lmmuno Histochemical Profile of Endometrium in Patients With Genital Endometriosis

The aim of present study was to investigate the occurence of different lymphocyte subsets in the endometrium of endometriosis patients and in healthy women on every day of the menstrual cycle with special emphasis to the proliferative activity of endometrial cells with Ki-S3 antibody. We also conducted immunohistochemical studies of T-lymphocytes, B-lympho-cytes, macrophages, natural-killer-cells and also of antigens class II of the histocompatibility complex (HLA-DR) during the different phases of the menstrual cycle in endometriosis and non-endometriosis patients

Subgeneric classification of the bee genus Rediviva Friese (Hymenoptera: Apiformes: Melittidae)

peer reviewe

Precision measurement of the E2E2 transition strength to the 21+^+_1 state of 12^{12}C

The form factor of the electromagnetic excitation of $^{12}$C to its 2$^+_1$ state was measured at extremely low momentum transfers in an electron scattering experiment at the S-DALINAC. A combined analysis with the world form factor data results in a reduced transition strength $B(E2; 2^+_1\rightarrow 0^+_1) =7.63(19)$ e$^2$fm$^4$ with an accuracy improved to 2.5\%. In-Medium-No Core Shell Model results with interactions derived from chiral effective field theory are capable to reproduce the result. A quadrupole moment $Q(2^+_1) = 5.97(30)$ efm$^2$ can be extracted from the strict correlation with the $B((E2)$ strength emerging in the calculations.Comment: 6 pages, 6 figures, submitted to Phys. Rev.

A Fast Algorithm Finding the Shortest Reset Words

In this paper we present a new fast algorithm finding minimal reset words for finite synchronizing automata. The problem is know to be computationally hard, and our algorithm is exponential. Yet, it is faster than the algorithms used so far and it works well in practice. The main idea is to use a bidirectional BFS and radix (Patricia) tries to store and compare resulted subsets. We give both theoretical and practical arguments showing that the branching factor is reduced efficiently. As a practical test we perform an experimental study of the length of the shortest reset word for random automata with $n$ states and 2 input letters. We follow Skvorsov and Tipikin, who have performed such a study using a SAT solver and considering automata up to $n=100$ states. With our algorithm we are able to consider much larger sample of automata with up to $n=300$ states. In particular, we obtain a new more precise estimation of the expected length of the shortest reset word $\approx 2.5\sqrt{n-5}$.Comment: COCOON 2013. The final publication is available at http://link.springer.com/chapter/10.1007%2F978-3-642-38768-5_1

Gastrointestinal Tract As Entry Route for Hantavirus Infection

Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice. As model for intestinal virus translocation we performed infection experiments with human intestinal Caco-2 monolayers. In animal experiments we infected Syrian hamsters with PUUV via the intragastric route and tested seroconversion and protective immunity against subsequent Andes virus challenge. Results: PUUV retained infectivity in gastric juice at pH >3. The virus invaded Caco-2 monolayers in association with endosomal antigen EEA1, followed by virus replication and loss of epithelial barrier function with basolateral virus occurrence. Cellular disturbance and depletion of the tight junction protein ZO-1 appeared after prolonged infection, leading to paracellular leakage (leak flux diarrhea). Moreover, animal experiments led to dose-dependent seroconversion and protection against lethal Andes virus challenge. Conclusions: We provide evidence that hantavirus can infect the organism via the alimentary tract and suggest a novel aspect of hantavirus infection and pathogenesis. Significance: Hantaviruses are zoonotic pathogens causing severe hemorrhagic fevers worldwide. They are transmitted to humans by small mammals. To date, these viruses were thought to infect exclusively through the airborne route by inhalation of aerosols from infectious animal droppings or by rodent bites. In our work we could show that the alimentary tract is an alternative path of infection for hantaviruses, meaning a new association of virus and disease. These findings have impact on current textbook knowledge and bring many implications for hantavirus epidemiology and outbreak prevention measures

Site-Directed Insertion: Decision Problems, Maximality and Minimality

Site-directed insertion is an overlapping insertion operation that can be viewed as analogous to the overlap assembly or chop operations that concatenate strings by overlapping a suffix and a prefix of the argument strings. We consider decision problems and language equations involving site-directed insertion. By relying on the tools provided by semantic shuffle on trajectories we show that one variable equations involving site-directed insertion and regular constants can be solved. We consider also maximal and minimal variants of the site-directed insertion operation

Algebraic synchronization criterion and computing reset words

We refine a uniform algebraic approach for deriving upper bounds on reset thresholds of synchronizing automata. We express the condition that an automaton is synchronizing in terms of linear algebra, and obtain upper bounds for the reset thresholds of automata with a short word of a small rank. The results are applied to make several improvements in the area. We improve the best general upper bound for reset thresholds of finite prefix codes (Huffman codes): we show that an $n$-state synchronizing decoder has a reset word of length at most $O(n \log^3 n)$. In addition to that, we prove that the expected reset threshold of a uniformly random synchronizing binary $n$-state decoder is at most $O(n \log n)$. We also show that for any non-unary alphabet there exist decoders whose reset threshold is in $\varTheta(n)$. We prove the \v{C}ern\'{y} conjecture for $n$-state automata with a letter of rank at most $\sqrt[3]{6n-6}$. In another corollary, based on the recent results of Nicaud, we show that the probability that the \v{C}ern\'y conjecture does not hold for a random synchronizing binary automaton is exponentially small in terms of the number of states, and also that the expected value of the reset threshold of an $n$-state random synchronizing binary automaton is at most $n^{3/2+o(1)}$. Moreover, reset words of lengths within all of our bounds are computable in polynomial time. We present suitable algorithms for this task for various classes of automata, such as (quasi-)one-cluster and (quasi-)Eulerian automata, for which our results can be applied.Comment: 18 pages, 2 figure

Growth of nanowire arrays from micron-feature templates

Here, we present a two-step annealing procedure to imprint nanofeatures on SiO2 starting from metallic microfeatures. The first annealing transforms the microfeatures into gold nanoparticles and the second imprints these nanoparticles into the SiO2 layer with nanometric control. The resulting nanohole arrays show a high ensemble uniformity. As a potential application, the nanohole mask is used as a selective mask for the Ga self-assisted growth of GaAs nanowires (NWs). Thus, for the first time, a successful implementation of nano-self-imprinting that links high-throughput microlithography with bottom-up NW growth is shown. The beneficial hole morphology of the SiO2 mask promotes high Ga droplet contact angles with the silicon substrate and the formation of single droplets in the mask holes. This droplet predeposition configuration enables a high vertical yield of NWs. Thus, this article describes a new protocol to grow NW devices that combines simultaneously nanosized holes and parallel processing

Multi-orbital and density-induced tunneling of bosons in optical lattices

We show that multi-orbital and density-induced tunneling have a significant impact on the phase diagram of bosonic atoms in optical lattices. Off-site interactions lead to density-induced hopping, the so-called bond-charge interactions, which can be identified with an effective tunneling potential and can reach the same order of magnitude as conventional tunneling. In addition, interaction-induced higher-band processes also give rise to strongly modified tunneling, on-site and bond-charge interactions. We derive an extended occupation-dependent Hubbard model with multi-orbitally renormalized processes and compute the corresponding phase diagram. It substantially deviates from the single-band Bose-Hubbard model and predicts strong changes of the superfluid to Mott-insulator transition. In general, the presented beyond-Hubbard physics plays an essential role in bosonic lattice systems and has an observable influence on experiments with tunable interactions.Comment: 21 pages, 7 figure

Home-based voluntary HIV counselling and testing found highly acceptable and to reduce inequalities

<p>Abstract</p> <p>Background</p> <p>Low uptake of voluntary HIV counselling and testing (VCT) in sub-Saharan Africa is raising acceptability concerns which might be associated with ways by which it is offered. We investigated the acceptability of home-based delivery of counselling and HIV testing in urban and rural populations in Zambia where VCT has been offered mostly from local clinics.</p> <p>Methods</p> <p>A population-based HIV survey was conducted in selected communities in 2003 (n = 5035). All participants stating willingness to be HIV tested were offered VCT at home and all counselling was conducted in the participants' homes. In the urban area post-test counselling and giving of results were done the following day whereas in rural areas this could take 1-3 weeks.</p> <p>Results</p> <p>Of those who indicated willingness to be HIV tested, 76.1% (95%CI 74.9-77.2) were counselled and received the test result. Overall, there was an increase in the proportion ever HIV tested from 18% before provision of home-based VCT to 38% after. The highest increase was in rural areas; among young rural men aged 15-24 years up from 14% to 42% vs. for urban men from 17% to 37%. Test rates by educational attainment changed from being positively associated to be evenly distributed after home-based VCT.</p> <p>Conclusions</p> <p>A high uptake was achieved by delivering HIV counselling and testing at home. The highest uptakes were seen in rural areas, in young people and groups with low educational attainment, resulting in substantial reductions in existing inequalities in accessing VCT services.</p