Polar coherent states in bilayer graphene under a constant uniform magnetic field

Symmetries associated with the Hamiltonian describing bilayer graphene subjected to a constant magnetic field perpendicular to the plane of the bilayer are calculated using polar coordinates. These symmetries are then applied to explain some fundamental properties, such as the spectrum and the integer pseudo-spin character of the eigenfunctions. The probability and current densities of the bilayer Hamiltonian have also been calculated in polar coordinates and shown to be gauge invariant and scalar under generalized rotations. We also define appropriate coherent states of this system as eigenfunctions, with complex eigenvalues, of a suitable chose annihilation operator. In this framework, symmetries are also useful to show the meaning of the complex eigenvalue in terms of expected values. The local current density of these coherent states is shown to exhibit a kind of radial component interference effect, something that has gone unnoticed until now. Some of these results that have just been exposed are graphically illustrated throughout the manuscript

Cough reflex testing with inhaled capsaicin in the study of chronic cough

AbstractObjectives: To assess the utility of capsaicin test in the differential diagnosis of non-productive causes of chronic cough and to examine the effects of treatment on this reflex. Participants: 86 healthy volunteers and 101 patients with chronic cough: asthma (n: 54), gastroesophageal reflux (n: 35) and post-nasal drip syndrome (n: 12). Design: Prospective intervention trial. Spirometry, bronchoprovocation test with histamine (PC20), and cough challenge with ascending concentrations of capsaicin (0.49–500 μM) were initially performed in all subjects. Patients were treated for 3 months according to the origin of the cough. Concentrations that elicited two (C2) and five or more coughs (C5) were determined before and after treatment.Results: In healthy subjects, cough sensitivity to capsaicin was not influenced by gender or smoking status; however, women with chronic cough were more sensitive to cough challenge than men. C2 and C5 were significantly lower in patients with asthma or gastroesophageal reflux than in post-nasal drip syndrome. No significant correlation was observed between the capsaicin cough threshold and PC20. Cough sensitivity did not improve significantly in most patients with asthma or gastroesophageal reflux despite adequate medical treatment during 3 months. Discriminative value of capsaicin test to differentiate healthy subjects from patients with asthma or reflux was poor. Conclusions: Cough sensitivity to inhaled capsaicin is a safe and reproducible tool in the study of chronic cough. However, its usefulness for the management and differential diagnosis is limited

Optimized Feature Subset Selection Using Genetic Algorithm for Preterm Labor Prediction Based on Electrohysterography

[EN] Electrohysterography (EHG) has emerged as an alternative technique to predict preterm labor, which still remains a challenge for the scientific-technical community. Based on EHG parameters, complex classification algorithms involving non-linear transformation of the input features, which clinicians found difficult to interpret, were generally used to predict preterm labor. We proposed to use genetic algorithm to identify the optimum feature subset to predict preterm labor using simple classification algorithms. A total of 203 parameters from 326 multichannel EHG recordings and obstetric data were used as input features. We designed and validated 3 base classifiers based on k-nearest neighbors, linear discriminant analysis and logistic regression, achieving F1-score of 84.63 ± 2.76%, 89.34 ± 3.5% and 86.87 ± 4.53%, respectively, for incoming new data. The results reveal that temporal, spectral and non-linear EHG parameters computed in different bandwidths from multichannel recordings provide complementary information on preterm labor prediction. We also developed an ensemble classifier that not only outperformed base classifiers but also reduced their variability, achieving an F1-score of 92.04 ± 2.97%, which is comparable with those obtained using complex classifiers. Our results suggest the feasibility of developing a preterm labor prediction system with high generalization capacity using simple easy-to-interpret classification algorithms to assist in transferring the EHG technique to clinical practice.This work was supported by the Spanish Ministry of Economy and Competitiveness, the European Regional Development Fund (MCIU/AEI/FEDER, UE RTI2018-094449-A-I00-AR) and by the Generalitat Valenciana (AICO/2019/220).Nieto-Del-Amor, F.; Prats-Boluda, G.; Martínez-De-Juan, JL.; Díaz-Martínez, MDA.; Monfort-Ortiz, R.; Diago-Almela, VJ.; Ye Lin, Y. (2021). Optimized Feature Subset Selection Using Genetic Algorithm for Preterm Labor Prediction Based on Electrohysterography. Sensors. 21(10):1-15. https://doi.org/10.3390/s21103350S115211

Late Holocene climate variability in the southwestern Mediterranean region: an integrated marine and terrestrial geochemical approach

A combination of marine (Alboran Sea cores, ODP 976 and TTR 300 G) and terrestrial (Zoñar Lake, Andalucia, Spain) geochemical proxies provides a high-resolution reconstruction of climate variability and human influence in the southwestern Mediterranean region for the last 4000 years at inter-centennial resolution. Proxies respond to changes in precipitation rather than temperature alone. Our combined terrestrial and marine archive documents a succession of dry and wet periods coherent with the North Atlantic climate signal. A dry period occurred prior to 2.7 cal ka BP – synchronously to the global aridity crisis of the third-millennium BC – and during the Medieval Climate Anomaly (1.4–0.7 cal ka BP). Wetter conditions prevailed from 2.7 to 1.4 cal ka BP. Hydrological signatures during the Little Ice Age are highly variable but consistent with more humidity than the Medieval Climate Anomaly. Additionally, Pb anomalies in sediments at the end of the Bronze Age suggest anthropogenic pollution earlier than the Roman Empire development in the Iberian Peninsula. The Late Holocene climate evolution of the in the study area confirms the see-saw pattern between the eastern and western Mediterranean regions and the higher influence of the North Atlantic dynamics in the western Mediterranean

DUDAS DE ENFERMERÍA EN EL MANEJO DE LA HISTORIA CLÍNICA. ASPECTOS JURÍDICOS

  As part of the changes produced within the nursing profession, the registration of the activities carried out proves to be necessary for the management of quality care, keeping in mind the legal aspect and development of nursing training. According to Spanish Act 41/2002, clinical history is the array of documents related to the care process of every patient, including the identification of doctors and health professionals that have intervened in the care. Its objective is to facilitate sanitary care, paying attention to aspects such as training and research, evaluation of the quality of care, administration and medical-legal.   The Spanish Act 41/2002 determines which documents are obligatory and should be present in the clinical history. Among these are the care planning sheets, the records of therapeutic work and vital signs. All these should be present in each one of the moments along with the correspondent identification of the people carrying out the action, as these imply legal responsibility, as long as law compliance is guaranteed. Therefore, nursing must understand and fulfill the regulation regarding the use of clinical history.   Nursing records are the documental tool where all the information of nursing activity is collected regarding a specific patient, assessment, received treatment, and progression. Nursing records are an essential part of the clinical history and therefore, have similar functions; the main one being treatment, focused on providing maximum quality care, as well as the researcher-trainer, management and contribution to the development of our profession. Other objectives are legal because the records are the documented testimony of the professional actions upon the Court requirements.  Dentro de los cambios producidos en la profesión enfermera, el registro de las actividades realizadas se revela como imprescindible para administrar unos cuidados de calidad, sin olvidar el punto de vista legal y el desarrollo de la formación en Enfermería. Según la Ley 41/2002, la Historia Clínica comprende el conjunto de documentos relativos a los procesos asistenciales de cada paciente, con la identificación de los médicos y los profesionales sanitarios que han intervenido en ellos, y tiene como fin principal facilitar la asistencia sanitaria, sin obviar aspectos como la docencia e investigación, la evaluación calidad asistencial, la administrativa y la médico-legal.La Ley 41/2002 determina los documentos obligatorios que deben estar presentes en la Historia clínica. Entre ellos se encuentran las hojas de planificación de los cuidados, el registro de las aplicaciones terapéuticas y el registro de las constantes. Todos ellos deben estar presentes en cada uno de los episodios con la correspondiente identificación de la persona que lo realiza, pues implica responsabilidad jurídica, en tanto en cuanto hay que garantizar el cumplimiento de la ley. Por ello enfermería debe conocer y cumplir lo legislado respecto al uso de la Historia clínica.Los registros de enfermería son el soporte documental donde queda recogida toda la información sobre la actividad enfermera referente a una persona concreta, valoración, tratamiento recibido y su evolución. Los Registros de Enfermería son parte fundamental de la Historia Clínica y como tal tienen funciones similares; la principal sería la asistencial, enfocada a prestar unos cuidados de la máxima calidad, sin olvidar la docente-investigadora, de gestión y la contribución al desarrollo de nuestraprofesión. Otras de sus finalidades es la jurídico-legal, pues los registros constituyen el testimonio documental de los actos del profesional a requerimiento de los tribunale

Late Holocene climate variability in the southwestern Mediterranean region: an integrated marine and terrestrial geochemical approach

10 páginas, 5 figuras, 1 tabla.A combination of marine (Alboran Sea cores, ODP 976 and TTR 300 G) and terrestrial (Zoñar Lake, Andalucia, Spain) geochemical proxies provides a high-resolution reconstruction of climate variability and human influence in the southwestern Mediterranean region for the last 4000 years at inter-centennial resolution. Proxies respond to changes in precipitation rather than temperature alone. Our combined terrestrial and marine archive documents a succession of dry and wet periods coherent with the North Atlantic climate signal. A dry period occurred prior to 2.7 cal ka BP – synchronously to the global aridity crisis of the third-millennium BC – and during the Medieval Climate Anomaly (1.4–0.7 cal ka BP). Wetter conditions prevailed from 2.7 to 1.4 cal ka BP. Hydrological signatures during the Little Ice Age are highly variable but consistent with more humidity than the Medieval Climate Anomaly. Additionally, Pb anomalies in sediments at the end of the Bronze Age suggest anthropogenic pollution earlier than the Roman Empire development in the Iberian Peninsula. The Late Holocene climate evolution of the in the study area confirms the see-saw pattern between the eastern and western Mediterranean regions and the higher influence of the North Atlantic dynamics in the western Mediterranean.Projects LIMNOCLIBER REN 2003-09130- C02-02, CALIBRE CGL 2006-13327-c04/CLI, CGL-2006-2956- BOS, CGL2009-07603 (MICINN), 200800050084447 (MARM) and RNM 05212 (Junta de Andalucía), we also thanks Projects GRACCIE (CSD2007- 00067) and CTM2009-07715 (MICINN), Research Group 0179 (Junta de Andalucía) and the Training- Through-Research Programme.Peer reviewe

BRCA1 polymorphism in breast cancer patients from Argentina

Breast cancer is the most common type of cancer in females in Argentina, with an incidence rate similar to that in the USA. However, the contribution of the BRCA1 or BRCA2 mutation in breast cancer incidence has not yet been investigated in Argentina. In order to evaluate which BRCA1 polymorphisms or mutations characterize female breast cancer in Argentina, the current study enrolled 206 females with breast cancer from several hospitals from the southeast of Argentina. A buccal smear sample was obtained in duplicate from each patient and the DNA samples were processed for polymorphism analysis using the single-strand conformational polymorphism technique. The polymorphisms in BRCA1 were investigated using a combination of 15 primers to analyze exons 2, 3, 5, 20 and 11 (including the 11.1 to 11.12 regions). The BRCA1 mutations were confirmed by direct sequencing. Samples were successfully examined from 154 females and, among these, 16 mutations were identified in the BRCA1 gene representing 13.9% of the samples analyzed. One patient was identified with a polymorphism in exon 2 (0.86%), four in exon 20 (3.48%), four in exon 11.3 (3.48%), one in exon 11.7 (0.86%), two in exon 11.8 (1.74%), one in exon 11.10 (0.86%) and one in exon 11.11 (0.86%). The most prevalent alteration in BRCA1 was located in exon 11 (11 out of 16 patients; 68.75%). The objective of our next study is to evaluate the prevalence of mutations in the BRCA2 gene and analyze the BRCA1 gene in the healthy relatives of BRCA1 mutation carriers.Fil: Jaure, Omar David Argentino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Alonso, Eliana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Aguilera Braico, Diego Máximo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Nieto, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Orozco, Manuela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Morelli, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; ArgentinaFil: Ferro, Alejandro M.. Hospital Italiano; ArgentinaFil: Barutta, Elena. Medifem; ArgentinaFil: Vincent, Esteban. Medifem; ArgentinaFil: Martínez, Domingo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Municipal de Agudos Dr. Leónidas Lucero; ArgentinaFil: Martínez, Ignacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital Municipal de Agudos Dr. Leónidas Lucero; ArgentinaFil: Maegli, Maria Ines. Provincia de Buenos Aires. Ministerio de Salud. Hospital Municipal de Agudos Dr. Leónidas Lucero; ArgentinaFil: Frizza, Alejandro. Medifem; ArgentinaFil: Kowalyzyn, Ruben. Clínica Viedma; ArgentinaFil: Salvadori, Marisa. Hospital Dr. Lucio Molas; ArgentinaFil: Ginestet, Paul. Provincia de Buenos Aires. Ministerio de Salud. Hospital y Maternidad Municipal Pigüé; ArgentinaFil: Gonzalez Donna, Maria L.. Hospital Italiano; ArgentinaFil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentin