508 research outputs found

    Premium: An R package for profile regression mixture models using dirichlet processes

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    PReMiuM is a recently developed R package for Bayesian clustering using a Dirichlet process mixture model. This model is an alternative to regression models, nonparametrically linking a response vector to covariate data through cluster membership (Molitor, Papathomas, Jerrett, and Richardson 2010). The package allows binary, categorical, count and continuous response, as well as continuous and discrete covariates. Additionally, predictions may be made for the response, and missing values for the covariates are handled. Several samplers and label switching moves are implemented along with diagnostic tools to assess convergence. A number of R functions for post-processing of the output are also provided. In addition to fitting mixtures, it may additionally be of interest to determine which covariates actively drive the mixture components. This is implemented in the package as variable selection

    Green-Kubo formula for weakly coupled system with dynamical noise

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    We study the Green-Kubo (GK) formula κ(ε,ξ)\kappa (\varepsilon, \xi) for the heat conductivity of an infinite chain of dd-dimensional finite systems (cells) coupled by a smooth nearest neighbour potential εV\varepsilon V. The uncoupled systems evolve according to Hamiltonian dynamics perturbed stochastically by an energy conserving noise of strength ξ\xi. Noting that κ(ε,ξ)\kappa (\varepsilon, \xi) exists and is finite whenever ξ>0\xi> 0, we are interested in what happens when the strength of the noise ξ0\xi \to 0. For this, we start in this work by formally expanding κ(ε,ξ)\kappa (\varepsilon, \xi) in a power series in ε\varepsilon, κ(ε,ξ)=ε2n2εn2κn(ξ)\kappa (\varepsilon, \xi) = \varepsilon^2 \sum_{n\ge 2} \varepsilon^{n-2} \kappa_n (\xi) and investigating the (formal) equations satisfied by κn(ξ\kappa_n (\xi. We show in particular that κ2(ξ)\kappa_2 (\xi) is well defined when no pinning potential is present, and coincides formally with the heat conductivity obtained in the weak coupling (van Hove) limit, where time is rescaled as ε2t\varepsilon^{-2}t, for the cases where the latter has been established \cite{LO, DL}. For one-dimensional systems, we investigate κ2(ξ)\kappa_2 (\xi) as ξ0\xi\to 0 in three cases: the disordered harmonic chain, the rotor chain and a chain of strongly anharmonic oscillators. Moreover, we formally identify κ2(ξ)\kappa_2 (\xi) with the conductivity obtained by having the chain between two reservoirs at temperature TT and T+δTT+\delta T, in the limit δT0\delta T\to 0, NN \to \infty, ε0\varepsilon \to 0.Comment: New version with many improvement

    Design for six sigma (DFSS) applied to a new eco-motorbike

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    The primary purpose of this work is to organize, in the best possible way, the design of an ecological transport vehicle, using an advanced design methodology, namely design for six sigma (DFSS). The DFSS is indeed a design approach, able to implement, in a logical and integrated way, other advanced methodologies of systematic design, such as quality function deployment (QFD), TRIZ (in Russian, Teorija Resenija Izobretatel'skich Zadac), benchmarking, top-flop analysis and others, in order to propose design solutions oriented both to quality and innovation, for satisfying customers. The above described has been demonstrated through the application of DFSS to a case study in which the set up phase of an industrial project was completed, without having overlooked any aspect useful for obtaining a new attractive product. The case study concerns the application of DFSS to a new low-polluting motorcycle. At the end of the work, the designer obtained the achievement of the conceptual project

    Synthesis of monodispersed Ag-doped bioactive glass nanoparticles via surface modification

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    © 2016 by the authors.Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications

    Role of Direct Aging and Solution Treatment on Hardness, Microstructure and Residual Stress of the A357 (AlSi7Mg0.6) Alloy Produced by Powder Bed Fusion

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    Applying additive manufacturing (AM) technologies to the fabrication of aluminum automotive components, with an optimized design, may result in improved vehicle light weighting. However, the post-process heat treatment of such alloys has to be customized for the particular AM microstructure. The present study is aimed at investigating the effect of different heat treatments on the microstructure, hardness and residual stress of the A357 (AlSi7Mg0.6) heat-treatable alloy produced by laser-based powder bed fusion (LPBF, also known as selective laser melting). There are two major issues to be addressed: (1) relieving the internal residual stress resulting from the process and (2) strengthening the alloy with a customized heat treatment. Therefore, stress-relief annealing treatment, direct aging of the as-built alloy and a redesigned T6 treatment (consisting of a shortened high-temperature solution treatment followed by artificial aging) were examined. Comparable hardness values were reached in the LPBF alloy with optimized direct aging and T6 treatments, but complete relief of the residual stress was obtained only with T6. Microstructural analyses also suggested that, because of the supersaturated solid solution, different phenomena were involved in direct aging and T6 treatment

    Instability statistics and mixing rates

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    We claim that looking at probability distributions of \emph{finite time} largest Lyapunov exponents, and more precisely studying their large deviation properties, yields an extremely powerful technique to get quantitative estimates of polynomial decay rates of time correlations and Poincar\'e recurrences in the -quite delicate- case of dynamical systems with weak chaotic properties.Comment: 5 pages, 5 figure

    Virtual mechanical product disassembly sequences based on disassembly order graphs and time measurement units

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    Recently, the approach that defines the total life cycle assessment (LCA) and the end of life (EoL) in the early design phases is becoming even more promising. Literature evidences many advantages in terms of the saving of costs and time and in the fluent organization of the whole design process. Design for disassembly (DfD) offers the possibility of reducing the time and cost of disassembling a product and accounts for the reusing of parts and of the dismantling of parts, joints, and materials. The sequence of disassembly is the ordered way to extract parts from an assembly and is a focal item in DfD because it can deeply influence times and operations. In this paper, some disassembly sequences are evaluated, and among them, two methods for defining an optimal sequence are provided and tested on a case study of a mechanical assembly. A further sequence of disassembly is provided by the authors based on experience and personal knowledge. All three are analyzed by the disassembly order graph (DOG) approach and compared. The operations evaluated have been converted in time using time measurement units (TMUs). As result, the best sequence has been highlighted in order to define a structured and efficient disassembly

    Industrial Design Structure: a straightforward organizational integration of DFSS and QFD in a new industry and market reality

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    Purpose: The aim of this research is to enlighten the methodology model of Industrial Design Structure (IDeS) that integrates the internal and external customer feedback embodied both in methods of quality function deployment (QFD) and as basis of design for six sigma (DFSS) steps to systematically bring the information across the entire organization, saving overall product development time and resources. Design/methodology/approach: The paper describes the state of the art enlightened to establish the disadvantages and challenges of other methods taken into consideration in the study like QFD and DFSS that, together with the need of companies to react fast to changes they need to straightforwardly implement product development information across all departments, leading to a mass customization infrastructure. Several application trials of this methodology have been cited. Findings: The IDeS method has established to been able to integrate other well-known methodologies to gather technical specifications starting from voice of customers (VOCs) like QFD that served to canalize the generalist approach of define, measure, analyze, design and verify (DMADV) of DFSS in order to reach into a larger share of the organization and englobe by following the overall product design steps of an industrial project. Research limitations/implications: The research approach chosen for this document presents the concept of a methodology ought to operate most internal branches in a company driven by product design requirements and guidelines. Therefore, researchers are encouraged to develop further studies on the IDeS method are required in order to adapt this methodology to specific management tools that would help to ease information gathering for immediate analysis and modification. Practical implications: The paper implicates that a need to interchange information systematically across all subdivisions in the organization, as brisk response to VOC reactions is needed to thrive in the market nowadays, leading to a fast product customization scene. However, the industry is heading into adopting an individual customer-centered product conceptualization ought to be driven by design as a key for individualizing an object. Afterward by taking this concept broadly and adopting it would lead to implement a company organization that would be directly affected by the customer's input. Social implications: The methodology described aims to enable organizations to portray fast and accurate product prototyping, by exploiting technologies from Industry 4.0. Originality/value: This concept proposes a method to canalize the implementation of DFSS by using the DMADV approach, whilst assessing the challenges of adaptation and keeping up with cultural pace that impacts the behavior of buying and consumption and moreover implementing a seamless communication within all departments in the organization to share the development progress and change requests by using similar information technology tools. This would imply important savings in resources, whilst delivering quality products to the society

    Design for Six Sigma and TRIZ for Inventive Design Applied to Recycle Cigarette Butts

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    A deep research and analysis of a “critical waste” object has been carried out, understood as a subject that does not fare high on the separate collection and recycling system yet: the cigarette butt. This acknowledged social waste is the first among all the garbage detected everywhere around neighborhoods worldwide, and is therefore the epicenter of a situation so worrying that it is necessary to find a solution concerning the environmental pollution. The present exercise was developed, by means of proper product design methods like TRIZ and QFD driven by DFSS rulings, to conceive of new products and services in order to create incentive for the smokers to lessen the environmental pollution problem. The social implications are about the possibility of modifying the bad habits of the smokers and making the user act consciously towards the environment. Throwing the cigarette-stub in the new collection device, rather than on the ground, enables users to enjoy both moral and economic returns. The “Buttalo” service is aimed to incentivize the population to fight against environmental pollution whilst helping smokers to be conscious about it
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