Replacing dietary carbohydrate with calcium salts of fatty acids and the effects to finishing lamb feedlot performance and carcass characteristics

2010 Spring.Includes bibliographic references (pages 16-19).The objective of this study was to investigate the performance and physiological effects imposed on finishing lamb (n = 60, BW x= 41.6 ± 1.4 kg) feedlot performance and carcass characteristics by replacing dietary carbohydrate with calcium salts of fatty acids (CSF A). Upon arrival, lambs were weighed on 2 consecutive d and randomly assigned to 1 of 4 dietary concentrations of CSF A. Treatments included 1) 0% CSF A (Control); 2) 4% CFSA; 3) 7% CSFA and 4) 11% CSFA on a DM basis. Diets were formulated to be isoenergetic (TDN basis) and isonitrogenous (DIP and UIP) and consisted of 75% concentrate, and 25% roughage ( com silage). Ration TDN was kept similar between treatments; rations with less com had a higher concentration of CSF A-pellet. Intake was controlled to balance TDN per kilogram of BW across treatments; all treatments met 2006 NRC requirements for growing lambs [18]. Lambs were weighed and bled every 14 ± 2 d. Blood samples were analyzed for glucose, lactate and insulin concentrations. On d 61, lambs were transported and slaughtered at a commercial abattoir. Hot carcass weight (HCW) was determined at the time of slaughter, and longissimus muscle (LM), liver and subcutaneous adipose tissue samples were collected at slaughter and snap-frozen for later analysis of FA composition. Longissimus muscle area (LMA) and back fat (BF) carcass measurements were determined after 48 h storage at 0°C chill. There was a treatment by time interaction for overall ADG (P = 0.01). Lambs receiving 11 % CSFA had lower ADG, lighter HCW (P < 0.001) and smaller LMA (P < 0.01) than all other treatments. Control lambs had greater (P < 0.05) BF than lambs receiving 11 % CSF A, but had similar BF to lambs receiving 4 and 7% CSF A. There was no treatment effect on dressing percentage. There was a treatment by time interaction observed for blood glucose (P = 0.02); lambs fed the control diet had a tendency to have higher blood glucose concentrations. Blood insulin values were not different (P = 0.36) between treatments, and insulin to glucose ratios were similar among treatments. Overall blood lactate levels had a tendency to be lower as dietary CSF A concentration increased, although not significantly (P = 0.11). Fatty acid profiles for LM, liver and subcutaneous adipose were similar across treatments. Overall, the data suggest that CSF A can be used to replace a carbohydrate source such as com; at rates up to 7% DMI before performance is negatively affected

The ballot initiative process does not make people moregenerally knowledgeable about politics

Do ballot initiatives help to improve people’s knowledge about politics? In new research which uses election survey data from more than 120,000 voters across 48 states Nicholas R. Seabrook, Joshua J. Dyck and Edward L. Lascher, Jr. find that ballot initiatives have no positive effect on general political knowledge. They write that these results hold no matter how often ballot initiatives are used, how many initiatives are on the ballot during an election, and how much money was spent by the initiative’s supporters and opponents

A 10-year retrospective review of Salmonella infections at the Children\u27s Hospital in London, Ontario

OBJECTIVES: To describe Salmonella infections in children presenting to the Children\u27s Hospital (London Health Sciences Centre, London, Ontario), to assess risk factors for infection and to examine whether younger children, particularly infants younger than 12 weeks of age, experience higher morbidity than older children. METHODS: A 10-year retrospective review of children with Salmonella infections at the Children\u27s Hospital was conducted. Patient demographics, risk factors for infection, clinical characteristics, bacteriology and outcome were collected from the hospital charts and laboratory records. Data were separated into groups based on age and recent use of antibiotics to analyze differences in outcomes. RESULTS: Sixty-six children with Salmonella infections presented to the Children\u27s Hospital over a 10-year period. Common risk factors for Salmonella infection included having sick contacts, living in a rural area, recent travel, contact with pets (especially reptiles) and exposure to local water. Younger age was associated with an increased likelihood of admission to hospital, treatment with antibiotics and a longer course of antibiotic therapy. This was true when comparing older infants with those younger than 12 weeks of age. Patients recently treated with antibiotics and those with significant underlying medical conditions were more likely to be admitted. CONCLUSIONS: A wider knowledge of the epidemiological risk factors for Salmonella infection may improve diagnosis. Higher admission rates were expected in children younger than 12 weeks of age, those recently treated with antibiotics and those who had a significant underlying medical condition. A prospective, multicentre study is needed to further address questions regarding increased illness severity and appropriate management of Salmonella infections in children younger than 12 weeks of age. ©2010 Pulsus Group Inc. All rights reserved

A geospatial approach to understanding inequalities in accessibility to primary care among vulnerable populations

Many Canadians experience unequal access to primary care services, despite living in a country with a universal health care system. Health inequalities affect all Canadians but have a much stronger impact on the health of vulnerable populations. Health inequalities are preventable differences in the health status or distribution of health resources as experienced by vulnerable populations. A geospatial approach was applied to examine how closely the distribution of primary care providers (PCPs) in London, Ontario meet the needs of vulnerable populations, including people with low income status, seniors, lone parents, and linguistic minorities. Using enhanced two step floating catchment area (E2SFCA) method, an index of geographic access scores for all PCPs and PCPs speaking French, Arabic, and Spanish were separately developed at the dissemination area (DA) level. To analyze how PCPs are distributed, comparative analyses were performed in association with specific vulnerable groups. Geographical accessibility to all PCPs, and PCPs who speak specific minority languages vary considerably across the city of London. Access scores for French- and Arabic-speaking PCPs are found comparatively high (mean = 2.85 and 1.01 respectively) as compared to Spanish-speaking PCPs (mean = 0.47). Additionally, many areas with high proportions of vulnerable populations experience low accessibility. Despite its exploratory nature, this study offers insight into intra-urban distributions of geographical accessibility to primary care resources for vulnerable groups. These findings can facilitate health researchers and policymakers in the development of recommendations to increase levels of accessibility of specific population groups in underserved areas

Development of a positive psychology intervention for patients with acute cardiovascular disease

The management of depression and other negative psychological states in cardiac patients has been a focus of multiple treatment trials, though such trials have not led to substantial improvements in cardiac outcomes. In contrast, there has been minimal focus on interventions to increase positive psychological states in cardiac patients, despite the fact that optimism and other positive states have been associated with superior cardiovascular outcomes. Our objective was to develop an 8-week, phone-based positive psychology intervention for patients hospitalized with acute cardiac disease (acute coronary syndrome or decompensated heart failure). Such an intervention would consist of positive psychology exercises adapted for this specific population, and it would need to be feasible for practitioners and patients in real-world settings. By adapting exercises that were previously validated in healthy individuals, we were able to generate a positive psychology telemedicine intervention for cardiac patients that focused on optimism, kindness, and gratitude. In addition, we successfully created a companion treatment manual for subjects to enhance the educational aspects of the intervention and facilitate completion of exercises. Finally, we successfully performed a small pilot trial of this intervention, and found that the positive psychology intervention appeared to be feasible and well-accepted in a cohort of patients with acute cardiac illness. Future studies should further develop this promising intervention and examine its impact on psychological and medical outcomes in this vulnerable population of cardiac patients

The Health Initiative Program for Kids (HIP Kids): Effects of a 1-Year Multidisciplinary Lifestyle Intervention on Adiposity and Quality of Life in Obese Children and Adolescents -- A Longitudinal Pilot Intervention Study

BACKGROUND: Though recent data suggest that multidisciplinary outpatient interventions can have a positive effect on childhood obesity, it is still unclear which program components are most beneficial and how they affect quality of life (QoL). The aim of this study was to determine if a 1-year multidisciplinary, family-centered outpatient intervention based on social cognitive theory would be effective in (i) preventing further increases in BMI and BMI z-score, and (ii) improving QoL in obese children and adolescents. METHODS: Obese children and adolescents 8-17 years of age and their families participated in this 1-year longitudinal pilot intervention study. The intervention consisted of fifteen 90-minute educational sessions led by a dietitian, exercise specialist, and social worker. Anthropometric measures, body composition, and QoL (Pediatric Quality of Life Inventory 4.0), were assessed at baseline, 3 months, and 12 months. Laboratory values were measured at baseline and 12 months. The primary outcome measures were change in BMI and BMI z-score, secondary outcome measures included change in QoL and body composition. A paired sample t-test was used to assess within-group differences and 95% confidence intervals were reported for the mean differences. RESULTS: 42 obese children and adolescents (21 girls) completed the 1-year intervention (mean age 12.8 ± 3.14 years). Mean baseline BMI was 31.96 ± 5.94 kg/m(2) and BMI z-score was +2.19 ± 0.34. Baseline QoL (self-assessments and parental assessments) was impaired: mean baseline scores were 74.5 ± 16.5 and 63.7 ± 19.4 for physical functioning and 69.0 ± 14.9 and 64.0 ± 18.3 for emotional functioning, respectively. At 12 months, BMI z-score had decreased (-0.07 ± 0.11, 95% CI: -0.11 to -0.04). BMI (0.80 ± 1.57 kg/m(2), 95% CI 0.31 to 1.29) and fat-free mass (4.02 ± 6.27 kg, 95% CI 1.90 to 6.14) increased, but % body fat and waist circumference did not. Both the parent-reported physical (11.3 ± 19.2, 95% CI 4.7 to 17.9) and emotional (7.7 ± 15.7, 95% CI 2.3 to 13.0) functioning QoL scores and the children\u27s self-reported physical (5.3 ± 17.1, 95% CI 0.5 to 11.1) and emotional (7.9 ± 14.3, 95% CI 3.2 to 12.7) functioning scores significantly improved. CONCLUSIONS: Following a 1-year intervention, the participants\u27 BMI z-scores and QoL improved, while other adiposity-related measures of body composition remained unchanged. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000015622

The global surface roughness of 25143 Itokawa

Surface roughness is an important metric in understanding how the geologic history of an asteroid affects its small-scale topography and it provides an additional means to quantitatively compare one asteroid with another. In this study, we report the first detailed global surface roughness maps of 25143 Itokawa at horizontal scales from 8--32~m. Comparison of the spatial distribution of the surface roughness of Itokawa with 433 Eros, the other asteroid for which this kind of analysis has been possible, indicates that the two asteroids are dominated by different geologic processes. On Itokawa, the surface roughness reflects the results of down-slope activity that moves fine grained material into geopotential lows and leaves large blocks in geopotential highs. On 433 Eros, the surface roughness is controlled by geologically-recent large impact craters. In addition, large longitudinal spatial variations of surface roughness could impact the role of YORP on Itokawa

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Synaptic transmission and long-term potentiation (LTP) in the CA1 region of hippocampal slices have been studied during ageing of a double transgenic mouse strain relevant to early-onset familial Alzheimer's disease (AD). This strain, which over-expresses both the 695 amino acid isoform of human amyloid precursor protein (APP) with K670N and M671L mutations and presenilin 1 with the A246E mutation, has accelerated amyloidosis and plaque formation. There was a decrease in synaptic transmission in both wildtype and transgenic mice between 2 and 9 months of age. However, preparing slices from 14 month old animals in kynurenic acid (1 mM) counteracted this age-related deficit. Basal transmission and paired-pulse facilitation was similar between the two groups at all ages (2, 6, 9 and 14 months) tested. Similarly, at all ages LTP, induced either by theta burst stimulation or by multiple tetani, was normal. These data show that a prolonged, substantially elevated level of A&#946; are not sufficient to cause deficits in the induction or expression of LTP in the CA1 hippocampal region.Published versio

Provinciality and the Art World: The Midland Group 1961- 1977

This paper takes as its focus the Midland Group Gallery in order to first, make a case for the consideration of the geographies of art galleries. Second, highlight the importance of galleries in the context of cultural geographies of the sixties. Third, discuss the role of provinciality in the operation of art worlds. In so doing it explicates one set of geographies surrounding the gallery – those of the local, regional and international networks that connected to produce art works and art space. It reveals how the interactions between places and practices outside of metropolitan and regional hierarchies provides a more nuanced insight into how art worlds operated during the sixties, a period of growing internationalism of art, and how contested definitions of the provincial played an integral role in this. The paper charts the operations of the Midland Group Gallery and the spaces that it occupied to demonstrate how it was representative of a post-war discourse of provincialism and a corresponding re-evaluation of regional cultural activity