Unemployment and Midlife Suicide Rates in Australia 2001-2015: Implications During the COVID-19 Pandemic

The world is experiencing a massive economic shock from the COVID-19 pandemic. Resulting unemployment and socioeconomic disruption have the potential to lead to a major upswing in the population rate of suicide in Europe and elsewhere. We assessed the association between midlife suicide rates and unemployment for Australia. For the midlife group we found a rapid decrease in the rate from 1970s to 1980s, but a more apparent increase after 2007. The increased male suicide rate coincided with the 2008 global financial crisis. The relationship between worsening employment outcomes, including suicide, is a great tragedy and deserves urgent further investigation

Design and installation of post-installed reinforcements: A state-of-the-art review

Post-installed reinforcement (PIR) helps facilitate retrofitting works, mitigate misplaced reinforcement problems, as well as support newly cast concrete members such as modular integrated construction. However, it has not been holistically addressed in major international reinforced concrete (RC) design codes. Nonetheless, based on established design philosophy and associated failure modes, the cast-in reinforcement design method in RC can be extended to design qualified PIR systems. The qualification of PIR system can be referenced to AC 308 (2016), European Assessment Document (EAD) 330087 (2018) and EAD 330499 (2017) in the US and Europe, respectively. In Hong Kong, PIR is conservatively limited to shear connections. Its assumption of pinned connection is less justifiable for some deep sections of beams, which may induce hogging moments, causing tension at the top reinforcement of the supports. In some cases of cantilever slabs, moment connections are necessary to maintain equilibrium. Hence, this paper reviews an up-to-date design methodology and installation guide to complement the Hong Kong Code of Practice for Structural Use of Concrete (HKBD) by referring to the recently published international design codes and documents. The proposal is useful to promote economical, sustainable and technically sound use of PIR system

Comparison of monsoon variations over groundwater hydrochemistry changes in small Tropical Island and its repercussion on quality

Study on the spatial and temporal distribution of groundwater hydrochemistry in the small tropical islands is important as their insular character may expose the groundwater aquifer to too many sources of pollution, especially salinization. A total of 216 groundwater samples were collected from the monitoring boreholes during two different monsoon seasons; pre- and post-monsoon. As overall, data of groundwater concentration illustrated a trend of Ca > Na > Mg > K and HCO3 > Cl > SO4 dominations with the major finding of two different groundwater types. Pre-monsoon reported Na-HCO3 and Ca-HCO3 types while post-monsoon were only dominated by the Ca-HCO3 type. The statistical analysis shows the in situ parameters (Temp, pH, EC, Salinity, DO, TDS and Eh) and major ions (Ca, Mg, Na, K, HCO3, Cl and SO4) were strongly correlated with the monsoon changes (p < 0.01). From the analysis, its reveals that the seasonal changes have significantly affects the groundwater composition. While, the analytical calculations of the ionic ratio (Na vs. Cl; Cl/HCO3 vs. Cl; Ca + Mg vs. SO4 + HCO3) describes the groundwater is influenced by the cation exchanges processes, simple mixing and water–rock interaction. Saturation indices of carbonate minerals shows strong correlationship (p < 0.01) with Ca constituent indicating solubility on minerals, which led to dissolution or precipitation condition of water. Results of present study contribute to a better understanding of a complex groundwater system and the hydrochemical processes related

Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy

Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by gait and postural disturbance, gaze palsy, apathy, decreased verbal fluency and dysexecutive symptoms, with some of these clinical features potentially having origins in degeneration of frontostriatal circuits and the mesencephalon. This hypothesis was investigated by manual segmentation of the caudate and putamen on MRI scans, using previously published protocols, in 15 subjects with PSP and 15 healthy age-matched controls. Midbrain atrophy was assessed by measurement of mid-sagittal area of the midbrain and pons. Shape analysis of the caudate and putamen was performed using spherical harmonics (SPHARM-PDM, University of North Carolina). The sagittal pons area/midbrain area ratio (P/M ratio) was significantly higher in the PSP group, consistent with previous findings. Significantly smaller striatal volumes were found in the PSP group - putamina were 10% smaller and caudate volumes were 17% smaller than in controls after controlling for age and intracranial volume. Shape analysis revealed significant shape deflation in PSP in the striatum, compared to controls; with regionally significant change relevant to frontostriatal and corticostriatal circuits in the caudate. Thus, in a clinically diagnosed and biomarker-confirmed cohort with early PSP, we demonstrate that neostriatal volume and shape are significantly reduced in vivo. The findings suggest a neostriatal and mesencephalic structural basis for the clinical features of PSP leading to frontostriatal and mesocortical-striatal circuit disruption. (C) 2011 Elsevier Ireland Ltd. All rights reserved

Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures

Niemann-Pick Type C disease (NPC) is a rare genetic disorder of lipid metabolism. A parameter related to horizontal saccadic peak velocity was one of the primary outcome measures in the clinical trial assessing miglustat as a treatment for NPC. Neuropathology is widespread in NPC, however, and could be expected to affect other saccadic parameters. We compared horizontal saccadic velocity, latency, gain, antisaccade error percentage and self-paced saccade generation in 9 adult NPC patients to data from 10 age-matched controls. These saccadic measures were correlated with appropriate MRI-derived brain structural measures (e.g., dorsolateral prefrontal cortex, frontal eye fields, supplemental eye fields, parietal eye fields, pons, midbrain and cerebellar vermis) and with measures of disease severity and duration. The best discriminators between groups were reflexive saccade gain and the two volitional saccade measures. Gain was also the strongest correlate with disease severity and duration. Most of the saccadic measures showed strongly significant correlations with neurophysiologically appropriate brain regions. While our patient sample is small, the apparent specificity of these relationships suggests that as new diagnostic methods and treatments become available for NPC, a broader range of saccadic measures may be useful tools for the assessment of disease progression and treatment efficacy.No external funding was received for this study. JCLL self-funded computational, travel and accommodation costs to conduct his component of this research in Melbourne

Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease

Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD

Conventional approach to harmonious coordinated Cadastral Database weakness

The eKadaster system depended solely on the use of coordinated cadastral database known as the National Digital Cadastral Database (NDCDB) with an expected accuracy of ±10cm. Till date, there is an approximately of 7.8 million land parcels and 21.9 million boundary markers in the NDCDB that covers the total area of 132,183 km2. However, the NDCDB accuracy of ±10cm is still not at a satisfactory acceptance level and the adjustment keeps continuing without carrying out verification to the data sources weakness of varying accuracy and input errors. Thus, the foremost important corrective is to ensure the adjustment input files to have the exact value of the sources by further divided the existing adjustment blocks into smaller blocks to verify the input data line by line. A well distributed cadastral control points and latest NDCDB accessibility are also extensively needed to plan and to strengthen the adjustment network. The comparison result of the randomly picked ground truthing points in the field has shown a significant impact on the displacement accuracy that meet the expected tolerance of ±10cm or better after the data input file is cleaned without input error. And to further strengthen the adjustment network in order to make NDCDB accuracy better, the current cadastral control points shall need to tie to a highest accuracy fundamental network

Nutritional Profile, Antioxidative and Antihyperglycemic Properties of Padina tetrastromatica from Tioman Island, Malaysia

Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. Padina tetrastromatica is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of P. tetrastromatica extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg−1 body weight of streptozotocin. Oral treatment with 200 and 400 mg kg−1 of P. tetrastromatica ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with P. tetrastromatica extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, P. tetrastromatica extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of P. tetrastromatica at 400 mg kg−1 dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of P. tetrastromatica.</jats:p

The empirical approach to strengthen coordinated cadastral database accuracy

The coordinated cadastral database in Malaysia is known as National Digital Cadastral Database (NDCDB) with an expected accuracy of ±10cm in rural and ±5cm in urban area. Till date, there are approximately 7.8 million land parcels and 22 million boundary markers in the NDCDB for the whole of Peninsular Malaysia and Federal Territory of Labuan covering total area of 132,183 km2. Since 2010, NDCDB block adjustment has been carried out continuously without giving prime concern to eliminate gross errors in the adjustment's input data. This approach aims to propose a methodology to improve the positional accuracy of the existing NDCDB through utilisation of the current eKadaster application. A comprehensive investigation in the office and field processes has been carried out to prove the efficiency of the methodology introduced. This investigation was focused on the East Coast Rail Link (ECRL) right of way (ROW) survey from Dungun to Besut where displacement of 1 to 6 meters relative to the NDCDB coordinates, as shown in the Land Acquisition (LA) Plan, have been identified. Areas involved are coded as Block T10701, T1100101 and T1100102 which are located in Lubuk Kawah and Pelagat Sub-districts, in the state of Terengganu. Positional accuracy of the NDCDB after adjustment was further verified by comparing the coordinates of randomly picked ground proofing points in the field using Real-Time Kinematic (RTK) observation. This will determine the Root Mean Square Error (RMSE) of the respective NDCDB Block based on actual observations and adjusted coordinate values. With that, it can be concluded that the proposed approach is reasonably practical and capable to improve and strengthen the positional accuracy of existing coordinated cadastral database used in Malaysia