Surges and Si IV bursts in the solar atmosphere. Understanding IRIS and SST observations through RMHD experiments

Surges often appear as a result of the emergence of magnetized plasma from the solar interior. Traditionally, they are observed in chromospheric lines such as H$\alpha$ 6563 \AA and Ca II 8542 \AA. However, whether there is a response to the surge appearance and evolution in the Si IV lines or, in fact, in many other transition region lines has not been studied. In this paper we analyze a simultaneous episode of an H$\alpha$ surge and a Si IV burst that occurred on 2016 September 03 in active region AR12585. To that end, we use coordinated observations from the Interface Region Imaging Spectrograph (IRIS) and the Swedish 1-m Solar Telescope (SST). For the first time, we report emission of Si IV within the surge, finding profiles that are brighter and broader than the average. Furthermore, the brightest Si IV patches within the domain of the surge are located mainly near its footpoints. To understand the relation between the surges and the emission in transition region lines like Si IV, we have carried out 2.5D radiative MHD (RMHD) experiments of magnetic flux emergence episodes using the Bifrost code and including the non-equilibrium ionization of silicon. Through spectral synthesis we explain several features of the observations. We show that the presence of Si IV emission patches within the surge, their location near the surge footpoints and various observed spectral features are a natural consequence of the emergence of magnetized plasma from the interior to the atmosphere and the ensuing reconnection processes.Comment: 13 pages, 8 figures. The Astrophysical Journal (Accepted

Kinematics and Magnetic Properties of a Light Bridge in a Decaying Sunspot

We present the results obtained by analyzing high spatial and spectral resolution data of the solar photosphere acquired by the CRisp Imaging SpectroPolarimeter at the Swedish Solar Telescope on 6 August 2011, relevant to a large sunspot with a light bridge (LB) observed in NOAA AR 11263. These data are complemented by simultaneous Hinode Spectropolarimeter (SP) observation in the Fe I 630.15 nm and 630.25 nm lines. The continuum intensity map shows a discontinuity of the radial distribution of the penumbral filaments in correspondence with the LB, which shows a dark lane (about 0.3" wide and about 8.0" long) along its main axis. The available data were inverted with the Stokes Inversion based on Response functions (SIR) code and physical parameters maps were obtained. The line-of-sight (LOS) velocity of the plasma along the LB derived from the Doppler effect shows motions towards and away from the observer up to 0.6 km/s, which are lower in value than the LOS velocities observed in the neighbouring penumbral filaments. The noteworthy result is that we find motions toward the observer up to 0.6 km/s in the dark lane where the LB is located between two umbral cores, while the LOS velocity motion toward the observer is strongly reduced where the LB is located between an umbral core at one side and penumbral filaments on the other side. Statistically, the LOS velocities correspond to upflows/downflows andcomparing these results with Hinode/SP data, we conclude that the surrounding magnetic field configuration (whether more or less inclined) could have a role in maintaining the conditions for the process of plasma piling up along the dark lane. The results obtained from our study support and confirm outcomes of recent magnetohydro-dynamic simulations showing upflows along the main axis of a LBs

Deciphering the solar coronal heating: Energizing small-scale loops through surface convection

The solar atmosphere is filled with clusters of hot small-scale loops commonly known as Coronal Bright Points (CBPs). These ubiquitous structures stand out in the Sun by their strong X-ray and/or extreme-ultraviolet (EUV) emission for hours to days, which makes them a crucial piece when solving the solar coronal heating puzzle. In addition, they can be the source of coronal jets and small-scale filament eruptions. Here we present a novel 3D numerical model using the Bifrost code that explains the sustained CBP heating for several hours. We find that stochastic photospheric convective motions alone significantly stress the CBP magnetic field topology, leading to important Joule and viscous heating concentrated around the CBP's inner spine at a few megameters above the solar surface. We also detect continuous upflows with faint EUV signal resembling observational dark coronal jets and small-scale eruptions when H$_{\alpha}$ fibrils interact with the reconnection site. We validate our model by comparing simultaneous CBP observations from SDO and SST with observable diagnostics calculated from the numerical results for EUV wavelengths as well as for the H$_{\alpha}$ line using the Multi3D synthesis code. Additionally, we provide synthetic observables to be compared with Hinode, Solar Orbiter, and IRIS. Our results constitute a step forward in the understanding of the many different facets of the solar coronal heating problem.Comment: Accepted in ApJL. 9 pages, 5 figures, 2 movie

Dynamic properties along the neutral line of a delta spot inferred from high-resolution observations

Delta (δ) spots are complex magnetic configurations of sunspots characterized by umbrae of opposite polarity sharing a common penumbra. In order to investigate the fine structure of the region separating the two magnetic polarities of a δ spot, we studied the morphology, the magnetic configuration, and the velocity field in such a region using observations of active region (AR) NOAA 11267 obtained with the CRisp Imaging SpectroPolarimeter (CRISP) at the Swedish Solar Telescope on 2011 August 6. The analysis of CRISP data shows upflows and downflows of ~ ± 3 km s–1 in proximity of the δ spot polarity inversion line (PIL), and horizontal motions along the PIL of the order of ~1 km s–1. The results obtained from the SIR inversion of CRISP data also indicate that the transverse magnetic field in the brighter region separating the two opposite magnetic polarities of the δ spot is tilted about ~45° with respect to the PIL. Solar Dynamics Observatory/Helioseismic and Magnetic Imager observations confirm the presence of motions of ~ ± 3 km s–1 in proximity of the PIL, which were observed to last 15 hr. From the data analyzed, we conclude that the steady, persistent, and subsonic motions observed along the δ spot PIL can be interpreted as being due to Evershed flows occurring in the penumbral filaments that show a curved, wrapped configuration. The fluting of the penumbral filaments and their bending, continuously increased by the approaching motion of the negative umbra toward the positive one, give rise to the complex line-of-sight velocity maps that we observed. © 2014. The American Astronomical Society. All rights reserved

‘McDonald’s Is Good for My Social Life’. Developing Health Promotion Together with Adolescent Girls from Disadvantaged Neighbourhoods in Amsterdam

There is limited knowledge about key factors that enable adolescent girls with a low socioeconomic position (SEP) to adopt a healthy lifestyle. This paper aims to better understand the comp

Mild Coronavirus Disease 2019 (COVID-19) Is Marked by Systemic Oxidative Stress:A Pilot Study

Oxidative stress has been implicated to play a critical role in the pathophysiology of coronavirus disease 2019 (COVID-19) and may therefore be considered as a relevant therapeutic target. Serum free thiols (R-SH, sulfhydryl groups) comprise a robust marker of systemic oxidative stress, since they are readily oxidized by reactive oxygen species (ROS). In this study, serum free thiol concentrations were measured in hospitalized and non-hospitalized patients with COVID-19 and healthy controls and their associations with relevant clinical parameters were examined. Serum free thiol concentrations were measured colorimetrically (Ellman’s method) in 29 non-hospitalized COVID-19 subjects and 30 age-, sex-, and body-mass index (BMI)-matched healthy controls and analyzed for associations with clinical and biochemical disease parameters. Additional free thiol measurements were performed on seven serum samples from COVID-19 subjects who required hospitalization to examine their correlation with disease severity. Non-hospitalized subjects with COVID-19 had significantly lower concentrations of serum free thiols compared to healthy controls (p = 0.014), indicating oxidative stress. Serum free thiols were positively associated with albumin (St. β = 0.710, p < 0.001) and inversely associated with CRP (St. β = −0.434, p = 0.027), and showed significant discriminative ability to differentiate subjects with COVID-19 from healthy controls (AUC = 0.69, p = 0.011), which was slightly higher than the discriminative performance of CRP concentrations regarding COVID-19 diagnosis (AUC = 0.66, p = 0.042). This study concludes that systemic oxidative stress is increased in patients with COVID-19 compared with healthy controls. This opens an avenue of treatment options since free thiols are amenable to therapeutic modulation

Velocities measured in small scale solar magnetic elements

We have obtained high resolution spectrograms of small scale magnetic structures with the Swedish 1-m Solar Telescope. We present Doppler measurements at 0\farcs{2} spatial resolution of bright points, ribbons and flowers and their immediate surroundings, in the C {\small{I}} 5380.3 {\AA} line (formed in the deep photosphere) and the two Fe {\small{I}} lines at 5379.6 {\AA} and 5386.3 {\AA}. The velocity inside the flowers and ribbons are measured to be almost zero, while we observe downflows at the edges. These downflows are increasing with decreasing height. We also analyze realistic magneto-convective simulations to obtain a better understanding of the interpretation of the observed signal. We calculate how the Doppler signal depends on the velocity field in various structures. Both the smearing effect of the non-negligible width of this velocity response function along the line of sight and of the smearing from the telescope and atmospheric point spread function are discussed. These studies lead us to the conclusion that the velocity inside the magnetic elements are really upflow of the order 1--2 km s${}^{-1}$ while the downflows at the edges really are much stronger than observed, of the order 1.5--3.3 km s${}^{-1}$

COMPARE LAAO: Rationale and design of the randomized controlled trial "COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy"

Contains fulltext : 252137.pdf (Publisher’s version ) (Open Access)BACKGROUND: Left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). In patients with a long-term or permanent contraindication for OAC randomized controlled trial (RCT) data is lacking. STUDY OBJECTIVES: To assess the efficacy and safety of LAAO in AF patients who are ineligible to use OAC. The co-primary efficacy endpoint is (1) time to first occurrence of stroke (ischemic, hemorrhagic, or undetermined) and (2) time to first occurrence of the composite of stroke, transient ischemic attack (TIA), and systemic embolism (SE). The primary safety endpoint is the 30-day rate of peri-procedural complications. STUDY DESIGN: This is a multicenter, investigator-initiated, open-label, blinded endpoint (PROBE), superiority-driven RCT. Patients with AF, a CHA₂DS₂-VASc score ≥2 for men and ≥3 for women and a long-term or permanent contraindication for OAC will be randomized in a 2:1 fashion to the device- or control arm. Patients in the device arm will undergo percutaneous LAAO and will receive post-procedural dual antiplatelet therapy (DAPT) per protocol, while those in the control arm will continue their current treatment consisting of no antithrombotic therapy or (D)APT as deemed appropriate by the primary responsible physician. In this endpoint-driven trial design, assuming a 50% lower stroke risk of LAAO compared to conservative treatment, 609 patients will be followed for a minimum of 1 and a maximum of 5 years. Cost-effectiveness and budget impact analyses will be performed to allow decision-making on reimbursement of LAAO for the target population in the Netherlands. SUMMARY: The COMPARE LAAO trial will investigate the clinical superiority in preventing thromboembolic events and cost-effectiveness of LAAO in AF patients with a high thromboembolic risk and a contraindication for OAC use. NCT TRIAL NUMBER: NCT04676880

Numerical study of anharmonic vibrational decay in amorphous and paracrystalline silicon

The anharmonic decay rates of atomic vibrations in amorphous silicon (a-Si) and paracrystalline silicon (p-Si), containing small crystalline grains embedded in a disordered matrix, are calculated using realistic structural models. The models are 1000-atom four-coordinated networks relaxed to a local minimum of the Stillinger-Weber interatomic potential. The vibrational decay rates are calculated numerically by perturbation theory, taking into account cubic anharmonicity as the perturbation. The vibrational lifetimes for a-Si are found to be on picosecond time scales, in agreement with the previous perturbative and classical molecular dynamics calculations on a 216-atom model. The calculated decay rates for p-Si are similar to those of a-Si. No modes in p-Si reside entirely on the crystalline cluster, decoupled from the amorphous matrix. The localized modes with the largest (up to 59%) weight on the cluster decay primarily to two diffusons. The numerical results are discussed in relation to a recent suggestion by van der Voort et al. [Phys. Rev. B {\bf 62}, 8072 (2000)] that long vibrational relaxation inferred experimentally may be due to possible crystalline nanostructures in some types of a-Si.Comment: 9 two-column pages, 13 figure

Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates

Protein drugs play an important role in modern day medicine. Typically, these proteins are formulated as liquids requiring cold chain processing. To circumvent the cold chain and achieve better storage stability, these proteins can be dried in the presence of carbohydrates. We demonstrate that thermal gradient mid- and far-infrared spectroscopy (FTIR and THz-TDS, respectively) can provide useful information about solid-state protein carbohydrate formulations regarding mobility and intermolecular interactions. A model protein (BSA) was lyophilized in the presence of three carbohydrates with different size and protein stabilizing capacity. A gradual increase in mobility was observed with increasing temperature in formulations containing protein and/or larger carbohydrates (oligo- or polysaccharides), lacking a clear onset of fast mobility as was observed for smaller molecules. Furthermore, both techniques are able to identify the glass transition temperatures (T-g) of the samples. FTIR provides additional information as it can independently monitor changes in protein and carbohydrate bands at the T-g. Lastly, THz-TDS confirms previous findings that protein-carbohydrate interactions decrease with increasing molecular weight of the carbohydrate, which results in decreased protein stabilization