Synthesis of aryl-substituted thieno[3,2-b]thiophene derivatives and their use for N,S-heterotetracene construction

Fiesselmann thiophene synthesis was applied for the convenient construction of thieno[3,2-b]thiophene derivatives. Thus, new 5- or 6-aryl-3-hydroxythieno[3,2-b]thiophene-2-carboxylates were obtained by condensation of 5- or 4-aryl-3-chlorothiophene-2-carbox-ylates, respectively, with methyl thioglycolate in the presence of potassium tert-butoxide. The saponification of the resulting esters, with decarboxylation of the intermediating acids, gave the corresponding thieno[3,2-b]thiophen-3(2H)-ones. The latter ketones were used to synthesize new N,S-heterotetracenes, namely 9H-thieno[2',3':4,5]thieno[3,2-b]indoles by their treatment with arylhydrazines in accordance with the Fischer indolization reaction. © 2019 Demina et al.; licensee Beilstein-Institut.Russian Foundation for Basic Research, RFBR: 18-33-20083This study was supported by the Russian Foundation for Basic Research, Grant No. 18-33-20083

Contents of heavy metals in fructicose epiphytic lichens of Karelia as indicator of atmospheric transport of pollutants

Results of studies of heavy metals contents in fruticose epiphytic lichens in Karelia are presented and the influence of different sources on the elemental composition of lichens has been estimated. It has been shown, that long-range atmospheric transport influences strongly the accumulation of Pb, Zn, Cd, Sb. For Al, Fe and Co lithogenic source is the main one. In the Northern Karelia atmospheric transport of Cu, Co and Ni from metallurgic enterprises of the Murmansk Region is important source of these elements

Regional aspects of sectoral digitalization : problems and prospects

Purpose: At present, high and sometimes record indicators have been achieved for the individual branches of agricultural production. Further intensive development of agriculture is due to the search for new ways to increase labor productivity and lower production costs which is the main aim of this research. Design/Methodology/Approach: The methodological basis served as a systematic approach, which ensured comprehensiveness and purposefulness. Analytical, abstract-logical, economic-statistical, monographic and experimental research methods were also used in this work to examine problems and prospects of sectoral digitalization. Findings: The agro-industrial complex demonstrates the growth of production indicators and is on the rise. The target indicators, laid down in the Food Security Doctrine, have already been achieved by many indices. To a large extent, it is due to a significant increase in the agro-industrial complex. Practical implications: A proposed platform that would ensure a breakthrough in further technical modernization of production, can be created only if the technologies are improved based on their digitalization and orientation towards a specific consumer. Originality/Value: The pin-point introduction of digital technologies in agricultural production confirms the high efficiency of the full innovative technical modernization. The proposed digital transformation of management in the agro-industrial complex of Russia is the value of this research with its originality compared to other ideas.peer-reviewe

On elliptic solutions of the quintic complex one-dimensional Ginzburg-Landau equation

The Conte-Musette method has been modified for the search of only elliptic solutions to systems of differential equations. A key idea of this a priory restriction is to simplify calculations by means of the use of a few Laurent series solutions instead of one and the use of the residue theorem. The application of our approach to the quintic complex one-dimensional Ginzburg-Landau equation (CGLE5) allows to find elliptic solutions in the wave form. We also find restrictions on coefficients, which are necessary conditions for the existence of elliptic solutions for the CGLE5. Using the investigation of the CGLE5 as an example, we demonstrate that to find elliptic solutions the analysis of a system of differential equations is more preferable than the analysis of the equivalent single differential equation.Comment: LaTeX, 21 page

Use of multiparametric analysis of meteor showers for their parental bodies' genetic parameters determination

© Published under licence by IOP Publishing Ltd. In this paper, the possibility of multiparametric analysis application for studying genetic connections between meteor showers and their parental bodies is considered. The modern methods of determining such connections take into account some parameters of parental bodies, such as size, orbital elements, and chemical composition. Obviously, all of these parameters refer to different physical substances. In this regard, simultaneous estimation of the impact of those parameters may be carried out with a given probability using regression analysis. The aim of this work is to develop a method of robust estimation of genetic parameters and use it for asteroid and meteor genetic connections analysis

Parton Distributions Working Group

The main focus of this working group was to investigate the different issues associated with the development of quantitative tools to estimate parton distribution functions uncertainties. In the conclusion, we introduce a "Manifesto" that describes an optimal method for reporting data.Comment: Report of the Parton Distributions Working Group of the 'QCD and Weak Boson Physics workshop in preparation for Run II at the Fermilab Tevatron'. Co-Conveners: L. de Barbaro, S.A. Keller, S. Kuhlmann, H. Schellman, and W.-K. Tun

Charm-sea Contribution to High-p_T \psi Production at the Fermilab Tevatron

The direct production of $J/\psi(\psi')$ at large transverse momentum, $p_T \gg M_{J/\psi}$, at the Fermilab Tevatron is revisited. It is found that the sea-quark initiated processes dominate in the high-$p_T$ region within the framework of color-singlet model, which is not widely realized. We think this finding is enlightening for further investigation on the charmonium production mechanism.Comment: Conclusions not changed, to appear in J. of Phys.

Changes in loading distribution in patients with Charcot foot during long-term follow-up

Background. The inactive stage of the diabetic Charcot arthropathy foot (CA) is characterised by fixed foot deformities and an absence of inflammation. However, it remains unclear if the shape of the foot and its biomechanics change during long-term follow-up. Aim. To evaluate changes in loading distribution of the affected foot, in patients with inactive CA, during long-term follow-up. Materials and methods. Twenty seven patients with unilateral inactive CA (19 females, 8 males) were studied. Computer pedography (emed AT, novel gmbh) was performed and baseline and the last studies were analysed. Maximal peak pressures (PP) were obtained for the first and the last studies and the percentage of the PP change was calculated for the total follow-up period and for periods: 24 months, 2448 months, 48 months. Results. PP increased: under the hallux 50%; 1st metatarsal30.7%; 2nd toe20%; 2nd toe6%; midfoot9%. PP decreased under 35 toes up to 67%. Significant changes at the first period were found under 35 toes only (62%). The increase in loading under the other parts of the foot appeared at 24 months; however, these changes became significant between 24 and 48 months and peaked after 48 months of follow-up. The maximal increase of PP was noticed under the hallux, the 2nd toe, metatarsals 13 and the midfoot. Conclusions. We revealed the gradual redistribution of PP, under the different parts of the foot, in patients with inactive CA. This redistribution reflects changes in the shape of the affected foot. The loading increased under the hallux, the 2nd toe and the corresponding metatarsals, 3rd metatarsal and midfoot, and decreased under the 35 toes. These changes increased during the follow-up, becoming more pronounced after 4 or more years. Our data may be useful for constructing custom-made footwear for patients with CA

Successful long-term prophylaxis of hereditary pregnancy-associated angioedema with plasma-derived C1-inhibitor concentrate: a case report

Hereditary angioedema (HAE) is a rare autosomal dominant disease caused by quantitative (type I) or functional (type II) deficiency in C1 esterase inhibitor (C1-INH). It may be caused by new mutations in up to 20% of patients. Prevalence of HAE is uncertain but is estimated to be approximately 1 case per 50,000 persons, without known differences among ethnic groups. C1-INH protein is a serine protease inhibitor that is important in controlling vascular permeability by acting on the initial phase of the complement activation, blood clotting, and fibrinolysis. Deficiency in functional C1-INH protein permits release of bradykinin, a key mediator of vascular permeability. Symptoms typically begin since childhood, worsening at puberty, and persist throughout the life, with unpredictable clinical course. The patients with HAE suffer from recurrent, acute attacks of edema that can affect any body sites, causing potentially life-threatening disorders (laryngeal edema). Results of clinical studies show that minor traumas, stress and medical interventions may be frequent precipitants of swelling episodes, but many attacks occur without an apparent cause. Pregnancy-associated hormonal changes may affect the course of C1-INH angioedema attacks by worsening, improving, or having no impact at all, but a higher percentage of pregnant women experienced an increase in C1-INH-HAE attack rates. Therapeutic options for patients with HAE are limited during pregnancy. C1-INH concentrate is recommended as the first-line therapy for pregnant women with HAE for on-demand treatment, shortterm and long-term prophylaxis, due to its safety and efficiency. Other therapies, e.g., treatment with fresh frozen plasma, androgens, icatibant, antifibrinolytics, may show variable efficacy, or cause undesirable side effects. The case below illustrates the successful treatment of HAE in a pregnant woman with C1 esterase inhibitor (C1-INH) concentrate. This patient had a very mild course of HAE during her lifetime and didn’t get any treatment. During pregnancy, she experienced a significant increase in the frequency of attacks, and the decision was made to start replacement therapy with a plasma-derived, double virus-inactivated C1-INH concentrate as a long-term prophylaxis throughout the full term of her pregnancy, before, during and after the cesarean section delivery