Experimental investigation of the mechanical properties of dry microbraids and microbraid reinforced polymer composites

AbstractThis paper presents a comprehensive series of mechanical tests performed on two high performance polymeric fibres, microbraids and microbraid reinforced polymer composites (mBRPC). Quasi-static tests were performed on the raw materials and the effect of different gauge lengths and strain rates investigated. Then, microbraids having sub-millimetre diameters were manufactured from the raw yarns using a Maypole-type braiding machine. The effects of different braid architectures, number of braided yarns and bias angles were assessed through a series of tensile tests on dry microbraids. A novel and unique manufacturing method of aligning microbraids in a unidirectional fashion via robotised filament winding was developed to manufacture microbraid reinforced polymer composites (mBRPC). Quasi-static tensile tests performed on mBRPC showed improved mechanical properties, for certain architectures, with respect to those noted for unidirectional composites manufactured using same technique

Finite element simulation of the braiding process

Braiding is one of the most common technique employed for the manufacture of fabrics and ropes. It is also commonly used to produce near-net shaped preforms for advanced fibre reinforced composites. This paper presents an explicit finite element approach to create and simulate the braiding process for the virtual manufacture of 2D braids. The process starts from the definition of an analytical function which describes the movement of the carriers on a braiding track plate. Models of idealised Maypole-type braiding machines are built and used to shape virtual yarns into braids. This procedure can be used in a parameter control fashion, to optimise or to create virtual braided structures, which can serve as input for other structural analyses. It is emphasised that multiple cylinders are required for the modelling of a multifilament yarn to achieve better correlation with the experimental results. A parametric study is presented to investigate the effect of the number of virtual cylinders to represent a real yarn and the shape of the final braid. Excellent correlation was found between the virtual models and the experimental results when comparing the braid angle and yarn width

Understanding the thickness effect on the tensile strength property of Dyneema®HB26 laminates

In this study, an experimental and numerical investigation is presented on the effect of thickness and test rate within the pseudo static regime on the tensile properties of Dyneema®HB26 laminates. A detailed experimental presentation on the tensile testing of different thickness is presented and highlights the commonly seen observation that the tensile strength of a laminate reduces as a function of the specimen thickness. To understand these experimental observations, a constitutive material model of the individual macro fibril is developed and applied to modelling the fibre and upscaling to the laminate. The modelling strategy is implemented into ls-dyna and used to perform a parameter study on the specimen geometries used in the experimental study. The model assumes that the fibril strength is a function of the amorphous volume within the fibre and hence fibril. It can be observed that the experimental behaviour can be simulated by modelling the interface between laminate plies and the fibril, and hence fibre failure. The weak interfaces from the fibril to the laminate scale make the testing of fibres and laminates very difficult. Hence, it is proposed that the intrinsic fibril strength should be used as a measure of strength, and the fundamental strength is determined through numerical studies

Self-heating effect on ultra-high molecular weight polyethylene fibres and composites

This paper investigates the self-heating effect observed during testing ultra-high molecular weight polyethylene (UHMWPE) fibres and their composites, in particular Dyneema® SK76 fibres and Dyneema® HB26 laminates. Monotonic and cyclic tests were carried out at strain rates between 0.00833 s−1 and 250 s−1, frequencies up to 20 Hz, and different mean stress, amplitude stress and stress ratios to evaluate the self-heating effect developing in the materials. Measurements of the specimen’s temperature were carried out using a thermochromic liquid crystal paint and an infrared sensor. Experimental results showed that the temperature increased during fibre testing by as much as 13.2 ± 0.2 °C and, even though the maximum temperature was below the melting temperature of the material, melting was observed. Tension-tension cyclic tests showed that the fatigue life of the coupon specimens significantly depended on the testing conditions. In some cases, the measured temperature was as high as 102 ± 1 °C. Depending on the fatigue parameters, the laminates showed two different types of failure modes: mechanical or thermal. Hence, it is important to take into account self-heating effects when designing engineering parts reinforced with UHMWPE fibres

Use of an alternative method to evaluate erythema severity in a clinical trial: difference in vehicle response with evaluation of baseline and postdose photographs for effect of oxymetazoline cream 1·0% for persistent erythema of rosacea in a phase IV study.

BackgroundOnce-daily topical oxymetazoline cream 1·0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments.ObjectivesTo evaluate critically the methodology of clinical trials that require live, static patient assessments by determining whether assessment of erythema is different when reference to the baseline photograph is allowed.MethodsIn two identically designed, randomized, phase III trials, adults with persistent facial erythema of rosacea applied oxymetazoline or vehicle once daily. This phase IV study evaluated standardized digital facial photographs from the phase III trials to record ≥ 1-grade Clinician Erythema Assessment (CEA) improvement at 1, 3, 6, 9 and 12 h postdose.ResultsAmong 835 patients (oxymetazoline n = 415, vehicle n = 420), significantly greater proportions of patients treated with oxymetazoline vs. vehicle achieved ≥ 1-grade CEA improvement. For the comparison between phase IV study results and the original phase III analysis, when reference to baseline photographs was allowed while evaluating post-treatment photographs, the results for oxymetazoline were similar to results of the phase III trials (up to 85.7%), but a significantly lower proportion of vehicle recipients achieved ≥ 1-grade CEA improvement (up to 29.7% [phase 4] vs. 52.3% [phase 3]; P<0.001). In the phase IV study, up to 80·2% of patients treated with oxymetazoline achieved at least moderate erythema improvement vs. up to 22·9% of patients treated with vehicle. The association between patients' satisfaction with facial skin redness and percentage of erythema improvement was statistically significant.ConclusionsAssessment of study photographs, with comparison to baseline, confirmed significant erythema reduction with oxymetazoline on the first day of application. Compared with the phase III trial results, significantly fewer vehicle recipients attained ≥ 1-grade CEA improvement, suggesting a mitigated vehicle effect. This methodology may improve the accuracy of clinical trials evaluating erythema severity

Weekly paclitaxel as first-line chemotherapy in elderly advanced breast cancer patients: a phase II study of the Gruppo Italiano di Oncologia Geriatrica (GIOGer)

Background: First-line chemotherapy regimens suitable for elderly advanced breast cancer patients are still not defined. Patients and methods: Women with stage III or IV breast cancer aged >_70 years were enrolled in a phase II study aimed to evaluate both activity and toxicity of weekly paclitaxel. Among 46 planned patients, at least 18 responses and not more than seven unacceptable toxic events are required for a favourable conclusion. Paclitaxel 80 mg/m2 was administered weekly for 3 weeks every 28 days. Results: Unacceptable toxicity occurred in seven out of 46 patients evaluated for toxicity [15.2%; exact 95% confidence interval (CI) 7.6% to 28.2%] and was represented by one case of febrile neutropenia, one case of severe allergic reaction and five cases of cardiac toxicity. Among 41 patients evaluated for response, a complete response occurred in two (4.9%) patients and a partial response in 20 (48.8%), with an overall response rate of 53.7% (exact 95% CI 38.7% to 67.9%). The median progression-free survival was 9.7 months (95% CI 8.5\u201318.7) and median survival was 35.8 months (95% CI 19\u2013not defined). Conclusions: Weekly paclitaxel is highly active in elderly advanced breast cancer patients. Data on cardiovascular complications, however, indicate the need for a careful monitoring of cardiac function before and during chemotherap

Identification of the highest dose of docetaxel associable with active doses of epirubicin. Results from a dose-finding study in advanced breast cancer patients

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Impaired fas-fas ligand interactions result in greater recurrent herpetic stromal keratitis in mice

Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. One of the key factors that limit inflammation of the cornea is the expression of Fas ligand (FasL). We demonstrate that infection of the cornea with HSV-1 results in increased functional expression of FasL and that mice expressing mutations in Fas (lpr) and FasL (gld) display increased recurrent HSK following reactivation compared to wild-type mice. Furthermore, both gld and lpr mice took longer to clear their corneas of infectious virus and the reactivation rate for these strains was significantly greater than that seen with wild-type mice. Collectively, these findings indicate that the interaction of Fas with FasL in the cornea restricts the development of recurrent HSK