14 research outputs found
The Cold Pressor Test as a Predictor of Prolonged Postoperative Pain, a Prospective Cohort Study
The Obesity Paradox: Body Mass Index Complication Rates Vary by Gender and Age Among Primary Total Hip Arthroplasty Patients
Mechanosensitivity before and after hysterectomy: a prospective study on the prediction of acute and chronic postoperative pain
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases
BACKGROUND: Myosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in nonâalcoholic fatty liver disease (NAFLD). In this study, we assessed the relationship between myosteatosis and NAFLD and their association with overall survival in patients with colorectal liver metastases undergoing partial hepatectomy. METHODS: Patients were selected from a prospective cohort of 289 consecutive patients with colorectal liver metastases. All patients with a preoperative computed tomography (CT)âscan and liver biopsy obtained during surgery were included. If available a second preâoperative CT scan was used to calculate changes in body composition over time. Muscle radiation attenuation was defined as the average Hounsfield units on CT of all muscle tissue at the L3 level. Liver biopsies were graded by a liver pathologist using the steatosis, activity, and fibrosis scoring system for NAFLD. RESULTS: Twoâhundred and eighteen patients had an available liver biopsy of which 131 patients had two available preâoperative CT scans with an average time interval of 3.2Â months. Oneâhundred and thirtyâfive (62%) biopsies were classified as NAFLD. In multivariable Coxâregression analysis, NAFLD [hazard ratio (HR): 1.8, 95%âconfidence interval (CI) 1.0â3.0, PÂ =Â 0.037], increase in myosteatosis (HR 1.8, 95%âCI 1.1â2.9, PÂ =Â 0.018), and skeletal muscle loss (HR 1.7, 95%âCI 1.0â2.9, PÂ =Â 0.035) were independently associated with shorter overall survival while high visceral adipose tissue fat content was associated with longer overall survival (HR: 0.7, 95%âCI 0.5â0.9, PÂ =Â 0.014). CONCLUSIONS: Ectopic fat content of liver as well as skeletal muscle tissue is independently associated with shorter overall survival in patients with colorectal liver metastases, while increased visceral adipose tissue fat content is associated with longer overall survival