Virial Expansion of the Nuclear Equation of State

We study the equation of state (EOS) of nuclear matter as function of density. We expand the energy per particle (E/A) of symmetric infinite nuclear matter in powers of the density to take into account 2,3,. . .,N-body forces. New EOS are proposed by fitting ground state properties of nuclear matter (binding energy, compressibility and pressure) and assuming that at high densities a second order phase transition to the Quark Gluon Plasma (QGP) occurs. The latter phase transition is due to symmetry breaking at high density from nuclear matter (locally color white) to the QGP (globally color white). In the simplest implementation of a second order phase transition we calculate the critical exponent ? by using Landau's theory of phase transition. We find ? = 3. Refining the properties of the EOS near the critical point gives ? = 5 in agreement with experimental results. We also discuss some scenarios for the EOS at finite temperatures

Hydrogenation of PAH cations:A first step towards H2 formation

Molecular hydrogen is the most abundant molecule in the universe. A large fraction of H2 forms by association of hydrogen atoms adsorbed on polycyclic aromatic hydrocarbons (PAHs), where formation rates depend crucially on the H sticking probability. We have experimentally studied PAH hydrogenation by exposing coronene cations, confined in a radiofrequency ion trap, to gas phase atomic hydrogen. A systematic increase of the number of H atoms adsorbed on the coronene with the time of exposure is observed. Odd coronene hydrogenation states dominate the mass spectrum up to 11 H atoms attached. This indicates the presence of a barrier preventing H attachment to these molecular systems. For the second and fourth hydrogenation, barrier heights of 72 +- 6 meV and 40 +- 10 meV, respectively are found which is in good agreement with theoretical predictions for the hydrogenation of neutral PAHs. Our experiments however prove that the barrier does not vanish for higher hydrogenation states. These results imply that PAH cations, as their neutral counterparts, exist in highly hydrogenated forms in the interstellar medium. Due to this catalytic activity, PAH cations and neutrals seem to contribute similarly to the formation of H2.Comment: 8 pages, 4 figures, accepted for publication in ApJ Letter: Astrophysical Journal LET30123R 201

STUDY OF THE O-18+Ni-64 TWO-NEUTRON TRANSFER REACTION AT 84 MeV BY MAGNEX

A study of the two-neutron transfer reaction of the O-18 + Ni-64 system at 84 MeV incident energy to the ground and first 2(+) excited state of the residual Ni-66 nucleus is presented. The experiment was performed at the INFN-LNS (Italy) by using the large acceptance MAGNEX spectrometer. Theoretical models are used in order to disentangle the competition between long-range and short-range correlations

Long-range versus short-range correlations in the two-neutron transfer reaction Ni 64 (O 18, O 16) Ni 66

Recently, various two-neutron transfer studies using the (18O,16O) reaction were performed with a large success. This was achieved because of a combined use of the microscopic quantum description of the reaction mechanism and of the nuclear structure. In the present work we use this methodology to study the two-neutron transfer reaction of the 18O+64Ni system at 84 MeV incident energy, to the ground and first 2+ excited state of the residual 66Ni nucleus. All the experimental data were measured by the large acceptance MAGNEX spectrometer at the Instituto Nazionale di Fisica Nucleare \u2013Laboratori Nazionali del Sud (Italy). We have performed exact finite range cross section calculations using the coupled channel Born approximation (CCBA) and coupled reaction channel (CRC) method for the sequential and direct two-neutron transfers, respectively. Moreover, this is the first time that the formalism of the microscopic interaction boson model (IBM-2) was applied to a two-neutron transfer reaction. From our results we conclude that for two-neutron transfer to the ground state of 66Ni, the direct transfer is the dominant reaction mechanism, whereas for the transfer to the first excited state of 66Ni, the sequential process dominates. A competition between long-range and short-range correlations is discussed, in particular, how the use of two different models (Shell model and IBM's) help to disentangle long- and short-range correlations

Persistent Transport Barrier on the West Florida Shelf

Analysis of drifter trajectories in the Gulf of Mexico has revealed the existence of a region on the southern portion of the West Florida Shelf (WFS) that is not visited by drifters that are released outside of the region. This so-called ``forbidden zone'' (FZ) suggests the existence of a persistent cross-shelf transport barrier on the southern portion of the WFS. In this letter a year-long record of surface currents produced by a Hybrid-Coordinate Ocean Model simulation of the WFS is used to identify Lagrangian coherent structures (LCSs), which reveal the presence of a robust and persistent cross-shelf transport barrier in approximately the same location as the boundary of the FZ. The location of the cross-shelf transport barrier undergoes a seasonal oscillation, being closer to the coast in the summer than in the winter. A month-long record of surface currents inferred from high-frequency (HF) radar measurements in a roughly 60 km $\times$ 80 km region on the WFS off Tampa Bay is also used to identify LCSs, which reveal the presence of robust transient transport barriers. While the HF-radar-derived transport barriers cannot be unambiguously linked to the boundary of the FZ, this analysis does demonstrate the feasibility of monitoring transport barriers on the WFS using a HF-radar-based measurement system. The implications of a persistent cross-shelf transport barrier on the WFS for the development of harmful algal blooms on the shoreward side of the barrier are considered.Comment: Submitted to Geophysical Research Letter

Characterisation of silicon strip detectors with a binary readout chip for X-ray imaging

In this paper we describe the development of a multichannel readout system for X-ray measurements using silicon strip detectors. The developed system is based on a binary readout architecture and optimised for detection of X-rays of energies in the range 6}30 keV. The critical component of the system is the 32-channel front-end chip, RX32N, which has been optimised for low noise performance, small channel to channel variation and high counting rate operation. The performance of the chip is demonstrated by measurements of complex X-ray spectra using silicon strip and pad detectors. The obtained results allow to use the system at room temperature with the detection threshold in the range from 500 to 10 000 electrons, which is enough in many crystallographic and medical imaging applications. ( 2000 Elsevier Scienc

Fipronil and Ivermectin Treatment of Cattle Reduced the Survival and Ovarian Development of Field-Collection Anopheles Albimanus in a Pilot Trial Conducted in Northern Belize

Background: Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is efective against vector species that feed indoors at night and rest inside the house afterwards. In Central America, malaria vectors have diferent behaviours and are typically exophagic (i.e., bite outdoors), exophilic (i.e., remain outdoors after feeding), and zoophagic (i.e., as likely to feed on non-humans as humans). Thus, malaria elimination in Central America may require additional tactics. This pilot study investigated whether commercially-available products used to treat livestock for ticks could also be used to kill and/or sterilize zoophagic malaria vectors that feed on treated cattle in Belize. Methods: Cattle were treated with either a pour-on formulation of 1% fpronil (3 heifers) or injection of 1% ivemectin (1 heifer). Control heifers (n=2) were left untreated. Field-collected Anopheles albimanus contained in screen-top cages were strapped onto cattle at 2, 5, 7, and 14 days after treatment. Mosquito mortality was monitored once a day for 4 successive days. Surviving mosquitoes were dissected to assess blood meal digestion and ovarian development. Results: A total of 1078 female An. albimanus mosquitoes were fed and monitored for mortality. Both fpronil and ivermectin signifcantly reduced survivorship of An. albimanus for up to 7 days after treatment. By 14 days, efcacy had declined. The ivermectin treatment completely lost its efectiveness and even though the fpronil-treated heifers were still killing signifcantly more mosquitoes than the untreated heifers, the amount of mosquito killing had diminished greatly. Both treatments signifcantly reduced ovary development in mosquitoes fed on treated cattle for the duration of the 2-week trial. Conclusions: Treatment of cattle in northern Belize with topical fpronil and injectable ivermectin had signifcant lethal and sublethal efects on wild An. albimanus females. These results suggest that eforts towards eliminating residual transmission of malaria by zoophagic vectors in Central America may beneft by the judicious, targeted treatment of livestock with mosquitocidal compounds, such as fpronil or ivermectin

Students Take Lead to Educate Faculty on the Use of Sex and Gender Terminology in Pre-clinical Courses

TOP WINNER Student leaders in the Lesbian, Gay, Bisexual and Transgender People in Medicine student run organization at the Medical College of Wisconsin noticed that curricular language around sex and gender was absent and/or incorrect in the pre-clinical medical school (M1/M2) courses. After reaching out to the M2 Endocrine/Repro Unit course director, students prepared a report to present to all M1/M2 Course Directors. Objectives: One goal of the report was to “educate the educators” so that faculty would have better understanding of the distinction between sex and gender. Ultimately this would translate to the students and improve overall future patient care. Methods: A presentation was developed and given at the quarterly M1/M2 course director meeting (Fall 2019). Information included statistics from the 2015 US Transgender Survey which underscored that ignorance surrounding sex versus gender terminology could result in an environment in which patients do not seek care. The student presentation comprehensively explained the definitions of sex, gender, cisgender and transgender. Course directors were given action items to evaluate their courses and afirm that terms were used appropriately. Student leaders provided contact information for faculty feedback. Conclusions/Impact: In February 2020, students reported of changes in some courses. For example, the M2 cardiovascular unit led off the session on women and heart disease with sex and gender definitions provided by students. Cardiovascular risks of hormonal therapy for transgender patients was included. Students noted that language around sex and gender in the M2 endocrine-repro unit was consistently correct (female not woman when discussing XX fetus). A M1 pharmacology lecture included the student\u27s definition slide as prelude to discussion of male/female differences in drug response. With little effort, students played an integral role in improving curricular content related to sex and gender medicine and further supporting the model that students are important drivers of change.https://jdc.jefferson.edu/sexandgenderhealth/1019/thumbnail.jp

Protocol for a prospective study evaluating circulating tumour cells status to predict radical prostatectomy treatment failure in localised prostate cancer patients (C-ProMeta-1)

BACKGROUND: Treatment decisions in prostate cancer (PCa) rely on disease stratification between localised and metastatic stages, but current imaging staging technologies are not sensitive to micro-metastatic disease. Circulating tumour cells (CTCs) status is a promising tool in this regard. The Parsortix® CTC isolation system employs an epitope-independent approach based on cell size and deformability to increase the capture rate of CTCs. Here, we present a protocol for prospective evaluation of this method to predict post radical prostatectomy (RP) PCa cancer recurrence. METHODS: We plan to recruit 294 patients diagnosed with unfavourable intermediate, to high and very high-risk localised PCa. Exclusion criteria include synchronous cancer diagnosis or prior PCa treatment, including hormone therapy. RP is performed according to the standard of care. Two blood samples (20 ml) are collected before and again 3-months after RP. The clinical team are blinded to CTC results and the laboratory researchers are blinded to clinical information. Treatment failure is defined as a PSA ≥ 0.2 mg/ml, start of salvage treatment or imaging-proven metastatic lesions. The CTC analysis entails enumeration and RNA analysis of gene expression in captured CTCs. The primary outcome is the accuracy of CTC status to predict post-RP treatment failure at 4.5 years. Observed sensitivity, positive and negative predictive values will be reported. Specificity will be presented over time. DISCUSSION: CTC status may reflect the true potential for PCa metastasis and may predict clinical outcomes better than the current PCa progression risk grading systems. Therefore establishing a robust biomarker for predicting treatment failure in localized high-risk PCa would significantly enhance guidance in treatment decision-making, optimizing cure rates while minimizing unnecessary harm from overtreatment. TRIAL REGISTRATION: ISRCTN17332543

Consistent reduction of charged D3-D7 systems

We provide a consistent reduction to five dimensions of the system of D3-branes at Calabi-Yau singularities coupled to D7-branes with world-volume gauge flux. The D3-branes source the dual to would-be conformal quiver theories. The D7-branes, which are homogeneously distributed in their transverse directions, are dual to massless matter in the fundamental representation at finite (baryon) density. We provide the five-dimensional action and equations of motion, and discuss a few sub-truncations. The reduction can be used in the study of transport properties and stability of D3-D7 charged systems.Comment: 23 pages. v2: references added and minor change