First Results of the LUX Dark Matter Experiment

LUX (Large Underground Xenon) is a dark matter direct detection experiment deployed at the 4850' level of the Sanford Underground Research Facility (SURF) in Lead, SD, operating a 370 kg dual-phase xenon TPC. Results of the first WIMP search run were presented in late 2013, for the analysis of 85.3 live-days with a fiducial volume of 118 kg, taken during the period of April to August 2013. The experiment exhibited a sensitivity to spin-independent WIMP-nucleon elastic scattering with a minimum upper limit on the cross section of 7.6×10−46cm2 at a WIMP mass of 33 GeV/c 2 , becoming the world's leading WIMP search result, in conflict with several previous claimed hints of discovery.Peer Reviewe

Technical Results from the Surface Run of the LUX Dark Matter Experiment

We present the results of the three-month above-ground commissioning run of the Large Underground Xenon (LUX) experiment at the Sanford Underground Research Facility located in Lead, South Dakota, USA. LUX is a 370 kg liquid xenon detector that will search for cold dark matter in the form of Weakly Interacting Massive Particles (WIMPs). The commissioning run, conducted with the detector immersed in a water tank, validated the integration of the various sub-systems in preparation of the underground deployment. Using the data collected, we report excellent light collection properties, achieving 8.4 photoelectrons per keV for 662 keV electron recoils without an applied electric field, measured in the center of the WIMP target. We also find good energy and position resolution in relatively high-energy interactions from a variety of internal and external sources. Finally, we have used the commissioning data to tune the optical properties of our simulation and report updated sensitivity projections for spin-independent WIMP-nucleon scattering.Peer Reviewe

The Large Underground Xenon (LUX) Experiment

The Large Underground Xenon (LUX) collaboration has designed and constructed a dual-phase xenon detector, in order to conduct a search for Weakly Interacting Massive Particles(WIMPs), a leading dark matter candidate. The goal of the LUX detector is to clearly detect (or exclude) WIMPS with a spin independent cross section per nucleon of $2\times 10^{-46}$ cm$^{2}$, equivalent to $\sim$1 event/100 kg/month in the inner 100-kg fiducial volume (FV) of the 370-kg detector. The overall background goals are set to have $<$1 background events characterized as possible WIMPs in the FV in 300 days of running. This paper describes the design and construction of the LUX detector.Peer Reviewe

Vingança e temporalidade: os Tupinambás

Dóceis, os Tupinambás3 convertiam-se à fé dos jesuítas. Dóceis, decerto, mas inconstantes, queixavam-se os padres: “ lo que yo tengo por maior obstáculo para la gente de todas estas naciones es su propia condición, que ninguna cosa sienten mucho, ni pérdida espiritual ni temporal suya, de ninguna cosa tienen sentimiento mui sensible, ni que les dure; y así sus contricciones, sus deseos de seren buenos, todo es tan remiso, que no se puede hombre certificar de él” (Pe. Luís da Grã a Pe. Inácio de Loyola. Piratininga, 8 de junho de 1556, CPJB 11:294). Uma mesma inconstância não os incitava a resistir à conversão, mas tampouco a perseverar: “com hum anzol que lhea dê, os converterei a todos, e com outro os tornarei a desconverter” ... (Diálogo da Conversão do Gentio, CPJB II: 320)

Radon-related Backgrounds in the LUX Dark Matter Search

The LUX detector is currently in operation at the Davis Campus at the 4850’ level of the Sanford Underground Research Facility (SURF) in Lead, SD to directly search for WIMP dark matter. Knowing the type and rate of backgrounds is critical in a rare, low energy event search, and LUX was designed, constructed, and deployed to mitigate backgrounds, both internal and external. An important internal background are decays of radon and its daughters. These consist of alpha decays, which are easily tagged and are a tracer of certain backgrounds, and beta decays, some of which are not as readily tagged and present a background for the WIMP search. We report on studies of alpha decay and discuss implications for the WIMP search.Peer Reviewe

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps favors accumulation of mutations in isoniazid targets, thus establishing a MDR phenotype. The study was based on the in vitro induction of an isoniazid resistant phenotype by prolonged serial exposure of M. tuberculosis strains to the critical concentration of isoniazid employed for determination of drug susceptibility testing in clinical isolates. Results show that susceptible and rifampicin monoresistant strains exposed to this concentration become resistant to isoniazid after three weeks; and that resistance observed for the majority of these strains could be reduced by means of efflux pumps inhibitors. RT-qPCR assessment of efflux pump genes expression showed overexpression of all tested genes. Enhanced real-time efflux of ethidium bromide, a common efflux pump substrate, was also observed, showing a clear relation between overexpression of the genes and increased efflux pump function. Further exposure to isoniazid resulted in the selection and stabilization of spontaneous mutations and deletions in the katG gene along with sustained increased efflux activity. Together, results demonstrate the relevance of efflux pumps as one of the factors of isoniazid resistance in M. tuberculosis. These results support the hypothesis that activity of efflux pumps allows the maintenance of an isoniazid resistant population in a sub-optimally treated patient from which isoniazid genetically resistant mutants emerge. Therefore, the use of inhibitors of efflux should be considered in the development of new therapeutic strategies for preventing the emergence of MDR-TB during treatment