Recorded displacements in a landslide slope due to regional and teleseismic earthquakes

Regional and teleseismic earthquakes can induce displacements along joints in a landslideinvolved rocky slope in Central Italy. The rarity of these effects is due to specific physical properties of the seismic signals associated with: (i) the energy content, (ii) the distribution of relative energy and peak of ground acceleration related to the ground motion components and (iii) the spectral amplitude distribution in the frequency domain; these properties allow the triggering earthquakes to be distinguished from the others. The observed effects are relevant when compared to the direction of the landslide movement and the dimensions of the involved rock mass volume. The landslide movement is less constrained in the direction parallel to the dip of the slope and the landslide dimensions are associated with characteristic periods that control the landslide deformational response in relation to the spectral content of the ground motion. The earthquake-induced displacements are significant because they have the same order of magnitude as the average annual cumulative displacement based on a decade of strain measurements within the slope

Seismic monitoring system for landslide hazard assessment and risk management at the drainage plant of the Peschiera Springs (Central Italy)

The assessment of landslide hazards and design of strategies for managing the related risk have been widely studied topics in the scientific community due to the settlements, infrastructures and tourist and cultural heritage sites that may be threatened by deformations involving unstable slopes. Engineering geological and geophysical techniques have been recently integrated in multidisciplinary approaches to study gravity-induced slope instabilities and monitor their evolution. The slope that hosts the Peschiera Springs drainage plant (Central Italy) is involved in a mass rock creep process associated with deep karst dissolution. Due to the importance of this infrastructure, which provides water to the Rome aqueduct, an accelerometric network was installed in 2008, and a nanoseismic array was added in 2014. In this paper, data recorded by the nanoseismic array were used to locate 397 microseismic events related to the slope instability process, distinguished into two types with different waveforms: 16 failures and 381 collapses. The failures were distributed throughout the slope, while the collapses exhibited two spatially separate clusters below the groundwater level, at a depth where karst processes produce cavities. The clusters were analysed as two distinct microseismic sources characterised by specific frequency-magnitude curves of events that describe their attitude to produce events of different magnitudes. Regarding the accelerometric network, an automated procedure was developed for quickly analysing the seismic records, which include signals from teleseisms and near- to far-field earthquakes that can induce deformation in the landslide-involved slope. The results obtained by the two seismic monitoring systems were integrated with the aim of implementing a landslide hazard matrix based on the statistical frequency of the occurrence of such events and their probability of exceedance during a reference period, providing a useful tool for managing the related landslide risk

A Prototype Fast Multiplicity Discriminator for ALICE L0 Trigger

The design details and test results of a prototype Multiplicity Discriminator (MD) for the ALICE L0 Trigger electronics are presented. The MD design is aimed at the earliest trigger decision founded on a fast multiplicity signal cut, in both options for the ALICE centrality detector: Micro Channel Plates or Cherenkov counters. The MD accepts detector signals with an amplitude range of plus-minus 2.5 V, base duration of 1.8 ns and rise time of 300-400 ps. The digitally controlled threshold settings give an accuracy better than 0.4% at the maximum amplitude of the accepted pulses. The MD internal latency of 15 ns allows for a decision every LHC bunch crossing period, even for the 40 MHz of p-p collisions

Analisis Sistem Antrean Pelayanan Di Kantor Pertanahan Kota Semarang

Kantor Pertanahan Kota Semarang in charge of the land with an area of 373.70 km2 coverage, every day crowded with visitors who want to take care of the land petition. However, the high number of applicants who must be served not proportional to the number of care facilities available to the applicant should enter the waiting list queue or experiencing situation. This situation occurs in almost all counters, namely Counter 1 Land Information, Counter 2 Registration, Counter 3 Payment, and Counter 4 Product Delivery. Therefore, the required analysis is based on the model line system in accordance with the conditions of service which can then be used to address the issue queue. Based on the analysis, the model system is the best line in counter 1 land information (M/M/1): (GD/∞/∞). Counter 2 registration which is divided into 7 sub-counters have a model (M/M/2): (GD/∞/∞) to sub counters 2A, 2B, 2C, 2E/F, 2G, 2H, and the model (M/M/4): (GD/∞/∞) to sub counter 2D. Counter 3 payment (M/M/2): (GD/∞/∞). Counter 4 is the product delivery (M/M/2): (GD/∞/∞)

Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin

Objectives: We speculated that in patients with hypercholesterolemia CD40L overexpression could depend on low-density lipoprotein (LDL)-induced enhanced intraplatelet formation of O-2(.-) and statin could reduce platelet CD40L via interference with platelet O-2(.-) production. Background: CD40L is a protein with inflammatory and thrombotic properties. CD40L is upregulated in platelets from hypercholesterolemic (HC) patients but the underlying mechanism is unclear. Methods: Collagen-induced platelet CD40L and platelet O-2(.-) expression were investigated in 40 HC patients and 40 healthy subjects. HC patients were then randomized to either a diet (n = 20) (group A) or atorvastatin 10 mg day (n = 20) (group B); the above variables were measured at baseline and after 3 and 30 days of treatment. O-2(.-) and CD40L were also measured in vitro in LDL-treated platelets with or without nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor or atorvastatin added. Results: Compared with controls, HC patients showed higher values of platelet CD40L (P < 0.001) and O-2(.-) (P < 0.001). Platelet CD40L was significantly correlated with O-2(.-) (P < 0.001). The interventional trial showed no changes in group A and a significant and parallel decrease in platelet CD40L (P < 0.001) and O-2(.-) (P < 0.001) in group B. In vitro studies demonstrated that LDL-induced platelet CD40L and GP IIb/IIIa (PAC1 binding) activation via the NADPH oxidase pathway. CD40L upregulation was counteracted by atorvastatin in a dose-dependent fashion. Conclusions: This study suggests that in patients with hypercholesterolemia platelet CD40L is upregulated via NADPH oxidase-dependent O-2(.-) generation. Atorvastatin downregulated CD40L with an oxidative stress-mediated mechanism likely involving platelet NADPH oxidase, an effect that seemed to be independent of its cholesterol-lowering action

Vitamin C inhibits platelet expression of CD40 ligand

Upon stimulation with agonists, platelets express CD40 ligand (CD40L), a transmembrane protein implicated in the initiation and progression of atherosclerotic disease. We have recently discovered that oxidative stress plays a major role in platelet CD40L expression. In this study, we sought to determine whether vitamin C, a known antioxidant, is able to influence platelet CD40L expression. In vitro experiments were done by stimulating platelets with collagen in the presence or absence of vitamin C (50-100 mu M) or vehicle as control. An in vivo study was done in 10 healthy subjects who were randomized to intravenous infusion of placebo or 1 g vitamin C for 45 min in a crossover design. At the end of infusion platelet CD40L and O2- were measured. The in vitro study demonstrated that vitamin C dose dependently inhibited platelet CD40L expression without affecting agonist-induced platelet aggregation. In subjects treated with placebo no changes of platelet CD40L and O2- were observed; conversely, vitamin C infusion caused a significant and parallel decrease of platelet O2- (-70%, P < 0.001) and CD40L (-68%, P < 0.001). Platelet aggregation was not modified by either treatment. This study suggests that water-soluble antioxidants, which scavenge superoxide radicals, may reduce platelet CD40L expression. (c) 2005 Elsevier Inc. All rights reserved

gp91phox-dependent expression of platelet CD40 ligand

Background-CD40 ligand (CD40L) expression on platelets is mediated by agonists, but the underlying mechanism is still unclear. Methods and Results-CD40L expression was measured in platelets from healthy subjects both with and without the addition of antioxidants or a phospholipase A2 (PLA2) inhibitor and in platelets from 2 patients with an inherited deficiency of gp91phox. Immunoprecipitation analysis was also performed to determine whether normal platelets showed gp91phox expression. Unlike catalase and mannitol, superoxide dismutase inhibited agonist-induced platelet CD40L expression in healthy subjects. Immunoprecipitation analysis also showed that platelets from healthy subjects expressed gp91phox. In 2 male patients with inherited gp91phox deficiency, collagen-, thrombin-, and arachidonic acid-stimulated platelets showed an almost complete absence of superoxide anion (O2-) and CD40L expression. Incubation of platelets from healthy subjects with a PLA2 inhibitor almost completely prevented agonist-induced O2- and CD40L expression. Conclusions-These data provide the first evidence that platelet CD40L expression occurs via arachidonic acid-mediated gp91phox activation

Engineering-geology model of the seismically-induced Cerda landslide

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A Rapid Procedure for the Simultaneous Determination of Eugenol, Linalool and Fatty Acid Composition in Basil Leaves

Eugenol and linalool are often the most abundant volatile compounds found in basil (Ocimum basilicum L., Lamiaceae) leaves, and they are interesting for the aroma they provide and for their numerous beneficial bioactivities. Their determination is thus needed for several purposes. In the present study, to avoid the previous isolation of essential oil, the direct solvent extraction is proposed coupled with a transmethylation to convert acyl lipids into fatty acids methyl esters (FAMEs), thus assessing the possible simultaneous analysis of eugenol and linalool with FAMEs by gas chromatography coupled to flame ionization detector (GC-FID). The method has been validated and applied to ten basil leaves samples in which eugenol and linalool were found in mean concentrations of 2.80 +/- 0.15 and 1.01 +/- 0.04 g kg(-1) (dry weight), respectively. FAMEs composition was dominated by linolenic acid (52.1-56.1%) followed by palmitic acid (19.3-22.4%) and linoleic acid (9.6-11.3%). The ratio of n6-polyunsaturated fatty acids (PUFAs)/n3-PUFAs was in the range of 0.17-0.20 in the investigated samples. The proposed method exploits a rapid procedure requiring 40 min, making use of a small amount of solvent and allowing the simultaneous determination of molecules contributing to assess the quality of this worldwide appreciated herb

Proteinuria in focal segmental glomerulosclerosis: role of circulating factors and therapeutic approach.

The clinical course of primary Focal Segmental Glomerulosclerosis (FSGS) is frequently complicated by nephrotic range proteinuria and progression to renal failure. The high recurrence rate of the disease in transplanted kidney suggests the hypothesis that such patients have a circulating factor that alters glomerular capillary permeability. In recent years some authors found that serum from patients with FSGS increases glomerular permeability to albumin and partially identified the permeability factor (PF) as a protein of 30-50 Kd m.w. The removal of this protein by means of Plasma Exchange (PE) or plasma Immunoadsorption by Protein A (IA) decreased proteinuria. In this report we provide preliminary data about the prevalence of PF and the therapeutic effect of its removal by IA, in 3 pts with recurrence in the transplanted kidney, and 4 with FSGS of the native kidneys. They were resistant to corticosteroids (CS) and immunosuppressive (IS) therapy. 10 IA sessions were performed in 4 weeks: if a remission was achieved IA was gradually tapered. The level of PF in the serum was measured by an in vitro assay to determine the glomerular permeability to albumin. The FSGS was histologically proven in all cases and the degree of evolution was evaluated. PF levels, serum creatinine, daily proteinuria and serum albumin were monitored. The 3 patients with recurrent FSGS had a normalization of the PF levels; 2 had a clinical remission. In FSGS of native kidneys PF was elevated in 3/4 cases; 1 had a clinical remission; 2 with extensive sclerohyalinosis and 1 without PF levels did not improve. Our results confirm that most patients with FSGS have high PF serum levels and suggest that its removal can be beneficial