive optics