Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Electrochemical studies of tamsulosin hydrochloride using multiwalled carbon nanotube-modified glassy carbon sensor

A differential pulse voltammetric sensor for the determination of tamsulosin hydrochloride (TAM) using multiwalled carbon nanotubes (MWNTs)–Nafion-modified glassy carbon electrode (GCE) has been developed. MWNTs were dispersed in water with the help of Nafion and were used to modify the surface of GCE via solvent evaporation. At MWNT-modified electrode, TAM gave a well-defined oxidation peak at a potential of 1084 mV in 0.1 M acetate buffer solution of pH 5. Compared to the bare electrode, the peak current of TAM showed a marked increase and the peak potential showed a negative deviation. The determination conditions, such as the amount of MWNT–Nafion suspension, pH of the supporting electrolyte and scan rate, were optimised. Under optimum conditions, the oxidation peak current was proportional to the concentration of TAM in the range 1 × 1023 M–3 × 1027 M with a detection limit of 9.8 × 1028 M. The developed sensor showed good stability, selectivity and was successfully used for the determination of TAM in pharmaceutical formulations and urine samplesCochin University of Science and TechnologyMicro & Nano Letters, 2011, Vol. 6, Iss. 10, pp. 867–87

Environmental issues of Polybrominated Diphenyl Ethers

Polybrominated diphenyl ethers (PBDEs) are among the emerging contaminants that have been traced in almost all environmental compartments for the past 30 years. Their continued application as flame-retardant additives, persistence in nature due to fluorine groups, global atmospheric transport, and analytical challenges due to interferences and different properties of congeners indicate the urgent need of finding solutions to their use. The increasing level of PBDEs in the environment and especially human tissues is alarming due to their potential neurological effects, cancer proliferation, and thyroid hormone imbalance. Therefore, strict regulations need to be applied in all countries to control the PBDEs production consumption and disposal into the environment. Studies have shown that conventional wastewater treatment plants are unable to degrade PBDEs resulting in the transport of 60–90% of PBDEs to soil through biosolids application. On the other hand, advanced treatment processes, such as ultraviolet light, advanced oxidation, and photocatalytic degradation showed promising potential for removing PBDEs from wastewater (70–100% degradation efficiency). PBDEs can be replaced by natural flame retardants, such as nanoclay or new polymers, such as bishydroxydeoxybenzoin which have no environmental or health problems compared to PBDEs.Fil: Taheran, M.. Université du Québec a Montreal; CanadáFil: Komtchou, S.. Université du Québec a Montreal; CanadáFil: Lonappan, L.. Université du Québec a Montreal; CanadáFil: Naji, T.. Université du Québec a Montreal; CanadáFil: Brar, Satinder Kaur. Université du Québec a Montreal; CanadáFil: Cledón, Maximiliano. Univerity Institut national de la recherche scientifique; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Drogui, Patrick. Université du Québec a Montreal; Canad

The Simons Observatory: impact of bandpass, polarization angle and calibration uncertainties on small-scale power spectrum analysis

We study the effects due to mismatches in passbands, polarization angles, and temperature and polarization calibrations in the context of the upcoming cosmic microwave background experiment Simons Observatory (SO). Using the SO multi-frequency likelihood, we estimate the bias and the degradation of constraining power in cosmological and astrophysical foreground parameters assuming different levels of knowledge of the instrumental effects. We find that incorrect but reasonable assumptions on the values of all the systematics examined here can have important effects in cosmological analyses, hence requiring marginalization approaches at likelihood level. When doing so, we find that the most relevant effect is due to bandpass shifts. When marginalizing over them, the posteriors of parameters describing astrophysical microwave foregrounds (such as radio point sources or dust) get degraded, while cosmological parameters constraints are not significantly affected. Marginalization over polarization angles with up to 0.25∘ uncertainty causes an irrelevant bias ≲0.05σ in all parameters. Marginalization over calibration factors in polarization broadens the constraints on the effective number of relativistic degrees of freedom Neff by a factor 1.2, interpreted here as a proxy parameter for non standard model physics targeted by high-resolution CMB measurements

The Simons Observatory: impact of bandpass, polarization angle and calibration uncertainties on small-scale power spectrum analysis

International audienceWe study the effects due to mismatches in passbands, polarization angles, and temperature and polarization calibrations in the context of the upcoming cosmic microwave background experiment Simons Observatory (SO). Using the SO multi-frequency likelihood, we estimate the bias and the degradation of constraining power in cosmological and astrophysical foreground parameters assuming different levels of knowledge of the instrumental effects. We find that incorrect but reasonable assumptions on the values of all the systematics examined here can have important effects in cosmological analyses, hence requiring marginalization approaches at likelihood level. When doing so, we find that the most relevant effect is due to bandpass shifts. When marginalizing over them, the posteriors of parameters describing astrophysical microwave foregrounds (such as radio point sources or dust) get degraded, while cosmological parameters constraints are not significantly affected. Marginalization over polarization angles with up to 0.25$^\circ$ uncertainty causes an irrelevant bias $\lesssim 0.05 \sigma$ in all parameters. Marginalization over calibration factors in polarization broadens the constraints on the effective number of relativistic degrees of freedom $N_\mathrm{eff}$ by a factor 1.2, interpreted here as a proxy parameter for non standard model physics targeted by high-resolution CMB measurements

The Simons Observatory: impact of bandpass, polarization angle and calibration uncertainties on small-scale power spectrum analysis

International audienceWe study the effects due to mismatches in passbands, polarization angles, and temperature and polarization calibrations in the context of the upcoming cosmic microwave background experiment Simons Observatory (SO). Using the SO multi-frequency likelihood, we estimate the bias and the degradation of constraining power in cosmological and astrophysical foreground parameters assuming different levels of knowledge of the instrumental effects. We find that incorrect but reasonable assumptions on the values of all the systematics examined here can have important effects in cosmological analyses, hence requiring marginalization approaches at likelihood level. When doing so, we find that the most relevant effect is due to bandpass shifts. When marginalizing over them, the posteriors of parameters describing astrophysical microwave foregrounds (such as radio point sources or dust) get degraded, while cosmological parameters constraints are not significantly affected. Marginalization over polarization angles with up to 0.25$^\circ$ uncertainty causes an irrelevant bias $\lesssim 0.05 \sigma$ in all parameters. Marginalization over calibration factors in polarization broadens the constraints on the effective number of relativistic degrees of freedom $N_\mathrm{eff}$ by a factor 1.2, interpreted here as a proxy parameter for non standard model physics targeted by high-resolution CMB measurements

The Simons Observatory: impact of bandpass, polarization angle and calibration uncertainties on small-scale power spectrum analysis

International audienceWe study the effects due to mismatches in passbands, polarization angles, and temperature and polarization calibrations in the context of the upcoming cosmic microwave background experiment Simons Observatory (SO). Using the SO multi-frequency likelihood, we estimate the bias and the degradation of constraining power in cosmological and astrophysical foreground parameters assuming different levels of knowledge of the instrumental effects. We find that incorrect but reasonable assumptions on the values of all the systematics examined here can have important effects in cosmological analyses, hence requiring marginalization approaches at likelihood level. When doing so, we find that the most relevant effect is due to bandpass shifts. When marginalizing over them, the posteriors of parameters describing astrophysical microwave foregrounds (such as radio point sources or dust) get degraded, while cosmological parameters constraints are not significantly affected. Marginalization over polarization angles with up to 0.25$^\circ$ uncertainty causes an irrelevant bias $\lesssim 0.05 \sigma$ in all parameters. Marginalization over calibration factors in polarization broadens the constraints on the effective number of relativistic degrees of freedom $N_\mathrm{eff}$ by a factor 1.2, interpreted here as a proxy parameter for non standard model physics targeted by high-resolution CMB measurements

Real-time image processor for detection of rare cells and particles in flow at 37 MHz line scans per second

We describe a real-time image processor that has enabled a new automated flow through microscope to screen cells in flow at 100,000 cells/s and a record false positive rate of one in a million. This unit is integrated with an ultrafast optical imaging modality known as serial time-encoded amplified microscopy (STEAM) for blur-free imaging of particles in high-speed flow. We show real-time image-based identification and screening of budding yeast cells and rare breast cancer cells in blood. The system generates E-slides (an electronic version of glass slides) on which particles of interest are digitally analyzed