Progress and Redemption: A Jewish Values Critique of Steven Pinker\u27s Enlightenment Now

Progress and Redemption: A Jewish Values Critique of Steven Pinker’s Enlightenment Now ABSTRACT Steven Pinker’s book, Enlightenment Now: The Case for Reason, Science, Humanism, and Progress, tells a provocative story. The central thesis is that about three hundred years ago human values and practices began to coalesce in ways that have allowed humans to live longer, healthier, safer, and more productive lives. Particularly convincing to the reader are the measured data and informative tables Pinker uses throughout the text to illustrate and to confirm his story of exponential human progress. He tracks the changes to a broad set of variables, across scores of domains, over hundreds of years. The Jewish values critique is based on an examination of two ancient Jewish practices: Sabbath observance and the performance of acts of loving-kindness. This critique does not nullify Pinker’s deeper message about the meaning of science, but it does suggest that Pinker’s view, while necessary is not sufficient for living a fully human life. A more encompassing and useful narrative than Pinker’s would include the practice of science as a legitimate source of human meaning and values among many other practices, including those legitimated outside of a scientific paradigm. Unlike Pinker’s either/or story, the story I want to tell here is both/and. In Section I, the paper summarizes the most important criticisms that have been lodged at Pinker. In Section II, I argue that despite these criticisms, Pinker’s general story survives the onslaught. In Section III, I offer a more encompassing narrative that includes Pinker’s story but, based on a Jewish values critique, offers a more inclusive perspective on the search for human meaning in what often does seem like an indifferent universe

Effects of Geopolitical Strain on Global Pharmaceutical Supply Chain Design and Drug Shortages

Pharmaceutical supply chains are global and exhibit geographic and industrial concentration for some drugs. In this context, geopolitical risk and company decisions threaten drug availability, where countries with low manufacturing capacity are most at risk. We present the first supply chain design model that considers geopolitical strain, i.e., export bans and export ban-induced price increases, and the role of alliances in mitigating those risks. Uncertainty is also included in suppliers, production, and demand. The model takes the company's perspective as a decision-maker looking to locate plants and minimize costs by satisfying worldwide demand. The model is solved by integrating the Sample Average Approximation and L-shaped methods. Our case study is based on vincristine, a generic oncology drug. We find that geopolitical strain may reduce shortages in the short term and affect investment decisions and their outcomes. Bilateral alliances between nations result in minor improvements for the company and drug shortages. The results also reveal disparities in drug access. The global expected shortage at the base case is 21%. For high and upper-middle-income countries, expected shortages are 3.1% and 3.7%. However, expected shortages are 98.7% and 95.2% for low and lower-middle-income countries. New pricing policies may improve drug access

A Convolutional Neural Network-based Patent Image Retrieval Method for Design Ideation

The patent database is often used in searches of inspirational stimuli for innovative design opportunities because of its large size, extensive variety and rich design information in patent documents. However, most patent mining research only focuses on textual information and ignores visual information. Herein, we propose a convolutional neural network (CNN)-based patent image retrieval method. The core of this approach is a novel neural network architecture named Dual-VGG that is aimed to accomplish two tasks: visual material type prediction and international patent classification (IPC) class label prediction. In turn, the trained neural network provides the deep features in the image embedding vectors that can be utilized for patent image retrieval and visual mapping. The accuracy of both training tasks and patent image embedding space are evaluated to show the performance of our model. This approach is also illustrated in a case study of robot arm design retrieval. Compared to traditional keyword-based searching and Google image searching, the proposed method discovers more useful visual information for engineering design.Comment: 11 pages, 11 figure

Effects of high temperature on survival, symbiotic performance and genomic modifications of bean nodulating Rhizobium strains.

High temperatures can affect the survival, establishment and symbiotic properties of Rhizobium strains. Bean nodulating Rhizobium strains are considered particularly sensitive because on this strains genetic recombinations and/or deletions occur frequently, thus compromising the use of these bacteria as inoculants. Rhizobium tropici and R. leguminosarum bv. phaseoli strains isolated from cerrado soils were exposed to thermal stress and the strains' growth, survival and symbiotic relationships as well as alterations in their genotypic and phenotypic characteristics were analysed. After successive thermal shocks at 45 degrees C for four hours, survival capacity appeared to be strain-specific, independent of thermo-tolerance and was more apparent in R. tropici strains. Certain R. leguminosarum bv. phaseoli strains had significant alterations in plant dry weight and DNA patterns obtained by AP-PCR method. Rhizobium tropici strains (with the exception of FJ2.21) were more stable than R. leguminosarum bv. phaseoli strains because no significant phenotypic alterations were observed following thermal treatments and they maintained their original genotypic pattern after inoculation in plants.

On the ill-posedness result for the BBM equation

We prove that the initial value problem (IVP) for the BBM equation is ill-posed for data in Hs(R), s < 0 in the sense that the ow-map u0 7! u(t) that associates to initial data u0 the solution u cannot be continuous at the origin from Hs(R) to even D0(R) at any _xed t > 0 small enough. This result is sharp.Fundação para a Ciência e a Tecnologia (FCT

Homoclinic standing waves in focussing DNLS equations --Variational approach via constrained optimization

We study focussing discrete nonlinear Schr\"{o}dinger equations and present a new variational existence proof for homoclinic standing waves (bright solitons). Our approach relies on the constrained maximization of an energy functional and provides the existence of two one-parameter families of waves with unimodal and even profile function for a wide class of nonlinearities. Finally, we illustrate our results by numerical simulations.Comment: new version with revised introduction and improved condition (A3); 16 pages, several figure

VivaxGEN: An open access platform for comparative analysis of short tandem repeat genotyping data in Plasmodium vivax populations.

BACKGROUND: The control and elimination of Plasmodium vivax will require a better understanding of its transmission dynamics, through the application of genotyping and population genetics analyses. This paper describes VivaxGEN (http://vivaxgen.menzies.edu.au), a web-based platform that has been developed to support P. vivax short tandem repeat data sharing and comparative analyses. RESULTS: The VivaxGEN platform provides a repository for raw data generated by capillary electrophoresis (FSA files), with fragment analysis and standardized allele calling tools. The query system of the platform enables users to filter, select and differentiate samples and alleles based on their specified criteria. Key population genetic analyses are supported including measures of population differentiation (FST), expected heterozygosity (HE), linkage disequilibrium (IAS), neighbor-joining analysis and Principal Coordinate Analysis. Datasets can also be formatted and exported for application in commonly used population genetic software including GENEPOP, Arlequin and STRUCTURE. To date, data from 10 countries, including 5 publicly available data sets have been shared with VivaxGEN. CONCLUSIONS: VivaxGEN is well placed to facilitate regional overviews of P. vivax transmission dynamics in different endemic settings and capable to be adapted for similar genetic studies of P. falciparum and other organisms

Co-periodic stability of periodic waves in some Hamiltonian PDEs

International audienceThe stability theory of periodic traveling waves is much less advanced than for solitary waves, which were first studied by Boussinesq and have received a lot of attention in the last decades. In particular, despite recent breakthroughs regarding periodic waves in reaction-diffusion equations and viscous systems of conservation laws [Johnson–Noble–Rodrigues–Zumbrun, Invent math (2014)], the stability of periodic traveling wave solutions to dispersive PDEs with respect to 'arbitrary' perturbations is still widely open in the absence of a dissipation mechanism. The focus is put here on co-periodic stability of periodic waves, that is, stability with respect to perturbations of the same period as the wave, for KdV-like systems of one-dimensional Hamiltonian PDEs. Fairly general nonlinearities are allowed in these systems, so as to include various models of mathematical physics, and this precludes complete integrability techniques. Stability criteria are derived and investigated first in a general abstract framework, and then applied to three basic examples that are very closely related, and ubiquitous in mathematical physics, namely, a quasilinear version of the generalized Korteweg–de Vries equation (qKdV), and the Euler–Korteweg system in both Eulerian coordinates (EKE) and in mass Lagrangian coordinates (EKL). Those criteria consist of a necessary condition for spectral stability , and of a sufficient condition for orbital stability. Both are expressed in terms of a single function, the abbreviated action integral along the orbits of waves in the phase plane, which is the counterpart of the solitary waves moment of instability introduced by Boussinesq. However, the resulting criteria are more complicated for periodic waves because they have more degrees of freedom than solitary waves, so that the action is a function of N + 2 variables for a system of N PDEs, while the moment of instability is a function of the wave speed only once the endstate of the 1 solitary wave is fixed. Regarding solitary waves, the celebrated Grillakis–Shatah– Strauss stability criteria amount to looking for the sign of the second derivative of the moment of instability with respect to the wave speed. For periodic waves, stability criteria involve all the second order, partial derivatives of the action. This had already been pointed out by various authors for some specific equations, in particular the generalized Korteweg–de Vries equation — which is special case of (qKdV) — but not from a general point of view, up to the authors' knowledge. The most striking results obtained here can be summarized as: an odd value for the difference between N and the negative signature of the Hessian of the action implies spectral instability, whereas a negative signature of the same Hessian being equal to N implies orbital stability. Furthermore, it is shown that, when applied to the Euler–Korteweg system, this approach yields several interesting connexions between (EKE), (EKL), and (qKdV). More precisely, (EKE) and (EKL) share the same abbreviated action integral, which is related to that of (qKdV) in a simple way. This basically proves simultaneous stability in both formulations (EKE) and (EKL) — as one may reasonably expect from the physical point view —, which is interesting to know when these models are used for different phenomena — e.g. shallow water waves or nonlinear optics. In addition, stability in (EKE) and (EKL) is found to be linked to stability in the scalar equation (qKdV). Since the relevant stability criteria are merely encoded by the negative signature of (N + 2) × (N + 2) matrices, they can at least be checked numerically. In practice, when N = 1 or 2, this can be done without even requiring an ODE solver. Various numerical experiments are presented, which clearly discriminate between stable cases and unstable cases for (qKdV), (EKE) and (EKL), thus confirming some known results for the generalized KdV equation and the Nonlinear Schrödinger equation, and pointing out some new results for more general (systems of) PDEs

Metastatic melanoma in an esophagus demonstrating Barrett esophagus with high grade dysplasia

BACKGROUND: Metastatic melanoma involving the esophagus is rare; the occurrence of metastatic melanoma in a background of Barrett esophagus is rarer still. We report a case of an 80 year-old male who presented to our institution for workup of Barrett esophagus with high-grade dysplasia and who proved to have metastatic melanoma occurring in the background of Barrett esophagus, the first report of this kind, to our knowledge, in the English literature. CASE PRESENTATION: An 80 year-old Caucasian male was diagnosed at an outside institution with Barrett’s esophagus with high grade dysplasia and presented to our institution for therapy. The patient underwent endoscopic mucosal resection using a band ligation technique of an area of nodularity within the Barrett esophagus. Microscopic examination demonstrated extensive Barrett esophagus with high-grade dysplasia as well as a second tumor which was morphologically different from the surrounding high-grade dysplasia and which was positive for S-100, HMB 45 and Melan-A on immunohistochemistry, consistent with melanoma. Further workup of the patient demonstrated multiple radiologic lesions consistent with metastases. Molecular studies demonstrated that the melanoma was positive for the 1799T>A (V600E) mutation in the BRAF gene. The overall features of the tumor were most consistent with metastatic melanoma occurring in a background of Barrett esophagus with high-grade dysplasia. CONCLUSION: This case demonstrates a unique intersection between a premalignant condition (Barrett esophagus with high grade dysplasia) and a separate malignancy (melanoma). This report also shows the utility of molecular testing to support the hypothesis of primary versus metastatic disease in melanoma

Percepção de estudantes de psicologia sobre a informática em sua formação profissional

Neste artigo analisa-se uma pesquisa de natureza qualitativa, cujo objetivo era explorar a percepção de 45 alunos de psicologia de diferentes universidades da cidade de Santiago do Chile, sobre a incorporação da informática como apoio para a aprendizagem em sua formação profissional. A informação foi coletada através de entrevistas semiestruturadas e analisou-se mediante o processo de codificação da Teoría Fundamentada. Os resultados mostram como categorias principais, o conhecimento da informática, a valoração da informática, e os fatores que obstaculizam o uso desta. Da codificação seletiva se desprende uma alta valoração da informática como ferramenta econômica e cômoda, mas também se observa uma alta reticência dos alunos diante de sua utilização no trabalho profissional tradicional do psicólogo. Encontraram-se fatores pessoais e institucionais nos que se baseia a valoração, a motivação e o nível de conhecimento dos estudantes diante do uso de ferramentas informáticas.This paper analyses a qualitative research aimed to exploring the perception of 45 psychology students from different universities in Santiago de Chile, about incorporating information systems to support learning in their professional training. Data were collected through semi structured interviews and their analysis was based on Grounded Theory's coding process. Results show that the major categories are computer knowledge, appreciation of computers and factors that hinder their use. From the selective coding a positive evaluation emerges of information systems as an economic and useful tool. However, there is also a high reluctance on the part of the students regarding the use of such tools in the psychologist' traditional professional work. Personal and organizational factors were found as bases for students' assessment, motivation and level of knowledge facing the use of these tools.En este artículo se analiza una investigación de naturaleza cualitativa, cuyo objetivo era explorar la percepción de 45 alumnos de psicología de diferentes universidades de la ciudad de Santiago de Chile, sobre la incorporación de la informática como apoyo para el aprendizaje en su formación profesional. La información se recolectó a través de entrevistas semiestructuradas y se analizó mediante el proceso de codificación de la Teoría Fundamentada. Los resultados muestran como categorías principales, el conocimiento de la informática, la valoración de la informática, y los factores que obstaculizan el uso de ésta. De la codificación selectiva se desprende una alta valoración de la informática como herramienta económica y cómoda, pero también se observa una alta reticencia de los alumnos frente a su utilización en el trabajo profesional tradicional del psicólogo. Se encontraron factores personales e institucionales en los cuales se fundamenta la valoración, la motivación y el nivel de conocimiento de los estudiantes frente al uso de herramientas informáticas