1,014 research outputs found
Finite Size Scaling Analysis of Biased Diffusion on Fractals
Diffusion on a T fractal lattice under the influence of topological biasing
fields is studied by finite size scaling methods. This allows to avoid
proliferation and singularities which would arise in a renormalization group
approach on infinite system as a consequence of logarithmic diffusion. Within
the scheme, logarithmic diffusion is proved on the basis of an analysis of
various temporal scales such as first passage time moments and survival
probability characteristic time. This confirms and puts on firmer basis
previous renormalization group results. A careful study of the asymptotic
occupation probabilities of different kinds of lattice points allows to
elucidate the mechanism of trapping into dangling ends, which is responsible
of the logarithmic time dependence of average displacement.Comment: 17 pages TeX, 3 Postscript figure
The Effect Of Msh On Thymidine Incorporation By Keratinocytes In The Epidermal Melanin Unit
Epidermal melanocytes were observed in the black but not in the white skin of black-and-white spotted guinea pigs. In experiments designed to determine whether melanocyte-stimulating hormone (MSH) affects the incorporation of thymidine by keratinocyte nuclei of the epidermal melanin unit, the labeling index was the same in all skin before MSH administration. After MSH injections, the level of [3H]thymidine incorporation in keratinocytes increased significantly in black skin but not in white. We suggest that through the mediation of melanocytes MSH indirectly affects keratinocytes in the epidermal melanin unit
Effect of Polydispersity and Anisotropy in Colloidal and Protein Solutions: an Integral Equation Approach
Application of integral equation theory to complex fluids is reviewed, with
particular emphasis to the effects of polydispersity and anisotropy on their
structural and thermodynamic properties. Both analytical and numerical
solutions of integral equations are discussed within the context of a set of
minimal potential models that have been widely used in the literature. While
other popular theoretical tools, such as numerical simulations and density
functional theory, are superior for quantitative and accurate predictions, we
argue that integral equation theory still provides, as in simple fluids, an
invaluable technique that is able to capture the main essential features of a
complex system, at a much lower computational cost. In addition, it can provide
a detailed description of the angular dependence in arbitrary frame, unlike
numerical simulations where this information is frequently hampered by
insufficient statistics. Applications to colloidal mixtures, globular proteins
and patchy colloids are discussed, within a unified framework.Comment: 17 pages, 7 figures, to appear in Interdiscip. Sci. Comput. Life Sci.
(2011), special issue dedicated to Prof. Lesser Blu
Can Polarity-Inverted Surfactants Self-Assemble in Nonpolar Solvents
We investigate the self-assembly process of a surfactant with inverted
polarity in water and cyclohexane using both all-atom and coarse grained hybrid
particle-field molecular dynamics simulations. Unlike conventional surfactants,
the molecule under study, proposed in a recent experiment, is formed by a rigid
and compact hydrophobic adamantane moiety, and a long and floppy triethylene
glycol tail. In water, we report the formation of stable inverted micelles with
the adamantane heads grouping together into a hydrophobic core, and the tails
forming hydrogen bonds with water. By contrast, microsecond simulations do not
provide evidence of stable micelle formation in cyclohexane. Validating the
computational results by comparison with experimental diffusion constant and
small-angle X-ray scattering intensity, we show that at laboratory
thermodynamic conditions the mixture resides in the supercritical region of the
phase diagram, where aggregated and free surfactant states co-exist in
solution. Our simulations also provide indications about how to escape this
region, to produce thermodynamically stable micellar aggregates.Comment: 14 pages, 10 Figures, accepted for publication (2020
Self-assembly mechanism in colloids: perspectives from Statistical Physics
Motivated by recent experimental findings in chemical synthesis of colloidal
particles, we draw an analogy between self-assembly processes occurring in
biological systems (e.g. protein folding) and a new exciting possibility in the
field of material science. We consider a self-assembly process whose elementary
building blocks are decorated patchy colloids of various types, that
spontaneously drive the system toward a unique and predetermined targeted
macroscopic structure.
To this aim, we discuss a simple theoretical model -- the Kern-Frenkel model
-- describing a fluid of colloidal spherical particles with a pre-defined
number and distribution of solvophobic and solvophilic regions on their
surface. The solvophobic and solvophilic regions are described via a
short-range square-well and a hard-sphere potentials, respectively.
Integral equation and perturbation theories are presented to discuss
structural and thermodynamical properties, with particular emphasis on the
computation of the fluid-fluid (or gas-liquid) transition in the
temperature-density plane.
The model allows the description of both one and two attractive caps, as a
function of the fraction of covered attractive surface, thus interpolating
between a square-well and a hard-sphere fluid, upon changing the coverage.
By comparison with Monte Carlo simulations, we assess the pros and the cons
of both integral equation and perturbation theories in the present context of
patchy colloids, where the computational effort for numerical simulations is
rather demanding.Comment: 14 pages, 7 figures, Special issue for the SigmaPhi2011 conferenc
LTE transmission exploiting pulse width modulation in fibre optic links
Recently it has been demonstrated that pulse width modulation (PWM) can represent a viable solution for the analog optical fronthaul alternative to standard radio over fibre, which still avoids the bandwidth expansion of the digital fronthaul. The PWM encodes the analog samples at the transmitter onto the duration of the on/off keyed optical signal, splitting the sampling and quantization of the radio signal between remote radio units (RRUs) and baseband units (BBUs). In particular in this contribution we demonstrate the capabilities of optical PWM for the transport of LTE signals to support the centralized access network (C-RAN) fronthaul in fibre optic link up to 10-km of standard single mode fibre. The generation and analysis of the radio signals is provided by software modules compliant with the LTE standard which allowed to analyse performance results for the different LTE carriers, channels and services. The PWM optical signal connecting RRUs to BBUs is generated by either directly modulating a DFB laser or an externally seeded reflective semiconductor optical amplifier (RSOA). Both devices could be exploited inside a wavelength division multiplexed passive optical network (WDM PON) architecture where the various RRU-to-BBU links are pooled through virtual point-to-point connections at different wavelengths
The dose makes the poison: A case report of acquired methemoglobinemia
Background: Methemoglobinemia (MET) should be suspected in cases where cyanosis is not associated with signs and symptoms of lung and/or heart disease, or in a cyanotic child exhibiting discrepancies in the partial pressure of oxygen in the arterial blood, the blood oxygen saturation, and the clinical assessment. Case presentation: A 10-month-old girl was taken to the Pediatric Emergency Department for the acute, sudden development of significant peroral cyanosis associated with gray pigmentation of the skin. The problem was evidenced approximately one hour after she ingested a homemade puree of mixed vegetables, mainly composed of potatoes and chards that had been prepared three days before and had been kept in the refrigerator since then. Physical examination revealed that the child was very pale, conscious, and without respiratory distress. Oxygen saturation of hemoglobin in the arterial blood (SpO2) was 94%. Respiratory, cardiovascular, and abdominal evaluations did not reveal any signs of disease. A venous blood sample showed chocolate-colored blood with a pH of 7.404, a partial pressure of CO2 (pCO2) of 40.6 mmHg, a partial pressure of oxygen (pO2) of 21.3 mmHg, a bicarbonate level of 24 mmol/L, and an oxygen saturation (SO2%) of 47.7%. CO-oximetry carried out simultaneously identified a methemoglobin level of 22%. MET was suspected, and oxygen via nasal cannula at a rate of 4 L/min was given with only a slight increase in oxygen saturation (96%). Slow intravenous injection of methylene blue 1 mg/kg over a period of 5 minutes was initiated. The peripheral oxygen saturation (SpO2) gradually improved to 100% over the next 20 minutes. Forty minutes later, venous blood gas analysis showed a methemoglobin level of 0.9% with a complete resolution of cyanosis; supplemental oxygen via nasal cannula was therefore discontinued. During the next 36 hours, the patient remained hemodynamically stable with good oxygenation on room air. Conclusions: This case report shows that recognition of acquired MET in a child with sudden cyanosis onset requires a high index of suspicion. In daily activities, there is a need to pay particular attention when homemade vegetable soups for child alimentation are prepared. The consumption of vegetable soups must occur immediately after preparation. Storage in a refrigerator must last no more than 24 hours and if longer storage is needed, vegetable soups should be frozen
Repetitive Mild Traumatic Brain Injury Impairs Performance in a Rodent Assay of Cognitive Flexibility
Mild traumatic brain injury (mTBI) occurs in almost 80% of the 3 million reported cases of TBI-related emergency department visits each year in the United States. The majority of mTBIs, sometimes classified as concussions, are due to sports-related activities and typically occur repeatedly over the course of an athlete’s career. mTBI symptoms are generally classified as either somatic or neuropsychiatric/cognitive in nature and include impairments in prefrontal cortex mediated functions, including attention, memory, processing speed, reaction times, problem solving, and cognitive flexibility. To date, there remains a major gap in our understanding of the behavioral manifestations, underlying neurobiology, and treatment of mTBI. An even greater gap exists in our understanding of the consequences of repeated mTBI incidents. The goal of the present study was to examine the effects of repetitive mTBI within a rodent assay of cognitive flexibility. Rats were exposed to a series of three closed head injuries (controlled cortical impact model) within a week prior to performing an automated strategy shifting task, which required rats to learn and shift strategies according to changing task demands. Rats initially acquired a visual cue strategy in which a light illuminated above one of two possible levers (left or right) indicated the correct response for reward. Twenty-four hours after initial acquisition, rats again performed the task using the visual cue strategy followed by a series of strategy shifting and reversal learning challenges. Repetitive mTBI reduced throughput scores, a performance index that blends accuracy and response speed, and increased reaction times within the task. These results indicate that performance and task efficiency in an operant test of cognitive flexibility are impaired after repetitive mTBI. As such, this model presents a useful approach for further investigating the behavioral deficits and potential treatment strategies for patients who have experienced multiple mTBI insults
A corresponding states approach to Small-Angle-Scattering for polydisperse ionic colloidal fluids
Approximate scattering functions for polydisperse ionic colloidal fluids are
obtained by a corresponding states approach. This assumes that all pair
correlation functions of a polydisperse fluid are
conformal to those of an appropriate monodisperse binary fluid (reference
system) and can be generated from them by scaling transformations. The
correspondence law extends to ionic fluids a {\it scaling approximation} (SA)
successfully proposed for nonionic colloids in a recent paper. For the
primitive model of charged hard spheres in a continuum solvent, the partial
structure factors of the monodisperse binary reference system are evaluated by
solving the Orstein-Zernike (OZ) integral equations coupled with an approximate
closure. The SA is first tested within the mean spherical approximation (MSA)
closure, which allows analytical solutions. The results are found in good
overall agreement with exact MSA predictions up to relevant polidispersity. The
SA is shown to be an improvement over the ``decoupling approximation'' extended
to the ionic case. The simplicity of the SA scheme allows its application also
when the OZ equations can be solved only numerically. An example is then given
by using the hypernetted chain (HNC) closure. Shortcomings of the SA approach,
its possible use in the analysis of experimental scattering data and other
related points are also briefly addressed.Comment: 29 pages, 7 postscript figures (included), Latex 3.0, uses aps.sty,
to appear in Phys. Rev. E (1999
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