Description strategies to make an interactive science simulation accessible

Interactive simulations are increasingly important in science education, yet most are inaccessible to blind learners. In developing an accessible prototype of a PhET interactive science simulation, we encountered significant challenges in providing screen reader access, including the need to: 1) describe unpredictable event sequences, 2) cue productive interactions, and 3) to simultaneously convey multiple changes. To address these challenges, we extended existing practices for verbal description of visual interactive content, and we created new strategies for developing rich description for accessible interactive science simulations

Clustered Star Formation in W75 N

We present 2" to 7" resolution 3 mm continuum and CO(J=1-0) line emission and near infrared Ks, H2, and [FeII] images toward the massive star forming region W75 N. The CO emission uncovers a complex morphology of multiple, overlapping outflows. A total flow mass of greater than 255 Msun extends 3 pc from end-to-end and is being driven by at least four late to early-B protostars. More than 10% of the molecular cloud has been accelerated to high velocities by the molecular flows (> 5.2 km/s relative to v{LSR}) and the mechanical energy in the outflowing gas is roughly half the gravitational binding energy of the cloud. The W75 N cluster members represent a range of evolutionary stages, from stars with no apparent circumstellar material to deeply embedded protostars that are actively powering massive outflows. Nine cores of millimeter-wavelength emission highlight the locations of embedded protostars in W75 N. The total mass of gas & dust associated with the millimeter cores ranges from 340 Msun to 11 Msun. The infrared reflection nebula and shocked H2 emission have multiple peaks and extensions which, again, suggests the presence of several outflows. Diffuse H2 emission extends about 0.6 parsecs beyond the outer boundaries of the CO emission while the [FeII] emission is only detected close to the protostars. The infrared line emission morphology suggests that only slow, non-dissociative J-type shocks exist throughout the pc-scale outflows. Fast, dissociative shocks, common in jet-driven low-mass outflows, are absent in W75 N. Thus, the energetics of the outflows from the late to early B protostars in W75 N differ from their low-mass counterparts -- they do not appear to be simply scaled-up versions of low-mass outflows.Comment: Astrophysical Journal, in press. 23 pages plus 10 figures (jpg format). See http://www.aoc.nrao.edu/~dshepher/science.shtml for reprint with full resolution figure

Steroid Hormone Synthesis by Vaccinia Virus Suppresses the Inflammatory Response to Infection

The 3β-hydroxysteroid dehydrogenase (3β-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Vaccinia virus (VV) also synthesizes steroid hormones with a 3β-HSD enzyme (v3β-HSD) encoded by gene A44L. Here we examined the effects of v3β-HSD in VV disease using wild-type (vA44L), deletion (vΔA44L), and revertant (vA44L-rev) viruses in a murine intranasal model. Loss of A44L was associated with an attenuated phenotype. Early (days 1–3) after infection with vΔA44L or control viruses the only difference observed between groups was the reduced corticosterone level in lungs and plasma of vΔA44L-infected animals. Other parameters examined (body weight, signs of illness, temperature, virus titres, the pulmonary inflammatory infiltrate, and interferon [IFN]-γ levels) were indistinguishable between groups. Subsequently, vΔA44L-infected animals had reduced weight loss and signs of illness, and displayed a vigorous pulmonary inflammatory response. This was characterized by rapid recruitment of CD4+ and CD8+ lymphocytes, enhanced IFN-γ production and augmented cytotoxic T lymphocyte activity. These data suggest that steroid production by v3β-HSD contributes to virus virulence by inhibiting an effective inflammatory response to infection

Re-living anatomy: medical student use of lecture capture

Lecture capture resources have become common place within UK Higher education to enhance and support learning in addition to the tradition lecture. These resources can be particularly useful for medical students in anatomy teaching where time dedicated to anatomy within the curriculum has been reduced compared to previous generations(1). This study aimed to investigate how lecture capture aided student learning Qualitative feedback was also collected in view to further improve the resources to cater for the student’s need

The pursuit of ignorance:The UK’s anti-lobbying clause will jeopardise evidence informed policy making

No abstract available

Programmable display pushbuttons on the Space Station's telerobot control panel

The Man-Systems Telerobotics Laboratory at NASA's Johnson Space Center and supported by Lockheed, is working to ensure that the Flight Telerobotic Servicer (FTS) to be used on the Space Shuttle (Orbiter) and the Space Station has a well designed user interface from a Human Factors perspective. The FTS, which is a project led by NASA's Goddard Space Flight Center, will be a telerobot used for Space Station construction, maintenance, and satellite repair. It will be directly controlled from workstations on the Orbiter and the Space Station and monitored from a ground workstation. The FTS will eventually evolve into a more autonomous system, but in the short-term the system will be manually operated (teleoperated) for many tasks. This emphasizes the importance of the human/telerobot interface on this system. This phase of the FTS workstation evaluation covers a preliminary study of programmable display pushbuttons (PDP's). The PDP is constructed of a matrix of directly addressable electroluminescent (EL) pixels which can be used to form dot-matrix characters. PDP's can be used to display more than one message and to control more than one function. Since the PDP's have these features, then a single PDP may possibly replace the use of many single-function pushbuttons, rotary switches, and toggle switches, thus using less panel space. It is of interest to determine if PDP's can be used to adequately perform complex hierarchically structured task sequences. The objective of this investigation was to compare the performance of experienced and inexperienced Remote Manipulator System (RMS) operators while performing an RMS like task on simulated PDP and non-PDP computer prototypes so that guidelines governing the use of programmable display pushbuttons on the FTS workstation could be created. The functionality of the RMS on the Orbiter was used as a model for this evaluation since the functionality of the FTS at the time of this writing has not been solidified

Arsenic methylation patterns before and after changing from high to lower concentrations of arsenic in drinking water.

Inorganic arsenic (In-As), an occupational and environmental human carcinogen, undergoes biomethylation to monomethylarsonate (MMA) and dimethylarsinate (DMA). It has been proposed that saturation of methylation capacity at high exposure levels may lead to a threshold for the carcinogenicity of In-As. The relative distribution of urinary In-As, MMA, and DMA is used as a measure of human methylation capacity. The most common pathway for elevated environmental exposure to In-As worldwide is through drinking water. We conducted a biomarker study in northern Chile of a population chronically exposed to water naturally contaminated with high arsenic content (600 micrograms/l). In this paper we present the results of a prospective follow-up of 73 exposed individuals, who were provided with water of lower arsenic content (45 micrograms/l) for 2 months. The proportions of In-As, MMA, and DMA in urine were compared before and after intervention, and the effect of other factors on the distribution of arsenic metabolites was also analyzed. The findings of this study indicate that the decrease in arsenic exposure was associated with a small decrease in the percent In-As in urine (from 17.8% to 14.6%) and in the MMA/DMA ratio (from 0.23 to 0.18). Other factors such as smoking, gender, age, years of residence, and ethnicity were associated mainly with changes in the MMA/DMA ratio, with smoking having the strongest effect. Nevertheless, the factors investigated accounted for only about 20% of the large interindividual variability observed. Genetic polymorphisms in As-methylating enzymes and other co-factors are likely to contribute to some of the unexplained variation. The changes observed in the percent In-As and in the MMA/DMA ratio do not support an exposure-based threshold for arsenic methylation in humans

Methylation study of a population environmentally exposed to arsenic in drinking water.

Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. We conducted a large biomarker study in northern Chile of a population chronically exposed to high levels of arsenic in drinking water. We report the results of the methylation study, which focused on the effects of exposure and other variables on the percent InAs, MMA, DMA, and the ratio of MMA to DMA in urine. The study consisted of 122 people in a town with arsenic water levels around 600 micrograms/l and 98 participants in a neighboring town with arsenic levels in water of about 15 micrograms/l. The corresponding mean urinary arsenic levels were 580 micrograms/l and 60 micrograms/l, of which 18.4% and 14.9% were InAs, respectively. The main differences were found for MMA:DMA; exposure, smoking, and being male were associated with higher MMA:DMA, while longer residence, Atacameño ethnicity, and being female were associated with lower MMA:DMA. Together, these variables explained about 30% of the variability in MMA:DMA. Overall, there was no evidence of a threshold for methylation capacity, even at very high exposures, and the interindividual differences were within a much wider range than those attributed to the variables investigated. The differences in percent InAs were small and within the ranges of other studies of background exposure levels. The biological significance of MMA:DMA, which was more than 1.5 times greater in the exposed group, and its relationship to sex, length of exposure, and ethnicity need further investigation because its relevance to health risk is not clear

Recent results and new hardware developments for protein crystal growth in microactivity

Protein crystal growth experiments have been performed on 16 space shuttle missions since April, 1985. The initial experiments utilized vapor diffusion crystallization techniques similar to those used in laboratories for earth-based experiments. More recent experiments have utilized temperature induced crystallization as an alternative method for growing high quality protein crystals in microgravity. Results from both vapor diffusion and temperature induced crystallization experiments indicate that proteins grown in microgravity may be larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth

Birthing While Black: The Maternal Health Experiences in Kansas

The state of maternal health and infant mortality in the United States is far worse than 33 developed countries (CDCP NCHS, 2018). Black mothers and infants die at twice the rate in comparison to mothers and infants of other races (CDC, 2020). Infant mortality is the death of a child before the age of one. The Sisters and Brothers for Healthy Infants Initiative focuses on education, community engagement, elevating the voices of Black mothers and fathers, and a community birthday party to celebrate Black infants first birthday. This signature event is known as Celebrate Day 366, a day to share information Black infant mortality, co-parenting, and fatherhood, conduct a community conversation on birth equity, and celebrate Black babies first birthday. This paper reflects the results from a panel discussion of community members and stakeholders in Kansas sharing their experiences with maternal and infant mortality. The Health Equity Framework four main components (systems of power, relationships and networks, individual factors, physiological pathways, that are integral to the inequities in maternal health and infant mortality was used to guide our research analysis (Peterson, et. al 2020). As a part of the qualitative content analysis, five themes emerged: 1) stress during pregnancy; 2) advocacy; 3) innovation of technology not equating to health equity; 4) realization of inferior care; and 5) racism and stereotypes. The themes reflected similar lived experiences amongst Black mothers, fathers, and physicians surrounding maternal health and infant mortality inequities. The results of the CD366 panel discussion highlight the importance of exploring how, if at all, Black mothers and fathers, are benefiting from the birthing experience