Quality-weld parameters for microwelding techniques and equipment

Limited-amplitude, controlled-decay process improves the reliability of microwelding. The system consists in building a capacitor-discharge welder for control of the shape of the weld pulse. Standard welders may be modified

Morphine activates neuroinflammation in a manner parallel to endotoxin

Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors. We demonstrate that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation. Small-molecule inhibitors, RNA interference, and genetic knockout validate the TLR4/MD-2 complex as a feasible target for beneficially modifying morphine actions. Disrupting TLR4/MD-2 protein–protein association potentiated morphine analgesia in vivo and abolished morphine-induced proinflammation in vitro, the latter demonstrating that morphine-induced proinflammation only depends on TLR4, despite the presence of opioid receptors. These results provide an exciting, nonconventional avenue to improving the clinical efficacy of opioids.Xiaohui Wang, Lisa C. Loram, Khara Ramos, Armando J. de Jesus, Jacob Thomas, Kui Cheng, Anireddy Reddy, Andrew A. Somogyi, Mark R. Hutchinson, Linda R. Watkins and Hang Yi

Quality weld parameters for microwelding techniques and equipment Final report

Amplitude controlled welding process for electronic circuit module

Collisional Effects on Nonlinear Ion Drag Force for Small Grains

The ion drag force arising from plasma flow past an embedded spherical grain is calculated self-consistently and non-linearly using particle in cell codes, accounting for ion-neutral collisions. Using ion velocity distribution appropriate for ion drift driven by a force field gives wake potential and force greatly different from a shifted Maxwellian distribution, regardless of collisionality. The low-collisionality forces are shown to be consistent with estimates based upon cross-sections for scattering in a Yukawa (shielded) grain field, but only if non-linear shielding length is used. Finite collisionality initially enhances the drag force, but only by up to a factor of 2. Larger collisionality eventually reduces the drag force. In the collisional regime, the drift distribution gives larger drag than the shift distribution even at velocities where their collisionless drags are equal. Comprehensive practical analytic formulas for force that fit the calculations are provided.Comment: Fig 1. corrected in this versio

RSRM-11 (36OW011) ballistics mass properties (STS-35)

The propulsion performance and reconstructed mass properties data from Thiolol's RSRM-11 motors which were assigned to the STS-35 launch are contained. The Thiokol manufacturing designations for the motors were 360W011A/360W011B, which are referred to as RSRM-11A and RSRM-B, respectively. The launch of STS-35 occurred on 2 December 1990 at the Eastern Test Range (ETR). The data contained herein was input to the STS-35 Flight Evaluation Report. The SRM propellant, TP-H1148, is a composite type solid propellants, formulated of polybutediene acrylic acid, acryonitrile terpolymer binder, epoxy curing agent, ammonium perchlorate oxidizer, and aluminum powder fuel. A small amount of burning rate catalyst (iron oxide) was added to achieve the desired propellant burn rate. The propellant evaluation and raw material information for the RSRM-11 are included. The ballistic performance presented was based on the Operational Flight Instrumentation (OFI) 12.5 sample per second pressure data for the steady state and tail off portion of the pressure trace. Recent studies have shown that the transducers are affected by the measuring system at KSC and temperature gradients created by the igniter heaters. Therefore, an adjustment to the data from each transducer is made to make the initial reading match the atmospheric pressure at the time of launch

Preface: Anne Jordan—Robbie Case Memorial Award Winner

Anne Jordan: Robbie Case Memorial Award Winne

Closet Case : \u3cem\u3eBoy Scouts of America v. Dale\u3c/em\u3e and the Reinforcement of Gay, Lesbian, Bisexual, and Transgender Invisibility

This Article argues that the Supreme Courts decision in Boy Scouts of America v. Dale misapplies and ignores controlling First Amendment precedent and incorrectly dermes sexual identity as a clinical or biological imposition that exists apart from expression or speech. This Article provides a doctrinal alternative to Dale that would protect vital interests in both equality and liberty and that would not condition, as does Dale, sexual equality upon the silencing of gay, lesbian, bisexual, and transgender individuals

Supporting At-Risk Learners: Introduction

[No abstract

Not without Political Power: Gays and Lesbians, Equal Protection and the Suspect Class Doctrine

The Supreme Court purportedly utilizes the suspect class doctrine in order to balance institutional concerns with the protection of important constitutional rights. The Court, however, inconsistently applies this doctrine, and it has not precisely defined its contours. The political powerlessness factor is especially undertheorized and contradictorily applied. Nevertheless, this factor has become salient in recent equal protection cases brought by gay and lesbian plaintiffs. A growing body of and federal and state-court precedent addresses the flaws of the Court\u27s suspect class doctrine. This Article discusses the inadequacies of the suspect class doctrine and highlights problems within the emerging scholarship and precedent that criticizes the Supreme Court\u27s errors. This Article offers two alternatives approaches that could inform a new theory of equal protection for all subordinate classes