Critical behavior of the compact 3d U(1) theory in the limit of zero spatial coupling

Critical properties of the compact three-dimensional U(1) lattice gauge theory are explored at finite temperatures on an asymmetric lattice. For vanishing value of the spatial gauge coupling one obtains an effective two-dimensional spin model which describes the interaction between Polyakov loops. We study numerically the effective spin model for N_t=1,4,8 on lattices with spatial extension ranging from L=64 to L=256. Our results indicate that the finite-temperature U(1) lattice gauge theory belongs to the universality class of the two-dimensional XY model, thus supporting the Svetitsky-Yaffe conjecture.Comment: 17 pages, 5 figures; two references added, a few comments included, title changed; version to appear on J. Stat. Mec

The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study

Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system. Unfortunately, patients affected by this disease have a very poor prognosis, due to high level of invasiveness and resistance to standard therapies. Although the molecular profile of GBM has been extensively investigated, the events responsible for its pathogenesis and progression remain largely unknown. Histone Deacetylases (HDAC) dependent epigenetic modifications and transforming growth factor (TGF)-β/Smad pathway seem to play an important role in GBM tumorigenesis, resistance to common therapies and poor clinical outcome. The aim of this study was to evaluate the involvement and the possible interaction between these two molecular cascades in the pathogenesis and prognosis of GBM. Immunohistochemistry (IHC) was performed on microdissected GBM samples, collected from 14 patients (6 men and 8 women) ranging in age from 43 to 74 years. The patients were previously divided, on the basis of their overall survival (OS), into two groups: short and long OS. Patients with poor prognosis showed hyperexpression of HDAC4 and HDAC6, an activation of the TGF-β/Smad pathway, with high levels of IL-13, Smad2, PDGF and MMP3 expression, compared to the long survivors. The short OS group exhibits a decrease in Smad 7 expression and also low levels of p21 immunostaining, which represents a common target of the two pathways. The IHC data was confirmed by quantitative analysis and Immunoblotting. Our preliminary results suggest that both HDAC4 and HDAC6 together with the TGF-β/Smad pathway may be involved in progression of GBM and this cross talking could be a useful prognostic marker in this deadly disease

An agent-based signal processing in-node environment for real-time human activity monitoring based on wireless body sensor networks

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Critical behavior of the compact 3d U(1) gauge theory on isotropic lattices

We report on the computation of the critical point of the deconfinement phase transition, critical indices and the string tension in the compact three dimensional U(1) lattice gauge theory at finite temperatures. The critical indices govern the behavior across the deconfinement phase transition in the pure gauge U(1) model and are generally expected to coincide with the critical indices of the two-dimensional XY model. We studied numerically the U(1) model for N_t=8 on lattices with spatial extension ranging from L=32 to L=256. Our determination of the infinite volume critical point on the lattice with N_t=8 differs substantially from the pseudo-critical coupling at L=32, found earlier in the literature and implicitly assumed as the onset value of the deconfined phase. The critical index $\nu$ computed from the scaling of the pseudo-critical couplings with the extension of the spatial lattice agrees well with the XY value $\nu$=1/2. On the other hand, the index $\eta$ shows large deviation from the expected universal value. The possible reasons of such behavior are discussed in details.Comment: 15 pages, 7 figures; version accepted for publication on J. Stat. Mech

Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program

OBJECTIVE: Endothelial dysfunction (ED) predisposes to venous thrombosis (VT) and post-thrombotic syndrome (PTS), a long-term VT-related complication. Sulodexide (SDX) is a highly purified glycosaminoglycan with antithrombotic, pro-fibrinolytic and anti-inflammatory activity used in the treatment of chronic venous disease (CVD), including patients with PTS. SDX has recently obtained clinical evidence in the “extension therapy” after initial-standard anticoagulant treatment for the secondary prevention of recurrent deep vein thrombosis (DVT). Herein, we investigated how SDX counteracts ED. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVEC) were used. Metabolic and non metabolic-induced ED was induced by treating with methylglyoxal (MGO) or irradiation (IR), respectively. Bafilomycin A1 was used to inhibit autophagy. The production of reactive oxygen species (ROS), tetrazolium bromide (MTT) assay for cell viability, terminal de-oxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for cell apoptosis, Real-time PCR and Western blot analysis for gene and protein expression were used. RESULTS: SDX protected HUVEC from MGO- or IR-induced apoptosis by counteracting the activation of the intrinsic and extrinsic caspase cascades. The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFα, IL1, IL6, IL8), c) DNA damage induced by MGO or IR. These effects were reduced when autophagy was inhibited. CONCLUSIONS: Data herein collected indicate the ability of SDX to counteract ED induced by metabolic or non-metabolic stresses by involving the intracellular autophagy pathway. Our experience significantly increases the knowledge of the mechanisms of action of SDX against ED and supports the use of SDX in the treatment of CVD, PTS and in the secondary prevention of recurrent DVT

LONG-TERM TEMPERATURE MONITORING OF VOLCANIC AREAS BY DISTRIBUTED OPTICAL FIBER SENSORS

We present the first results of long- term monitoring of temperature profiles at the Campi Flegrei caldera. The measurements were carried out along a 76 meters-deep borehole already equipped with a borehole strain-meter. We installed a cable containing a loop of optical fiber in order to use a fiber-optics distributed sensor based on stimulated Brillouin scattering. The obtained data are consistent with results of both deep and surface geothermal explorations and indicate that geothermal gradient can be efficiently measured and monitored by the proposed technique

Mecanismos de transferência de massa na desidratação osmótica de goiaba em soluções de sacarose, sucralose e açúcar invertido.

O objetivo deste trabalho foi avaliar o efeito da concentração de soluções de sacarose, sucralose e açúcar invertido sobre a cinética da desidratação osmótica de pedaços de goiaba. Frações de 1/12 do fruto foram imersas em soluções de sacarose a 0,5 e 0,4 g mL-1, de sacarose a 0,3 g mL-1 + sucralose a 0,2 g L-1 e em xarope de açúcar invertido, a 50 ºC, por 2 h, sob agitação de 60 min. A solução de açúcar invertido promoveu maior perda de água e redução de massa nas amostras de goiaba submetidas à desidratação osmótica. O melhor desempenho foi obtido para o tratamento em solução de sacarose a 0,4 g mL-1, com perda de água e redução de massa semelhantes aos valores obtidos na imersão em solução de sacarose a 0,5 g mL-1 e ganho de sólidos similar ao observado em solução de sacarose a 0,3 g mL-1