3,802 research outputs found
Homogeneous geodesics of non-unimodular Lorentzian Lie groups and naturally reductive Lorentzian spaces in dimension three
We determine, for all three-dimensional non-unimodular Lie groups equipped
with a Lorentzian metric, the set of homogeneous geodesics through a point.
Together with the results of [C] and [CM2], this leads to the full
classification of three-dimensional Lorentzian g.o. spaces and naturally
reductive spaces
Pseudo-K\"ahler Lie algebras with abelian complex structures
We study Lie algebras endowed with an abelian complex structure which admit a
symplectic form compatible with the complex structure. We prove that each of
those Lie algebras is completely determined by a pair (U,H) where U is a
complex commutative associative algebra and H is a sesquilinear hermitian form
on U which verifies certain compatibility conditions with respect to the
associative product on U. The Riemannian and Ricci curvatures of the associated
pseudo-K\"ahler metric are studied and a characterization of those Lie algebras
which are Einstein but not Ricci flat is given. It is seen that all
pseudo-K\"ahler Lie algebras can be inductively described by a certain method
of double extensions applied to the associated complex asssociative commutative
algebras
GABA-B receptor function in healthy volunteers, a pharmacokinetic and pharmacodynamic study of two doses of baclofen compared to placebo
AIMS AND HYPOTHESIS To assess the subjective and objective effects of baclofen on brain function in healthy volunteers. BACKGROUND Recent evidence suggests baclofen, a γ-aminobutyric acid type B (GABA-B) receptor agonist, reduces alcohol consumption and craving and promotes abstinence in alcoholics. However, characterisation of the GABA-B receptor system in clinical addiction is limited, and it is unclear why some patients require, or tolerate, higher doses to treat alcoholism. This study assesses the effects of baclofen on brain function in healthy volunteers to inform future studies investigating the sensitivity of GABA-B receptors in alcohol addiction. METHODS Eight healthy male volunteers completed a double blind randomised 3-way cross over study, receiving oral placebo (vitamin C 100mg), 10mg and 60mg baclofen. Subjective and objective measurements were taken at baseline (before medication) and at +30mins, 1, 2, 3, 4 and 6 hours after dosing. Objective measures included blood plasma samples, heart rate and blood pressure. Subjective measures included; the Subjective High Assessment Questionnaire (SHAS), visual analogue scales for sleepy, relaxed, tense and alert and a motor coordination task (zig-zag task). Pharmacokinetic data was obtained using liquid chromatography mass-spectrometry (LC-MS) to measure plasma baclofen concentrations. RESULTS 60mg Baclofen showed changes in subjective measures peaking at 2 hours post dosing compared with placebo, including a significant increase (p<0.05) in total SHAS scores with individual items, including feeling ‘drunk or intoxicated’, effects of alcohol and ‘muddled or confused’ particular affected.. Systolic blood pressure was significantly increased (p<0.05) at the 2 hours post 60mg dose. For both 10mg and 60mg baclofen, peak plasma concentration was achieved 60 minutes post dose. Pharmacokinetic data will be presented. There were no significant changes in these measures between 10mg Baclofen and placebo. CONCLUSIONS The objective and subjective measures used in this study are able to differentiate between placebo and 60mg baclofen. These findings will inform further research investigating the sensitivity of GABA-B receptors in alcohol addiction
An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels
Slow inactivation of Kv1 channels involves conformational changes near the selectivity filter. We examine such changes in Shaker channels lacking fast inactivation by considering the consequences of mutating two residues, T449 just external to the selectivity filter and V438 in the pore helix near the bottom of the selectivity filter. Single mutant T449F channels with the native V438 inactivate very slowly, and the canonical foot-in-the-door effect of extracellular tetraethylammonium (TEA) is not only absent, but the time course of slow inactivation is accelerated by TEA. The V438A mutation dramatically speeds inactivation in T449F channels, and TEA slows inactivation exactly as predicted by the foot-in-the-door model. We propose that TEA has this effect on V438A/T449F channels because the V438A mutation produces allosteric consequences within the selectivity filter and may reorient the aromatic ring at position 449. We investigated the possibility that the blocker promotes the collapse of the outer vestibule (spring-in-the-door) in single mutant T449F channels by an electrostatic attraction between a cationic TEA and the quadrupole moments of the four aromatic rings. To test this idea, we used in vivo nonsense suppression to serially fluorinate the introduced aromatic ring at the 449 position, a manipulation that withdraws electrons from the aromatic face with little effect on the shape, net charge, or hydrophobicity of the aromatic ring. Progressive fluorination causes monotonically enhanced rates of inactivation. In further agreement with our working hypothesis, increasing fluorination of the aromatic gradually transforms the TEA effect from spring-in-the-door to foot-in-the-door. We further substantiate our electrostatic hypothesis by quantum mechanical calculations
On the local existence of maximal slicings in spherically symmetric spacetimes
In this talk we show that any spherically symmetric spacetime admits locally
a maximal spacelike slicing. The above condition is reduced to solve a
decoupled system of first order quasi-linear partial differential equations.
The solution may be accomplished analytical or numerically. We provide a
general procedure to construct such maximal slicings.Comment: 4 pages. Accepted for publication in Journal of Physics: Conference
Series, Proceedings of the Spanish Relativity Meeting ERE200
High multiplicity W+jets predictions at NLO
In these proceedings we present results from a recent calculation for the
production of a W boson in conjunction with five jets at next-to-leading order
in perturbative QCD. We also use results at lower multiplicities to extrapolate
the cross section to the same process with six jets.Comment: 5 pages, Proceedings for the DIS2013 conferenc
The BlackHat Library for One-Loop Amplitudes
We present recent next-to-leading order (NLO) results in perturbative QCD
obtained using the BlackHat software library. We discuss the use of n-tuples to
separate the lengthy matrix-element computations from the analysis process. The
use of n-tuples allows many analyses to be carried out on the same phase-space
samples, and also allows experimenters to conduct their own analyses using the
original NLO computation.Comment: Talk given at ACAT 2013, Beijing, China, May 16--21, 2013; 6 pages, 2
figures; added reference
Universality in W+Multijet Production
We study -boson production accompanied by multiple jets at 7 TeV at the
LHC. We study the jet-production ratio, of total cross sections for +- to
+()-jet production, and the ratio of distributions in the total
transverse hadronic jet energy . We use the ratios to
extrapolate the total cross section, and the differential distribution in
, to +6-jet production. We use the BlackHat software
library in conjunction with SHERPA to perform the computations.Comment: Merge of Moriond 2014 and Loops & Legs 2014 proceedings, 6 pages, 2
figure
Quantitative analysis of the dripping and jetting regimes in co-flowing capillary jets
We study a liquid jet that breaks up into drops in an external co-flowing
liquid inside a confining microfluidic geometry. The jet breakup can occur
right after the nozzle in a phenomenon named dripping or through the generation
of a liquid jet that breaks up a long distance from the nozzle, which is called
jetting. Traditionally, these two regimes have been considered to reflect the
existence of two kinds of spatiotemporal instabilities of a fluid jet, the
dripping regime corresponding to an absolutely unstable jet and the jetting
regime to a convectively unstable jet. Here, we present quantitative
measurements of the dripping and jetting regimes, both in an unforced and a
forced state, and compare these measurements with recent theoretical studies of
spatiotemporal instability of a confined liquid jet in a co-flowing liquid. In
the unforced state, the frequency of oscillation and breakup of the liquid jet
is measured and compared to the theoretical predictions. The dominant frequency
of the jet oscillations as a function of the inner flow rate agrees
qualitatively with the theoretical predictions in the jetting regime but not in
the dripping regime. In the forced state, achieved with periodic laser heating,
the dripping regime is found to be insensitive to the perturbation and the
frequency of drop formation remains unaltered. The jetting regime, on the
contrary, amplifies the externally imposed frequency, which translates in the
formation of drops at the frequency imposed by the external forcing. In
conclusion, the dripping and jetting regimes are found to exhibit the main
features of absolutely and convectively unstable flows respectively, but the
frequency selection in the dripping regime is not ruled by the absolute
frequency predicted by the stability analysis.Comment: 10 pages, 12 figures, to appear in Physics of Fluid
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