55 research outputs found
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Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.
BackgroundThe long time from exposure to potentially harmful chemicals until breast cancer occurrence poses challenges for designing etiologic studies and for implementing successful prevention programs. Growing evidence from animal and human studies indicates that distinct time periods of heightened susceptibility to endocrine disruptors exist throughout the life course. The influence of environmental chemicals on breast cancer risk may be greater during several windows of susceptibility (WOS) in a woman's life, including prenatal development, puberty, pregnancy, and the menopausal transition. These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. Breast cancer research focused on these breast cancer WOS will accelerate understanding of disease etiology and prevention.Main textDespite the plausible heightened mechanistic influences of environmental chemicals on breast cancer risk during time periods of change in the mammary gland's structure and function, most human studies of environmental chemicals are not focused on specific WOS. This article reviews studies conducted over the past few decades that have specifically addressed the effect of environmental chemicals and metals on breast cancer risk during at least one of these WOS. In addition to summarizing the broader evidence-base specific to WOS, we include discussion of the NIH-funded Breast Cancer and the Environment Research Program (BCERP) which included population-based and basic science research focused on specific WOS to evaluate associations between breast cancer risk and particular classes of endocrine-disrupting chemicals-including polycyclic aromatic hydrocarbons, perfluorinated compounds, polybrominated diphenyl ethers, and phenols-and metals. We outline ways in which ongoing transdisciplinary BCERP projects incorporate animal research and human epidemiologic studies in close partnership with community organizations and communication scientists to identify research priorities and effectively translate evidence-based findings to the public and policy makers.ConclusionsAn integrative model of breast cancer research is needed to determine the impact and mechanisms of action of endocrine disruptors at different WOS. By focusing on environmental chemical exposure during specific WOS, scientists and their community partners may identify when prevention efforts are likely to be most effective
Two photon annihilation of Kaluza-Klein dark matter
We investigate the fermionic one-loop cross section for the two photon
annihilation of Kaluza-Klein (KK) dark matter particles in a model of universal
extra dimensions (UED). This process gives a nearly mono-energetic gamma-ray
line with energy equal to the KK dark matter particle mass. We find that the
cross section is large enough that if a continuum signature is detected, the
energy distribution of gamma-rays should end at the particle mass with a peak
that is visible for an energy resolution of the detector at the percent level.
This would give an unmistakable signature of a dark matter origin of the
gamma-rays, and a unique determination of the dark matter particle mass, which
in the case studied should be around 800 GeV. Unlike the situation for
supersymmetric models where the two-gamma peak may or may not be visible
depending on parameters, this feature seems to be quite robust in UED models,
and should be similar in other models where annihilation into fermions is not
helicity suppressed. The observability of the signal still depends on largely
unknown astrophysical parameters related to the structure of the dark matter
halo. If the dark matter near the galactic center is adiabatically contracted
by the central star cluster, or if the dark matter halo has substructure
surviving tidal effects, prospects for detection look promising.Comment: 17 pages, 3 figures; slightly revised versio
Equilibrium configurations of two charged masses in General Relativity
An asymptotically flat static solution of Einstein-Maxwell equations which
describes the field of two non-extreme Reissner - Nordstr\"om sources in
equilibrium is presented. It is expressed in terms of physical parameters of
the sources (their masses, charges and separating distance). Very simple
analytical forms were found for the solution as well as for the equilibrium
condition which guarantees the absence of any struts on the symmetry axis. This
condition shows that the equilibrium is not possible for two black holes or for
two naked singularities. However, in the case when one of the sources is a
black hole and another one is a naked singularity, the equilibrium is possible
at some distance separating the sources. It is interesting that for
appropriately chosen parameters even a Schwarzschild black hole together with a
naked singularity can be "suspended" freely in the superposition of their
fields.Comment: 4 pages; accepted for publication in Phys. Rev.
Determining Supersymmetric Parameters With Dark Matter Experiments
In this article, we explore the ability of direct and indirect dark matter
experiments to not only detect neutralino dark matter, but to constrain and
measure the parameters of supersymmetry. In particular, we explore the
relationship between the phenomenological quantities relevant to dark matter
experiments, such as the neutralino annihilation and elastic scattering cross
sections, and the underlying characteristics of the supersymmetric model, such
as the values of mu (and the composition of the lightest neutralino), m_A and
tan beta. We explore a broad range of supersymmetric models and then focus on a
smaller set of benchmark models. We find that by combining astrophysical
observations with collider measurements, mu can often be constrained far more
tightly than it can be from LHC data alone. In models in the A-funnel region of
parameter space, we find that dark matter experiments can potentially determine
m_A to roughly +/-100 GeV, even when heavy neutral MSSM Higgs bosons (A, H_1)
cannot be observed at the LHC. The information provided by astrophysical
experiments is often highly complementary to the information most easily
ascertained at colliders.Comment: 46 pages, 76 figure
Eight-Dimensional Mid-Infrared/Optical Bayesian Quasar Selection
We explore the multidimensional, multiwavelength selection of quasars from
mid-IR (MIR) plus optical data, specifically from Spitzer-IRAC and the Sloan
Digital Sky Survey (SDSS). We apply modern statistical techniques to combined
Spitzer MIR and SDSS optical data, allowing up to 8-D color selection of
quasars. Using a Bayesian selection method, we catalog 5546 quasar candidates
to an 8.0 um depth of 56 uJy over an area of ~24 sq. deg; ~70% of these
candidates are not identified by applying the same Bayesian algorithm to
4-color SDSS optical data alone. Our selection recovers 97.7% of known type 1
quasars in this area and greatly improves the effectiveness of identifying
3.5<z<5 quasars. Even using only the two shortest wavelength IRAC bandpasses,
it is possible to use our Bayesian techniques to select quasars with 97%
completeness and as little as 10% contamination. This sample has a photometric
redshift accuracy of 93.6% (Delta Z +/-0.3), remaining roughly constant when
the two reddest MIR bands are excluded. While our methods are designed to find
type 1 (unobscured) quasars, as many as 1200 of the objects are type 2
(obscured) quasar candidates. Coupling deep optical imaging data with deep
mid-IR data could enable selection of quasars in significant numbers past the
peak of the quasar luminosity function (QLF) to at least z~4. Such a sample
would constrain the shape of the QLF and enable quasar clustering studies over
the largest range of redshift and luminosity to date, yielding significant
gains in our understanding of quasars and the evolution of galaxies.Comment: 49 pages, 14 figures, 7 tables. AJ, accepte
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Allocentric versus egocentric spatial memory in autism spectrum disorder
Individuals with Autism Spectrum Disorder (ASD) present difficulties in forming relations among items and context. This capacity for relational binding is also involved in spatial navigation and research on this topic in ASD is scarce and inconclusive. Using a computerised version of the Morris Water Maze task, ASD participants showed particular difficulties in performing viewpoint independent (allocentric) navigation, leaving viewpoint dependent navigation (egocentric) intact. Further analyses showed that navigation deficits were not related to poor visual short-term memory or mental rotation in the ASD group. The results further confirm the need of autistic individuals for support at retrieval and have important implications for the design of signposts and maps
Have Atmospheric Cerenkov Telescopes Observed Dark Matter?
Two ground-based experiments have recently independently detected TeV
-rays from the direction of the Galactic center. The observations made
by the VERITAS and CANGAROO collaborations are unexpected, although not
impossible to interpret in terms of astrophysical sources. Here we examine in
detail whether the observed -rays may arise from the more exotic
alternative of annihilations of dark matter particles clustered in the center
of the Galaxy.Comment: 19 pages, 7 figure
Effects of Scale-Dependent Non-Gaussianity on Cosmological Structures
The detection of primordial non-Gaussianity could provide a powerful means to
test various inflationary scenarios. Although scale-invariant non-Gaussianity
(often described by the formalism) is currently best constrained by
the CMB, single-field models with changing sound speed can have strongly
scale-dependent non-Gaussianity. Such models could evade the CMB constraints
but still have important effects at scales responsible for the formation of
cosmological objects such as clusters and galaxies. We compute the effect of
scale-dependent primordial non-Gaussianity on cluster number counts as a
function of redshift, using a simple ansatz to model scale-dependent features.
We forecast constraints on these models achievable with forthcoming data sets.
We also examine consequences for the galaxy bispectrum. Our results are
relevant for the Dirac-Born-Infeld model of brane inflation, where the
scale-dependence of the non-Gaussianity is directly related to the geometry of
the extra dimensions.Comment: 43 pages, 9 figures; references added, submitted to JCAP; typo
corrected in Table 1, minor changes to the tex
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