Monitoring ethnic minorities in the Netherlands

Item does not contain fulltextThe article first summarises the history of ethnic minority policy in the Netherlands and the development of the ‘ethnic minority’ and ‘allochthonous’ categories, which are peculiar in comparative perspective in emphasising socio-economic disadvantage as a constitutive dimension of minority status and in setting the minority question within the broader Dutch political principle of ‘pillarisation’. The article then examines the use of statistics in public policy, in a context where the national census has been discontinued since 1971, focusing more specifically on the case of education, where major statistical efforts have been devoted to identifying patterns of disadvantage and integration. Finally, the article briefly examines current debates on the situation of ethnic minorities in the Netherlands in the context of growing questioning of established Dutch models of minority policy.13 p

Dynamical Organization around Turbulent Bursts

The detailed dynamics around intermittency bursts is investigated in turbulent shell models. We observe that the amplitude of the high wave number velocity modes vanishes before each burst, meaning that the fixed point in zero and not the Kolmogorov fixed point determines the intermittency. The phases of the field organize during the burst, and after a burst the field oscillates back to the laminar level. We explain this behavior from the variations in the values of the dissipation and the advection around the zero fixed point.Comment: 4 pages, REVTex, 3 figures in one ps-fil

Exact Resummations in the Theory of Hydrodynamic Turbulence: III. Scenarios for Anomalous Scaling and Intermittency

Elements of the analytic structure of anomalous scaling and intermittency in fully developed hydrodynamic turbulence are described. We focus here on the structure functions of velocity differences that satisfy inertial range scaling laws $S_n(R)\sim R^{\zeta_n}$, and the correlation of energy dissipation $K_{\epsilon\epsilon}(R) \sim R^{-\mu}$. The goal is to understand the exponents $\zeta_n$ and $\mu$ from first principles. In paper II of this series it was shown that the existence of an ultraviolet scale (the dissipation scale $\eta$) is associated with a spectrum of anomalous exponents that characterize the ultraviolet divergences of correlations of gradient fields. The leading scaling exponent in this family was denoted $\Delta$. The exact resummation of ladder diagrams resulted in the calculation of $\Delta$ which satisfies the scaling relation $\Delta=2-\zeta_2$. In this paper we continue our analysis and show that nonperturbative effects may introduce multiscaling (i.e. $\zeta_n$ not being linear in $n$) with the renormalization scale being the infrared outer scale of turbulence $L$. It is shown that deviations from K41 scaling of $S_n(R)$ ($\zeta_n\neq n/3$) must appear if the correlation of dissipation is mixing (i.e. $\mu>0$). We derive an exact scaling relation $\mu = 2\zeta_2-\zeta_4$. We present analytic expressions for $\zeta_n$ for all $n$ and discuss their relation to experimental data. One surprising prediction is that the time decay constant $\tau_n(R)\propto R^{z_n}$ of $S_n(R)$ scales independently of $n$: the dynamic scaling exponent $z_n$ is the same for all $n$-order quantities, $z_n=\zeta_2$.Comment: PRE submitted, 22 pages + 11 figures, REVTeX. The Eps files of figures will be FTPed by request to [email protected]

Inertial- and Dissipation-Range Asymptotics in Fluid Turbulence

We propose and verify a wave-vector-space version of generalized extended self similarity and broaden its applicability to uncover intriguing, universal scaling in the far dissipation range by computing high-order (\leq 20\/) structure functions numerically for: (1) the three-dimensional, incompressible Navier Stokes equation (with and without hyperviscosity); and (2) the GOY shell model for turbulence. Also, in case (2), with Taylor-microscale Reynolds numbers 4 \times 10^{4} \leq Re_{\lambda} \leq 3 \times 10^{6}\/, we find that the inertial-range exponents (\zeta_{p}\/) of the order - p\/ structure functions do not approach their Kolmogorov value p/3\/ as Re_{\lambda}\/ increases.Comment: RevTeX file, with six postscript figures. epsf.tex macro is used for figure insertion. Packaged using the 'uufiles' utilit

Statistics of Dissipation and Enstrophy Induced by a Set of Burgers Vortices

Dissipation and enstropy statistics are calculated for an ensemble of modified Burgers vortices in equilibrium under uniform straining. Different best-fit, finite-range scaling exponents are found for locally-averaged dissipation and enstrophy, in agreement with existing numerical simulations and experiments. However, the ratios of dissipation and enstropy moments supported by axisymmetric vortices of any profile are finite. Therefore the asymptotic scaling exponents for dissipation and enstrophy induced by such vortices are equal in the limit of infinite Reynolds number.Comment: Revtex (4 pages) with 4 postscript figures included via psfi

Blueprints for Medieval hydroclimate

According to tree ring and other records, a series of severe droughts that lasted for decades afflicted western North America during the Medieval period resulting in a more arid climate than in subsequent centuries. A review of proxy evidence from around the world indicates that North American megadroughts were part of a global pattern of Medieval hydroclimate that was distinct from that of today. In particular, the Medieval hydroclimate was wet in northern South America, dry in mid-latitude South America, dry in eastern Africa but with strong Nile River floods and a strong Indian monsoon. This pattern is similar to that accompanying persistent North American droughts in the instrumental era. This pattern is compared to that associated with familiar climate phenomena. The best fit comes from a persistently La Nin ̃ a-like tropical Pacific and the warm phase of the so-called Atlantic Multidecadal Oscillation. A positive North Atlantic Oscillation (NAO) also helps to explain the Medieval hydroclimate pattern. Limited sea surface temperature reconstructions support the contention that the tropical Pacific was cold and the subtropical North Atlantic was warm, ideal conditions for North American drought. Tentative modeling results indicate that a multi-century La Nina-like state could have arisen as a coupled atmosphere–ocean response to high irradiance and weak volcanism during the Medieval period and that this could in turn have induced a persistently positive NAO state. A La Nina-like state could also induce a strengthening of the North Atlantic meridional overturning circulation, and hence warming of the North Atlantic Ocean, by (i) the ocean response to the positive NAO and by shifting the southern mid-latitude westerlies poleward which (ii) will increase the salt flux from the Indian Ocean into the South Atlantic and (iii) drive stronger Southern Ocean upwelling

California Current System response to late Holocene climate cooling in southern California

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95512/1/grl24588.pd

Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice

RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be fully characterized. A molecular and phenotypic comparison of a genetic knockout mouse and the corresponding knockdown version would help clarify the utility of the RNAi approach. Here, we used hydrodynamic delivery of small interfering RNA (siRNA) to knockdown peroxisome proliferator activated receptor alpha (Ppara), a gene that is central to the regulation of fatty acid metabolism. We found that Ppara knockdown in the liver results in a transcript profile and metabolic phenotype that is comparable to those of Ppara(−/−) mice. Combining the profiles from mice treated with the PPARα agonist fenofibrate, we confirmed the specificity of the RNAi response and identified candidate genes proximal to PPARα regulation. Ppara knockdown animals developed hypoglycemia and hypertriglyceridemia, phenotypes observed in Ppara(−/−) mice. In contrast to Ppara(−/−) mice, fasting was not required to uncover these phenotypes. Together, these data validate the utility of the RNAi approach and suggest that siRNA can be used as a complement to classical knockout technology in gene function studies

PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in causing a phenotypic response. Genome-wide RNA interference (RNAi) phenotypic screening has emerged as an effective tool in unveiling the genes essential for specific cellular functions and biological activities. However, eliciting the relative contribution of and sufficiency relationships among the genes identified remains challenging. In the rodent, the most widely used animal model in preclinical studies, it is unrealistic to exhaustively examine all potential interactions by RNAi screening. Application of existing computational approaches to infer regulatory networks with biological outcomes in the rodent is limited by the requirements for a large number of targeted permutations. Therefore, we developed a two-step relay method that requires only one targeted perturbation for genome-wide de novo pathway discovery. Using expression profiles in response to small interfering RNAs (siRNAs) against the gene for peroxisome proliferator-activated receptor α (Ppara), our method unveiled the potential causal sufficiency order network for liver hypertrophy in the rodent. The validity of the inferred 16 causal transcripts or 15 known genes for PPARα-induced liver hypertrophy is supported by their ability to predict non-PPARα–induced liver hypertrophy with 84% sensitivity and 76% specificity. Simulation shows that the probability of achieving such predictive accuracy without the inferred causal relationship is exceedingly small (p < 0.005). Five of the most sufficient causal genes have been previously disrupted in mouse models; the resulting phenotypic changes in the liver support the inferred causal roles in liver hypertrophy. Our results demonstrate the feasibility of defining pathways mediating drug-induced toxicity from siRNA-treated expression profiles. When combined with phenotypic evaluation, our approach should help to unleash the full potential of siRNAs in systematically unveiling the molecular mechanism of biological events

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis

Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human papillomavirus on HPV infections, anogenital wart diagnoses, and cervical intraepithelial neoplasia grade 2+ (CIN2+)to summarise the most recent evidence about the effectiveness of HPV vaccines in real-world settings and to quantify the impact of multiple age-cohort vaccination.Methods In this updated systematic review and meta-analysis, we used the same search strategy as in our previous paper. We searched MEDLINE and Embase for studies published between Feb 1, 2014, and Oct 11, 2018. Studies were eligible if they compared the frequency (prevalence or incidence) of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed CIN2+) between pre-vaccination and post-vaccination periods among the general population and if they used the same population sources and recruitment methods before and after vaccination. Our primary assessment was the relative risk (RR) comparing the frequency (prevalence or incidence) of HPV-related endpoints between the pre-vaccination and post-vaccination periods. We stratified all analyses by sex, age, and years since introduction of HPV vaccination. We used random-effects models to estimate pooled relative risks.Findings We identified 1702 potentially eligible articles for this systematic review and meta-analysis, and included 65 articles in 14 high-income countries: 23 for HPV infection, 29 for anogenital warts, and 13 for CIN2+.After 5\u20138 years of vaccination, the prevalence of HPV 16 and 18 decreased significantly by 83% (RR 0\ub717, 95% CI 0\ub711\u20130\ub725) among girls aged 13\u201319 years, and decreased significantly by 66% (RR 0\ub734, 95% CI 0\ub723\u20130\ub749) among women aged 20\u201324 years. The prevalence of HPV 31, 33, and 45 decreased significantly by 54% (RR 0\ub746, 95% CI 0\ub733\u20130\ub766) among girls aged 13\u201319 years. Anogenital wart diagnoses decreased significantly by 67% (RR 0\ub733, 95% CI 0\ub724\u20130\ub746) among girls aged 15\u201319 years, decreased significantly by 54% (RR 0\ub746, 95% CI 0.36\u20130.60) among women aged 20\u201324 years, and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub753\u20130\ub789) among women aged 25\u201329 years. Among boys aged 15\u201319 years anogenital wart diagnoses decreased significantly by 48% (RR 0\ub752, 95% CI 0\ub737\u20130\ub775) and among men aged 20\u201324 years they decreased significantly by 32% (RR 0\ub768, 95% CI 0\ub747\u20130\ub798). After 5\u20139 years of vaccination, CIN2+ decreased significantly by 51% (RR 0\ub749, 95% CI 0\ub742\u20130\ub758) among screened girls aged 15\u201319 years and decreased significantly by 31% (RR 0\ub769, 95% CI 0\ub757\u20130\ub784) among women aged 20\u201324 years.Interpretation This updated systematic review and meta-analysis includes data from 60 million individuals and up to 8 years of post-vaccination follow-up. Our results show compelling evidence of the substantial impact of HPV vaccination programmes on HPV infections and CIN2+ among girls and women, and on anogenital warts diagnoses among girls, women, boys, and men. Additionally, programmes with multi-cohort vaccination and high vaccination coverage had a greater direct impact and herd effects